LOCUS       NP_001032796             819 aa            linear   ROD 02-JUN-2024
DEFINITION  zinc finger protein 27 isoform 1 [Mus musculus].
ACCESSION   NP_001032796
VERSION     NP_001032796.1
DBSOURCE    REFSEQ: accession NM_001037707.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 819)
  AUTHORS   Wang,Y., Wen,Q., Chen,R., Gan,Z., Huang,X., Wang,P., Cao,X.,
            Zhao,N., Yang,Z. and Yan,J.
  TITLE     Iron-inhibited autophagy via transcription factor ZFP27 in
            Parkinson's disease
  JOURNAL   J Cell Mol Med 27 (22), 3614-3627 (2023)
   PUBMED   37668106
  REMARK    GeneRIF: Iron-inhibited autophagy via transcription factor ZFP27 in
            Parkinson's disease.
REFERENCE   2  (residues 1 to 819)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 819)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (residues 1 to 819)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   5  (residues 1 to 819)
  AUTHORS   Agata,Y., Matsuda,E. and Shimizu,A.
  TITLE     Rapid and efficient cloning of cDNAs encoding Kruppel-like zinc
            finger proteins by degenerate PCR
  JOURNAL   Gene 213 (1-2), 55-64 (1998)
   PUBMED   9630514
REFERENCE   6  (residues 1 to 819)
  AUTHORS   Chowdhury,K., Rohdewohld,H. and Gruss,P.
  TITLE     Specific and ubiquitous expression of different Zn finger protein
            genes in the mouse
  JOURNAL   Nucleic Acids Res 16 (21), 9995-10011 (1988)
   PUBMED   3143103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY776985.1, BY740816.1 and AC149283.2.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. All four variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.135128.1, AK147732.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..819
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 17.26 cM"
     Protein         1..819
                     /product="zinc finger protein 27 isoform 1"
                     /note="protein mKR4"
                     /calculated_mol_wt=92763
     Region          2..>38
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          93..123
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P10077.2)"
     Region          152..171
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     Region          179..199
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          207..227
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <212..372
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          235..255
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(240,242,244,246..247,250..251,254,268,270,274..275,
                     278..279,282,296,298,300,302..303,306..307,310)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          263..283
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          291..311
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          317..746
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          319..339
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          347..367
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          403..423
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(408,410,412,414..415,418..419,422,436,438,442..443,
                     446..447,450,464,466,468,470..471,474..475,478)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          431..451
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          459..479
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          487..507
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          515..535
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(520,522,524,526..527,530..531,534,548,550,554..555,
                     558..559,562,576,578,580,582..583,586..587,590)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          543..563
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          571..591
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          599..619
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          627..647
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          655..675
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          683..703
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          711..731
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(716,718,720,722..723,726..727,730,744,746,750..751,
                     754..755,758,772,774,776,778..779,782..783,786)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          739..759
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          752..775
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          767..787
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          795..815
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..819
                     /gene="Zfp27"
                     /gene_synonym="mkr-4; mszf76; Zfp-27"
                     /coded_by="NM_001037707.1:328..2787"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS21076.1"
                     /db_xref="GeneID:22689"
                     /db_xref="MGI:MGI:99174"
ORIGIN      
        1 mdvtidfsre ewqhldpaqr slyrdvvqet yshlrsveel qqigdqkkty qqighksasd
       61 mvfitktlga eschdysgvr kvihvnsyiv lppkrprhwd ppedepkhss dlqthdesng
      121 lkrtkritey gkisscinte hiltgeklpd hnqcgkvlgy kqipcqyqki htgeksyeca
      181 efgkiftqks qlrvhvtspt geklyvcvec gkacsqtsef lthqkthtre kpykcgdcgk
      241 sffqvsslfr hrrihtgekl ydcshcgkgf synsdlrihq kihtgekrhg cvdcgkaftq
      301 kstlrmhqki htgerayvci ecgqafiqkt hlvahrriht gekpyacdgc gkaflsksql
      361 lvhqrihsrv rpcvsldrak pfssapnllp rkkvqmreks sicaecgkaf tyrseliihq
      421 rthtgekpyq cgdcgkaftq ksaltvhrri htgeksyvcv kcglafvqra hldahqviht
      481 gekpyqcghc gkfftsksql hvhkrihtge kpyvcsncgk afanrsnlit hqkthtgeka
      541 yvcarcgkaf tqrsdlvthq rihtgekpyg cstcgkaftq kshlsiheki htgerqygcr
      601 dcgkafnqks ilivhqkiht gekphvcaec grafirksnf ithqrihtge kpygctdcgk
      661 sftsksqllv hrpihtgekp yvcaecgkaf sgrsnlskhq kthtgekpya csecgksfrq
      721 kselithhri htgekpydcg dcgksftkks qlqvhqriht gekpyrcaec gkaftdrsnl
      781 nkhqtthtge kpykcvvcgk gfvqksvlsi henvhtsav
//
