LOCUS       NM_012017               3597 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus zinc finger protein 346 (Zfp346), transcript variant
            1, mRNA.
ACCESSION   NM_012017
VERSION     NM_012017.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3597)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3597)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3597)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3597)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3597)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   6  (bases 1 to 3597)
  AUTHORS   Yang,M., Wu,S., Su,X. and May,W.S.
  TITLE     JAZ mediates G1 cell-cycle arrest and apoptosis by positively
            regulating p53 transcriptional activity
  JOURNAL   Blood 108 (13), 4136-4145 (2006)
   PUBMED   16931621
  REMARK    GeneRIF: JAZ is a novel negative regulator of cell growth by
            positively regulating p53.
REFERENCE   7  (bases 1 to 3597)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3597)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3597)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   10 (bases 1 to 3597)
  AUTHORS   Yang,M., May,W.S. and Ito,T.
  TITLE     JAZ requires the double-stranded RNA-binding zinc finger motifs for
            nuclear localization
  JOURNAL   J Biol Chem 274 (39), 27399-27406 (1999)
   PUBMED   10488071
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB612150.1, CV562260.1, CX564256.1, BU706820.1, AK033852.1 and
            AK084710.1.
            
            On Dec 20, 2006 this sequence version replaced NM_012017.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF083339.1, BC055075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               BB612150.1         3-206
            205-871             CV562260.1         1-667
            872-1455            CX564256.1         217-800
            1456-2008           BU706820.1         111-663
            2009-3428           AK033852.1         338-1757
            3429-3597           AK084710.1         1904-2072
FEATURES             Location/Qualifiers
     source          1..3597
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.8 cM"
     gene            1..3597
                     /gene="Zfp346"
                     /gene_synonym="Jaz; Znf346"
                     /note="zinc finger protein 346"
                     /db_xref="GeneID:26919"
                     /db_xref="MGI:MGI:1349417"
     exon            1..210
                     /gene="Zfp346"
                     /gene_synonym="Jaz; Znf346"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..920
                     /gene="Zfp346"
                     /gene_synonym="Jaz; Znf346"
                     /note="isoform 1 is encoded by transcript variant 1; just
                     another zinc finger protein"
                     /codon_start=1
                     /product="zinc finger protein 346 isoform 1"
                     /protein_id="NP_036147.1"
                     /db_xref="CCDS:CCDS26539.1"
                     /db_xref="GeneID:26919"
                     /db_xref="MGI:MGI:1349417"
                     /translation="MECPAPDATDAADPGEAGPYKGSEEPEGREPDGVRFDRERARRL
                     WEAVSGAQPAGREEVEHMIQKNQCLFTSTQCKVCCAMLISESQKLAHYQSKKHANKVK
                     RYLAIHGMETIKGDVKRLDSDQKSSRSKDKNHCCPICNMTFSSPAVAQSHYLGKTHAK
                     SLKLKQQSTKGAALQQNREMLDPDKFCSLCHSTFNDPAMAQQHYMGKRHRKQETKLKL
                     MAHYGRLADPAVSDLPAGKGYPCKTCKIVLNSIEQYQAHVSGFKHKNQSPKTLVTLGS
                     QTPVQTQPTPKDSSTVQD"
     exon            211..314
                     /gene="Zfp346"
                     /gene_synonym="Jaz; Znf346"
                     /inference="alignment:Splign:2.1.0"
     exon            315..407
                     /gene="Zfp346"
                     /gene_synonym="Jaz; Znf346"
                     /inference="alignment:Splign:2.1.0"
     exon            408..552
                     /gene="Zfp346"
                     /gene_synonym="Jaz; Znf346"
                     /inference="alignment:Splign:2.1.0"
     exon            553..738
                     /gene="Zfp346"
                     /gene_synonym="Jaz; Znf346"
                     /inference="alignment:Splign:2.1.0"
     exon            739..832
                     /gene="Zfp346"
                     /gene_synonym="Jaz; Znf346"
                     /inference="alignment:Splign:2.1.0"
     exon            833..3597
                     /gene="Zfp346"
                     /gene_synonym="Jaz; Znf346"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3330..3335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp346"
                     /gene_synonym="Jaz; Znf346"
                     /note="hexamer: AATAAA"
     polyA_site      3356
                     /gene="Zfp346"
                     /gene_synonym="Jaz; Znf346"
                     /note="major polyA site"
     regulatory      3576..3581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp346"
                     /gene_synonym="Jaz; Znf346"
                     /note="hexamer: ATTAAA"
     polyA_site      3594
                     /gene="Zfp346"
                     /gene_synonym="Jaz; Znf346"
ORIGIN      
        1 tgcgcagctt cttaacggcg cgtcttgccg gaaagatgga gtgtcctgcg cccgatgcta
       61 cggatgctgc ggaccctgga gaagccggac cgtacaaggg ctccgaggag ccggagggtc
      121 gggaaccgga cggagtgcgc tttgaccgcg agagggcgcg tcgcctgtgg gaagctgtgt
      181 ccggtgcgca gccggcgggg agggaggaag tggaacacat gatccagaag aaccagtgtc
      241 tcttcaccag cacccagtgt aaggtctgct gtgccatgct gatttctgag tctcagaagc
      301 tggcgcatta ccagagcaaa aaacatgcca acaaagtgaa gagataccta gcaatccatg
      361 gaatggagac aataaagggg gacgtgaaga ggctagactc agatcagaag agcagcagaa
      421 gcaaagacaa gaaccactgc tgccccatct gtaacatgac cttttcctcc cctgctgtgg
      481 cacagtcgca ctacctgggg aagacccacg caaagagcct aaagctgaag cagcagtcca
      541 ctaagggggc agccttgcag cagaatagag agatgctaga cccagacaaa ttctgcagcc
      601 tctgccattc aacattcaac gaccctgcca tggctcagca acattatatg ggcaagagac
      661 acaggaagca ggagactaag ctcaaactca tggcacacta tgggcggctg gcggaccctg
      721 ctgtctctga cttaccagct gggaagggct acccctgcaa gacgtgtaaa atagtgctga
      781 actccataga gcagtaccaa gctcacgtca gtggcttcaa acacaaaaac cagtcaccca
      841 aaacattggt gacactcggg agccagacgc cagtgcaaac acaacccact ccaaaggact
      901 caagcacagt gcaagactaa agctgtccct gcctggtcag cctggtggga cagccataag
      961 ccagttcctg gtgactgctt agccgtggct ccttcctcct cctctcttat atccgaagaa
     1021 tgtggaggca tgaggccaac ttgggctgca gatctgcaga tagcctgact gcgcccagat
     1081 gcagctcctc ctgcccctct tgagcatggc cctataggcc atggcaggag acagggctct
     1141 gagaagacct gaggtgaagg tttagaggtt ggccttcccc acccctctgg gtgtatgtcc
     1201 tacagtcccg atgtctgttt ttactctcaa ggtcagttgg gagcaaggtc ctgcagagaa
     1261 gggagagcac tgtctctggg ctccaggcag ctttgtgtag aaatgtggag ctaatgtgtc
     1321 atttcctatc cctcaagtgt gcaggcttgc taggtataga tcctgccaac catgaagtct
     1381 cccagaaaac agagtctccg gcagagcact gccatctccg ctgcctgctg tctctccagt
     1441 tccctcgtgg tgctaggcag ctgcagcagc tcggcgtcag aggagacttg agtgcccact
     1501 ggggtcctga taggcaccta agggggtgca ccaacccagg gccatgtgag aaagtctcct
     1561 acctgctatg ttccttgatt ctgtgccctt gtaggtaact gcctcctgcc agcctactaa
     1621 aaggtcactt ggtgttagct ctatgccctt gtgtagtggg cgatcctacc cagttgctgt
     1681 ggtgctatcc ctcccttgac ctcctcaaga agattctggg ggaactaaaa aggaatttag
     1741 aactggtgca ggttctacag agagcaatag ggtccccaga ccctaacctg agaaattcct
     1801 tctgggtttg tgtcctggga tccactgcag tgggtttata cataactgtg gatggagcag
     1861 gtcttccagg aagtattcct aaagcttgta gagataaaac agcttccttg ttagtgtcat
     1921 tgggtaccaa gtagagatgg ggcagggctt aaactcttgt tctttggtca ctcaaccaag
     1981 aaaaaaaatt tcttctgtga gtcatgctgt aaccccaggg ctgaggttga tactgctatg
     2041 acatccccac acagttggcc cccagtgtcc ttaataacaa tcttacccag gaaaggtctc
     2101 cctgctgccc taagcccaac ccagttcatc ccccagctaa gggattgatt cttgagatag
     2161 tcactctggc tactgagtgg gggactgcga agaggccagt gtgaaaactg tgtccatact
     2221 gctgctggtc tccagggcac tcccttcagg gtagatgtcc aggatgttgt cttaagtgca
     2281 ggatgtgtga gtgactgggt ggtagtgctg aagacaggtg tcctttccca ctccacttaa
     2341 agagctgtcg gagttttcct tgaagtcctc ctaggccgac tggtccttgg gagagccttt
     2401 tatttgactc ataagtaaca aggcaaagag cgttatagct tagaaactca tgcagatggg
     2461 ccagaccaag caccaccagc cccaggtcct tgtagcacac tgctctgggc accagcggcc
     2521 cctagctcct gacttaagct cttgactcct ggcattggtt ctctgctttc agcttcccaa
     2581 ctgtaggcct cctcagcagt cttcctagaa gtctgtgcca gaactggtgt cagaattagt
     2641 aaagagcatg aagtagggaa ccaaagggta aggccctgaa tgggctgact gaccattagc
     2701 ccttgtcttg gaagacctct gtgtttaaat ggattcagga gtccctacca gcttcatgtc
     2761 cagcactgcg agtatggaaa ccctagaagt agctcgctgt tgccctttgg aagctcacac
     2821 acttaaaaat catgatttgg agagtctcat ggggcaagtg ggagtgtcca ggacacaagc
     2881 aataacagcg tggagtagaa ggctgagaga aatggctggt ctctgtggct ttgtttcatg
     2941 tagcccaggc tagtctcaga tttgtcatct gggaggctag ccttgagctg cttgctgacc
     3001 ctcccacctc tgccttcctg gttctgggat ggtgggcacg tgcccccatg tcccacatca
     3061 gctttcatcc atgttattgt gggttgcttg gtttgctttg gtttttcagg atggggcctc
     3121 attgtgtagc tctgactgtc ctggaactca ctctgtaggc cttgaactca gctccacctg
     3181 cctccctccc aagtgctgcc attaaaggcg tgtgccacca tgcctgaatg agaggttttt
     3241 taatactatc tagtagtcct ttatttggat cagtcacaac ctagctttgt actgttgaaa
     3301 tcgtattgtt tccctttgag gttatcttga ataaagctgc tgtaaaaact gtgtcatccg
     3361 atgtgtgcgc tcttccactc agagaagggg atggacaatg gacacttctt accttgtttt
     3421 tttttttttt agccagtggt tctggtgttg ttcagttcgt aagggcccca gttcctacta
     3481 agtatttcca gtcttcaaag ttagttgttc tgacggcaac ccagaagttg tacccagggg
     3541 cccagtcttt taataaagag cattcttatt tcagcattaa aacaaacaaa aatagtc
//
