LOCUS       NM_178845               2076 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus zinc finger protein 277 (Zfp277), transcript variant
            2, mRNA.
ACCESSION   NM_178845
VERSION     NM_178845.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2076)
  AUTHORS   Xie,G., Peng,Z., Liang,J., Larabee,S.M., Drachenberg,C.B.,
            Yfantis,H. and Raufman,J.P.
  TITLE     Zinc finger protein 277 is an intestinal transit-amplifying cell
            marker and colon cancer oncogene
  JOURNAL   JCI Insight 7 (4), e150894 (2022)
   PUBMED   35015732
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2076)
  AUTHORS   Cheng,K., Xie,G., Khurana,S., Heath,J., Drachenberg,C.B.,
            Timmons,J., Shah,N. and Raufman,J.P.
  TITLE     Divergent effects of muscarinic receptor subtype gene ablation on
            murine colon tumorigenesis reveals association of M3R and zinc
            finger protein 277 expression in colon neoplasia
  JOURNAL   Mol Cancer 13, 77 (2014)
   PUBMED   24694019
  REMARK    GeneRIF: Our results identify a novel candidate mouse gene, Zfp277,
            whose expression pattern is compatible with a role in mediating
            divergent effects of Chrm3 and Chrm1 gene ablation on murine
            intestinal neoplasia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2076)
  AUTHORS   Negishi,M., Saraya,A., Mochizuki,S., Helin,K., Koseki,H. and
            Iwama,A.
  TITLE     A novel zinc finger protein Zfp277 mediates transcriptional
            repression of the Ink4a/arf locus through polycomb repressive
            complex 1
  JOURNAL   PLoS One 5 (8), e12373 (2010)
   PUBMED   20808772
  REMARK    GeneRIF: Zfp277 in the transcriptional regulation of the Ink4a/Arf
            locus and the recruitment of PRC1 to the Ink4a/Arf locus
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2076)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   5  (bases 1 to 2076)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 2076)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2076)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2076)
  AUTHORS   Liang,H., Guo,W. and Nagarajan,L.
  TITLE     Chromosomal mapping and genomic organization of an evolutionarily
            conserved zinc finger gene ZNF277
  JOURNAL   Genomics 66 (2), 226-228 (2000)
   PUBMED   10860669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY206876.1, AK075945.1 and AC123855.4.
            
            On May 28, 2009 this sequence version replaced NM_178845.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting protein (isoform 2) is
            shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156529.1, AK075945.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY206876.1         1-10
            11-534              AK075945.1         2-525
            535-535             AC123855.4         103551-103551       c
            536-1562            AK075945.1         527-1553
            1563-2076           AC123855.4         83257-83770         c
FEATURES             Location/Qualifiers
     source          1..2076
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 18.06 cM"
     gene            1..2076
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /note="zinc finger protein 277"
                     /db_xref="GeneID:246196"
                     /db_xref="MGI:MGI:1890393"
     exon            1..125
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1405
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 277 isoform 2"
                     /protein_id="NP_849173.2"
                     /db_xref="CCDS:CCDS25894.1"
                     /db_xref="GeneID:246196"
                     /db_xref="MGI:MGI:1890393"
                     /translation="MAASEVQGLPVDPREAGVRGVRGGIGHTDHEDSKDCILEPLSLP
                     ESPGGTTALEGSPSVPCIFCEEHFPMAEQDKLLKHMIIEHKIVIADVKLVADFRRYIL
                     YWRKRFTEQPITDFCSVIRINSTAPFEEQDNYYLLCDALPEDRILREELQKHKLKEVL
                     DQQQRERNDTSFHGVCMFCSEEFRGNRSVLLNHMAREHAFNIGLPDNIVNCAEFLCTL
                     QKKLDNLQCLYCEKTFRDKNTLKDHMRKKQHRRINPKNREYDRFYVINYLELGKSWEE
                     VQSEDDRELLDLQEDDWSDWQEYPVSAVCLFCEKQEETIDKLYVHMKDTHEFDLLRIK
                     SELGLNFYQQVKLVNFIRRQVHQCKCYSCHVKFKSKADLRTHMEDTKHTSLLPDRKTW
                     DQLEYYFPTYENDTLLCTLSDSESDLTAQEQTENVPVISEDTSRLCALKQSSVLNQLL
                     LQGCLEN"
     exon            126..327
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /inference="alignment:Splign:2.1.0"
     exon            328..416
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /inference="alignment:Splign:2.1.0"
     exon            417..499
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /inference="alignment:Splign:2.1.0"
     exon            500..591
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /inference="alignment:Splign:2.1.0"
     exon            592..702
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /inference="alignment:Splign:2.1.0"
     exon            703..835
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /inference="alignment:Splign:2.1.0"
     exon            836..903
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1000
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1043
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1218
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..2076
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1544..1549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /note="hexamer: AATAAA"
     polyA_site      1576
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /note="major polyA site"
ORIGIN      
        1 tacggcccgc ccctttctac tgtgccaggt aatggctgct agtgaggtcc aggggcttcc
       61 tgtggacccc cgggaggctg gggtccgcgg ggtccgcggc ggaatcggac acacagatca
      121 tgaagacagt aaagactgta tcctggagcc gctttccctg ccagagagtc caggtggcac
      181 caccgcttta gaagggtctc catctgtgcc ttgtattttc tgtgaagaac attttcccat
      241 ggctgaacaa gacaaacttt tgaagcacat gattatcgag cataagattg tcatagctga
      301 tgtgaagctc gttgcagatt tccgaaggta cattttatac tggaggaaaa ggttcactga
      361 acagcccatc actgattttt gcagcgtgat aagaatcaat tccacagctc catttgagga
      421 acaagacaac tattatttgt tatgtgatgc attaccagaa gatagaatcc tcagagaaga
      481 gcttcaaaaa cacaaactga aagaagttct ggatcagcaa cagcgagagc gaaatgatac
      541 aagctttcat ggtgtgtgca tgttttgcag tgaggaattt cgcggaaaca gatctgtact
      601 gttgaaccac atggccagag aacatgcttt caacattggt ttgccagaca acattgtaaa
      661 ttgcgctgaa ttcctatgca cattgcaaaa gaaactggac aatttacagt gtttgtactg
      721 tgagaagacc ttcagagaca aaaacaccct taaagatcac atgagaaaaa agcagcatcg
      781 taggatcaat ccaaaaaaca gagaatatga ccgattctat gtcatcaatt acttggaact
      841 cgggaagtca tgggaagagg tgcagtcaga agacgaccgc gagctgctgg accttcagga
      901 agacgactgg tctgattggc aggagtaccc agtctctgct gtgtgtctct tttgtgaaaa
      961 gcaagaggag acaatagata aactctatgt gcacatgaag gacacacatg agtttgatct
     1021 cctcagaata aagtcagagc ttggattaaa tttctatcag caagtgaagc tggtcaattt
     1081 cattagaagg caagttcacc aatgcaagtg ctacagttgc catgtaaagt tcaaatccaa
     1141 agcagattta aggactcaca tggaagacac taaacacacc tcactgcttc ctgacaggaa
     1201 gacatgggat caactggagt attatttccc cacctatgag aatgacactc tcctgtgtac
     1261 actgtctgac agtgaaagtg acctaacagc tcaagagcaa acggaaaatg tccccgtcat
     1321 cagtgaagat acgtccagac tgtgtgcttt aaaacagagc agtgttctca accaattgct
     1381 actccagggg tgcctggaaa actaggagaa gctgctgcag gcacagtgtc acctggtttt
     1441 ctcctgtgag acacagacaa gttcagattt gattgtccac acagcattat tcacggctga
     1501 aatcatggtt gttgttaatg aaaatttttc aagaaataag aaaaataaaa cattttgttt
     1561 ttatacttgg actgaagaaa ctttgtcatt atcttggatg attttatttc ataaactcat
     1621 gattatctac aatatggaga acgtacaagt cacaaacatt caaatggatg accctgactt
     1681 taacccattg tttagtctcc ttcctacagg cctgtcattt atcaagtcac agagttcagt
     1741 gtgatttctg tactaaattg ggaacttgtg aatgattaaa acaagaccca ctgaagcaaa
     1801 gaaaggtggc caaagatctg gataatgcac aaactggact atttaaatat aatccaaacc
     1861 tgattgtatt acagcgttat tgtttccctg ttacaaaccc catagaaatg ggcatagtgt
     1921 aattaacctt actcttcccc aaaatatatg tgtacctatg tatgcatttt ccctgatata
     1981 tattataata gcaatagtaa caaagataag taccactgtc tatgaacata actggagtgg
     2041 tattataaca ctcaataaag ttaaaagaaa ctttcc
//
