LOCUS       NM_001360208            3630 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus zinc finger protein 30 (Zfp30), transcript variant 2,
            mRNA.
ACCESSION   NM_001360208
VERSION     NM_001360208.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3630)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3630)
  AUTHORS   Laudermilk,L.T., Tovar,A., Homstad,A.K., Thomas,J.M.,
            McFadden,K.M., Tune,M.K., Cowley,D.O., Mock,J.R., Ideraabdullah,F.
            and Kelada,S.N.P.
  TITLE     Baseline and innate immune response characterization of a Zfp30
            knockout mouse strain
  JOURNAL   Mamm Genome 31 (7-8), 205-214 (2020)
   PUBMED   32860515
  REMARK    GeneRIF: Baseline and innate immune response characterization of a
            Zfp30 knockout mouse strain.
REFERENCE   3  (bases 1 to 3630)
  AUTHORS   Chen,W., Schwalie,P.C., Pankevich,E.V., Gubelmann,C., Raghav,S.K.,
            Dainese,R., Cassano,M., Imbeault,M., Jang,S.M., Russeil,J.,
            Delessa,T., Duc,J., Trono,D., Wolfrum,C. and Deplancke,B.
  TITLE     ZFP30 promotes adipogenesis through the KAP1-mediated activation of
            a retrotransposon-derived Pparg2 enhancer
  JOURNAL   Nat Commun 10 (1), 1809 (2019)
   PUBMED   31000713
  REMARK    GeneRIF: Using murine and human in vitro and in vivo models, study
            demonstrated that ZFP30 promotes adipogenesis by directly targeting
            and activating a retrotransposon-derived Pparg2 enhancer. Through
            mechanistic studies, study further show that ZFP30 recruits the
            co-regulator KAP1, which acts as a ZFP30 co-activator in this
            adipogenic context.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3630)
  AUTHORS   Laudermilk,L.T., Thomas,J.M. and Kelada,S.N.
  TITLE     Differential Regulation of Zfp30 Expression in Murine Airway
            Epithelia Through Altered Binding of ZFP148 to rs51434084
  JOURNAL   G3 (Bethesda) 8 (2), 687-693 (2018)
   PUBMED   29242385
  REMARK    GeneRIF: Data indicate zinc finger protein 148 (ZFP148) as a
            transcription factor that differentially binds to the zinc finger
            protein 30 protein (Zfp30) promoter region harboring rs51434084.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3630)
  AUTHORS   Rutledge,H., Aylor,D.L., Carpenter,D.E., Peck,B.C., Chines,P.,
            Ostrowski,L.E., Chesler,E.J., Churchill,G.A., de Villena,F.P. and
            Kelada,S.N.
  TITLE     Genetic regulation of Zfp30, CXCL1, and neutrophilic inflammation
            in murine lung
  JOURNAL   Genetics 198 (2), 735-745 (2014)
   PUBMED   25114278
  REMARK    GeneRIF: Zfp30 is expressed in airway epithelia in the normal mouse
            lung and Zfp30 expression in vitro affects CXCL1 responses to an
            immune stimulus.
REFERENCE   6  (bases 1 to 3630)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 3630)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 3630)
  AUTHORS   Denny,P. and Ashworth,A.
  TITLE     Zfp30, a KRAB domain containing zinc finger protein gene, maps to
            mouse chromosome 7
  JOURNAL   Mamm Genome 5 (10), 643-645 (1994)
   PUBMED   7849402
REFERENCE   9  (bases 1 to 3630)
  AUTHORS   Ashworth,A. and Denny,P.
  TITLE     Zinc finger protein genes in the mouse genome
  JOURNAL   Mamm Genome 1 (3), 196-200 (1991)
   PUBMED   1797234
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156934.1.
            
            On Jan 30, 2018 this sequence version replaced XM_017322135.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (b)
            has the same N- and C-termini but is 1 aa shorter compared to
            isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6116558.7184.1,
                                           SRR7652917.149736.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-934               AC156934.1         74733-75666         c
            935-1063            AC156934.1         73331-73459         c
            1064-1190           AC156934.1         71459-71585         c
            1191-1286           AC156934.1         70198-70293         c
            1287-3630           AC156934.1         64931-67274         c
FEATURES             Location/Qualifiers
     source          1..3630
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 17.26 cM"
     gene            1..3630
                     /gene="Zfp30"
                     /gene_synonym="2610306P15Rik; Zfp-30"
                     /note="zinc finger protein 30"
                     /db_xref="GeneID:22693"
                     /db_xref="MGI:MGI:99178"
     exon            1..934
                     /gene="Zfp30"
                     /gene_synonym="2610306P15Rik; Zfp-30"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1063
                     /gene="Zfp30"
                     /gene_synonym="2610306P15Rik; Zfp-30"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1190
                     /gene="Zfp30"
                     /gene_synonym="2610306P15Rik; Zfp-30"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1286
                     /gene="Zfp30"
                     /gene_synonym="2610306P15Rik; Zfp-30"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..3630
                     /gene="Zfp30"
                     /gene_synonym="2610306P15Rik; Zfp-30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2898..2903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp30"
                     /gene_synonym="2610306P15Rik; Zfp-30"
                     /note="hexamer: AATAAA"
     polyA_site      2925
                     /gene="Zfp30"
                     /gene_synonym="2610306P15Rik; Zfp-30"
     regulatory      3609..3614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp30"
                     /gene_synonym="2610306P15Rik; Zfp-30"
                     /note="hexamer: AATAAA"
     polyA_site      3630
                     /gene="Zfp30"
                     /gene_synonym="2610306P15Rik; Zfp-30"
                     /note="major polyA site"
ORIGIN      
        1 gcattgaagc agcgagaaag agacacacac agccccacct ccaaccccct tcccctgacc
       61 aagagctagg ggcctggctc gcagcctccg cggggctgga agcccagaac ctagtcaaag
      121 aagctagtgg cagtcggact ctcaggcttg agatctgatg tcccagagcc ttcagtacca
      181 cggtcccgtc cgtagcactt tggtgccgcc gctgcagcgc tgaccgcgct ggcaacccac
      241 cctcccggga tacccgtcag ctgggtggtc cccggtctcg tgcggcctac gctcttctcc
      301 ggggacccgc tctgaggacc cctgggactc aggtggcccg ttcgtgggta cagctgccgt
      361 gctgacgcgc tgcacctaaa ccccggcctg gctgtggaca aggaccgaga gggaaggcgg
      421 gggccgcgac ttgcacggtg gagataccct gtgcagaacc ttagattccc ggcgggcctg
      481 gggagcagag aaccggggga cacctcggac ctaaggctgg gcagccccgg actggtaact
      541 ggtgaagcag agtggccgaa gcagcaaact cgggcacggg tgactgtggg ctgctgtagt
      601 ctatctcgct tgctgggatc atacggatgg ggtcagcctg gagccctgaa gcttggaagg
      661 ggattctgat caatttcaga aaagcgtagg ggtgaggcca gaggacgtgg tggcatacac
      721 ctgacttctc gggatttggg aggtggaggc agggggagta ggcgctcaag gtcattctct
      781 actgcctaac gttgggttgc aagagagaaa aagaaaagag aagaagaagg aaagaagaga
      841 aaagaaaaga aacaaggcct ggagtgtctg ccagtcttca gaagagaccc tagaagccag
      901 cagctactac ttctgtttaa aacagagatt atgtctctag aacagttctg ctctcatggc
      961 tgcaccctct ccctccagct ctagcctctg tgaacggctt caccaggaca tgatcctcga
     1021 ggaagaacaa gccagttctt gcgattctgg aatcatggct catagtacgg tgatgttcag
     1081 agatgtggct gtgggctttt ctcaggaaga gtgggagtgc ctgagtgcct acgagaggga
     1141 tctgtacaga gatgtgatgc tagagaacta cagccacttg gtgtcactgg gatgttccat
     1201 ttctaagcca gatgtgatca ccctgttgga acaagggaag gagccgtgga tgattgtgag
     1261 ggctgagaag agaaggtgga gccgagatct ggaatccaga tacagcagta acgggttact
     1321 tccagaaaag aatacttacg aaattaatct atctccgtgg gaaataatgg gaagaattca
     1381 aaggcgtggc cccgaagact cccttttggg gaaagacttt gaatataaaa tatatgaaga
     1441 acaagagaac tctcataggg tatatttcag acacgtgata aaaaccacct ctggaaaaag
     1501 acctcggtac agaaaacgca cacctgttag tctctatcag aaaactccta acggagaaaa
     1561 gccctacgaa tgtggggagt gtgggaaggc tttcaaagtc cgccaacaac ttactttcca
     1621 tcagaggatc cacaccggcg agaagcccta cgaatgcaag gaatgtggca aagccttccg
     1681 acagtgcgcc cacctcagtc gccatcagag gatccacgcc tctgacaagc tctatgaatg
     1741 taagaagtgt gcaaagatct tcacgtgtag ctcggacctt cgagggcatc agaggtctca
     1801 cgtgggcgag aagccctacg attgtaaaga gtgcgggaag gcctttcgag tccgtggaca
     1861 gctcatgctc caccagagga tccacaccgg tgagaagccc tacgcatgca cggagtgcgg
     1921 caagagcttc cggcaggtag cgcacctcac tcggcatcag aggctcaaca gtggcagctc
     1981 acgccacgag tgtaaggagt gcggccgggc tttcctgtgc agcacgggcc tccggctgca
     2041 tcacaaactg cacacgggag agaaacccta cgactgcaag gagtgtggga aggcgttccg
     2101 ggtgaggcag cagctcaccc tgcacgagag gatccacacc ggcgagaagc ccttcgactg
     2161 caaggagtgc gggaagacct tcagccgcgg ctaccatctc accctccacc agaggatcca
     2221 cactggggag aagccttacg agtgtaagga gtgccgcaag ttcttccgcc ggtactcgga
     2281 gctcatttcc caccagggca ttcacatcgg ggagaaaccc tatgactgca aggagtgcgg
     2341 aaaggctttt aggctgttct cccagctgac tcagcaccag agcattcatt ttggtgagaa
     2401 gccctataaa tgtatggaat gtgagaagac tttcagactc ctctcacaac tgacgcagca
     2461 tcagagcatt cacacgggcg agaagcctta cgattgtaag gagtgcggga aagcctttcg
     2521 cctccactcg tctctcattc agcaccagag aatccactct ggcgagaagc cgtacaaatg
     2581 tacggagtgt aagaaggcct tccgtcaaca ctcacacctc acctaccatc agcgaattca
     2641 taagaatttg taaggaccct tctacgaatc cttgccttgc aaatgtacta aggagcagta
     2701 ggaaatcaga aaattctaga agaaaaaaag gtttgaatcc ttattttgct gtgttcataa
     2761 gtaacagcat aaaaggtcaa aggaaaaaaa tggtaaactt ttggaaattc tttcgtaaat
     2821 gtataaaagg tattttgtct tactgtacac ctacctaagg gcatagtcag ggtaccaact
     2881 cattttgaaa attaataaat aaaaagaatt gtcgtttagc ctgcataaac tctccgagtg
     2941 actgaaagtg gttgaggtac acagttctta gagtgtttca tcagaatcac gcagagtcat
     3001 atggaattaa gaagttgtat caggaaaacc attgtgtaat aacatacagt ggagcagcga
     3061 ttctcagcct gtgggtcccg accctctgag ggtagagcca ccctttctca ggagtcacct
     3121 aggaccatcg agacacagat tcgcattatg atccattaca gtagcaaaat tacagttatg
     3181 aagtagcaac acgtgattta atggtgggag tcaccacagc atgaggaact gtattaaagg
     3241 gtcacagcgt tagggaggtt gagaaccact gctctagaat tcagccatga tagactggct
     3301 tgtacttggt agtgaatagg tcaggctgcc aggatgtgaa cctactgatc cgtcttgcca
     3361 ccagtgtagc acagtaaagc gtcccgtgtc ttccactgcg acattgtgat attcccacct
     3421 aactcaacgc accaaacctc taaatcaatg agacaaccac caacattaaa aaaaaaaaaa
     3481 aaaaaagagt caaaaaacat ataatctagg ccagatcttc acaatctttc ttgtgtgttt
     3541 tttttctacg tattcaagag tgaagtgaat tttgtttgta aacttaaaaa aaaaactttc
     3601 ttaaaagtaa taaagacatt tttacaggta
//
