LOCUS       NM_207671              13926 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus zinc finger protein 318 (Zfp318), transcript variant
            1, mRNA.
ACCESSION   NM_207671
VERSION     NM_207671.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 13926)
  AUTHORS   Waters,L.R., Ahsan,F.M., Ten Hoeve,J., Hong,J.S., Kim,D.N.H.,
            Minasyan,A., Braas,D., Graeber,T.G., Zangle,T.A. and Teitell,M.A.
  TITLE     Ampk regulates IgD expression but not energy stress with B cell
            activation
  JOURNAL   Sci Rep 9 (1), 8176 (2019)
   PUBMED   31160601
  REMARK    GeneRIF: Ampk regulates IgD expression but not energy stress with B
            cell activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13926)
  AUTHORS   Ishizuka,M., Ohtsuka,E., Inoue,A., Odaka,M., Ohshima,H., Tamura,N.,
            Yoshida,K., Sako,N., Baba,T., Kashiwabara,S., Okabe,M., Noguchi,J.
            and Hagiwara,H.
  TITLE     Abnormal spermatogenesis and male infertility in testicular zinc
            finger protein Zfp318-knockout mice
  JOURNAL   Dev Growth Differ 58 (7), 600-608 (2016)
   PUBMED   27385512
  REMARK    GeneRIF: Zfp318 is expressed as a functional protein in testicular
            germ cells and plays an important role in meiosis during
            spermatogenesis.
REFERENCE   3  (bases 1 to 13926)
  AUTHORS   Pioli,P.D., Debnath,I., Weis,J.J. and Weis,J.H.
  TITLE     Zfp318 regulates IgD expression by abrogating transcription
            termination within the Ighm/Ighd locus
  JOURNAL   J Immunol 193 (5), 2546-2553 (2014)
   PUBMED   25057009
  REMARK    GeneRIF: This finding indicates that Zfp318, in a novel manner,
            functions by repressing recognition of the transcriptional
            termination site at the 3' end of the terminal IgM-encoding exon
REFERENCE   4  (bases 1 to 13926)
  AUTHORS   Enders,A., Short,A., Miosge,L.A., Bergmann,H., Sontani,Y.,
            Bertram,E.M., Whittle,B., Balakishnan,B., Yoshida,K., Sjollema,G.,
            Field,M.A., Andrews,T.D., Hagiwara,H. and Goodnow,C.C.
  TITLE     Zinc-finger protein ZFP318 is essential for expression of IgD, the
            alternatively spliced Igh product made by mature B lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 111 (12), 4513-4518 (2014)
   PUBMED   24616512
  REMARK    GeneRIF: findings identify ZFP318 as a crucial factor regulating
            the expression of the two major antibody isotypes on the surface of
            most mature B cells
REFERENCE   5  (bases 1 to 13926)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 13926)
  AUTHORS   Tao,R.H., Kawate,H., Ohnaka,K., Ishizuka,M., Hagiwara,H. and
            Takayanagi,R.
  TITLE     Opposite effects of alternative TZF spliced variants on androgen
            receptor
  JOURNAL   Biochem Biophys Res Commun 341 (2), 515-521 (2006)
   PUBMED   16446156
  REMARK    GeneRIF: in the unique regulation system of AR-mediated
            transactivation, two spliced isoforms of TZF act as coactivator and
            corepressor, respectively
REFERENCE   7  (bases 1 to 13926)
  AUTHORS   Ishizuka,M., Kawate,H., Takayanagi,R., Ohshima,H., Tao,R.H. and
            Hagiwara,H.
  TITLE     A zinc finger protein TZF is a novel corepressor of androgen
            receptor
  JOURNAL   Biochem Biophys Res Commun 331 (4), 1025-1031 (2005)
   PUBMED   15882980
REFERENCE   8  (bases 1 to 13926)
  AUTHORS   Ishizuka,M., Ohshima,H., Tamura,N., Nakada,T., Inoue,A., Hirose,S.
            and Hagiwara,H.
  TITLE     Molecular cloning and characteristics of a novel zinc finger
            protein and its splice variant whose transcripts are expressed
            during spermatogenesis
  JOURNAL   Biochem Biophys Res Commun 301 (4), 1079-1085 (2003)
   PUBMED   12589823
  REMARK    GeneRIF: Molecular cloning and characteristics of a novel zinc
            finger protein and its splice variant whose transcripts are
            expressed during spermatogenesis.
REFERENCE   9  (bases 1 to 13926)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 13926)
  AUTHORS   Inoue,A., Ishiji,A., Kasagi,S., Ishizuka,M., Hirose,S., Baba,T. and
            Hagiwara,H.
  TITLE     The transcript for a novel protein with a zinc finger motif is
            expressed at specific stages of mouse spermatogenesis
  JOURNAL   Biochem Biophys Res Commun 273 (2), 398-403 (2000)
   PUBMED   10873617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ161473.1, AW457229.1, CD542244.1, CT009572.21, AK157779.1,
            AC151275.3 and BU704885.1.
            
            On Nov 13, 2013 this sequence version replaced NM_207671.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927934.2164801.1,
                                           SRR7345562.4126041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-386               CJ161473.1         1-386
            387-808             AW457229.1         33-454
            809-1381            CD542244.1         7-579
            1382-1766           CT009572.21        7600-7984           c
            1767-3762           AK157779.1         1-1996
            3763-13376          AC151275.3         90531-100144        c
            13377-13926         BU704885.1         1-550
FEATURES             Location/Qualifiers
     source          1..13926
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..13926
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /note="zinc finger protein 318"
                     /db_xref="GeneID:57908"
                     /db_xref="MGI:MGI:1889348"
     exon            1..565
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..6787
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testicular zinc finger protein"
                     /codon_start=1
                     /product="zinc finger protein 318 isoform 1"
                     /protein_id="NP_997554.2"
                     /db_xref="CCDS:CCDS28827.2"
                     /db_xref="GeneID:57908"
                     /db_xref="MGI:MGI:1889348"
                     /translation="MYRSGSRSSVSSHRSKDGSASGPPPGRPVGASSGPTRRPSSPPP
                     PSCSSLRLPARRHRSPSGHRGRWASPSPPRGRRGSPSPPRGRRASPSPTRGRRASPSP
                     PRGRRGSPSPPRARRGSPSPPRSRRHYPPGLGGFRGSIRGESRADFARDGRGDHPGGG
                     GGSRRRSPGLCSDSSLEESLRITVGNDHFCVSTPERRRLSDRLGSPVDGLQDMDRDDL
                     TDDSVFTRSSQCSRGLERYISREEGPLSPFLGQLDEDYRTRETFLHRPEFSPQSSCHD
                     ELLRGTERNRDKLKSSSYSIRSEERSREAKRPRYDDTEKVHSSGGDHSSFTSGTRNYR
                     QRRSSPSPRFLDPEFRELDLARRKREEEEEQSRSLSQELVGVGDDQIGCSIPGLAGVL
                     TTSEPGYSLQRPEEVPMMPKKSILKKRIEADMKPSLQLESFSSGASSGEDHPLYSEHS
                     PLPLSGAIAAFTSEIENKGTTVEADLKEPQSNLYQWGPLREIPKDNSEKFDSFLGFKE
                     KLDLKAEGLEQQTDFLLPHERASQDGSGFSRILSMLADPTITQEKRRRSFPDIEDEEK
                     FLYGDEEEDIKSESPLKSLEDPESAGTRQKANSLPSTPAVKLESLEESNPEYAKIHNL
                     LKTIGLDIGVAEIGKLAARTQERLHGKKPSSRPSADRRLSADRHLSGDRHFSADRCSS
                     VEHSFTADWRSSDPHRPESRETHHSNTQSPEVSHPHPASPVDPYLRTKNSPPFLKSDH
                     PVCHVSGPEVVGSGFQSSVAVRCMLPSAPSTPIRLPHSAALSQFHIPGASQFAAARIP
                     PNYQGSVIPSASFDAYRHYMAYAASRWPMYPASQPPSHPLSDPHRLLPVTKQAARSRP
                     NLRVIPTVTPAKPKQEIPVLGSISVKRIPVRVSIPSLIKYNPKKISDEKNRASQKQKV
                     IEEREKLKTEQEARQKKMFYLTTELERLHKQQGEMLRKKRREKDGHKDPLLMEVSRLQ
                     DSIMKDIAELHKETEEAEKKQSELDKVAQILGIDIFDKSLKSSNDSKESTEKPEKEKS
                     KSPEKELSPSNSSSSNKESKMNEKSCIKSPSSTESLQPTVKQSDQPVAAYEYYDAGSH
                     WCKDCNTTCGTMFDFFTHMHNKKHTQTLDPYNRPWASKTQSEAKQDTVKRTDKITVPA
                     KGSEFLIPVTGFYCQLCEEFLGDPISGEQHVKGHQHNENYKKYVEENPLYEERRNLDR
                     QAGLAVVLETERRRQNELKRKLNEKPKEEKIEKKARIVREVKEDDKAPGELEEQLSED
                     GSAPEKGEVKGNASLRPQVKEEVKKEPSVASIAASFGKFSWKKPEKEEEKGSVVTPGA
                     PKEDTVETSKDRDDGKAEVGKAKPIKIKLSGKTVIAHTSPWTPVVTTSTQTKIRPNLP
                     IPSTVLRKSGSATVSKPAPLNTFLSIKSSGTSTKPLPVVKESSSDLLLPPDIISKAFG
                     GEEVVLKGSPEEKVELAEKNEPSQVPEQMLALLPPPPPPPPPPPPPPPPPPPQAVPQL
                     SAPSPAQANVVLTPVKSNSVISQTFSLGFQGPNILNPGLPVAFMASEQPTVIPSDETA
                     PGVSESDWDQTLISMLVRPPPPLSSVFSEQAKKLEKRNSCLATANAKDLYDIFYSSGG
                     KGAHETKLSSSTLANGESSSLPRTESSDFSSTCTLNSSMSSEDLPQCSALVTATEISN
                     LENPISKGMESTGKWSVVDQIDPKSRDSTYSFLQPLTRLYQNKPYEIVSPKTDTLVMW
                     TSGSSQNDTHKDRPPEGKIRFDLGEPGPPGTDSTSHLSDTHCQTNGPQKLIEINLIDN
                     QNKNQEVYQSEGCRESEMKRKTELKGKVATEEEEEEEEEGANSIEDSNSNHGNRNTWE
                     GEIGQPKLSTVDKKGEQSSKLMTGHENTSKVVIELSPSLPSKRTKIDLFPSLLQNPKS
                     MPELLLLSPAGSGLCLKRQEIWERPEKPGLEDVELQGTRPELTVTIESKVLENFDTTH
                     LEVEGFASLRNLGDMHANFHNSQTEQTRRSPTALSEKMSEEISVSSVMCNPSSSSDIE
                     PVPSFSGFPLESPKTLVLNFETEGAHSSSNSRNGRITSNSLETGHPVENVGHDLGGER
                     THQALDLLAGGMLSEDVKETSPLQKDLLRMESTTVSPSGLGPSPCLPDLVDFVTRTPG
                     VPKQKPCSPLSEPDAFLKCSSLEMGSPPPEILSVSVSEVAVPQVSEDNDSALNLVKTP
                     PSGSPSRDQVVGGNVSPREMPEQEAAVDVIPDHTRSNVYNSQDYLNG"
     exon            566..717
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /inference="alignment:Splign:2.1.0"
     exon            718..1360
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..2812
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2912
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3214
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3415
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /inference="alignment:Splign:2.1.0"
     exon            3416..3515
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /inference="alignment:Splign:2.1.0"
     exon            3516..3634
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /inference="alignment:Splign:2.1.0"
     exon            3635..13921
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7723..7728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /note="hexamer: AATAAA"
     regulatory      7731..7736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /note="hexamer: ATTAAA"
     polyA_site      7743
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /note="major polyA site"
     polyA_site      7747
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
     regulatory      7799..7804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /note="hexamer: AATAAA"
     polyA_site      7819
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /note="major polyA site"
     regulatory      13900..13905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
                     /note="hexamer: AATAAA"
     polyA_site      13921
                     /gene="Zfp318"
                     /gene_synonym="2610034E08Rik; D530032D06Rik; TZF; Znf318"
ORIGIN      
        1 ggtgtccgcg gcggcggtgc ctgcggctgt ggcggcacgc tcccgagcgg cgtccgcggc
       61 gctcccggta gccatgtacc gcagtggctc ccgctcctcc gtctcttcgc accggtcgaa
      121 agacggcagc gcgagcggcc ctccgccggg ccgtcccgtg ggcgcctcct caggccccac
      181 acgccgcccc tcgtcgccgc cgccgccctc ttgctcctcg ctgcggctcc ccgcccgccg
      241 ccaccgctcg ccctcaggcc accgcggccg ctgggcctcg ccgtccccgc ctcggggtcg
      301 tcgcggctcc ccgtccccgc cccgcggccg ccgggcctca ccgtctccga cccgcggccg
      361 ccgggcctcg ccatcccctc cgcggggtcg tcgtggctcc ccgtccccgc cgcgcgcccg
      421 tcgcggctcc ccgtcgccac cgcggagccg gcgacactac ccacctggcc tgggtggctt
      481 ccgaggcagc attcgaggcg agtcccgcgc cgacttcgcc cgggacggcc gcggagacca
      541 tccaggcggc ggcggcggca gtcggagacg ttctcctggt ctgtgttctg attcttcttt
      601 ggaggagagt ttaaggatca cagttggcaa tgaccacttc tgtgttagca caccagagcg
      661 gcggcggctc agtgaccggc tgggatctcc agtggatggt ctgcaggaca tggacaggga
      721 tgacctgact gatgattctg tcttcactcg aagctcccag tgttctcggg gtcttgaacg
      781 atacatttct cgggaggagg gaccacttag tcccttcttg ggacaacttg atgaggacta
      841 ccgaacaaga gaaacttttc tgcatcgacc tgagtttagt ccccagagca gttgtcatga
      901 tgaattgttg aggggaacag agcggaatag agacaaactt aaaagctcct cctattccat
      961 acgatctgag gaaagaagcc gggaggccaa aaggccccgt tatgatgaca cagagaaggt
     1021 acacagctca ggaggggatc actcaagttt tacatctggg actcgaaact atcggcagcg
     1081 aagaagcagc ccaagcccta ggtttctaga tcccgagttt cgagaactgg accttgccag
     1141 gcgaaagcga gaggaagaag aggaacaaag taggagcttg agtcaagagc tggtgggtgt
     1201 tggtgatgat cagattggct gttccatccc tggcttggca ggagtcctaa ccacatcaga
     1261 gcctggatat tctttgcagc ggcctgagga agtacctatg atgcccaaga agtccattct
     1321 gaagaaacga attgaagcgg acatgaagcc ttccttgcag cttgagagct tttctagcgg
     1381 tgccagctct ggtgaagatc accctcttta ttctgaacat tcacctcttc ctctaagtgg
     1441 tgctattgct gcttttactt cagagattga aaacaagggg actacagtgg aggctgacct
     1501 gaaagagcct cagagtaacc tataccagtg gggccccctc cgtgagatac ctaaagacaa
     1561 cagtgaaaaa tttgacagtt ttctaggctt taaggaaaaa ttggatttga aggctgaggg
     1621 acttgagcaa cagacagatt tcttactgcc ccatgagaga gctagccagg acggcagtgg
     1681 cttttctcga attctgagca tgttggctga tcctaccatt acacaggaaa aaagaagacg
     1741 tagcttccct gatattgagg atgaggagaa atttctctat ggggatgaag aagaggatat
     1801 aaaatcagaa tctccactta agtccctgga ggaccccgag agtgcaggta cgagacagaa
     1861 ggcaaactct ctgccctcaa ctccagctgt aaagctagaa tcactagaag aaagcaatcc
     1921 agaatatgcc aagattcaca acttgcttaa gaccataggg ctggatattg gagtagcaga
     1981 aattggtaaa ttggctgcac gaacccagga gagacttcat ggcaagaagc catcatcacg
     2041 cccctcagct gaccgacgtt tgtcagctga ccgacacttg tctggtgacc gacacttttc
     2101 agctgaccgc tgttcctcag ttgagcacag tttcacagct gattggcgct catcagaccc
     2161 tcacagaccg gagagtaggg agacacatca tagcaatact cagtccccag aagtatctca
     2221 tccacaccca gcttccccgg tggatcctta cttgcgcacc aaaaatagcc ctccattcct
     2281 aaagtctgac catccagtgt gccatgtttc aggaccagag gtagttggca gtgggtttca
     2341 atcatctgtt gctgttcggt gcatgttgcc atcagcccca tctaccccaa ttagacttcc
     2401 tcactctgct gcgttgtctc agtttcatat accaggggcc tctcagtttg ctgcagctcg
     2461 gatacctcca aattatcagg gatctgtcat tccctctgcc tcctttgatg catataggca
     2521 ctacatggca tatgcagcct caaggtggcc tatgtatcct gcctctcaac caccaagcca
     2581 ccctttatct gaccctcata ggctattacc agtaaccaaa caagctgctc gtagtcgtcc
     2641 caatctccgg gtgatcccta ctgtgactcc tgcaaagccc aaacaagaaa taccagtact
     2701 aggctcaatt tctgtaaagc gaattcctgt tcgggtgtcc attccatcac tcataaaata
     2761 taatccaaag aagatctctg atgagaagaa ccgtgcctcc cagaagcaga aggttattga
     2821 agagagagaa aaactgaaaa ctgaacagga agcccggcaa aagaaaatgt tttatctcac
     2881 gactgagttg gagcggctcc ataaacagca aggggagatg ttgcgtaaga agcgaaggga
     2941 gaaggatggt cacaaagatc cacttctgat ggaggtgagt cgacttcagg atagtattat
     3001 gaaggacatt gccgagctac ataaagagac agaagaagca gaaaagaagc agtctgaact
     3061 ggacaaagtg gctcagatct tgggaattga tatctttgat aaatccctga aatcttcaaa
     3121 tgacagtaaa gagtctacag agaagcctga aaaagaaaaa tctaagagcc cagaaaaaga
     3181 gttgtcaccc tcaaactctt cctctagcaa caaggaatca aaaatgaatg aaaagtcctg
     3241 tattaagagc cctagttcta ctgaaagcct ccaaccaact gttaagcagt ctgaccagcc
     3301 tgttgctgct tatgagtatt atgatgctgg cagtcactgg tgcaaagact gcaataccac
     3361 ctgtgggacc atgtttgact tcttcaccca tatgcacaat aagaagcaca cacagacact
     3421 ggatccctac aacagacctt gggcttcaaa gacccagagt gaggctaagc aagacactgt
     3481 aaagcgaact gacaagataa ctgttcctgc aaaaggctct gagtttctga ttcctgtcac
     3541 tgggttttac tgccaactct gtgaggaatt tttgggggat ccaatttctg gagagcagca
     3601 tgtcaagggt caccagcaca acgaaaacta caagaaatat gtggaagaaa acccattgta
     3661 tgaagaacga agaaatctgg accgccaagc tggcttggct gtcgttctag agacagagcg
     3721 gcgacggcaa aatgagctaa aacgcaaact taatgagaaa ccaaaggagg agaagataga
     3781 aaaaaaggca agaattgtga gagaagtaaa ggaagatgac aaagcccctg gagaactaga
     3841 ggagcagctc tcggaggatg ggagtgcccc tgagaaaggt gaggtgaagg ggaacgctag
     3901 cctcagaccc caggtgaaag aagaggtaaa gaaggagcca tcagtagcat caatagcagc
     3961 ttcttttgga aagttcagtt ggaagaagcc agaaaaagaa gaagaaaaag gttcagtggt
     4021 gaccccaggg gccccaaagg aagacacggt ggaaaccagt aaggacagag atgacggcaa
     4081 agctgaagtt ggaaaggcaa agcccatcaa aatcaagctt tctggaaaaa ctgtcattgc
     4141 acacaccagt ccctggacac ctgtcgttac gacttcaaca cagactaaga tccgacccaa
     4201 cttgcctatc ccatccacag tactccgcaa gtcaggttca gccacagtga gcaagcctgc
     4261 tcctcttaat acctttctgt ctatcaagtc ctctggaaca tccaccaagc ctctgccagt
     4321 ggttaaagag tcatcatcag atcttctctt gcctccagat atcatctcca aagcttttgg
     4381 aggagaagag gtggttctaa aagggtctcc agaggaaaaa gtggaactgg ctgaaaagaa
     4441 tgagccatcc caagtacctg agcaaatgct ggctctactt ccaccgccac cacctccacc
     4501 tccaccccca cctccacctc caccccctcc accaccccag gctgtacctc agctatctgc
     4561 cccatcccct gctcaagcaa atgttgtctt aactccagtt aaatctaatt cggtgatatc
     4621 tcagactttc agtcttgggt tccaaggtcc taacattttg aacccagggt tgcctgtggc
     4681 cttcatggcc tcagaacaac caactgtaat tccttctgat gagacagctc ctggggtgag
     4741 tgagagtgac tgggaccaga ccctaatctc tatgttagta cggcctccac cacccctttc
     4801 cagtgtattc agtgaacagg ccaaaaaatt agaaaagcga aattcgtgct tagccacagc
     4861 caatgctaag gacctgtatg atatattcta cagtagtggt ggaaaggggg cccatgagac
     4921 taagctgagt agtagtacat tagccaatgg ggaaagcagt agccttccta gaacagaaag
     4981 ttcagatttc tcctccactt gtactttgaa cagtagtatg tcctcagagg acctgcctca
     5041 atgtagtgct ttggtcactg ctactgaaat cagtaatctt gaaaatccta tttcaaaagg
     5101 tatggagtcc acagggaaat ggtctgttgt agatcagata gatcccaaaa gcagagacag
     5161 cacctatagc ttcctacagc ctctgacaag attataccaa aataagcctt atgaaatagt
     5221 ttccccaaag acagacactt tggtcatgtg gacttctggt tcttcccaga atgacactca
     5281 taaagataga cctccagagg ggaaaatcag atttgacctg ggagagccag ggccacctgg
     5341 tacagattca acttctcatc tatcagatac acactgtcaa accaacggac ctcagaagtt
     5401 gatagaaatt aacctcatag ataaccaaaa caagaaccaa gaggtatacc agtcagaggg
     5461 ttgcagagaa agtgaaatga agagaaagac tgaattaaaa ggaaaggtag caactgaaga
     5521 agaagaagaa gaagaagaag aaggtgccaa cagcatagaa gattctaatt caaaccatgg
     5581 caacagaaat acatgggaag gagaaatagg acaacccaag ttgtcaacag ttgacaaaaa
     5641 gggagaacag tctagcaaat tgatgaccgg acatgagaat acaagtaaag tagtaattga
     5701 attgagtccg tctctccctt ccaaaaggac aaaaatagat ttatttccgt cattgctcca
     5761 gaatccaaaa agcatgcctg aactacttct gctgtctcca gctggatcag gtttgtgttt
     5821 aaagagacaa gagatttggg agaggccaga aaaaccagga ttggaagatg tggagctaca
     5881 aggtacccgt ccagaactaa ctgtgacaat agaaagcaaa gttttggaaa actttgacac
     5941 tacacactta gaggtagagg ggtttgcatc tctgaggaat ctgggggata tgcatgccaa
     6001 tttccacaat agtcagacag aacagacacg gaggtcacca actgccctgt cagagaaaat
     6061 gtctgaagaa atttctgtgt catctgtcat gtgtaatcct tccagttcca gtgacattga
     6121 accagtacca tctttttctg gatttccatt agaatctccc aaaactttgg tgcttaactt
     6181 tgaaacagag ggtgcacata gctcatctaa ttccagaaat gggagaatca cctctaactc
     6241 tttggaaact ggacaccctg tggaaaatgt tggccacgac ttaggaggtg agagaacaca
     6301 ccaggccctt gacctcttag ctggaggaat gttgtctgag gacgtaaaag aaacttcgcc
     6361 actacagaaa gatttactca gaatggaatc caccacagtc agtccttcag gccttggacc
     6421 atctccttgc cttccagacc ttgttgattt tgtcacacgg acacctggag ttccaaaaca
     6481 aaaaccatgt tctccacttt ctgagccaga tgcctttctc aagtgtagtt cactggagat
     6541 gggatcacca cctccagaaa ttctgagtgt gtctgtctca gaggtagcag ttcctcaagt
     6601 aagtgaagac aatgacagtg ctttgaattt ggtaaaaact ccaccctcag gctccccctc
     6661 aagggatcag gtagttggag gcaatgtgag ccctcgggaa atgcctgaac aagaagctgc
     6721 agttgatgtc atcccagacc acacaaggtc caatgtttat aacagtcagg actacttaaa
     6781 tggatgaatc attagatttt ggaaaatgga tcccaagact agttggcaat ctcatctgga
     6841 accggcacag taaatgttct ttggagtttt aaaaaaaaaa aaaaaagcct tctcttccct
     6901 ctttccctta aaaatactag acaaaataag ttttaacaac ttctctacat atctgtaaag
     6961 aaaagtattt tctgttaatt tttttaattt ttggccaaat tattttctct ttgtcattaa
     7021 agtcaaatgt ctatctggct caccacaaag tgttctttga ttttggcttt gaggctgcca
     7081 tttctggaat aaggggggat gggaaacagc tgacttcaat taccgtgctg tatattaccg
     7141 tgctgtatac ctatctactt ttctgggcag ctgatggagc tctggaagaa acaccaaagc
     7201 ctgctggaaa ggaaagcgtt tgaagaaaga attgtcctcc tgtaggttcc attccttcgg
     7261 atgggcctac cttaccattg ttaggacagc gtgagtagac ctgcttgctc ttctcacttt
     7321 cctcattggc ttattaatta gctccttact ttgttgcctt tgcttcaaat ggtttgagtc
     7381 accaacagac ttgtttggga gtggcctcag taaatgacag aaaaactgac aggctcagtt
     7441 ttggaagaca gcaaactggt aaggttcatt cctggctcgg tgccaggaac atttgtgttt
     7501 tggagctcac ttttagtttt gaaacggcct ttgctcgtta tattgtgatc cagtacattt
     7561 tatgttaaat tgtttatcag ccatttctgt tgtgaactgt agaagatctt aaattgggat
     7621 tggactcact ctctgttcca caaacataga tgtaaccctc tacctctcct tacccaactt
     7681 attaccacca tactgtgatg ttttgggttg tacattttgt ttaataaaag attaaagaat
     7741 ttatgaagtt ggcttggaca agtttaaatc catttttaat gtgttaaatt ttttttggaa
     7801 taaatgtatt catcttctac ttcttcctgt atgtttgtct tgacaccaca caaattggaa
     7861 cttcaaaaga aactagaata gtgaatggct gccctgtcca ctgcagccta caactgtcct
     7921 tctccagagc cacttccttc tcatcaggat cagagattgt acagtctccc ctgtgctgcc
     7981 agagtgtaga gggaaggtgg ctcccccagg cacttctgga agtggagctc tgaatgggca
     8041 ttcaggtgct gggtgggatg cacttgggag tcagggagcc catgcctcgg ggttcaaaac
     8101 tgttgcagtt tcctcatgct gttcctttgt cagactgtgt aacctgcttc aacagagact
     8161 tgagcagagc cagcctccgc ctgctcctca gcattccttc aattcctttc tgcagggttc
     8221 ctgtcccatt gccttatcta cagaacccct agtttgagtt tggtgagaat attttgtttt
     8281 ttagactctt aattccaact tacaagttct gacctctgtt gtgaaaaggc atggatgtga
     8341 gagtccttga ctacgtcccc gccatttgct ttgccttgtt tttgatgagt ttctttacat
     8401 cattgtgttc tagttggcat ttgtctttat tcctttaaag gtgagggtta ttacttcatc
     8461 tcagaatcaa atatgtacag aatccgagta accttggtag gagtgggaga gagtatgaga
     8521 atgcatgcac atggatgtca gaagacagct ttgaggagtt gattctgggg gctggacgtg
     8581 ggccatcagt ggaagcacgt ctacatactg ttcctcgggt cttaagctaa agtttgagtt
     8641 gagtgttctc ttggcctgga aaccatagag tgactcaaaa aattgctctt agaaaagctt
     8701 aaactcagtg gattttaaaa gatcacttct tcagaaaact gctcctttct tgttatagga
     8761 ggttatctat gggaatttaa ggaaaaataa atttaaatgc cagtttgtac tgactttcag
     8821 gcctcagttc cgcttctctc ttggggagag aaattaatca tacctagatt taacttcact
     8881 ccctaggttg ggggggcagg tacttggaag gagtagaaag gacaaggcaa taaataccta
     8941 aggagggcag acctaccata ggcagccaga gccaaaactc cacagaggac ggtgagcctt
     9001 aactttccct tataactgca gaatggcttc ggggcttatt ctaaagttgt ctgtaaatct
     9061 agggtttcct ctggaatagt ccctggaagg aatggcattc ttcaactcta ccctgaaccc
     9121 acagagggaa cagattttag gacactagtt tgcaggaagt gctgccatcg ccctttgata
     9181 aactgcatct agctttggag cctgtccaga gaagccatgt gaaagtgcag aactctagtc
     9241 cagtagcagg tacttagaca ttttaaaggt ttatcttatg gaactaaaag tttggtcatg
     9301 gggctggaga gatggctcag cagttaagag cactgactgc tcttccagag gtctcaagtt
     9361 caatacccag tacccgcatg gtgactcact gccatctgca atgggatctg atgccctctt
     9421 ctggtgtgtt tgtagacagc tacagtgtac tcatataaat aaaataaatc ttttaaaaaa
     9481 gattttaaaa cagtttgacc ttggaggtga ggaatgggct ctggtctttt acacaggctt
     9541 tgttgcaata tcattatgtt taagtccaga acaatttttt tcttaattta tgttcattgg
     9601 tgttttgcct gcatgtatgt ctgtgtgacc gtgtcagaag ccccagacct gggattacag
     9661 acaggtatga gctgccatgt gggtgctgga gattgaaccc agatactctg gaatagcagc
     9721 tagtgttctt aactgctgag ctttctcttt agttcccccc ttccttctaa atttttactc
     9781 gacaacttca gcagtaagaa attaacagta gtgtttaaat atggacaaat gcctactttc
     9841 acccagttct ttcagttatt ccctgaaagg cccctgtgct ttgtgaatgc tttttttctg
     9901 ctgtatatag catcttttcc ctatttataa ctggtctcac agagcctgta atactctagt
     9961 gctctttctg ctaatactac tgagcaatac agtaaagtag tcttcaccta tttcatctct
    10021 caaaactgag aaagcaaaaa aagggttttg catacaaaaa tatgtcttgt ccgattgtca
    10081 gcttctggga ctgaagaaaa tggacatgca agatataatt acagtggcgg gagggtaagt
    10141 agaaggatgc tcgggagcgt gtgaagctgt taaggagggg tggtttcatt ttcacgtatt
    10201 tcaaagaact gggtctcctc actgaggctt atgtactaga tccagtaaga atccaagtcc
    10261 tcacttgttg acagtttaga tgaaaatata taaatataga gtatatctga ctttttttag
    10321 aatttgcatt tttatgcatt tgtataatta gtgactgttt aatccactgt agcacgaata
    10381 tctaggtggt tctttctttc tttctttctt tctttctttc tttctttctt tctttctaag
    10441 atgatagtta aaacattccc ttttctcact ccaaaccctc ctatatatcc ttcctcgctc
    10501 tgtttcaaat tcaggaccca ctttttcatt cattgttatt acatgcatat atatgtacat
    10561 atatatatgt ctgattataa gcagcctata taatgtcact tgtatgtgtg tattcagggc
    10621 tctatttcta ttaaataatc agttgatgtg ctcttctctg gagaagcctg tttctcagca
    10681 tgccttggtt tcctatagtt ccttgtgtag gttgaagcct cataggtgtg tctgttggta
    10741 tcttccttgc tcagctgatg tctaggcagt cacgatgatg agactttatg ggtgtacctc
    10801 ctggcattac taggagacac aatctcacag caaactttcg gatcctctgg ctctttctta
    10861 caatgcttcg cgctccccga acctcaagtg caggggtatt ttgtatatgt atccattgat
    10921 ccattgggcc taggtagagt ttgattttgc aattatgttt atttaatttc attttggtct
    10981 tatgtgatgt gttttttttt ttttaaagac agcttctcac actagtccag gctagcctag
    11041 aattaactgt gcagaaaagg ctagacctaa atttataaaa gtcttcttgc ctttacctct
    11101 caagggccag gattacaggt atatgccaac atatctggct tgcttgtata atttaattct
    11161 gtatacaata atagtctcat ggatagtaca atttttaaag tttataattg taaaaaaaaa
    11221 ataaccagta tccagatacc ttgacccata tacacttgga aggaaatatc cataagtgtg
    11281 tatgcttatg tagaagcatt taacatggtt ataattttat ttctgtgcgt ctgttggcta
    11341 atccatgtgc actgactgcg ctataagaga aatcactctt tgcttactct gcttttctcc
    11401 ctttgtattc atagtgcaca attgccctcc cctccaatag aaaatctcaa taaaaatgtt
    11461 ggaaaaaatc actatggtaa tagttatttt ccttaactga ctgtcaatac ttagcaattt
    11521 gtatatggat taaaactcag ttgctgccta tgtctgctgg gtgcttagca ttctagaagc
    11581 caactgtctt tttgttctcc tgtcctggtt ctttgtgtac aaagctctgt ggaagttaat
    11641 gcgatcaagt tcgcaggcgg tcctctcgta cagtaacatt ctggagccat ggtaccagat
    11701 gagatgggga acactgccct tacacctcct agaaaagaaa ctgaaatgta aggaggtcac
    11761 ctgactaagc taagagctgc taagaaaagg ctggaggcat tttgagaacg ctgattttca
    11821 actggtctga ctttcagtgc tggtgccagc tggtcagact ccagacttcc tgtgatctag
    11881 ctgaagaagt aattcagtgt tttatgtcct aatatcttct tgacatttca gcaaaactaa
    11941 aactaactgt ttcattcatg ggtaaaaata aaaacataaa agattatctt tcaggggaaa
    12001 actaattttg tttgtattga ctgctctgtt tcaacttctg acaatgaaaa tgcattttat
    12061 ataaaaatac tttatacatg taaaaagtat aaattcacac acaagacaag attatgttgg
    12121 agttgtctgg tactaaaaaa aattataaat ctgggttttg ttttgttttt ttaatccttc
    12181 tgtgtgctaa aacccatttt ttttcaaagc tgtgtttaac ctctgtcatt tgttttcttt
    12241 ccatcagtac caatagatcc tgggttttta cccctcaaga cttaataaac tactgccact
    12301 gttctcaggg caatacacct tctttaagaa tctccagcca tttttttatt ttgcttatgt
    12361 acaaacactt ggacattaaa tgttataaat caagacattt gtcttcacaa agcttacttg
    12421 actgcaagtc cacaacagat atcaaagttg ttgctacaga caatagaatg gaagataatg
    12481 catatctaga tgtaaggacc taaagcttta tgggcttttg ttccttccat tcatgaagga
    12541 gccagggcaa tcaatagaga aaggtttgta gttggtgaga tggttcagca ggtaaaggta
    12601 ctcgctgcca agtctaatga cccgagttca atcccacccg tatatacggt agaagaaaat
    12661 aactgactcc taaaagctgt cctctgattt ccatgtgttt gtacctacat acataccccc
    12721 cccacacaca caaaagtaag gagttttgca gaaaataagt atgtttaagg taagtgaatg
    12781 agcaggaaga aaatagaaac aattatataa tgaaagaaca aaagaactga aagaagggtt
    12841 ggagacagtt gagaagatag gagcctgtac tgggtagttg ccagcatgta catctggtgg
    12901 ctcatggcca cctgtgactc cagcttctgg agatctgatg ccctcttgtg gcttctctgg
    12961 gcaccctcac ttatgtgcac ccctaccctg tacacacaca cacacacaca cacacacaca
    13021 cacacacaca aaaaaaaaaa aaccaacatt taaaaatcct tcaaatatgg gctagagaga
    13081 tggctcagca gctaagagca ctgacagttc ttccagaggt cctaagttca atttccagca
    13141 accacatggt ggctcacaac catctgatgg gatctgatgc cctcttctgg agtgtctcac
    13201 aaaacagcga cagtgtactc acatatataa aataaatcaa taaaaataaa gaatgtggag
    13261 aaagcaaaaa cataaaaacc atgttgaaga attattgcat ttcccctctg attctctgtt
    13321 aagattttat tcagctttcc tgtacctacc tactttacaa taactatgat cacattgtta
    13381 ctgcctctcg ctgatctatc tccttttctt tccaggggca gttccagaag tcttcacatt
    13441 ttcaaacgga aggactgaag cagatgtttc tgctccagga atgcagggat agaaaccaca
    13501 gagattatgg aaataatgtg cgtccttgtg gccagtagac agtccccctt aggtctgact
    13561 tacagaaggt gggcctggct gttcgcacct ttatggagaa agccctttca ttttagctac
    13621 caggaaccag tgattgggtg agtaaatatg tgtgttgtgt ccttctatct agaggaagaa
    13681 caagctaaga agagacacct tatctagcac agaataaagt actaaactcc acctctaatg
    13741 ttaaaattgt gggaactggt aagatgtttt agcaaaaaca cttcctgaca agcctgaggc
    13801 cctgagtttg aaccttgaga cccacataat ggaaagacag aaccaatccc tacgggttgt
    13861 cttctaactt ctatatatac cttggcatgt gcattaataa ataaatgtag ttataagaaa
    13921 aaaaaa
//
