LOCUS       NM_145547               3047 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger protein 189 (Zfp189), transcript variant
            1, mRNA.
ACCESSION   NM_145547
VERSION     NM_145547.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3047)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3047)
  AUTHORS   Xia,Z., Hu,B., Yang,M. and He,W.
  TITLE     Zinc finger protein 189 promotes the differentiation of lamina
            propria T helper 17.1 cells in dextran sulfate sodium-induced
            colitis
  JOURNAL   Autoimmunity 56 (1), 2189140 (2023)
   PUBMED   36942486
  REMARK    GeneRIF: Zinc finger protein 189 promotes the differentiation of
            lamina propria T helper 17.1 cells in dextran sulfate
            sodium-induced colitis.
REFERENCE   3  (bases 1 to 3047)
  AUTHORS   Teague,C.D., Picone,J.A., Wright,W.J., Browne,C.J., Silva,G.M.,
            Futamura,R., Minier-Toribio,A., Estill,M.E., Ramakrishnan,A.,
            Martinez-Rivera,F.J., Godino,A., Parise,E.M., Schmidt,K.H.,
            Pulido,N.V., Lorsch,Z.S., Kim,J.H., Shen,L., Neve,R.L., Dong,Y.,
            Nestler,E.J. and Hamilton,P.J.
  TITLE     CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron
            Subtypes Differentially Regulates Behavioral and Physiological
            Adaptations Over the Course of Cocaine Use
  JOURNAL   Biol Psychiatry 93 (6), 502-511 (2023)
   PUBMED   36253194
  REMARK    GeneRIF: CREB Binding at the Zfp189 Promoter Within Medium Spiny
            Neuron Subtypes Differentially Regulates Behavioral and
            Physiological Adaptations Over the Course of Cocaine Use.
REFERENCE   4  (bases 1 to 3047)
  AUTHORS   Lorsch,Z.S., Hamilton,P.J., Ramakrishnan,A., Parise,E.M.,
            Salery,M., Wright,W.J., Lepack,A.E., Mews,P., Issler,O.,
            McKenzie,A., Zhou,X., Parise,L.F., Pirpinias,S.T., Ortiz Torres,I.,
            Kronman,H.G., Montgomery,S.E., Loh,Y.E., Labonte,B., Conkey,A.,
            Symonds,A.E., Neve,R.L., Turecki,G., Maze,I., Dong,Y., Zhang,B.,
            Shen,L., Bagot,R.C. and Nestler,E.J.
  TITLE     Stress resilience is promoted by a Zfp189-driven transcriptional
            network in prefrontal cortex
  JOURNAL   Nat Neurosci 22 (9), 1413-1423 (2019)
   PUBMED   31427770
  REMARK    GeneRIF: Zfp189 in prefrontal cortical neurons...promotes
            behavioral resilience
REFERENCE   5  (bases 1 to 3047)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 3047)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY085925.1, AK051265.1, AK049475.1 and BY420591.1.
            
            On Feb 7, 2014 this sequence version replaced NM_145547.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021326.1, AK051265.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BY085925.1         4-44
            42-2336             AK051265.1         1-2295
            2337-3026           AK049475.1         2246-2935
            3027-3047           BY420591.1         369-389
FEATURES             Location/Qualifiers
     source          1..3047
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.55 cM"
     gene            1..3047
                     /gene="Zfp189"
                     /gene_synonym="C430015I23Rik"
                     /note="zinc finger protein 189"
                     /db_xref="GeneID:230162"
                     /db_xref="MGI:MGI:2444707"
     exon            1..420
                     /gene="Zfp189"
                     /gene_synonym="C430015I23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..2214
                     /gene="Zfp189"
                     /gene_synonym="C430015I23Rik"
                     /codon_start=1
                     /product="zinc finger protein 189"
                     /protein_id="NP_663522.2"
                     /db_xref="CCDS:CCDS18175.1"
                     /db_xref="GeneID:230162"
                     /db_xref="MGI:MGI:2444707"
                     /translation="MASPSPPLEPKEEWGYLDPAPRSLYKDVMMDSYGKLVSLDVLNR
                     NKDEEPTVKEELEKDIEPQGVIVTRIKSEIDQDPVGSETFELVGRLDKQRGIFLWEIP
                     RDSLSEEQKLFRGHTNVRKRPTSEEKCHKCEECGKRFVRKAHFIQHQRVHTGEKPFQC
                     NECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGERPYQCNQ
                     CKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTHTGEKPYHCTKCK
                     KSFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGKS
                     FSRSSFLIEHQRIHTGERPYQCQECGKSFSQLCNLTRHQRIHTGDKPHKCEECGKAFS
                     RSSGLIQHQRIHIREKTSPFSETKESFDPNCSLVIQQEVSPKEKSYKCDDCGKTFSVS
                     AHLVQHQRIHTGEKPYLCTVCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQLCN
                     LIRHQGVHTGNKPHKCEECGKAFSRNSGLIQHQRIHTGEKPYRCGKCDKSFSQQRSLV
                     NHQKIHAEVKTQEIYECDACGEAFTCQISLIQHQKLHIMWMQ"
     exon            421..505
                     /gene="Zfp189"
                     /gene_synonym="C430015I23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            506..3047
                     /gene="Zfp189"
                     /gene_synonym="C430015I23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2751..2756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp189"
                     /gene_synonym="C430015I23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2771
                     /gene="Zfp189"
                     /gene_synonym="C430015I23Rik"
                     /note="major polyA site"
     regulatory      2803..2808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp189"
                     /gene_synonym="C430015I23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2823
                     /gene="Zfp189"
                     /gene_synonym="C430015I23Rik"
                     /note="major polyA site"
     regulatory      3010..3015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp189"
                     /gene_synonym="C430015I23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3034
                     /gene="Zfp189"
                     /gene_synonym="C430015I23Rik"
                     /note="major polyA site"
ORIGIN      
        1 tttacggaag aaggcggtgg ctcgctccct gggcatgttg ggagttgtag ttggagcggt
       61 tccgcgaagg ctccgggtaa cgccttctgg tccgggggtg gtcggtagta gtgcagcttg
      121 actttgaggc ggaggaattg gcaacaagga ggagatatta cagggagacc ctaaggctag
      181 gcagcgggac agaggactgg gtttggggtt ggaggacagc cagacagaac gtctgatatg
      241 cccctaggaa cttgaccgct ccgagacaga ggcaggacca caccagaccc atccggtgag
      301 ccccttctcg ccgagcctta tttccaacag ccatctaggc ctcatcagag ccccaatgtc
      361 gtgtggctgc tattcctgaa cgaggcgatg gcgtccccaa gcccaccgct ggagccaaag
      421 gaggagtggg gttatctgga tccagctccg agaagcctgt ataaagatgt catgatggac
      481 agctacggaa agctggtctc gctggatgtt ttaaacagaa ataaagatga agagccaact
      541 gtgaaagaag aacttgagaa agatatcgag ccacagggtg taatagttac aagaatcaaa
      601 agtgaaattg atcaagatcc tgtgggtagc gaaacctttg aacttgttgg taggttagat
      661 aaacaaagag ggatcttttt gtgggaaata ccacgtgact ctctgagtga ggaacagaaa
      721 ctatttagag ggcacactaa tgtccgtaag agaccaactt cagaagagaa gtgtcataaa
      781 tgtgaagaat gtggaaaacg ttttgtccgc aaggcccatt tcattcagca tcaaagggtc
      841 cacacgggtg agaaaccttt tcagtgcaac gagtgtggga aaagcttcag tcgaagttcc
      901 tttgttattg aacatcagag aattcacact ggggaacgac cctatgagtg taattactgt
      961 gggaaaacct ttagtgtgag ctctaccctt attagacacc agagaatcca cactggagaa
     1021 aggccttacc agtgtaatca gtgtaaacag agcttcagcc agagaaggag ccttgtgaaa
     1081 caccaaagaa ttcacactgg tgagaaaccc cataaatgca gtgactgtgg aaaagccttc
     1141 agttggaaat cccaccttat tgagcatcag aggacccaca ctggtgagaa accctatcac
     1201 tgtaccaaat gcaagaaaag ttttagtcga aactcattgc ttgttgaaca ccagagaatt
     1261 cataccggag aaagacctca taagtgtggt gaatgtggga aagcgttcag attaagtaca
     1321 taccttatac aacaccaaaa aatacacact ggtgagaagc cttttctttg tattgaatgt
     1381 ggaaagagtt tcagtcggag ctcattcctt attgaacatc agaggatcca tacgggggaa
     1441 cgcccttatc agtgccaaga gtgcgggaaa agtttcagtc aactttgcaa ccttacccgt
     1501 catcagagaa ttcacacggg ggacaaaccc cacaagtgtg aggagtgtgg gaaagccttc
     1561 agtagaagct caggtctcat tcagcaccag agaatccata tcagggaaaa gacttcgcca
     1621 ttcagtgaaa ctaaggaaag ttttgatcca aactgcagtc tggttataca gcaggaagtc
     1681 tcccctaagg agaaatcgta caaatgcgat gactgtggga aaacgttcag tgtcagtgct
     1741 catcttgtac agcatcagag gatccacact ggtgagaagc cctacctgtg tactgtctgc
     1801 gggaaaagct tcagtcggag ctcgtttctt attgagcatc agagaatcca cactggggag
     1861 agaccctatc tgtgcagaca gtgtggcaaa agttttagtc aactttgtaa tctcatccgc
     1921 catcagggcg ttcacactgg taacaagccc cacaagtgtg aggagtgtgg gaaagccttc
     1981 agcaggaact caggtctcat tcagcaccag agaatccaca caggagagaa gccttatagg
     2041 tgtggaaaat gtgacaaaag ttttagtcaa cagcgcagcc ttgtcaacca tcagaagatc
     2101 catgcagagg tgaaaaccca ggaaatttat gaatgtgatg cctgcggcga agcctttact
     2161 tgtcagattt ctctaattca gcatcaaaag ttgcatatta tgtggatgca gtaaaattag
     2221 ggatatttta atgcttaaat ctgtgactag ctaccaaagt gcagttttaa tacggcccaa
     2281 cgtgggtcaa atatagtggt aaagcaaata cttgttggct tcatgaagaa tagtttctaa
     2341 agatcctatg aatagtgggc agtgcctgtg gggaactgac ttggcgatta ctagttgttt
     2401 tcatagccac agagatttga tttatctaag cctctaacct ttcagtagag tcgactgggc
     2461 aaggcatatg aggaaagttc tgaagggcac agtgaaatta gtgtaccgaa tagggagcaa
     2521 ctgatcctgg gaagctagga ataattcaaa agtcttatgt tgccatctcc tgtagttgcc
     2581 cttcagttct atgaagtttg actatacgtg tcaaacctca gtgactaagc aaatgtaatt
     2641 tgtgaaagtc cagatatttt caaagttgcc aaacagtgtt taaaactgtt caagaaattt
     2701 gtatggaaaa ttagttggtg aaagtttgga gctccagtac ttcccaggtt aataaaggcg
     2761 tgaatcatta agttgtaaag gcatttgtta gtgttaacaa ctaataaagg tattaccaag
     2821 gaatctttgg gagtgccttc tcctgagcca caaaatgggc cccaaaagaa aattactgat
     2881 ttattttgtg ctgcctcatc tgtgaaatct gtttgtaata ctatatcaac attactttat
     2941 tattcccaca taatcaggaa catgtaaaga aagatgtacg tattttgatt atcaagaact
     3001 ggaaataata ataaaaaaaa tgacctaaaa tgtatgctag aaagctg
//
