LOCUS       NM_026057               3187 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger protein 422 (Zfp422), transcript variant
            1, mRNA.
ACCESSION   NM_026057
VERSION     NM_026057.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3187)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3187)
  AUTHORS   Nie,Y., Cai,S., Yuan,R., Ding,S., Zhang,X., Chen,L., Chen,Y. and
            Mo,D.
  TITLE     Zfp422 promotes skeletal muscle differentiation by regulating EphA7
            to induce appropriate myoblast apoptosis
  JOURNAL   Cell Death Differ 27 (5), 1644-1659 (2020)
   PUBMED   31685980
  REMARK    GeneRIF: Zfp422 promotes skeletal muscle differentiation by
            regulating EphA7 to induce appropriate myoblast apoptosis.
REFERENCE   3  (bases 1 to 3187)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 3187)
  AUTHORS   Kim,S.M., Lee,J.H., Jabaiti,S., Lee,S.K. and Choi,J.Y.
  TITLE     Tbx22 expressions during palatal development in fetuses with
            glucocorticoid-/alcohol-induced C57BL/6N cleft palates
  JOURNAL   J Craniofac Surg 20 (5), 1316-1326 (2009)
   PUBMED   19816249
REFERENCE   5  (bases 1 to 3187)
  AUTHORS   Lee,S.K., Kim,Y.S., Lee,S.S., Lee,Y.J., Song,I.S., Park,S.C.,
            Kozak,C. and Yamada,Y.
  TITLE     Molecular cloning, chromosomal mapping, and characteristic
            expression in tooth organ of rat and mouse Krox-25
  JOURNAL   Genomics 83 (2), 243-253 (2004)
   PUBMED   14706453
  REMARK    GeneRIF: analysis revealed an intense expression of Krox-25 mRNA in
            rat and mouse teeth; results suggest that Krox-25 plays an
            important role as a transcription factor for the
            cytodifferentiation and amelogenesis of enamel epithelium.
REFERENCE   6  (bases 1 to 3187)
  AUTHORS   Gao,Y., Kobayashi,H. and Ganss,B.
  TITLE     The human KROX-26/ZNF22 gene is expressed at sites of tooth
            formation and maps to the locus for permanent tooth agenesis
            (He-Zhao deficiency)
  JOURNAL   J Dent Res 82 (12), 1002-1007 (2003)
   PUBMED   14630903
  REMARK    GeneRIF: human gene locus mapping assoicated with permanent tooth
            agenesis
REFERENCE   7  (bases 1 to 3187)
  AUTHORS   Teo,W., Chen,H., Poon,T. and Ganss,B.
  TITLE     Developmental expression pattern and DNA-binding properties of the
            zinc finger transcription factor Krox-26
  JOURNAL   Connect Tissue Res 44 Suppl 1, 161-166 (2003)
   PUBMED   12952191
REFERENCE   8  (bases 1 to 3187)
  AUTHORS   Ganss,B., Teo,W., Chen,H. and Poon,T.
  TITLE     Krox-26 is a novel C2H2 zinc finger transcription factor expressed
            in developing dental and osteogenic tissues
  JOURNAL   Connect Tissue Res 43 (2-3), 161-166 (2002)
   PUBMED   12489153
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY082381.1, AK082970.1,
            AK169251.1 and AK152681.1.
            
            On Oct 22, 2014 this sequence version replaced NM_026057.2.
            
            Summary: This gene encodes a putative C2H2 zinc finger
            transcription factor that may play a role in tooth development. A
            pseudogene related to this gene is located on chromosome 17.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849388,
                              SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY082381.1         2-23
            23-1015             AK082970.1         2-994
            1016-1661           AK169251.1         1241-1886
            1662-1816           AK152681.1         1625-1779
            1817-3187           AK082970.1         1796-3166
FEATURES             Location/Qualifiers
     source          1..3187
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 53.83 cM"
     gene            1..3187
                     /gene="Zfp422"
                     /gene_synonym="2900028O21Rik; KOX15; Krox-25-2; Krox-26;
                     Krox25; Krox26; Znf22"
                     /note="zinc finger protein 422"
                     /db_xref="GeneID:67255"
                     /db_xref="MGI:MGI:1914505"
     exon            1..69
                     /gene="Zfp422"
                     /gene_synonym="2900028O21Rik; KOX15; Krox-25-2; Krox-26;
                     Krox25; Krox26; Znf22"
                     /inference="alignment:Splign:2.1.0"
     exon            70..3187
                     /gene="Zfp422"
                     /gene_synonym="2900028O21Rik; KOX15; Krox-25-2; Krox-26;
                     Krox25; Krox26; Znf22"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..880
                     /gene="Zfp422"
                     /gene_synonym="2900028O21Rik; KOX15; Krox-25-2; Krox-26;
                     Krox25; Krox26; Znf22"
                     /note="Kruppel type zinc finger protein Krox26; zinc
                     finger protein Krox-25; zinc finger protein Krox-26"
                     /codon_start=1
                     /product="zinc finger protein 22"
                     /protein_id="NP_080333.1"
                     /db_xref="CCDS:CCDS20459.1"
                     /db_xref="GeneID:67255"
                     /db_xref="MGI:MGI:1914505"
                     /translation="MRLGKPKGGISRSASQGKAYESKRKTARQRQKWGVAIRFDSGLS
                     RRRRNVDEKPYKCAKCSKSFSQSSTLFQHKKIHTGKKSHKCADCGKSFFQSSNLIQHR
                     RIHTGEKPYKCDECGERFKQSSNLIQHQRIHTGEKPYCCDECGRCFSQSSHLIQHQRT
                     HTGEKPYQCEECDKCFSQSSHLRQHMKVHKEKKPHKRGKNARVKTHPVSWKRGKGRKA
                     VAGIRQVKGATSGLFKKKK"
     regulatory      2259..2264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp422"
                     /gene_synonym="2900028O21Rik; KOX15; Krox-25-2; Krox-26;
                     Krox25; Krox26; Znf22"
                     /note="hexamer: AATAAA"
     polyA_site      2284
                     /gene="Zfp422"
                     /gene_synonym="2900028O21Rik; KOX15; Krox-25-2; Krox-26;
                     Krox25; Krox26; Znf22"
                     /note="major polyA site"
     regulatory      3136..3141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp422"
                     /gene_synonym="2900028O21Rik; KOX15; Krox-25-2; Krox-26;
                     Krox25; Krox26; Znf22"
                     /note="hexamer: AATAAA"
     polyA_site      3155
                     /gene="Zfp422"
                     /gene_synonym="2900028O21Rik; KOX15; Krox-25-2; Krox-26;
                     Krox25; Krox26; Znf22"
ORIGIN      
        1 agctccgcgg ctagcagccc gcacttccgg cgggcgaggc gcgaggcggg caccgtggcg
       61 gcctgcgcga agggaattcc gagttgcgtc actctaggat atgagacctt agttcagaag
      121 ttcagaagac agtaggatct cttgccgaca catttgccta ctcaccatga ggttaggaaa
      181 gcccaaaggg ggtatttctc gaagcgccag ccaaggaaaa gcctatgaga gcaagcgcaa
      241 gacagcccgc cagcgacaga aatggggggt ggccattcgc ttcgactcgg gcttgagtcg
      301 acggagaagg aacgtggacg agaagcctta caagtgtgct aaatgctcca agagtttcag
      361 tcagagctcc acgctctttc agcacaagaa gatccatact gggaagaaat cccataaatg
      421 tgccgattgt gggaaaagtt tctttcagag ttctaacctc atccagcacc ggcggatcca
      481 cacgggggaa aagccctata agtgtgacga gtgtggagag agattcaagc agagctccaa
      541 tctcatccag caccagagga tccacaccgg cgagaagccc tactgctgtg atgagtgtgg
      601 ccggtgcttt agccagagtt cccacctcat tcagcaccag agaacccaca ccggagagaa
      661 gccctaccag tgtgaggagt gtgacaagtg cttcagccag agctcccatc tgaggcagca
      721 catgaaggtg cacaaagaaa agaagccaca taagaggggc aaaaatgcca gggtgaaaac
      781 tcacccggtg tcctggaaaa ggggcaaagg gaggaaggcg gtggctggga tccgccaggt
      841 aaagggagcc acttccggcc tttttaaaaa gaagaagtga aaggtagagg agaaagccgc
      901 tccgaagagt ggatgcttta cagtagagca cttagatacc gctcctccct agcatggaga
      961 cttcaggagt ttcatgacag tgcgctgaaa ctctgagtct agctgccctc atttccttta
     1021 aaaataaata aatttatgtg acatggagca gaaagaactg aaacaatagt ttggtaagaa
     1081 tttaatattc ttagcctcag ttgaaatcgc ttccctccat tttgataaaa agaatcatgt
     1141 tttcatgatc cactggcgtg ccaatgatta ctcttatttt tcggaatttc tgtatacgaa
     1201 atcattaaag aaagaaggaa tgggttttca gattctagga tcgactacat tttatgtttt
     1261 taatgttttg tagtttatta accattagta tcagcattga ctcagtattt gacatagtaa
     1321 aatgcattca gattcataga ttttggtttt tattagtgta tattgtacga agtaatgagc
     1381 ttccttttct ccaatgtgta tgaggtatct gtatgatgtg ctttgctcac acccaccgtt
     1441 accctcgccc acctcctcct ggttctcctt ttatcccaga gagttcccct ccacttaaaa
     1501 tgttgcccct agcgtctgtg aatgacagac agtgtgtttg gttatttttc tgcatccact
     1561 ttcctgtgcc tactgtaatg ttctctagtt caatccattc tccaagcaac aggactgtgg
     1621 cttttctttt tcgtctcaca gtctattgta gtgtttgaag gctttagcga caacccgctt
     1681 ttgtttgttt ctttccttct gctatgttag taaagggtga gaaggtctcc atgtggcttt
     1741 tcttttgttt ttgtactttt ttgtttctta ccatattctt agagatgtaa aggaatccaa
     1801 agtgagaaac tgcagacctc ctgctcctga ccgcacttct tgagatgctg atgctgtcac
     1861 tgctctgtca cttgctttct tgaaatggga atggtttgtg ttgaatcatg ccagtggcct
     1921 cacagcgtct acatgaataa actctgttac caggaaacct cgacttactt ccggctgaag
     1981 aactacaatg tcatagactg agctttgaat accaccgact atctaaaaca gatgtttatc
     2041 tacaagttac tggccagcac actgtagccc tgttagaact taactttttt tcttttttac
     2101 tttctagcaa ttgtttaaga agactagcat acatccttct tccaatgcca agcatatgtt
     2161 cctgatcagc cttcagttca tttttgttta ttgaatgcta atgttttctg atttttataa
     2221 tatcagttct tcctgtatta atgacaatta tccttaaaaa taaagattaa gatattttcg
     2281 catactacta tctattttac ttctgggaaa ttgtttgcag tgagttaaaa aactggtcac
     2341 agctttcagg agacttgttc tgctctttgt gatttttctc agatctgaac tttacctccc
     2401 tcctacaacc accaccaccc caccacccac gttttaatgg agagccatag cgtgtggcct
     2461 attgacaata gttacatcca acagagtatc caaagtgtct tataaggcta ttgcagacat
     2521 ctgttatgaa agacttgatc cttgacatcc tgttgtagcc aaatctctat agcagggatg
     2581 catccatgag gccctagtga gcatgtgtca gtctctgatt tgtgtgagat agcttcttgg
     2641 agaggaggag gggacacagg actaatccca ttttcttaag tcctgtgaat tgcccattct
     2701 ggtgacaacc acagtaaggc ctctctagta gttttgatag cttgcactct tatctaatag
     2761 atccacctgt gtttcttatt aaaatagaac acattcttca ggttttttgt ttgtttgttt
     2821 gtttgggttt ttttgttttt ttttttttgt tttttttgtt tttttttttt gagacagggt
     2881 ttctctgtat agccctggct gtcctggaac tcactttgta gaacaagctg gcctcgaact
     2941 cagaaatcca cctgtctctg cctcccaagt gctgggatta aaggcgtgtg ccaccaccac
     3001 acggccattc ttcaggtttt aatgtttgtt ttgtatgtgt tctgaaaacc tggaggctga
     3061 caggcatcaa agacactgat ctgtgggagg cttctatggt gaccagtgta ctttgtgttc
     3121 cattttagaa acgtcaataa aactcagaga tcgatcacaa gtgtataaaa ttaataaata
     3181 tactgtt
//
