LOCUS       NP_849173                457 aa            linear   ROD 27-APR-2025
DEFINITION  zinc finger protein 277 isoform 2 [Mus musculus].
ACCESSION   NP_849173
VERSION     NP_849173.2
DBSOURCE    REFSEQ: accession NM_178845.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 457)
  AUTHORS   Xie,G., Peng,Z., Liang,J., Larabee,S.M., Drachenberg,C.B.,
            Yfantis,H. and Raufman,J.P.
  TITLE     Zinc finger protein 277 is an intestinal transit-amplifying cell
            marker and colon cancer oncogene
  JOURNAL   JCI Insight 7 (4), e150894 (2022)
   PUBMED   35015732
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 457)
  AUTHORS   Cheng,K., Xie,G., Khurana,S., Heath,J., Drachenberg,C.B.,
            Timmons,J., Shah,N. and Raufman,J.P.
  TITLE     Divergent effects of muscarinic receptor subtype gene ablation on
            murine colon tumorigenesis reveals association of M3R and zinc
            finger protein 277 expression in colon neoplasia
  JOURNAL   Mol Cancer 13, 77 (2014)
   PUBMED   24694019
  REMARK    GeneRIF: Our results identify a novel candidate mouse gene, Zfp277,
            whose expression pattern is compatible with a role in mediating
            divergent effects of Chrm3 and Chrm1 gene ablation on murine
            intestinal neoplasia.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 457)
  AUTHORS   Negishi,M., Saraya,A., Mochizuki,S., Helin,K., Koseki,H. and
            Iwama,A.
  TITLE     A novel zinc finger protein Zfp277 mediates transcriptional
            repression of the Ink4a/arf locus through polycomb repressive
            complex 1
  JOURNAL   PLoS One 5 (8), e12373 (2010)
   PUBMED   20808772
  REMARK    GeneRIF: Zfp277 in the transcriptional regulation of the Ink4a/Arf
            locus and the recruitment of PRC1 to the Ink4a/Arf locus
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 457)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   5  (residues 1 to 457)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (residues 1 to 457)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 457)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 457)
  AUTHORS   Liang,H., Guo,W. and Nagarajan,L.
  TITLE     Chromosomal mapping and genomic organization of an evolutionarily
            conserved zinc finger gene ZNF277
  JOURNAL   Genomics 66 (2), 226-228 (2000)
   PUBMED   10860669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY206876.1, AK075945.1 and AC123855.4.
            
            On May 28, 2009 this sequence version replaced NP_849173.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting protein (isoform 2) is
            shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156529.1, AK075945.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 18.06 cM"
     Protein         1..457
                     /product="zinc finger protein 277 isoform 2"
                     /calculated_mol_wt=53460
     Region          176..263
                     /region_name="zf-C2H2_2"
                     /note="C2H2 type zinc-finger (2 copies); pfam12756"
                     /db_xref="CDD:463690"
     Region          227..249
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Region          305..402
                     /region_name="zf-C2H2_2"
                     /note="C2H2 type zinc-finger (2 copies); pfam12756"
                     /db_xref="CDD:463690"
     Region          360..382
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..457
                     /gene="Zfp277"
                     /gene_synonym="2410017E24Rik; NIRF4; Znf277"
                     /coded_by="NM_178845.3:32..1405"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS25894.1"
                     /db_xref="GeneID:246196"
                     /db_xref="MGI:MGI:1890393"
ORIGIN      
        1 maasevqglp vdpreagvrg vrggightdh edskdcilep lslpespggt talegspsvp
       61 cifceehfpm aeqdkllkhm iiehkiviad vklvadfrry ilywrkrfte qpitdfcsvi
      121 rinstapfee qdnyyllcda lpedrilree lqkhklkevl dqqqrerndt sfhgvcmfcs
      181 eefrgnrsvl lnhmarehaf niglpdnivn caeflctlqk kldnlqclyc ektfrdkntl
      241 kdhmrkkqhr rinpknreyd rfyvinylel gksweevqse ddrelldlqe ddwsdwqeyp
      301 vsavclfcek qeetidklyv hmkdthefdl lrikselgln fyqqvklvnf irrqvhqckc
      361 yschvkfksk adlrthmedt khtsllpdrk twdqleyyfp tyendtllct lsdsesdlta
      421 qeqtenvpvi sedtsrlcal kqssvlnqll lqgclen
//
