LOCUS       NM_001037707            3529 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus zinc finger protein 27 (Zfp27), transcript variant 1,
            mRNA.
ACCESSION   NM_001037707
VERSION     NM_001037707.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3529)
  AUTHORS   Wang,Y., Wen,Q., Chen,R., Gan,Z., Huang,X., Wang,P., Cao,X.,
            Zhao,N., Yang,Z. and Yan,J.
  TITLE     Iron-inhibited autophagy via transcription factor ZFP27 in
            Parkinson's disease
  JOURNAL   J Cell Mol Med 27 (22), 3614-3627 (2023)
   PUBMED   37668106
  REMARK    GeneRIF: Iron-inhibited autophagy via transcription factor ZFP27 in
            Parkinson's disease.
REFERENCE   2  (bases 1 to 3529)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3529)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 3529)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   5  (bases 1 to 3529)
  AUTHORS   Agata,Y., Matsuda,E. and Shimizu,A.
  TITLE     Rapid and efficient cloning of cDNAs encoding Kruppel-like zinc
            finger proteins by degenerate PCR
  JOURNAL   Gene 213 (1-2), 55-64 (1998)
   PUBMED   9630514
REFERENCE   6  (bases 1 to 3529)
  AUTHORS   Chowdhury,K., Rohdewohld,H. and Gruss,P.
  TITLE     Specific and ubiquitous expression of different Zn finger protein
            genes in the mouse
  JOURNAL   Nucleic Acids Res 16 (21), 9995-10011 (1988)
   PUBMED   3143103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY776985.1, BY740816.1 and AC149283.2.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. All four variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.135128.1, AK147732.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               BY776985.1         1-107
            108-681             BY740816.1         98-671
            682-3529            AC149283.2         180292-183139
FEATURES             Location/Qualifiers
     source          1..3529
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 17.26 cM"
     gene            1..3529
                     /gene="Zfp27"
                     /gene_synonym="mkr-4; mszf76; Zfp-27"
                     /note="zinc finger protein 27"
                     /db_xref="GeneID:22689"
                     /db_xref="MGI:MGI:99174"
     exon            1..51
                     /gene="Zfp27"
                     /gene_synonym="mkr-4; mszf76; Zfp-27"
                     /inference="alignment:Splign:2.1.0"
     exon            52..211
                     /gene="Zfp27"
                     /gene_synonym="mkr-4; mszf76; Zfp-27"
                     /inference="alignment:Splign:2.1.0"
     exon            212..312
                     /gene="Zfp27"
                     /gene_synonym="mkr-4; mszf76; Zfp-27"
                     /inference="alignment:Splign:2.1.0"
     exon            313..439
                     /gene="Zfp27"
                     /gene_synonym="mkr-4; mszf76; Zfp-27"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..2787
                     /gene="Zfp27"
                     /gene_synonym="mkr-4; mszf76; Zfp-27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein mKR4"
                     /codon_start=1
                     /product="zinc finger protein 27 isoform 1"
                     /protein_id="NP_001032796.1"
                     /db_xref="CCDS:CCDS21076.1"
                     /db_xref="GeneID:22689"
                     /db_xref="MGI:MGI:99174"
                     /translation="MDVTIDFSREEWQHLDPAQRSLYRDVVQETYSHLRSVEELQQIG
                     DQKKTYQQIGHKSASDMVFITKTLGAESCHDYSGVRKVIHVNSYIVLPPKRPRHWDPP
                     EDEPKHSSDLQTHDESNGLKRTKRITEYGKISSCINTEHILTGEKLPDHNQCGKVLGY
                     KQIPCQYQKIHTGEKSYECAEFGKIFTQKSQLRVHVTSPTGEKLYVCVECGKACSQTS
                     EFLTHQKTHTREKPYKCGDCGKSFFQVSSLFRHRRIHTGEKLYDCSHCGKGFSYNSDL
                     RIHQKIHTGEKRHGCVDCGKAFTQKSTLRMHQKIHTGERAYVCIECGQAFIQKTHLVA
                     HRRIHTGEKPYACDGCGKAFLSKSQLLVHQRIHSRVRPCVSLDRAKPFSSAPNLLPRK
                     KVQMREKSSICAECGKAFTYRSELIIHQRTHTGEKPYQCGDCGKAFTQKSALTVHRRI
                     HTGEKSYVCVKCGLAFVQRAHLDAHQVIHTGEKPYQCGHCGKFFTSKSQLHVHKRIHT
                     GEKPYVCSNCGKAFANRSNLITHQKTHTGEKAYVCARCGKAFTQRSDLVTHQRIHTGE
                     KPYGCSTCGKAFTQKSHLSIHEKIHTGERQYGCRDCGKAFNQKSILIVHQKIHTGEKP
                     HVCAECGRAFIRKSNFITHQRIHTGEKPYGCTDCGKSFTSKSQLLVHRPIHTGEKPYV
                     CAECGKAFSGRSNLSKHQKTHTGEKPYACSECGKSFRQKSELITHHRIHTGEKPYDCG
                     DCGKSFTKKSQLQVHQRIHTGEKPYRCAECGKAFTDRSNLNKHQTTHTGEKPYKCVVC
                     GKGFVQKSVLSIHENVHTSAV"
     exon            440..3529
                     /gene="Zfp27"
                     /gene_synonym="mkr-4; mszf76; Zfp-27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3130..3135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp27"
                     /gene_synonym="mkr-4; mszf76; Zfp-27"
                     /note="hexamer: AATATA"
     polyA_site      3151
                     /gene="Zfp27"
                     /gene_synonym="mkr-4; mszf76; Zfp-27"
                     /note="major polyA site"
     regulatory      3405..3410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp27"
                     /gene_synonym="mkr-4; mszf76; Zfp-27"
                     /note="hexamer: AGTAAA"
     polyA_site      3428
                     /gene="Zfp27"
                     /gene_synonym="mkr-4; mszf76; Zfp-27"
     polyA_site      3529
                     /gene="Zfp27"
                     /gene_synonym="mkr-4; mszf76; Zfp-27"
                     /note="major polyA site"
ORIGIN      
        1 gtgctgcttc cattgagtct taagggcaag aagtcatccg agatgattcc gcacttcttc
       61 ctcacagctc tgactgaact catagaggac cgctaagctt ctggttgctg agaggacagg
      121 gtctagaccc agcgtgatca tgccaactga ctggacttca accctggaag ctacaccact
      181 ggccccagag gatcttggga gctcatgtga ggtgtgagat acggagctgc ttcagactgt
      241 ccgcagcagc tgatcatgat ttgcctcgtg ctctagcagg ggtgtgattt ttgccagcag
      301 cagatagttt ctgaattagt gtccttcatg gatgtgacta tagatttcag cagagaggag
      361 tggcagcatc tagatcctgc tcaaaggagt ctctatcggg atgtggtgca ggagacctac
      421 agtcacctgc gctcagtgga agaactacag cagattggtg accagaaaaa gacctaccag
      481 caaataggac ataaatcagc gagtgatatg gttttcatca cgaagacgct gggtgcagag
      541 agttgccatg actactcagg cgttaggaag gtgattcatg tgaactcata cattgttctc
      601 cctcccaaga ggccacgtca ctgggaccca cctgaggatg agccgaagca tagttcagat
      661 ttacagactc atgatgaaag taatgggctg aagagaacta aaaggattac tgaatatggt
      721 aaaatttcat cctgtatcaa cactgaacat attctaacag gagagaaatt accggaccat
      781 aatcaatgtg gaaaagtcct cggttataaa caaatacctt gtcaatatca gaaaattcat
      841 actggggaga aatcatatga atgtgctgaa tttggaaaga tttttaccca gaagtcacag
      901 ctcagagtac acgtgacgtc tcctacagga gaaaaactct acgtgtgcgt cgaatgtggg
      961 aaggcatgtt ctcagacgtc agagttcctc acacatcaaa aaacccacac cagggagaag
     1021 ccctataaat gcggtgactg tggaaagtcc tttttccaag tatcttctct gttcaggcac
     1081 cggaggatcc acactggaga aaagctctac gactgtagcc attgtgggaa aggcttctct
     1141 tacaactcag acctcaggat acatcagaag atccatacag gagagaaacg ccatggctgc
     1201 gtcgactgtg gcaaagcctt cacacaaaag tccacactga ggatgcacca gaagatccac
     1261 acgggcgaga gggcctatgt ctgtattgag tgtggacagg cttttatcca gaagacacac
     1321 ctggtcgcac accgaagaat tcacactgga gagaagccat acgcgtgtga cggctgtggc
     1381 aaagccttcc tttccaagtc ccaactcctg gtccaccagc gaattcactc aagagtgagg
     1441 ccctgtgtat ctctcgaccg tgcgaaaccc ttcagcagcg ctcccaacct ccttccgcgt
     1501 aagaaagttc aaatgagaga gaaatcgtcc atctgcgcgg agtgtgggaa ggcctttacc
     1561 tacaggtcgg agctaatcat tcatcagaga actcacacgg gagagaagcc ttatcagtgc
     1621 ggggactgtg gcaaagcctt cacccagaag tcagccctca ccgtgcaccg aagaatccac
     1681 acgggggaga agtcgtatgt gtgtgtgaag tgcgggctag ccttcgtgca aagggcacac
     1741 ttggatgcac accaggtgat tcacactgga gaaaaacctt accagtgtgg tcattgtggg
     1801 aaattcttca cttccaagtc gcaactccac gtgcacaagc ggattcacac gggggaaaaa
     1861 ccctatgtgt gcagtaactg tgggaaggcc tttgccaaca ggtcaaatct catcacacat
     1921 cagaaaactc atacagggga gaaagcctat gtctgtgcaa ggtgtgggaa agcattcact
     1981 cagaggtcag acctggttac acaccagagg atacataccg gagagaagcc atatgggtgt
     2041 agcacctgcg ggaaagcctt tacccagaaa tcacacctca gtatacacga gaagattcac
     2101 accggagaga gacagtacgg atgccgagac tgtgggaaag ccttcaacca gaaatccata
     2161 ctcatcgtgc accagaaaat ccacacgggg gagaaaccgc acgtgtgtgc cgagtgcggg
     2221 cgagctttca tccgcaagtc caacttcatc acccatcagc gcatccatac tggcgagaaa
     2281 ccttatggat gcaccgactg cggcaagtcc tttacctcca agtcgcagct cctggtgcac
     2341 cggccaatcc acaccggcga gaaaccttac gtgtgtgccg agtgtgggaa agcctttagc
     2401 ggcaggtcaa atctcagcaa gcaccagaag actcacactg gggagaagcc gtacgcgtgt
     2461 tcagagtgtg ggaagtcctt caggcagaag tcagagctga ttacacacca cagaatccac
     2521 actggggaga agccgtacga ttgcggcgac tgcgggaaat ccttcactaa gaaatcccag
     2581 ctccaagtgc atcagcgaat tcacacagga gagaagccgt acagatgtgc cgagtgcggg
     2641 aaggccttca ccgataggtc caatttgaat aaacatcaaa caacacacac cggagagaaa
     2701 ccttataagt gtgtagtctg tgggaaaggc tttgtgcaga agtcagtgct cagcattcat
     2761 gagaatgttc acacctcggc agtatgagaa aggacccatt gaggacacgt cttatgtaat
     2821 tactgtctct ataggacaga ataatatgta tattattgta agtaaaaatg ccacatgaca
     2881 gtgtcacaca ttactgctca gaaaaagatc tcagagaagg cactgaatgg gattatgggg
     2941 caggacattt ctacttgctg agaagaaatt gcatcaattt gacacaatag aagcgttctc
     3001 atggtaaaaa acacagtgga acattgtcat caagttcttc acaagaaaga ttgtgtcaac
     3061 tcatgttgat gcaaaaatcc tgttggtgga gtatgtctac tgccaactaa ttacatggta
     3121 atctaatcta atataatgta catgacaggg accatcttct cttctgtcac ttgtttgctg
     3181 caaacattaa tagacctgtg ggtgtgtttg cattcttggt cagatctaac ataactggca
     3241 catccaatcc ttctgttgag agacatacac tacaggcctg ggtgtggcat ttcgtgccag
     3301 taattccagc ctttggggaa agctgaggca ggaggattac catgagttca agactagtct
     3361 gagctacagg gtaagacact gtctcaaaaa caagagaagg ccacagtaaa gacatagcct
     3421 aacacgaact tgaaagtgta cctggccttc ctgtcattta caccaggaca tgtcacagac
     3481 tttataagct accagtgcta tctttgtaaa aagaccaaca tgtctccta
//
