LOCUS       NM_001372420            3319 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus zinc finger protein 384 (Zfp384), transcript variant
            4, mRNA.
ACCESSION   NM_001372420 XM_006506199
VERSION     NM_001372420.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3319)
  AUTHORS   Atkinson EG, Adaway M, Horan DJ, Korff C, Klunk A, Orr AL, Ratz K,
            Bellido T, Plotkin LI, Robling AG and Bidwell JP.
  TITLE     Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells
            Enhances PTH-Induced Bone Formation
  JOURNAL   J Bone Miner Res 38 (1), 70-85 (2023)
   PUBMED   36321253
  REMARK    GeneRIF: Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor
            Cells Enhances PTH-Induced Bone Formation.
REFERENCE   2  (bases 1 to 3319)
  AUTHORS   Dickerson KM, Qu C, Gao Q, Iacobucci I, Gu Z, Yoshihara H, Backhaus
            EA, Chang Y, Janke LJ, Xu B, Wu G, Papachristou EK, D'Santos CS,
            Roberts KG and Mullighan CG.
  TITLE     ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute
            Leukemia
  JOURNAL   Blood Cancer Discov 3 (3), 240-263 (2022)
   PUBMED   35247902
REFERENCE   3  (bases 1 to 3319)
  AUTHORS   Yang S, Adaway M, Du J, Huang S, Sun J, Bidwell JP and Zhou B.
  TITLE     NMP4 regulates the innate immune response to influenza A virus
            infection
  JOURNAL   Mucosal Immunol 14 (1), 209-218 (2021)
   PUBMED   32152414
  REMARK    GeneRIF: NMP4 regulates the innate immune response to influenza A
            virus infection.
REFERENCE   4  (bases 1 to 3319)
  AUTHORS   Shao Y, Wichern E, Childress PJ, Adaway M, Misra J, Klunk A, Burr
            DB, Wek RC, Mosley AL, Liu Y, Robling AG, Brustovetsky N, Hamilton
            J, Jacobs K, Vashishth D, Stayrook KR, Allen MR, Wallace JM and
            Bidwell JP.
  TITLE     Loss of Nmp4 optimizes osteogenic metabolism and secretion to
            enhance bone quality
  JOURNAL   Am J Physiol Endocrinol Metab 316 (5), E749-E772 (2019)
   PUBMED   30645175
  REMARK    GeneRIF: loss of Nmp4 increases the magnitude of glycolysis upon
            the metabolic switch, which fuels the conversion of the osteoblast
            into a super-secretor of matrix resulting in more bone with
            improvements in intrinsic quality.
REFERENCE   5  (bases 1 to 3319)
  AUTHORS   Shao Y, Hernandez-Buquer S, Childress P, Stayrook KR, Alvarez MB,
            Davis H, Plotkin LI, He Y, Condon KW, Burr DB, Warden SJ, Robling
            AG, Yang FC, Wek RC, Allen MR and Bidwell JP.
  TITLE     Improving Combination Osteoporosis Therapy in a Preclinical Model
            of Heightened Osteoanabolism
  JOURNAL   Endocrinology 158 (9), 2722-2740 (2017)
   PUBMED   28637206
  REMARK    GeneRIF: The heightened osteoanabolism of the Nmp4-/- skeleton
            enhances the effectiveness of diverse osteoporosis treatments, in
            part by increasing hyperanabolic osteoprogenitors. Nmp4 provides a
            promising target pathway for identifying barriers to
            pharmacologically induced bone formation.
REFERENCE   6  (bases 1 to 3319)
  AUTHORS   Corveleyn A, Janssen H, Martini A, Somers R, Cools J and Marynen P.
  TITLE     Cellular transformation of NIH3T3 fibroblasts by CIZ/NMP4 fusions
  JOURNAL   J Cell Biochem 94 (6), 1112-1125 (2005)
   PUBMED   15669012
  REMARK    GeneRIF: transformation of 3T3 fibroblasts by CIZ/NMP4 fusions is
            dependent on DNA-binding and might involve transactivation of CIZ
            target genes
REFERENCE   7  (bases 1 to 3319)
  AUTHORS   Alvarez M, Shah R, Rhodes SJ and Bidwell JP.
  TITLE     Two promoters control the mouse Nmp4/CIZ transcription factor gene
  JOURNAL   Gene 347 (1), 43-54 (2005)
   PUBMED   15716059
  REMARK    GeneRIF: Two adjacent promoters of Nmp4 P(1) [-2521 nucleotide
            (nt)/-597 nt] and P(2) (-2521 nt/+1 nt) initiate transcription of
            alternative first exons (U(1) and U(2)).
REFERENCE   8  (bases 1 to 3319)
  AUTHORS   Nakamoto T, Shiratsuchi A, Oda H, Inoue K, Matsumura T, Ichikawa M,
            Saito T, Seo S, Maki K, Asai T, Suzuki T, Hangaishi A, Yamagata T,
            Aizawa S, Noda M, Nakanishi Y and Hirai H.
  TITLE     Impaired spermatogenesis and male fertility defects in
            CIZ/Nmp4-disrupted mice
  JOURNAL   Genes Cells 9 (6), 575-589 (2004)
   PUBMED   15189450
  REMARK    GeneRIF: Impaired spermatogenesis and male infertility occurred in
            Nmp4-disrupted mice.
REFERENCE   9  (bases 1 to 3319)
  AUTHORS   Torrungruang K, Shah R, Alvarez M, Bowen DK, Gerard R, Pavalko FM,
            Elmendorf JS, Charoonpatrapong K, Hock J, Rhodes SJ and Bidwell JP.
  TITLE     Osteoblast intracellular localization of Nmp4 proteins
  JOURNAL   Bone 30 (6), 931-936 (2002)
   PUBMED   12052465
  REMARK    GeneRIF: localization in the cytoplasm of osteoblasts
REFERENCE   10 (bases 1 to 3319)
  AUTHORS   Alvarez MB, Thunyakitpisal P, Rhodes SJ, Everett ET and Bidwell JP.
  TITLE     Assignment of Nmp4 to mouse chromosome 6 band F1 flanked by
            D6Mit134 and D6Mit255 using radiation hybrid mapping and
            fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 94 (3-4), 244-245 (2001)
   PUBMED   11856889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164563.4 and AC134529.6.
            
            On Aug 30, 2019 this sequence version replaced XM_006506199.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662772.1641814.1,
                                           SRR7345562.4720417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               AC164563.4         185501-185762
            263-322             AC164563.4         186644-186703
            323-393             AC164563.4         199942-200012
            394-631             AC164563.4         200296-200533
            632-679             AC164563.4         200768-200815
            680-1016            AC164563.4         201009-201345
            1017-1109           AC164563.4         202111-202203
            1110-1334           AC134529.6         74825-75049
            1335-1517           AC134529.6         75698-75880
            1518-1596           AC134529.6         77267-77345
            1597-1755           AC134529.6         79740-79898
            1756-3319           AC134529.6         80333-81896
FEATURES             Location/Qualifiers
     source          1..3319
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..3319
                     /gene="Zfp384"
                     /gene_synonym="C130073D16Rik; Ciz; Nmp4; NP"
                     /note="zinc finger protein 384"
                     /db_xref="GeneID:269800"
                     /db_xref="MGI:MGI:2443203"
     exon            1..262
                     /gene="Zfp384"
                     /gene_synonym="C130073D16Rik; Ciz; Nmp4; NP"
                     /inference="alignment:Splign:2.1.0"
     exon            263..322
                     /gene="Zfp384"
                     /gene_synonym="C130073D16Rik; Ciz; Nmp4; NP"
                     /inference="alignment:Splign:2.1.0"
     exon            323..393
                     /gene="Zfp384"
                     /gene_synonym="C130073D16Rik; Ciz; Nmp4; NP"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..2175
                     /gene="Zfp384"
                     /gene_synonym="C130073D16Rik; Ciz; Nmp4; NP"
                     /note="isoform 4 is encoded by transcript variant 4;
                     nuclear matrix protein 4"
                     /codon_start=1
                     /product="zinc finger protein 384 isoform 4"
                     /protein_id="NP_001359349.1"
                     /db_xref="GeneID:269800"
                     /db_xref="MGI:MGI:2443203"
                     /translation="MEESHFNSNPYFWPSIPTVSGQIENTMFINKMKDQLLPEKGCGL
                     APPHYPTLLTVPASVSLSSGISMDTESKSEQLTPHSQASVTQNITVVPVPSTGLMTAG
                     VSCSQRWRREGSQSRGPGLVITSPSGSLVTTASAAQTFPISAPMIVSALPPGSQALQV
                     VPDLSKKVASTLTEEGGGGGGGGGTVAPPKPPRGRKKKRMLESGLPEMNDPYVLAPGD
                     DDDHQKDGKTYRSEGNCGTGNGQSLGLMDSVPGSTTNLLCDPGCRMCSLTFYSKSEMQ
                     IHSKSHTETKPHKCPHCSKTFANSSYLAQHIRIHSGAKPYSCNFCEKSFRQLSHLQQH
                     TRIHSKMHTETIKPHKCPHCSKTFANTSYLAQHLRIHSGAKPYNCSYCQKAFRQLSHL
                     QQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDKPFKCHNCHRAYTDAASL
                     EAHLSTHTVKHAKVYTCTICSRAYTSETYLMKHMRKHNPPDLQQQVQAAAAAAAVAQA
                     QAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQPPPQPPHFQSPGAAP
                     QGGGGGDSNPNPPPQCSFDLTPYKPAEHHKDICLTVTTSTIQVEHLASS"
     exon            394..631
                     /gene="Zfp384"
                     /gene_synonym="C130073D16Rik; Ciz; Nmp4; NP"
                     /inference="alignment:Splign:2.1.0"
     exon            632..679
                     /gene="Zfp384"
                     /gene_synonym="C130073D16Rik; Ciz; Nmp4; NP"
                     /inference="alignment:Splign:2.1.0"
     exon            680..1016
                     /gene="Zfp384"
                     /gene_synonym="C130073D16Rik; Ciz; Nmp4; NP"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1109
                     /gene="Zfp384"
                     /gene_synonym="C130073D16Rik; Ciz; Nmp4; NP"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1334
                     /gene="Zfp384"
                     /gene_synonym="C130073D16Rik; Ciz; Nmp4; NP"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1517
                     /gene="Zfp384"
                     /gene_synonym="C130073D16Rik; Ciz; Nmp4; NP"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1596
                     /gene="Zfp384"
                     /gene_synonym="C130073D16Rik; Ciz; Nmp4; NP"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1755
                     /gene="Zfp384"
                     /gene_synonym="C130073D16Rik; Ciz; Nmp4; NP"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..3319
                     /gene="Zfp384"
                     /gene_synonym="C130073D16Rik; Ciz; Nmp4; NP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttccgggt gagtgtccag gagggcgggg gcccccccac acctcgcctc gcgcccccgc
       61 cctgcgggtg tctcgcgcgc cgcccggccg agcgtcgggg tccgtctggc gcctgcggtg
      121 catgccggcg agccccgcct cgcggttccg agcccgcgcc ccgcgggtcc tcccgctccc
      181 tcggctcctt ccttccccgg tgaccgccgc ccctcccgcg cgctggctct ggcgctggcg
      241 tcgccgccgc cgccgccgcc tgaaagttca ggagccctgg aaaggagaag gaataagacg
      301 acaggaggaa gagagagaga gggtagaatg gaagagtctc acttcaattc taacccgtac
      361 ttctggcctt ctatccccac agtctcaggg cagattgaaa acactatgtt catcaacaag
      421 atgaaggatc agctgttgcc agagaagggc tgtggactgg cgccacctca ctatcccact
      481 ttgctaactg tccctgcctc agtgtccctg tcctctggca tcagcatgga cacagagtcc
      541 aagtcagaac agctgacccc acacagtcag gcatctgtta cccagaatat cacagtggtt
      601 cctgtaccat ctacaggact catgactgcg ggagtctcct gttctcagag gtggagaaga
      661 gaagggagtc aatcaagggg tcctggtttg gtaatcacat ccccgtcagg ctctcttgtg
      721 accacagcct ccgcagctca gactttccct atttcggctc ccatgattgt ctcagctctt
      781 cccccgggct cgcaagccct acaggtggtc cctgacctct ccaagaaggt agcgtcaacc
      841 ctaactgagg aaggaggcgg aggtggtggt ggaggtggca ctgtggctcc tcctaaacct
      901 cctcggggcc gcaagaagaa gcggatgctg gagtcagggc ttcctgagat gaatgaccct
      961 tacgtccttg cccctgggga tgacgatgac catcagaaag atggcaagac ctacaggagc
     1021 gaagggaact gcggcacagg aaatggacag agccttgggc tcatggattc agttcccggc
     1081 tccaccacga acttgctgtg tgaccctggg tgccggatgt gctccctgac cttctactcc
     1141 aagtcggaga tgcagatcca ctccaagtca cacaccgaga ccaagcccca caagtgcccg
     1201 cactgctcca agaccttcgc caacagctcc tacctggccc agcacatccg gatccactca
     1261 ggggccaagc cctatagttg taacttctgt gagaaatcct tccgccagct ctcacatctg
     1321 cagcagcaca cccggattca ctccaagatg cacacggaga ccatcaagcc ccacaagtgc
     1381 ccgcactgct ccaagacctt cgccaacacc tcctacctgg ctcagcacct ccgtatccac
     1441 tcaggggcca agccctacaa ctgctcctac tgccagaagg ccttccgcca gctctcccac
     1501 ctccagcagc acacacgaat ccacactggt gatagaccat acaaatgtgc acacccgggc
     1561 tgtgagaagg ctttcacaca actctccaat ctgcagtctc acagacggca gcacaacaaa
     1621 gataaaccct tcaagtgcca caactgtcac cgagcatata cagacgcagc ctctctcgag
     1681 gctcacttat ctacacacac agtgaaacac gccaaggttt atacctgcac aatctgcagt
     1741 cgggcatata catcagaaac ataccttatg aaacatatgc gcaaacacaa ccctcctgat
     1801 cttcaacagc aagtgcaagc agcggcagca gcagcagcgg tggcccaggc ccaggcccag
     1861 gctcaggccc aagctcaagc ccaggcccaa gctcaagccc aggcccaagc tcaagcccag
     1921 gcccaggccc aggcccaggc ccaggcttca caggcgtcac agcagcagca gcagcagcag
     1981 ccaccgccac aaccaccaca cttccagtcc cctggggcag ctccccaggg agggggtggt
     2041 ggggacagca acccgaaccc tccaccccag tgttcctttg acttgacccc ctataagccg
     2101 gcagagcatc ataaagacat ctgcctcact gtcaccacca gcaccatcca ggtggagcac
     2161 ctggccagct cttagagatc cgtactgcca tccatcggaa cggggagaag tcctggtccc
     2221 tcctttgtca actcttcttg gtgggaaagt tctcttcttc cttgacaagt cctgtctcca
     2281 gctccttggg tctcaggcat ggcttttctt cgcaagataa ccatccttat tctcagctgc
     2341 tcctgattgg ccaaggaatc ctgagctgat agtgttatcc aacagccccc atccaggcag
     2401 agcttttaaa actggggctt ggtgcttgag agaaggatcc gctgggagct cacacatctt
     2461 atccagtgtg gggcgcttac ctttctctct cttcatcctc aaagttgagg ttgatggaag
     2521 actagtggct ggccctccca gataacagag aaggaagctc taaatgccac cagccttccg
     2581 ttctatgctt acctgtaaaa gaacagattt tgcacgtggc ctgacccctg tgagccattt
     2641 tcttcccctt ccgtggtctc actttatatt gggtgatgac tatacctttt tatttgtaag
     2701 ggggcaatag ctgattcatg gttgccaagg tgccagagat tccccggtga ccaagggtgg
     2761 cttaagagta tgagttattt ttccttaaca gcctccttcc ttctctgcca accaagggcc
     2821 tatatactca gtctcgctat cccagtccaa ggagctctgg gagctgtggt agctgtgttc
     2881 tctgcaatac cattcggtct tttgcagaga agggagaatt cagggcacac acaggactgg
     2941 acttagcctc cctaggtgcc acggtcagat gccggacatg gatttatata taaatatata
     3001 tatataaata tatatatata tacctgctca tcacggccat ctttgttgta accatttctg
     3061 tgtttataaa tgcattatct ctgagaattt tcatattgat gttttatttt tgtcttattt
     3121 ttttttctcc accttgtcct ctggccatgg cattttaatt ttcttttgac ttttaatttt
     3181 tttaatcatg ggagatttca gataaaataa tcaggaatta tacagttgtt ataaagcaat
     3241 ttaaaaatga aaatcttatg tacaaactaa ggggtgtttt tagaccattg tatagaaata
     3301 aattcatgtt taaggatga
//
