LOCUS       NM_001410522            3768 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus zinc finger protein 239 (Zfp239), transcript variant
            8, mRNA.
ACCESSION   NM_001410522
VERSION     NM_001410522.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3768)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3768)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3768)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3768)
  AUTHORS   Arranz,V., Dreuillet,C., Crisanti,P., Tillit,J., Kress,M. and
            Ernoult-Lange,M.
  TITLE     The zinc finger transcription factor, MOK2, negatively modulates
            expression of the interphotoreceptor retinoid-binding protein gene,
            IRBP
  JOURNAL   J Biol Chem 276 (15), 11963-11969 (2001)
   PUBMED   11278819
REFERENCE   5  (bases 1 to 3768)
  AUTHORS   Arranz,V., Harper,F., Florentin,Y., Puvion,E., Kress,M. and
            Ernoult-Lange,M.
  TITLE     Human and mouse MOK2 proteins are associated with nuclear
            ribonucleoprotein components and bind specifically to RNA and DNA
            through their zinc finger domains
  JOURNAL   Mol Cell Biol 17 (4), 2116-2126 (1997)
   PUBMED   9121460
REFERENCE   6  (bases 1 to 3768)
  AUTHORS   Arranz,V., Kress,M. and Ernoult-Lange,M.
  TITLE     Localization of zinc finger Mok2 gene to mouse chromosome 6, a new
            region of homology with human chromosome 19
  JOURNAL   Mamm Genome 7 (1), 77-78 (1996)
   PUBMED   8903737
REFERENCE   7  (bases 1 to 3768)
  AUTHORS   Ernoult-Lange,M., Arranz,V., Le Coniat,M., Berger,R. and Kress,M.
  TITLE     Human and mouse Kruppel-like (MOK2) orthologue genes encode two
            different zinc finger proteins
  JOURNAL   J Mol Evol 41 (6), 784-794 (1995)
   PUBMED   8587123
REFERENCE   8  (bases 1 to 3768)
  AUTHORS   Arranz,V., Kress,M. and Ernoult-Lange,M.
  TITLE     The gene encoding the MOK-2 zinc-finger protein: characterization
            of its promoter and negative regulation by mouse Alu type-2
            repetitive elements
  JOURNAL   Gene 149 (2), 293-298 (1994)
   PUBMED   7959005
REFERENCE   9  (bases 1 to 3768)
  AUTHORS   Ernoult-Lange,M., Kress,M. and Hamer,D.
  TITLE     A gene that encodes a protein consisting solely of zinc finger
            domains is preferentially expressed in transformed mouse cells
  JOURNAL   Mol Cell Biol 10 (1), 418-421 (1990)
   PUBMED   2104662
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153918.4.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR13422586.312580.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849380, SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AC153918.4         117838-118184       c
            348-609             AC153918.4         116988-117249       c
            610-789             AC153918.4         113556-113735       c
            790-1012            AC153918.4         113087-113309       c
            1013-1201           AC153918.4         112806-112994       c
            1202-1257           AC153918.4         110857-110912       c
            1258-3768           AC153918.4         107364-109874       c
FEATURES             Location/Qualifiers
     source          1..3768
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 55.62 cM"
     gene            1..3768
                     /gene="Zfp239"
                     /gene_synonym="Mok-2; Mok2; Znf239"
                     /note="zinc finger protein 239"
                     /db_xref="GeneID:22685"
                     /db_xref="MGI:MGI:1306812"
     exon            1..347
                     /gene="Zfp239"
                     /gene_synonym="Mok-2; Mok2; Znf239"
                     /inference="alignment:Splign:2.1.0"
     exon            348..609
                     /gene="Zfp239"
                     /gene_synonym="Mok-2; Mok2; Znf239"
                     /inference="alignment:Splign:2.1.0"
     exon            610..789
                     /gene="Zfp239"
                     /gene_synonym="Mok-2; Mok2; Znf239"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1012
                     /gene="Zfp239"
                     /gene_synonym="Mok-2; Mok2; Znf239"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1201
                     /gene="Zfp239"
                     /gene_synonym="Mok-2; Mok2; Znf239"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1257
                     /gene="Zfp239"
                     /gene_synonym="Mok-2; Mok2; Znf239"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..3768
                     /gene="Zfp239"
                     /gene_synonym="Mok-2; Mok2; Znf239"
                     /inference="alignment:Splign:2.1.0"
     CDS             2305..2910
                     /gene="Zfp239"
                     /gene_synonym="Mok-2; Mok2; Znf239"
                     /note="zinc finger protein MOK-2; Kruppel zinc finger
                     protein 2"
                     /codon_start=1
                     /product="zinc finger protein 239"
                     /protein_id="NP_001397451.1"
                     /db_xref="GeneID:22685"
                     /db_xref="MGI:MGI:1306812"
                     /translation="MAEKPYKCDKCGKGFTRSSSLLVHHSVHTGEKPFKCDRCGKGFS
                     QSSKLHIHKRVHTGEKPYACEECGMSFSQRSNLHIHQRVHTGERPYKCGECGKGFSQS
                     SNLHIHRCTHTGEKPYQCYECGKGFSQSSDLRIHLRVHTGEKPYHCGKCGQGFSQSSK
                     LLIHQRVHTGEKPYECSKCGKGFSQSSNLHIHQRVHRKELH"
     polyA_site      3768
                     /gene="Zfp239"
                     /gene_synonym="Mok-2; Mok2; Znf239"
                     /note="major polyA site"
ORIGIN      
        1 agaagaacaa tcgggctgtt ctggttaggg tgcctgtcag ccaatcctgc cagactgcga
       61 tcaatcccca ggatccacgg agaagaagga aggaggtgac tcctgcaagt tgtcctcgga
      121 tggccacacc cacgggggaa gggcttacac acacagaggg aaatatatga acaaaagata
      181 tttgtaaaaa gaagtctcaa gtctgaggtt taagagtttt gtgatgggct ttcacaacgt
      241 tcctggggac catgtgggct acagattgga tgttaatgtc acaggtttac ctagagatcc
      301 ttttgggaga cgactgcaca ctcagaaaac actctgaaat cctgttgcat catcataaca
      361 agtaaaagac accttggggg agtattttaa aactgtatgt gtctgcaacg aaaagagtgc
      421 acaacaactt gaactattca gggccaacca caacctcaaa ctgggggctc acaagagtga
      481 gcccatcgtc gccggaagtg agctcggaag tagcgctttc ctgcccgcag ccttctggga
      541 cttgtagttc gaatcctcga tgatgctcgg gagtcctgcg ttaccaggtg tgggttctac
      601 ctacaagagg tagaaagtcc ctcaaggttg acgtccgggt ggtggatgga tcgttcctgc
      661 tctgatgctg gcatttcatg ccactgcaga actgtgatga ctaaggaaga actgtgacta
      721 agctgcagag aagggctgca gcggcagaag tgaaccttgt attttctaga tccaggccgt
      781 tcttcataag tagctggaaa tacaggtcca caccaccaca cctcgtttgg gctggattta
      841 aagaagaagg ggtgtttctt aacatctcca gcagcaacgc tctggtcttt tttatttggc
      901 aaatccagtc ctcccacaga gaaagaaact cttcacccaa aggatggtga gctccctcaa
      961 ggcactgagg gattggaaaa taataaggac ttcacgaaga cgaacaacgt gtgcatagta
     1021 gattcttggg tcctgaaagc aagctcagag agtacaaggc acttgccatg aagtttgatg
     1081 acctgaattc agtctctggg acctactccc ccaagttctc ctctgacctt cacacagact
     1141 ccgtagcaag catgtgctca ccaacacaca atgtgcgcac actcaataca tttcttttaa
     1201 taactctgaa ggcatgacgg tttgagctct cgtgcccgca gtctgcttcc acagccggag
     1261 agtcaaacac aaattctgtg gagaatcttc aagagaaaga ccttcaagag tctggagaga
     1321 tgactcagaa accaagagca cccctagctc ctgtaagttc agtccccagc acccacatgg
     1381 tggctcacca tccatcactc cagttctagg agagccaagg acctctttca cctccatcag
     1441 gaccatactg gcatgtgctg cacaggcatc cttgcaggca aaacacttaa cacgtgaaat
     1501 aaaaatcttt aaagtgagag aaagagaaaa gacttcagga tttttcctag tggctgattt
     1561 tgaaagaaat ggccagtcag tagctggaag ttgagtttat attgtgaatc ttcaagaggt
     1621 acacaccaat actgaagtag attgctgtca aaagtgggga gaagtgtctt gccatatttc
     1681 ccaaaaccac agatttcggt gactctttaa agttatttca ccaacattga aagtggaaaa
     1741 aaaatttttt atctttgaaa tcctaagcca aataaccaga caggtctcct ctgaaatgtg
     1801 tgtgtgtgtg tggggggggg gagtctctct gcaactgaag aaagagggag agaaaaggaa
     1861 taagggagag tttcatccca cacaccactg ttgagagact ggtcaagtca agcttccagg
     1921 tgatgtgaca gaactggcac ctccaacatt ctctgctgag acaatgcgcc aaaaatgtct
     1981 cctttgactg taacagtaag gacattttta tagggacgtc accattagtc acttggagtc
     2041 ttcaaagaga gacgacacag aggaatccgg tgactggtga ttcctaggag atgcttatca
     2101 ccaacccaga tggtcacctc ttcaagaaaa tccccacttc agaacaactg tgcacgcgtg
     2161 atcggtgtag tgaggatttc attcagagct cagaactgat gagtcatcag agagaccacc
     2221 tgaaagaaaa agcctgcggg cgggagcatt gtggcagggc cttcactggc caatcaagtc
     2281 ccgtttccgc atcaggcagt ccacatggct gagaaacctt acaaatgcga caagtgcggg
     2341 aagggtttca ccaggagctc gagtctgctt gtccatcatt ccgtccatac cggtgagaaa
     2401 cctttcaagt gtgacaggtg tgggaagggc ttcagccaga gctcaaagct ccacatccac
     2461 aagagagtcc acaccggtga gaagccgtat gcgtgcgagg agtgcggtat gagcttcagt
     2521 cagcgatcca acctgcacat ccaccaacgt gtccacaccg gagagaggcc ctacaagtgt
     2581 ggggagtgcg gaaaaggctt cagccagagc tcgaacctcc acatccaccg gtgcacccac
     2641 acgggagaga agccgtacca gtgttacgaa tgtgggaaag gcttcagcca gagttcagac
     2701 cttcggatcc acctccgagt acacaccggg gaaaagccct accactgcgg caagtgtggg
     2761 cagggcttca gccagagctc caaactcctc atccatcaga gagtccacac gggtgagaag
     2821 ccgtatgagt gcagcaagtg tggcaagggc ttcagccaga gctcgaacct ccacatccac
     2881 cagcgggttc accgcaagga gcttcactaa gtaacatgag cccactcaga agacttttat
     2941 tgtaaagata aatatttttc acgaccgagt gtgcatatca gaggtagcat gcttgcctag
     3001 catgtatcag tccctgagtt tgagccctga tacgccccca cccacacaca cacacacacg
     3061 gtttccagct tattaatact ttgtgcatgt taggaatgtg tgttcatgca gagaggggta
     3121 tgtgtgttgt gctggtgtgt gcatgtatgt gtgcacgcac gtgtgtggac gtctgaggat
     3181 atctcagata ctacattctg tatgtgagac taggcatctg tctgtcacac atggtgtgta
     3241 atgtcaccaa gtaagccagg ccagagtccc atggatctaa ctgtctccac ttcccagctc
     3301 accgtggcta gggttgcgga tgtgtgccac cacatccaac ctttttatgt ggattctgtc
     3361 tcaagctttc tagacaagag ctttgctgcc taagctatgt cccagggctc cagtttaata
     3421 ctttaaactc ttacgtttga attcctcaaa ggaaagaaat agttaagggt tattccgata
     3481 tagcccctca cagaagaaat caatccgagt actcagcaca ttttatgtta tacagtgaat
     3541 gggttactct ggtttctcat atgggtagag tgtataatgc aattctgcca gtgttgttag
     3601 aattatattc tacatttttt aactgcaaga actctgtatt tttccaagca cagcatggtt
     3661 cccttcattc atattctctg agaaattgga attcatgttt cctctgaaat tatgtgcctt
     3721 gtttttcata ttccatttaa gtcctaaata gctctcttta aactgtga
//
