LOCUS       NM_001004149            2788 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus zinc finger protein 366 (Zfp366), mRNA.
ACCESSION   NM_001004149 XM_138810
VERSION     NM_001004149.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2788)
  AUTHORS   Zhang,S., Coughlan,H.D., Ashayeripanah,M., Seizova,S., Kueh,A.J.,
            Brown,D.V., Cao,W., Jacquelot,N., D'Amico,A., Lew,A.M., Zhan,Y.,
            Tonkin,C.J., Villadangos,J.A., Smyth,G.K., Chopin,M. and Nutt,S.L.
  TITLE     Type 1 conventional dendritic cell fate and function are controlled
            by DC-SCRIPT
  JOURNAL   Sci Immunol 6 (58) (2021)
   PUBMED   33811060
  REMARK    GeneRIF: Type 1 conventional dendritic cell fate and function are
            controlled by DC-SCRIPT.
REFERENCE   2  (bases 1 to 2788)
  AUTHORS   Tang,C., van den Bijgaart,R.J.E., Looman,M.W.G., Triantis,V.,
            Norskov Sondergaard,J., Ansems,M. and Adema,G.J.
  TITLE     DC-SCRIPT affects mammary organoids branching morphogenesis by
            modulating the FGFR1-pERK signaling axis
  JOURNAL   Dev Biol 463 (2), 101-109 (2020)
   PUBMED   32422143
  REMARK    GeneRIF: DC-SCRIPT affects mammary organoids branching
            morphogenesis by modulating the FGFR1-pERK signaling axis.
REFERENCE   3  (bases 1 to 2788)
  AUTHORS   Tang,C., van den Bijgaart,R.J.E., Looman,M.W.G., Tel-Karthaus,N.,
            de Graaf,A.M.A., Gilfillan,S., Colonna,M., Ansems,M. and Adema,G.J.
  TITLE     DC-SCRIPT deficiency delays mouse mammary gland development and
            branching morphogenesis
  JOURNAL   Dev Biol 455 (1), 42-50 (2019)
   PUBMED   31265831
  REMARK    GeneRIF: Findings show that zinc finger protein 366 (DC-SCRIPT)
            deficiency delays mammary gland morphogenesis in vivo and in vitro
            and indicate DC-SCRIPT as a modulator of mammary gland development.
REFERENCE   4  (bases 1 to 2788)
  AUTHORS   Chopin,M., Lun,A.T., Zhan,Y., Schreuder,J., Coughlan,H.,
            D'Amico,A., Mielke,L.A., Almeida,F.F., Kueh,A.J., Dickins,R.A.,
            Belz,G.T., Naik,S.H., Lew,A.M., Bouillet,P., Herold,M.J.,
            Smyth,G.K., Corcoran,L.M. and Nutt,S.L.
  TITLE     Transcription Factor PU.1 Promotes Conventional Dendritic Cell
            Identity and Function via Induction of Transcriptional Regulator
            DC-SCRIPT
  JOURNAL   Immunity 50 (1), 77-90 (2019)
   PUBMED   30611612
  REMARK    GeneRIF: this study shows that PU.1 promotes conventional dendritic
            cell identity and function via induction of transcriptional
            regulator DC-SCRIPT
REFERENCE   5  (bases 1 to 2788)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   6  (bases 1 to 2788)
  AUTHORS   Triantis,V., Moulin,V., Looman,M.W., Hartgers,F.C., Janssen,R.A.
            and Adema,G.J.
  TITLE     Molecular characterization of the murine homologue of the
            DC-derived protein DC-SCRIPT
  JOURNAL   J Leukoc Biol 79 (5), 1083-1091 (2006)
   PUBMED   16522745
  REMARK    GeneRIF: Taken together, these data show that DC-SCRIPT is
            well-conserved in evolution and that the mouse homologue is more
            than 80% homologous to the human protein.(DC-SCRIPT protein, mouse)
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070399.1.
            
            On Sep 9, 2004 this sequence version replaced XM_138810.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070399.1, SRR7652917.1103194.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2788
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 52.25 cM"
     gene            1..2788
                     /gene="Zfp366"
                     /gene_synonym="DC-SCRIPT; Znf366"
                     /note="zinc finger protein 366"
                     /db_xref="GeneID:238803"
                     /db_xref="MGI:MGI:2178429"
     exon            1..42
                     /gene="Zfp366"
                     /gene_synonym="DC-SCRIPT; Znf366"
                     /inference="alignment:Splign:2.1.0"
     exon            43..1379
                     /gene="Zfp366"
                     /gene_synonym="DC-SCRIPT; Znf366"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..2297
                     /gene="Zfp366"
                     /gene_synonym="DC-SCRIPT; Znf366"
                     /note="dendritic cell-specific transcript protein"
                     /codon_start=1
                     /product="zinc finger protein 366"
                     /protein_id="NP_001004149.1"
                     /db_xref="CCDS:CCDS26720.1"
                     /db_xref="GeneID:238803"
                     /db_xref="MGI:MGI:2178429"
                     /translation="MQKAMKMVKDEDGPLNAAAKSIPSFPHCLQPEASRGKAPQRHPF
                     PEALRGPFSQFRYEPSPGDLDGFPEVFEGGGSRKRKSMPTKVPYTHPAEEASIAQESK
                     SLGPPNLTLLFPQPQRPKCDSQMIDLCNVGLQFYRTLEHLGGKPVKQEPVKPSAMWPQ
                     PTPPAFLPAPYPYYPKVHPGLMFPFFVPSSSPFPFSRHTFLPKQPPEPVLPRKVEPLE
                     SEETKQKVERVDVNVQIDDSYYVDVGGAQKRWQCPTCEKSYTSKYNLVTHILGHSGIK
                     PHACSRCGKLFKQLSHLHTHMLTHQGTRPHKCQVCHKAFTQTSHLKRHMMQHSEVKPH
                     NCRVCSRGFAYPSELKAHEAKHASGRENICVECGLDFPTLAQLKRHLTTHRGPIQYNC
                     SECDKTFQYPSQLQNHMMKHKDIRPYICSECGMEFVQPHHLKQHSLTHKGVKEHKCGI
                     CGREFTLLANMKRHVLIHTNIRAYQCHLCYKSFVQKQTLKAHMIVHSDVKPFKCKLCG
                     KEFNRMHNLMGHLHLHSDSKPFKCLYCPSKFTLKGNLTRHMKVKHGVMERGLHSQGLG
                     RGRLVLVQSAGVLRNLEQEEPFDLSQKRSANGPMFQSDVDSTQDCLCQEEEEEAGEED
                     NCYEVEPYSPSLAPESQQLCAPEDLSTKQEQTLQDPGEGCRDQDAPEEQQEDRSEDHE
                     GSDIDCEGKDIDCAIREERLSSRLLQSGGQGPSFSDYLYFKHRDEGLKELLERKMEKQ
                     AVLLGI"
     exon            1380..1571
                     /gene="Zfp366"
                     /gene_synonym="DC-SCRIPT; Znf366"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1746
                     /gene="Zfp366"
                     /gene_synonym="DC-SCRIPT; Znf366"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..2758
                     /gene="Zfp366"
                     /gene_synonym="DC-SCRIPT; Znf366"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2740..2745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp366"
                     /gene_synonym="DC-SCRIPT; Znf366"
                     /note="hexamer: ATTAAA"
     polyA_site      2758
                     /gene="Zfp366"
                     /gene_synonym="DC-SCRIPT; Znf366"
                     /note="major polyA site"
ORIGIN      
        1 gtaaagcggt gggggctgct gcctctcagc cctcaggagc tgggaaactg cagaggatgc
       61 agaaggcaat gaagatggtc aaggatgagg acgggcccct caacgctgct gcgaaaagca
      121 tcccctcttt tccccactgt ctacagcccg aggcttcccg agggaaggct ccccaaagac
      181 accccttccc ggaagccctc cggggcccct tttcgcagtt tcggtatgaa ccttctccag
      241 gagaccttga tggattcccg gaggtcttcg agggaggagg gtcccggaaa cggaagagca
      301 tgcccaccaa ggtgccttac actcaccctg cagaagaagc ttcgattgct caggagagca
      361 agagcctggg ccctccgaac ctcactctac ttttcccgca gccacagcgc cccaagtgcg
      421 actcccagat gatcgatctg tgcaatgtgg gcctgcagtt ctaccgcacc ctggagcacc
      481 tggggggcaa acccgtcaag caagagccgg tgaaacccag tgccatgtgg ccccagccca
      541 cgcctcctgc cttcctgcct gcgccttacc cttactaccc caaagtccac ccgggactca
      601 tgttcccctt cttcgtgccc tcgtcctcac ccttcccctt cagcaggcac accttcctgc
      661 ccaagcagcc ccccgagcca gtgttacccc gcaaagtgga acccctggag agcgaggaga
      721 ccaaacagaa ggtggagagg gtggacgtga acgtccagat cgacgacagc tactacgtgg
      781 atgtgggtgg ggctcagaag cgctggcagt gccccacctg tgaaaagtcc tacacctcca
      841 agtacaacct ggtgacccac atcctgggcc acagcgggat caagccacac gcgtgctccc
      901 gttgtgggaa actcttcaaa cagctcagcc atctgcacac ccacatgctg acacaccagg
      961 gtacacggcc ccacaaatgc caggtgtgcc acaaggcctt cacccagacc agccacctga
     1021 agcgccacat gatgcagcac agcgaggtga agccgcacaa ctgtcgcgtg tgtagtcggg
     1081 gctttgccta ccccagcgag ctcaaggccc acgaggccaa acacgccagc gggcgcgaaa
     1141 acatttgtgt ggagtgcggc ctcgacttcc ccaccctggc tcagctgaag aggcacctca
     1201 ctacgcatag gggccccatc cagtacaact gctcggagtg cgacaagacc ttccagtatc
     1261 caagtcagct gcagaatcac atgatgaagc ataaggacat ccgtccctat atctgttccg
     1321 agtgtggcat ggagttcgtg caaccccatc acctcaagca acactcactc acccacaagg
     1381 gtgtgaagga acacaaatgc gggatctgtg ggcgtgagtt caccctgctg gccaacatga
     1441 agagacacgt gctgatccac accaacatcc gtgcctacca gtgtcatctc tgctacaaga
     1501 gcttcgtgca gaagcagacc ctcaaggctc acatgatcgt ccactcggat gtgaagcctt
     1561 tcaaatgcaa gctgtgtggg aaggaattca acagaatgca caacctgatg gggcacctgc
     1621 acctgcactc ggacagcaag cccttcaagt gtctctactg ccccagtaag ttcacgctga
     1681 aggggaacct gacccgccac atgaaggtca agcacggagt gatggagcga ggcctgcact
     1741 ctcaaggtct gggtagggga cgactcgtcc tggtgcagtc cgctggtgtc ctgaggaatc
     1801 tagagcagga ggaaccattt gacctctccc agaagcgcag tgcgaacggg ccaatgttcc
     1861 agtccgacgt ggacagcacg caggactgcc tctgccagga ggaggaggag gaggccgggg
     1921 aagaggacaa ctgctacgaa gtggagccct atagccccag tctggccccg gagagccagc
     1981 agctctgcgc gcctgaggat ctgtccacca agcaggagca gaccctgcag gaccctggag
     2041 aaggatgcag ggatcaggat gctccggaag agcagcagga ggacaggagc gaggaccacg
     2101 agggcagtga catagactgc gagggcaaag acatagactg tgccatcaga gaggagcgct
     2161 tgagcagccg gctgttgcaa agcggcggac agggcccctc gttttctgat tacttatact
     2221 tcaagcacag agatgagggc ttaaaagaat tgctagagag gaaaatggaa aaacaagcag
     2281 tccttttggg tatctaagtg aacggcttta aaattacatt tgaaaaagga gatctaggca
     2341 gttcaactat agctttccgt aagaactgtc atttgaagca aacgagagag tggcgccaat
     2401 ctttacaaat gactcagact aaatgcgtgg gtaacatcgg catctcaggt cctttcttgg
     2461 gcactcggca atttcataca cgtgcaggag ccctttggtg ttatcttaca catcacccac
     2521 atgatgaact gtgcattctt ctagatatct aactgcaagc tgaacctcaa ggtgctttta
     2581 gactgctttc ttctaacaca cagtgatgca aaagtctttc tagttgcaag agtgtggtgc
     2641 tcctgttatc ttaattagtg actatttagt tgcatttatg aaggttacag tatcataggt
     2701 gaaaatatta gtagctgtat atataaaaat atagcttcta ttaaataata gaaacacaaa
     2761 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
