LOCUS       NP_950192               1337 aa            linear   ROD 10-FEB-2025
DEFINITION  zinc finger protein 335 [Mus musculus].
ACCESSION   NP_950192 XP_287192 XP_908026 XP_918394 XP_927809 XP_991983
            XP_992017 XP_992054
VERSION     NP_950192.2
DBSOURCE    REFSEQ: accession NM_199027.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1337)
  AUTHORS   Liu,H., Feng,Z., Jiao,A., Lan,L., Ding,R., Li,W., Zheng,H., Su,Y.,
            Jia,X., Zhang,D., Yang,X., Zhang,L., Sun,L. and Zhang,B.
  TITLE     The Transcription Factor Zfp335 Promotes Differentiation and
            Survival of Effector Th1 Cells by Directly Regulating Lmna
            Expression
  JOURNAL   J Immunol 212 (11), 1714-1721 (2024)
   PUBMED   38598411
  REMARK    GeneRIF: The Transcription Factor Zfp335 Promotes Differentiation
            and Survival of Effector Th1 Cells by Directly Regulating Lmna
            Expression.
REFERENCE   2  (residues 1 to 1337)
  AUTHORS   Wang,X., Sun,L., Yang,B., Li,W., Zhang,C., Yang,X., Sun,Y.,
            Shen,X., Gao,Y., Ju,B., Gao,Y., Liu,D., Song,J., Jia,X., Su,Y.,
            Jiao,A., Liu,H., Zhang,L., He,L., Lei,L., Chen,W. and Zhang,B.
  TITLE     Zfp335 establishes eTreg lineage and neonatal immune tolerance by
            targeting Hadha-mediated fatty acid oxidation
  JOURNAL   J Clin Invest 133 (20), e166628 (2023)
   PUBMED   37843279
  REMARK    GeneRIF: Zfp335 establishes eTreg lineage and neonatal immune
            tolerance by targeting Hadha-mediated fatty acid oxidation.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1337)
  AUTHORS   Ratiu,J.J., Barclay,W.E., Lin,E., Wang,Q., Wellford,S., Mehta,N.,
            Harnois,M.J., DiPalma,D., Roy,S., Contreras,A.V., Shinohara,M.L.,
            Wiest,D. and Zhuang,Y.
  TITLE     Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-beta
            selection thymocytes
  JOURNAL   Nat Commun 13 (1), 5901 (2022)
   PUBMED   36202870
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1337)
  AUTHORS   Liu,H., Wang,X., Ding,R., Jiao,A., Zheng,H., Zhang,C., Feng,Z.,
            Su,Y., Yang,X., Lei,L., Sun,L., Zhang,L., Sun,C. and Zhang,B.
  TITLE     The Transcription Factor Zfp335 Promotes Differentiation and
            Persistence of Memory CD8+ T Cells by Regulating TCF-1
  JOURNAL   J Immunol 209 (5), 886-895 (2022)
   PUBMED   35914836
  REMARK    GeneRIF: The Transcription Factor Zfp335 Promotes Differentiation
            and Persistence of Memory CD8(+) T Cells by Regulating TCF-1.
REFERENCE   5  (residues 1 to 1337)
  AUTHORS   Wang,X., Jiao,A., Sun,L., Li,W., Yang,B., Su,Y., Ding,R., Zhang,C.,
            Liu,H., Yang,X., Sun,C. and Zhang,B.
  TITLE     Zinc finger protein Zfp335 controls early T-cell development and
            survival through beta-selection-dependent and -independent
            mechanisms
  JOURNAL   Elife 11, e75508 (2022)
   PUBMED   35113015
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1337)
  AUTHORS   Han,B.Y., Wu,S., Foo,C.S., Horton,R.M., Jenne,C.N., Watson,S.R.,
            Whittle,B., Goodnow,C.C. and Cyster,J.G.
  TITLE     Zinc finger protein Zfp335 is required for the formation of the
            naive T cell compartment
  JOURNAL   Elife 3, e03549 (2014)
   PUBMED   25343476
  REMARK    GeneRIF: Zinc finger protein Zfp335 is required for the formation
            of the naive T cell compartment.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 1337)
  AUTHORS   Zhao,X.S., Fu,W.Y., Chien,W.W., Li,Z., Fu,A.K. and Ip,N.Y.
  TITLE     p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of
            nuclear hormone receptor coregulator-interacting factor 1 (NIF-1)
  JOURNAL   PLoS One 9 (10), e110584 (2014)
   PUBMED   25329792
  REMARK    GeneRIF: p35 interacts with NIF-1 and regulates the subcellular
            localization of the protein independent of Cdk5-dependent
            phosphorylation. ...reveal a new mechanism of p35 in
            transcriptional regulation that does not require the kinase
            activity of Cdk5
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 1337)
  AUTHORS   Yang,Y.J., Baltus,A.E., Mathew,R.S., Murphy,E.A., Evrony,G.D.,
            Gonzalez,D.M., Wang,E.P., Marshall-Walker,C.A., Barry,B.J.,
            Murn,J., Tatarakis,A., Mahajan,M.A., Samuels,H.H., Shi,Y.,
            Golden,J.A., Mahajnah,M., Shenhav,R. and Walsh,C.A.
  TITLE     Microcephaly gene links trithorax and REST/NRSF to control neural
            stem cell proliferation and differentiation
  JOURNAL   Cell 151 (5), 1097-1112 (2012)
   PUBMED   23178126
  REMARK    GeneRIF: Znf335 null mice are embryonically lethal, and conditional
            knockout leads to severely reduced cortical size.
REFERENCE   9  (residues 1 to 1337)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   10 (residues 1 to 1337)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062921.1 and CN721033.1.
            
            On or before Feb 8, 2007 this sequence version replaced
            XP_287192.2, XP_908026.1, XP_918394.1, XP_927809.1, XP_992017.1,
            XP_992054.1, XP_991983.1, NP_950192.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157577.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1337
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.27 cM"
     Protein         1..1337
                     /product="zinc finger protein 335"
                     /note="NRC-interacting factor 1"
                     /calculated_mol_wt=145472
     Region          1..108
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A5K6.1)"
     Region          198..226
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A5K6.1)"
     Region          278..444
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A5K6.1)"
     Region          468..488
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          498..518
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          510..535
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          524..547
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          526..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          565..585
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(570,572,574,576..577,580..581,584,598,600,604..605,
                     608..609,612,629,631,633,635..636,639..640,643)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          577..602
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          593..613
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          624..644
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          652..673
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          681..700
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          733..767
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A5K6.1)"
     Region          963..999
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A5K6.1)"
     Site            976
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:G3V893; propagated from
                     UniProtKB/Swiss-Prot (A2A5K6.1)"
     Site            1007
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4Z2; propagated from
                     UniProtKB/Swiss-Prot (A2A5K6.1)"
     Region          1021..1041
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <1026..1126
                     /region_name="SFP1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; COG5189"
                     /db_xref="CDD:227516"
     Region          1049..1069
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(1054,1056,1058,1060..1061,1064..1065,1068,1082,1084,
                     1088..1089,1092..1093,1096,1110,1112,1114,1116..1117,
                     1120..1121,1125)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          1075..1099
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          1077..1097
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1089..1114
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          1105..1126
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            1149
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4Z2; propagated from
                     UniProtKB/Swiss-Prot (A2A5K6.1)"
     CDS             1..1337
                     /gene="Zfp335"
                     /gene_synonym="1810045J01Rik; NIF-1; Nif1; Znf335"
                     /coded_by="NM_199027.2:285..4298"
                     /db_xref="CCDS:CCDS38331.1"
                     /db_xref="GeneID:329559"
                     /db_xref="MGI:MGI:2682313"
ORIGIN      
        1 meenevesss daaprpgqpe epsesglgvc tseavsadss daatvpglte addsgvgqss
       61 dggnhsveev sesistdplp hgclpdsssv srgpvaempg gppalvhssv lpdpsmlvsd
      121 ctasssdlgs aidkiiesti gpdliqscit vtsgeeggae ttqylilqgp ddgapmassm
      181 ststlansla aiealadgpt stsacleppe epqgdpssva qqppapvtee ldlqsleamm
      241 evvvvqqfkc kmcqyrsstk atllrhmrer hfrpalaaaa aatgkrgrvr kwgtstktte
      301 edrpeeeeed ddivdagaid dleedsdynp aedeprgrql rlqrptpstp rprrrpgrpr
      361 klprletsdl hdgvgqplvs sqstqsppel qdleapsssg lralgkvgrg lvesgvsqsd
      421 aenaapscqd eadapprrrg rpsrrflgkk yrkyyykspk pllrpylcri cgsrflshed
      481 lrfhvnshea gdpqlfrclq csyrsrrwss lkehmfnhvg skpykcdecs ytsvyrkdvi
      541 rhaavhsqdr kkrpdptpkl ssfpcpvcgr vypmqkrltq hmkthstekp hmcdkcgksf
      601 kkrytfkmhl lthiqavanr rfkcefcefv cedkkallnh qlshvsdkpf kcsfcpyrtf
      661 redfllshva vkhtgakpfa ceychfstrh kknlrlhvrc rhansfeewg rrhpeeppsr
      721 rrpffslqqi eelkqqhsta pgpplsspgp eapqepapfq spetppllcp dalggttiiy
      781 qqgaeestav atqtaldlll nmsaqrelga talqvavvks egieaeltst ggqpspedtt
      841 prvvtlhmae sgssvaaesq lgpsdlqqia lpsgpfggas ysvitappve grtsasgppy
      901 reeppgeaaq avvvsdtlke agthyimaad gtqlhhielt adgsisfpsp dtlapgtkwp
      961 llqcggpprd gsevlsptkt hhmggsqgss tpppaashtl glvvpqspps aaasstkkfs
     1021 ckvcseafps raemeshkra hagpaafkcp dcpfsarqwp evrahmaqhs slrphqcnqc
     1081 sfasknkkdl rrhmlthtne kpfschvcgq rfnrnghlkf hiqrlhsidg rktgtstara
     1141 paqtiilnse eetlatlhta fqsshgvlgt erlqqalsqe hiivaqeqtv tnqeeatyiq
     1201 eitadgqtvq hlvtsdnqvq yiisqdgvqh llpqeyvvvp dghhiqvqeg qithiqyeqg
     1261 tpflqesqiq yvpvspsqql vtqaqleaaa hsavtavada amaqaqglfg teeavpeqih
     1321 qlqhqgieyd vitlsdd
//
