LOCUS       NM_001033299            5685 bp    mRNA    linear   ROD 13-AUG-2022
DEFINITION  Mus musculus zinc finger protein 217 (Zfp217), transcript variant
            1, mRNA.
ACCESSION   NM_001033299 XM_149258
VERSION     NM_001033299.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5685)
  AUTHORS   Zeng Q, Wang N, Zhang Y, Yang Y, Li S, Zheng R, Chai J, Qiao T and
            Jiang S.
  TITLE     Partial Deficiency of Zfp217 Resists High-Fat Diet-Induced Obesity
            by Increasing Energy Metabolism in Mice
  JOURNAL   Int J Mol Sci 22 (10), 5390 (2021)
   PUBMED   34065474
  REMARK    GeneRIF: Partial Deficiency of Zfp217 Resists High-Fat Diet-Induced
            Obesity by Increasing Energy Metabolism in Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5685)
  AUTHORS   Liu Q, Zhao Y, Wu R, Jiang Q, Cai M, Bi Z, Liu Y, Yao Y, Feng J,
            Wang Y and Wang X.
  TITLE     ZFP217 regulates adipogenesis by controlling mitotic clonal
            expansion in a METTL3-m(6)A dependent manner
  JOURNAL   RNA Biol 16 (12), 1785-1793 (2019)
   PUBMED   31434544
  REMARK    GeneRIF: ZFP217 regulates adipogenesis by controlling mitotic
            clonal expansion in a METTL3-m(6)A dependent manner.
REFERENCE   3  (bases 1 to 5685)
  AUTHORS   Song T, Yang Y, Wei H, Xie X, Lu J, Zeng Q, Peng J, Zhou Y, Jiang S
            and Peng J.
  TITLE     Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional
            and post-transcriptional regulation to promote adipogenic
            differentiation
  JOURNAL   Nucleic Acids Res 47 (12), 6130-6144 (2019)
   PUBMED   31037292
  REMARK    GeneRIF: Zfp217 couples gene transcription to m6A mRNA modification
            to facilitate adipogenesis.
REFERENCE   4  (bases 1 to 5685)
  AUTHORS   Kwak S, Kim TW, Kang BH, Kim JH, Lee JS, Lee HT, Hwang IY, Shin J,
            Lee JH, Cho EJ and Youn HD.
  TITLE     Zinc finger proteins orchestrate active gene silencing during
            embryonic stem cell differentiation
  JOURNAL   Nucleic Acids Res 46 (13), 6592-6607 (2018)
   PUBMED   29846698
  REMARK    GeneRIF: Zfp217 and Zfp516 facilitate Ctbp2-mediated repression on
            active embryonic stem cell genes during differentiation.
REFERENCE   5  (bases 1 to 5685)
  AUTHORS   Xiang H, Zhong ZX, Peng YD and Jiang SW.
  TITLE     The Emerging Role of Zfp217 in Adipogenesis
  JOURNAL   Int J Mol Sci 18 (7), E1367 (2017)
   PUBMED   28653987
  REMARK    GeneRIF: Three microRNAs (miR-503-5p, miR-135a-5p and miR-19a-3p)
            which target Zfp217 were found to suppress the process of
            adipogenesis. This is the first report showing that Zfp217 has the
            capacity to regulate adipogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5685)
  AUTHORS   Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu
            HS, Brennan J, Armstrong J, Little MH, McMahon AP and
            Southard-Smith EM.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5685)
  AUTHORS   Krig SR, Miller JK, Frietze S, Beckett LA, Neve RM, Farnham PJ,
            Yaswen PI and Sweeney CA.
  TITLE     ZNF217, a candidate breast cancer oncogene amplified at 20q13,
            regulates expression of the ErbB3 receptor tyrosine kinase in
            breast cancer cells
  JOURNAL   Oncogene 29 (40), 5500-5510 (2010)
   PUBMED   20661224
  REMARK    GeneRIF: results show that ZNF217 regulates ErbB3 expression
REFERENCE   8  (bases 1 to 5685)
  AUTHORS   Quinlan KG, Nardini M, Verger A, Francescato P, Yaswen P, Corda D,
            Bolognesi M and Crossley M.
  TITLE     Specific recognition of ZNF217 and other zinc finger proteins at a
            surface groove of C-terminal binding proteins
  JOURNAL   Mol Cell Biol 26 (21), 8159-8172 (2006)
   PUBMED   16940172
  REMARK    GeneRIF: These results identify a new CtBP interaction motif and
            establish ZNF217 as a transcriptional repressor protein that
            functions, at least in part, by associating with CtBP.
REFERENCE   9  (bases 1 to 5685)
  AUTHORS   Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, Chan F,
            MacCarthy-Morrogh L, Ponder BA, Nagase H, Burn J, Ball S, Almeida
            M, Linardopoulos S and Balmain A.
  TITLE     Identification of Stk6/STK15 as a candidate low-penetrance
            tumor-susceptibility gene in mouse and human
  JOURNAL   Nat Genet 34 (4), 403-412 (2003)
   PUBMED   12881723
REFERENCE   10 (bases 1 to 5685)
  AUTHORS   Buttitta L, Tanaka TS, Chen AE, Ko MS and Fan CM.
  TITLE     Microarray analysis of somitogenesis reveals novel targets of
            different WNT signaling pathways in the somitic mesoderm
  JOURNAL   Dev Biol 258 (1), 91-104 (2003)
   PUBMED   12781685
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844576.9, AK163381.1 and BC116330.1.
            
            [WARNING] On Oct 24, 2024 this sequence was replaced by
            NM_001033299.4.
            
            On Apr 28, 2009 this sequence version replaced NM_001033299.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AL844576.9         42582-42754         c
            174-666             AK163381.1         163-655
            667-3722            BC116330.1         146-3201
            3723-5685           AL844576.9         20177-22139         c
FEATURES             Location/Qualifiers
     source          1..5685
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 89.91 cM"
     gene            1..5685
                     /gene="Zfp217"
                     /gene_synonym="4933431C08Rik; Gm562; ZABC1; Znf217"
                     /note="zinc finger protein 217"
                     /db_xref="GeneID:228913"
                     /db_xref="MGI:MGI:2685408"
     exon            1..173
                     /gene="Zfp217"
                     /gene_synonym="4933431C08Rik; Gm562; ZABC1; Znf217"
                     /inference="alignment:Splign:2.1.0"
     exon            174..1908
                     /gene="Zfp217"
                     /gene_synonym="4933431C08Rik; Gm562; ZABC1; Znf217"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2025
                     /gene="Zfp217"
                     /gene_synonym="4933431C08Rik; Gm562; ZABC1; Znf217"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..3537
                     /gene="Zfp217"
                     /gene_synonym="4933431C08Rik; Gm562; ZABC1; Znf217"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3672
                     /gene="Zfp217"
                     /gene_synonym="4933431C08Rik; Gm562; ZABC1; Znf217"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..5685
                     /gene="Zfp217"
                     /gene_synonym="4933431C08Rik; Gm562; ZABC1; Znf217"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcggcgcg gccggggggg agggcgcaac agctgctgcg agcactttct gccccaacag
       61 tccccccgcc ggacgccggc cgcccgcccg cccgcgcagg gaccccgcgc ctgcactgtc
      121 cccgcgcgga cgagtagggg gcgcccgcgc cgctccctcg ccccgcgccg gagattttgg
      181 aaatcccttg tcttcacatt gccgggatca acgtcttgct caactgagcc actcaccagt
      241 ggagatggac agagctgttg ccctcgtgct gacgcacatc tgactcacag cctggggcag
      301 cttggatgcc ttgtttgtgc aaagagccat ctccatcact gagctctccc aagctccgga
      361 atatactcgt ccctctgacc ttagaggtgc tctgattttg acacccaggg ctcttagagg
      421 ttctgagtgg tgatatctca caggcggcct tattctaact gcagagatcc tcagcagata
      481 gtggattacc catcctgtca gaccctgaag tggttggcag catgccgacc cagtccctcc
      541 tcgtgtacat ggacgggccg gaagtcctca gcagctctct aggctcccag atggaggtgg
      601 atgatgctgt gcccataaaa gggccggtgg cagtcccctt ccgagctgct caggagaaga
      661 gcatggccgt ggcagagggc cacatgcccc tggattgcat gttctgcagc caggtcttct
      721 ctcaggcgga ggatctcagt cagcacgtgc tgctgcagca ccggcccacc ctctgcgagc
      781 cagctgtcct gcgtgtggag gccgagtacc taagtcccct tgataaagct ctggagccaa
      841 cagagccagc attggagaag agtggcgaag accccgagga gttgagctgt gatgtgtgtg
      901 ggcagacatt cccagtggct tttgatgttg agagccacat gaagaagcat aaggactcct
      961 tcacgtatgg gtgcagcatg tgcgggagga gattcaagga gccgtggttc ctgaagaacc
     1021 acatgcggac acacaatggc aagtctggca ccaggagcaa gcttcagcaa ggcatggaga
     1081 gtccagtcac catcaatgaa gtggtccagc cgcacgcccc tgggagcatc tccacgccct
     1141 acaagatctg catggtctgc ggcttcctct tcccaaataa gcagagcctc attgagcaca
     1201 gcaaggttca cgccaaagaa actgtcccca gtgccagcaa cgttgcccct gatgaccacc
     1261 gagaggaacc cacgtccccg agggaagagt tgctgcagtt tttgaacttg agacccagat
     1321 caactgcagg tagtacagtg aagcccatga cctgcatacc tcagcttgac ccgttcacca
     1381 cctaccaggc atggcagttg gctaccaaag gaaaagtggc cgttgcccag gaagaggtga
     1441 aagagtcagg ccaagaagga agcacagaca atgacgactc atgctcagag aaagaggaac
     1501 taggggaaat atgggttggg ggtaaggcgg aagggtctgg aaagtccaaa acaagtaaaa
     1561 gcagttgtcc aggtctctcc caagacaaag agaagcctag acatgctaat agtgaagtgc
     1621 cttctgggga tagtgacccc aagttgtcca gtagcaagga gaagcccacg cactgttctg
     1681 agtgcagcaa agccttcagg acataccacc agctcgtcct gcactcgagg gtgcacagga
     1741 aggacaggag gactgatgcc ctgtcaccca ccatggctgt ggatgcaagg cagcctggga
     1801 cctgctcccc agacctcagc accactctgg aagacagtgg ggccggggac cgagaagggg
     1861 gctctgaaga cgggtctgag gatggactcc ctgacgggct ccatttggat aaaaatgatg
     1921 atggaggaaa agcgaagccc ctcccgtcct cgagagagtg tagttactgt ggcaagtttt
     1981 tccgttcaaa ctattacctc aatattcatc tcagaacgca tacaggtgaa aaaccataca
     2041 aatgtgaatt ctgtgagtat gccgcagccc agaagacatc tctgaggtac cacttggaga
     2101 gacatcacaa agacaagcag ccggtggatg ctgccgctga gtccaaaagt gaaggccgga
     2161 gccaggagcc gcaggatgcg ctactaacgg ctgctgacag tgcgcagacc aaaaatttaa
     2221 agagatttct tgatggtgcc aaagatgtta agggaagccc acctgccaag cagcttaagg
     2281 agatgccttc tgtcttccag agtgttctct caccagcaca cagcaacgat actcaggatt
     2341 tccataaaca tgcagctgat agtgctgaga aagcgaggaa gagccctgcc cctacttatc
     2401 tggacatgca gagaaagaaa gcaggggagc ctcaggccag cagccctgtc tgcagactag
     2461 agggggttgg gtccttagca cgggaagctg gccataggga gaagatggat caggatgctg
     2521 actacagaca taagcccggt gctgactgcc aggacaggcc tttgaatcta tcccttgggc
     2581 cgctccacgc ctgtcctgca atctctttga gcaagtgtct gatccccagc attgcctgcc
     2641 ccttttgtac tttcaagacc ttttatccgg aagtccttat gatgcaccag agacttgagc
     2701 acaggtacaa ccctgacccg cacaagaacg gcagcagcaa gtctgtgctg aggaacaggc
     2761 gtaccgggtg ccctccggct ttgctgggaa aagatgtccc tcccttgtct ggcctgcaca
     2821 agcccaaggc caagactgcc ttctcaccac actcgaagtc cctgcactca gagaaggctc
     2881 ggcagggggc ctcggggcca agcaaagcac cccagacttc aggaccagac aacagcactt
     2941 tagccccaag taacctgaag tcacacaggt cacaacccaa tgctgggggc accagtgcca
     3001 ccaggcagca gcagtcagag ttgtttccca aaggtggcgt ccctgctgct atggataagg
     3061 tgaagagacc tgagccaaaa ctgaagtccc taccagcctc cccgtctcag tcccccctca
     3121 gcagtaataa tagcaacggt tctgttgagt atcccgtgaa ggttgacggc ccatgggcac
     3181 agcaagggag agactactac tgccatcgga attctggcag tgccgcagca gagtacagtg
     3241 agccacatcc caaaagactc aagtccagtg cggtgtccct ggacacagag catgcaggga
     3301 ccaatggcag aaggggcttt gagctcccca agtaccatgt ggtcaggagc atcacctcct
     3361 tgctaccacc agagtgtgtg cgcccaccgc ctgtgctgcc ccacaaagcc cgtttcctga
     3421 gccctgggga ggtggagtca cccagtgtgt tggctgtgca gaagccctac agtgcctctg
     3481 gacccctgta tacctgtgga cccgtgggac acgcaggagg cagcccagcc cttgaaggaa
     3541 agaggcctgt gtcacatcag cacctatcta acagcatgct gcagaagaga agctatgaga
     3601 attttattgg aaatacacat taccgaccaa atgacaaaaa accttgactt ctgattcttg
     3661 gggggggaaa aggtccctgg atgcaagtac acacttccac ggaatcatac attggttcat
     3721 cttctgagag cgcacaatag ctactgaaca agctgtgact gaactgtaca tagacctgag
     3781 aggagcagag aaggaacact acattctcta acgttctgtt aacctttgta ccaaatagca
     3841 ataaaaacga gtgggagccg ttgggcggtg cgccagaggg actgaaatct attttgtccc
     3901 taaatatttt tttaaagaat tgaccaaata agtttttttt tttttttgca tacttgagcg
     3961 ctgctgaaaa gaaatcattt ggggtagggt ggggtggggt gggcagggga tgttgtaaag
     4021 cttgcacctc aggtaactgt aaataccgac gtggtaaact tgcttgagta ctgtgtgtct
     4081 ccctcatgga gtgcgaggat ttgagcattt tctgcttctt tatgcttttt catttaaaac
     4141 atgttttaaa gcatattctc actgagtcta ttgtttgtct tcacattgct gatggaacga
     4201 aatgttgaca ctcagtgatg tgctgtgcat cttgaggtca gcaggcacta acctggcacc
     4261 ttttactcca gctggtagag ctagagctaa tgtgtacagg tgtcctggag ccccagcttg
     4321 ctgcctgggg tcttcggggg gaggggggct tttgagtggg tgttgcctac agagaagctg
     4381 cctctgtaga gtggccgatg tcacagagag ccaggctcca tggggagcca tctaagttct
     4441 tttcttttgg aagattgggt gtctcggaga gttgccatat ctccttgtgt gaattgcgtg
     4501 cttggaagca atttttaaag ggagtggaaa gcttagggaa atcgtttgta tttggagtct
     4561 tgctgtgtct ggtattggag gtgtggacac cttgagtctg ggtgagttgc tgctggctga
     4621 gccctcctgg caggcaggga gagaagacgc ctgggcctct ccattgtttg tttcccaggg
     4681 tgatttcctc agtgcacagg cagctcgaga tggagggagg acagccacca actagctcac
     4741 tcagcatttt aaacttgagt tcctttgata tctgagttta ttcaacagtt cttgggttta
     4801 gcaaacccaa aatattttat taagaaactg tttcaaagat aaatttgcac tgctcctttt
     4861 tcttgcccca cccctcctga tgggacaaaa gggtgaagag ctcaaagaac cccgactccc
     4921 ccctcccctc ccacctcatt gtgtaccatg aggggtcctt gggaaatgtc ttacctcttg
     4981 tgttgaatgg agacctgggt tgagatgtgt ctgctcttgt aggaagatct tttgtatcag
     5041 gaacatgtac actaggccct gttcccgtcc acaagctgag ccatatgtac ataagctaga
     5101 ctgttttctt aggtgtgcac ttttatagtc tgtttttgaa gattaacaca tttgcaaggt
     5161 gattgacacc atctttgcct aaatgcagtg agtgtacagg aagctcgttc tcgagacagt
     5221 acatacaaat ccggaggggg tcacatagac taggggccag aaagtatacc tgtatttaaa
     5281 aacgaaaaaa aaaaatcacc aaatctatta gaaaacaagt ccgagtgtgt aatgctgaaa
     5341 ttttggggcc tttcagattt ctctagctac attttctgaa tgcatgaaaa ttccaggttt
     5401 tttttttttt ctttcttaag cagcccttgt gcttcagtat gtccttgtca tcagtattaa
     5461 ctctgggata ctccgggctc tgtgtctttc cctgtgaggc gacagtacat gtgagaagag
     5521 gtacatttgt tggatttttg ttaatgtatt tatttcattc cagtttgatt tattttaatt
     5581 gttgatactt aagttgtcag tagacatgct ttatttatga tatatttcag cttaaagtta
     5641 tgttattata tgtggatgta aatatagatt tggtgtttta cagtt
//
