LOCUS       NM_177643               5271 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger protein 281 (Zfp281), transcript variant
            2, mRNA.
ACCESSION   NM_177643
VERSION     NM_177643.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5271)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5271)
  AUTHORS   Huang,X., Balmer,S., Lyu,C., Xiang,Y., Malik,V., Wang,H., Zhang,Y.,
            Cai,B., Xie,W., Hadjantonakis,A.K., Zhou,H. and Wang,J.
  TITLE     ZFP281 controls transcriptional and epigenetic changes promoting
            mouse pluripotent state transitions via DNMT3 and TET1
  JOURNAL   Dev Cell 59 (4), 465-481 (2024)
   PUBMED   38237590
  REMARK    GeneRIF: ZFP281 controls transcriptional and epigenetic changes
            promoting mouse pluripotent state transitions via DNMT3 and TET1.
REFERENCE   3  (bases 1 to 5271)
  AUTHORS   Chopp,L.B., Zhu,X., Gao,Y., Nie,J., Singh,J., Kumar,P., Young,K.Z.,
            Patel,S., Li,C., Balmaceno-Criss,M., Vacchio,M.S., Wang,M.M.,
            Livak,F., Merchant,J.L., Wang,L., Kelly,M.C., Zhu,J. and
            Bosselut,R.
  TITLE     Zfp281 and Zfp148 control CD4+ T cell thymic development and TH2
            functions
  JOURNAL   Sci Immunol 8 (89), eadi9066 (2023)
   PUBMED   37948511
  REMARK    GeneRIF: Zfp281 and Zfp148 control CD4[+] T cell thymic development
            and TH2 functions.
REFERENCE   4  (bases 1 to 5271)
  AUTHORS   Allegre,N., Chauveau,S., Dennis,C., Renaud,Y., Meistermann,D.,
            Estrella,L.V., Pouchin,P., Cohen-Tannoudji,M., David,L. and
            Chazaud,C.
  TITLE     NANOG initiates epiblast fate through the coordination of
            pluripotency genes expression
  JOURNAL   Nat Commun 13 (1), 3550 (2022)
   PUBMED   35729116
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5271)
  AUTHORS   Yan,P., Lu,J.Y., Niu,J., Gao,J., Zhang,M.Q., Yin,Y. and Shen,X.
  TITLE     LncRNA Platr22 promotes super-enhancer activity and stem cell
            pluripotency
  JOURNAL   J Mol Cell Biol 13 (4), 295-313 (2021)
   PUBMED   33049031
  REMARK    GeneRIF: LncRNA Platr22 promotes super-enhancer activity and stem
            cell pluripotency.
REFERENCE   6  (bases 1 to 5271)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 5271)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   8  (bases 1 to 5271)
  AUTHORS   Wang,Z.X., Teh,C.H., Chan,C.M., Chu,C., Rossbach,M., Kunarso,G.,
            Allapitchay,T.B., Wong,K.Y. and Stanton,L.W.
  TITLE     The transcription factor Zfp281 controls embryonic stem cell
            pluripotency by direct activation and repression of target genes
  JOURNAL   Stem Cells 26 (11), 2791-2799 (2008)
   PUBMED   18757296
  REMARK    GeneRIF: Zfp281 plays bifunctional roles in regulating gene
            expression within the network.
REFERENCE   9  (bases 1 to 5271)
  AUTHORS   Wang,J., Rao,S., Chu,J., Shen,X., Levasseur,D.N., Theunissen,T.W.
            and Orkin,S.H.
  TITLE     A protein interaction network for pluripotency of embryonic stem
            cells
  JOURNAL   Nature 444 (7117), 364-368 (2006)
   PUBMED   17093407
REFERENCE   10 (bases 1 to 5271)
  AUTHORS   Froussard,P., Chastagner,P., Somme,G., Abadie,A., Greene,W.,
            Theze,J. and Longacre,S.
  TITLE     p55 IL-2 receptor mRNA precursors in murine T lymphocyte nuclei
  JOURNAL   J Immunol 141 (4), 1358-1364 (1988)
   PUBMED   3135330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV581959.1, AK142218.1 and AC126606.16.
            
            On May 16, 2009 this sequence version replaced NM_177643.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142218.1, BC003243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AV581959.1         34-117
            85-3132             AK142218.1         2-3049
            3133-5271           AC126606.16        38018-40156         c
FEATURES             Location/Qualifiers
     source          1..5271
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 59.93 cM"
     gene            1..5271
                     /gene="Zfp281"
                     /gene_synonym="Znf281"
                     /note="zinc finger protein 281"
                     /db_xref="GeneID:226442"
                     /db_xref="MGI:MGI:3029290"
     exon            1..151
                     /gene="Zfp281"
                     /gene_synonym="Znf281"
                     /inference="alignment:Splign:2.1.0"
     exon            152..5271
                     /gene="Zfp281"
                     /gene_synonym="Znf281"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4900..4905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp281"
                     /gene_synonym="Znf281"
                     /note="hexamer: AATAAA"
     polyA_site      4922
                     /gene="Zfp281"
                     /gene_synonym="Znf281"
                     /note="major polyA site"
ORIGIN      
        1 gccgagcgcc cctctggtcc ggtcgaggac ttcccggcag acaccgcgcc gcggctgcgc
       61 agaagcgggg aggcttttaa ttccattgtg gagaggacgg cgttattttt attaactgga
      121 ggcgacggcg gctgcggcgg cggcggaacc cgcctcctcc ggggtatgaa aatcggcagc
      181 gggttcctta gcggcggcgg cggtcccagc agtagcggtg gtagcggctc cggcggcagc
      241 tccggcagcg ccagcggcgg cagcggcggc ggcaggagag cagagatgga gcccaccttc
      301 ccccagagta tggttatgtt caaccaccgg cttcccccgg tcaccagctt cacccggccg
      361 gcggggacgg ccgcccctcc cccgcagtgc gtgttatcct cctctacctc cgcagccccg
      421 gccgctgagc ccccccctcc gccagccccg gacatgactt tcaagaagga gccggcggcg
      481 tcagccgcgg ccttcccttc gcagaggacc tcctggggat tcttgcagtc cttggtgagc
      541 atcaagcagg agaaacctgc ggatcccgag gagcagccgt cccaccacca ccatcaccac
      601 caccactatg gggggctgtt cgctggggct gaagagcgat caccaggcct aggaggaggg
      661 gaagggggga gccacggcgt catccaagac ctcagtcttc tgcaccagca tgcccagcag
      721 caaccggccc agcaccaccg cgatgtatta ctgagcagcg gtagcaggac tgatgagcac
      781 ggcaaccagg agccaaagca ggacgctaac gtcaaaaagg caaagaggcc aaagccagaa
      841 tctcagggaa tcaaagccaa gaggaagcca agtgcatctt ccaaaccttt ggttggagag
      901 ggagaaggtg ccgtcctgtc cccaagtcag aaacctcata tctgtgatca ctgtagtgct
      961 gctttcagga gctcctacca cctgcggaga catgtcctca tccacacggg cgaaaggcct
     1021 ttccagtgca gccagtgtag tatgggtttc atccagaaat acctactgca gagacacgag
     1081 aaaattcaca gcagagagaa accctttggg tgcgatcagt gcagcatgaa gtttattcag
     1141 aagtaccata tggagagaca caagaggaca catagtggag aaaagccata caagtgtgac
     1201 acttgccaac agtatttttc aaggactgac agattgttga agcacaggcg cacgtgtggt
     1261 gaagccatag caaaaggagc cgctagtgca gaacctgggt catcaaacca taacagtatg
     1321 ggtaacctgg ctgtgttgtc tcagggaaat acaagttcct caaggagaaa gtcgaagtcg
     1381 aaaagcatag ctattgaaaa taaggaacac aagactggca aaacaaatga atcacaaatg
     1441 tcaaacaata taaacatgca gagttattca gtagaaatgc ctactgtgtc taccagtggg
     1501 agcataattg gcactggaat agatgaactg cagaaaaggg tgccaaaatt gatctttaag
     1561 aaaggaagca gaaagaatgc agataaaagc taccttaatt ttgtgtcacc gttaccagac
     1621 gtagttgggc agaaatcctt gtctggtaag ccaggtggct cacttggcat cgtatcgaat
     1681 aatagtgtgg agaccattag tcttctccaa agtacaagtg gcaagcaagg cccgataagt
     1741 agtaattatg atgatgccat gcagttttca aagaagagaa gatacctacc aactgccagc
     1801 agcaacagtg ccttttctat caatgtagga cacatggtct cccagcagtc agtcattcag
     1861 tctgcagggg tcagtgtttt ggacaatgag gcgccattgt cacttattga ctcctcagct
     1921 ctaaatgctg aaattaagtc ttgtcacgac aagtctggaa ttcctgatga ggttttacaa
     1981 agtattttgg atcagtactc tggcaaatca gaaacacaga aggaggatcc tttcaattta
     2041 acagaaccac gagtggattt acacacctca ggagaacact ctgaattggt tcaagaagaa
     2101 aatttgagcc caggcaccca aacaccttca aatgataaaa caagcatgtt gcaagaatac
     2161 tccaaatacc tccaacaggc tttcgaaaaa tccactaatg caggttttac tcttggacac
     2221 ggtttccaat ttgtcagctt gtcttcacct ctccacaacc acactttgtt tccagaaaaa
     2281 cagatataca ctacatctcc tttggagtgt ggttttggcc agtctgttac ctcagtgctg
     2341 ccatcttcgt tgccaaagcc tccttttggg atgttgtttg gatctcaacc aggtctttat
     2401 ttatctgctt tggatgctac acatcagcag ttgacacctt cccaggagct ggatgatctg
     2461 atagattctc agaagaactt agagacatca tcagccttcc agtcctcatc tcagaaattg
     2521 actagccaga aggaacaaca gaaaaattta gagtcctcaa cgagctttca gattccatct
     2581 caggagttag ctagccagat tgatcctcag aaagacatag agcctagaac aacgtaccag
     2641 attgagaact ttgcacaagc attcggttct cagtttaagt cgggcagcag ggtgccaatg
     2701 acctttatca ctaactctaa tggagaagtg gaccatagag taaggacttc agtgtcagat
     2761 ttctcagggt atacaaatat gatgtctgat gtaagtgagc catgtagtac aagagtaaag
     2821 acacccacca gccagagtta caggtaaggt ctcgagagtg accaggctgg gagtctaatg
     2881 taattttgtt ttattttgag aacactgcca ttggaatgtt tctacacgat cctattaaga
     2941 ataatgtaat gccctttcaa tgcaactttt catatttagt ttattttgtt agtgtgattt
     3001 tagctctgtt tgtattatga tttttaatca aaatcaatag attaaaaata gtttgacatt
     3061 caaagtgaca atgtttagca atcaaattta catgtataga ttgtcaggga atagcccaaa
     3121 agttttaaat gcaaaaacaa aaaaaataaa acaaaacaaa aaaagtacag aaaaaaaaaa
     3181 agaaaagaaa aaaggaaaaa aaaagaaact ttgttgctag gattaaggtt attctaattg
     3241 ctttactctc aggaaagtgt aataacgcat gggaattctg tacgttatca ccgtaatgga
     3301 atatccaatt tacaaatagt atgatacaca tttcgttgtt taagttaagg gatcttaaac
     3361 atttcagatt gctctttctg ggctaataga atatacattt catcatttaa gtaagggatc
     3421 gaaaacattt caagtgctat ctctgtctgg gctgatccaa aattctgaga ttgttggcta
     3481 cctatatttt gttgcagctt ttcaatgtac tccacacttc caaacccaga ttcattccag
     3541 attggtagaa caaatattct tagatctttg atcaaagcct ggaatgatag ctttaataaa
     3601 agaaagagga aaaaaaccat cctctttatc cacctgtaac aaggctgtaa ttccattaag
     3661 tgattctgtg aatgtcttct ctagtacagt gttaaaatta aaaacccaag tgtttggttg
     3721 gtttcagtat tagaaagtaa gttcaattca catagtctat tgaaatttgg ggtgtgcatt
     3781 attcatggcc taaaacattc tcttgtttaa gctattactc accaccttca cgtctgggtt
     3841 tggtatttgt tcttaacttc ttaaagttct gggccttctt gttccttctc cctgtcttga
     3901 tggtttcaat tttagagtga tttatcatct agaagataat tgattatgca ttttatatgt
     3961 cgtaagacat tcaaatacta aacaataggg taaacatccc tgactttgct tttcttttta
     4021 ttttgttaac aaacccaata ccgacttcca cgtacaagct atacatagat gtcaaagggt
     4081 tgtcatccta cctggtggca gagcttgtgt aacagataag agtgtgtatt cagtaatgac
     4141 atcagaactc tttgtgaaat tgcagccttt aatgtacatt ttgaaggggt gtattagtca
     4201 gtattgtaca gggatcttgt catcaaaact tgctatgaac gctaattgcc atttgaagct
     4261 actgataggc agtggctctg ctctaaacca ctttttagca attgtatttt ttcctgatta
     4321 tattttttaa tgtactttga tgtttatgct gatgagtttt tatgtacttt tggtggtgtt
     4381 tagtcttatg aactcttctg acgtcagaaa agtcccactg gttgtttgca gtctcattgt
     4441 gtaatcagcc taccacaggc ttccatgtat aataaagtaa ttaatattgt gcaagtgtaa
     4501 aacacttctg ttataaaagc agtgtttgga aaataagaaa ttattaaaaa tggttacaaa
     4561 atactagtta attccctttt cccaccttcc accttttagc tttagttagc taaagggtac
     4621 caacttgtca ttgaaagatt tttagaaatg tgtttaattc ttttaataca ctcagtacta
     4681 aaatgtctgt atgtcttatt aagtgcagta agttctgttg ggtacagaga caagtgtgat
     4741 caaagatgga gaggaccttt acccctgtat ctcttaagct gtaggatctc tctctctctt
     4801 ctcttttgtt ttatacaggt tttgaatttc tttaactttt attgtgtgta ctgaatacta
     4861 catatgtatt attctgattg tttgctctag tttactacca ataaaagtcc tgttaatcac
     4921 aacattgaag aaaggagata tcacttagtc tctgtggatt acatttcata aaatattcgt
     4981 attgatagta taaattgtaa cgtaggagct tgccgtttta ttgtatttat aatgtatttt
     5041 gtctttctag gtttatttaa aaatgcattg aatattttat ttgaggtgca caataatata
     5101 aagaatagaa atctaatgta aattacatta tgttgaaact aggctaacca tcctaaatat
     5161 tagggagatt atttattgag gctttattta aaatcatatc aaaatatttt tggcttaagg
     5221 tgttatatat ccttttgcct caaagggtta taataaaatt atagaatgat g
//
