LOCUS       NP_082611                576 aa            linear   ROD 11-OCT-2023
DEFINITION  zinc finger protein 248 isoform a [Mus musculus].
ACCESSION   NP_082611 XP_132810
VERSION     NP_082611.1
DBSOURCE    REFSEQ: accession NM_028335.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 576)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 576)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC082571.1 and AC140192.3.
            
            On Jan 24, 2005 this sequence version replaced XP_132810.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082571.1, SRR1660815.173846.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..576
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 55.86 cM"
     Protein         1..576
                     /product="zinc finger protein 248 isoform a"
                     /calculated_mol_wt=66426
     Region          8..68
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          379..399
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(384,386,388,390..391,394..395,398,412,414,418..419,
                     422..423,426,440,442,444,446..447,450..451,454)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          403..>469
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          407..427
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          435..455
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          459..>520
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          463..483
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          491..511
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(496,498,500,502..503,506..507,510,524,526,530..531,
                     534..535,538,552,554,556,558..559,562..563,566)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          503..526
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          519..539
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          531..556
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          547..567
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..576
                     /gene="Zfp248"
                     /gene_synonym="2810037F07Rik; E130106N01Rik"
                     /coded_by="NM_028335.2:354..2084"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS51884.1"
                     /db_xref="GeneID:72720"
                     /db_xref="MGI:MGI:1919970"
ORIGIN      
        1 mnksqeqvsf kdvcvdftke ewylldpaqk vlyrdvilen ysnfvsvghc vtkpdvifki
       61 eqgedpwipe ngfqchperk wkvddllesn qenqdghfwp lmftnkitnl egggntretp
      121 spdidsvssr sfllkvcdsc emnlknvsav iiskknysrk klnefnihkk plpdsrreki
      181 pvgikscdyd gerdgvrlcr dlarpvshqp feynetgqgf ceevalctsq nsqlgetlyk
      241 htecgrtfvd slklsvsqkt rlhtelhecs icrksfyvdl qfghhtalsg sspyerneye
      301 klfcdgtafi vhqeaytrki aqeykvsnrt wgkpalfkhq iiqmggkpye yyenrknfsk
      361 kshptqprrp hvgektfecg ecgkmfweks nltqhqrtht gekpyectec gkafcqkphl
      421 tnhqrthtge kpyeckqcgk tfcvksnlte hqrthtgekp yecnacrksf chrsaltvhq
      481 rthtgekpfi csecgksfcv ksnlivhqrt htgekpykcn ecgktfceks altkhqrtht
      541 gekpyechvc gktfsqrsvl tkhlrihtrv kallas
//
