LOCUS       NP_001074476             579 aa            linear   ROD 03-APR-2024
DEFINITION  zinc finger protein 382 isoform 1 [Mus musculus].
ACCESSION   NP_001074476 XP_001000443
VERSION     NP_001074476.1
DBSOURCE    REFSEQ: accession NM_001081007.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 579)
  AUTHORS   Ma,L., Yu,L., Jiang,B.C., Wang,J., Guo,X., Huang,Y., Ren,J.,
            Sun,N., Gao,D.S., Ding,H., Lu,J., Zhou,H., Zou,L., Gao,Y., Wang,L.,
            Sun,K., Ming,Y., Meng,Z., Tao,Y.X. and Yan,M.
  TITLE     ZNF382 controls mouse neuropathic pain via silencer-based
            epigenetic inhibition of Cxcl13 in DRG neurons
  JOURNAL   J Exp Med 218 (12) (2021)
   PUBMED   34762123
  REMARK    GeneRIF: ZNF382 controls mouse neuropathic pain via silencer-based
            epigenetic inhibition of Cxcl13 in DRG neurons.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164703.3.
            
            On Feb 6, 2007 this sequence version replaced XP_001000443.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.59896.1,
                                           SRR1660821.68555.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     Protein         1..579
                     /product="zinc finger protein 382 isoform 1"
                     /note="KRAB/zinc finger suppressor protein 1; multiple
                     zinc finger and krueppel-associated box protein KS1"
                     /calculated_mol_wt=66416
     Region          1..37
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RXC5.1)"
     Region          12..135
                     /region_name="Mediates interaction with TRIM28.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RXC5.1)"
     Region          40..81
                     /region_name="Represses transcription.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RXC5.1)"
     Region          42..102
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          105..240
                     /region_name="Represses transcription.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RXC5.1)"
     Region          303..319
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          325..579
                     /region_name="Required for transcriptional repression
                     activity, probably mediates sequence-specific DNA-binding.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RXC5.1)"
     Region          325..347
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          327..347
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          355..375
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          383..403
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <411..562
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          411..431
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(416,418,420,422..423,426..427,430,444,446,450..451,
                     454..455,458,472,474,476,478..479,482..483,486)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          439..459
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          467..487
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          495..515
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          523..543
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          551..571
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..579
                     /gene="Zfp382"
                     /gene_synonym="4930428B01Rik; 5930415A09Rik; KS1; Znf382"
                     /coded_by="NM_001081007.2:103..1842"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39877.1"
                     /db_xref="GeneID:233060"
                     /db_xref="MGI:MGI:3588204"
ORIGIN      
        1 mgrpgrkprg rarpglfpfp keelrqggss panlnamskg pvsfkdvtvd ftqeewqrld
       61 paqkalyrdv mlenychfis vgfhitkpdm irkleqgeel wterifpsqs yleeeevlvk
      121 fsdyqdkppk siviikhkkl ikerssvyge algknrvvsk tlfeyksdgk vlknisefis
      181 rdinpamgkl ggskewegsi ltskqekthp asilhkqigr alssewdlaq hqktqipeqr
      241 feynkcdssf lmtgvefphg rahrgggnfn yskdditlfe ksdlgihphd lmekkcssyn
      301 kygellcrks vfvmhpssqm derpfqcpyc gnsfrrksyl ieherihtge kpyiccqcgr
      361 afrqktaltl hekthtegkp ylcvdcgksf rqkatltrhh kahtgekaye ctqcgsafgk
      421 ksylidhqrt htgekpyqct ecgkafiqkt tltvhqrtht gekpyicsec gksfcqkttl
      481 tlhqrihtge kpyicsdcgk sfrqkailtv hyrihtgeks ngcpqcgkaf srksnlirhq
      541 kihtgekpye cqecgkffsc ksnlithqkt hktetmrfq
//
