LOCUS       NM_009549               3557 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus zinc finger protein 185 (Zfp185), transcript variant
            1, mRNA.
ACCESSION   NM_009549 XM_207027
VERSION     NM_009549.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3557)
  AUTHORS   Suzuki,S., Ando,F., Kitagawa,S., Hara,Y., Fujiki,T., Mandai,S.,
            Susa,K., Mori,T., Sohara,E., Rai,T. and Uchida,S.
  TITLE     ZNF185 prevents stress fiber formation through the inhibition of
            RhoA in endothelial cells
  JOURNAL   Commun Biol 6 (1), 29 (2023)
   PUBMED   36631535
  REMARK    GeneRIF: ZNF185 prevents stress fiber formation through the
            inhibition of RhoA in endothelial cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3557)
  AUTHORS   Liu,H., Xu,J., Lan,Y., Lim,H.W. and Jiang,R.
  TITLE     The Scleraxis Transcription Factor Directly Regulates Multiple
            Distinct Molecular and Cellular Processes During Early Tendon Cell
            Differentiation
  JOURNAL   Front Cell Dev Biol 9, 654397 (2021)
   PUBMED   34150754
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3557)
  AUTHORS   You,X., Wei,L., Fan,S., Yang,W., Liu,X., Wang,G., Man,Y., Pan,Z.
            and Feng,W.
  TITLE     Expression pattern of Zinc finger protein 185 in mouse testis and
            its role in regulation of testosterone secretion
  JOURNAL   Mol Med Rep 16 (2), 2101-2106 (2017)
   PUBMED   28627666
  REMARK    GeneRIF: ZNF185 was highly expressed in Leydig cells of the testis
            and involved in the secretion of testosterone and the knockdown of
            ZNF185 expression did not significantly affect cell cycle
            progression or apoptosis.
REFERENCE   4  (bases 1 to 3557)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   5  (bases 1 to 3557)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3557)
  AUTHORS   Raefski,A.S. and O'Neill,M.J.
  TITLE     Identification of a cluster of X-linked imprinted genes in mice
  JOURNAL   Nat Genet 37 (6), 620-624 (2005)
   PUBMED   15908953
REFERENCE   7  (bases 1 to 3557)
  AUTHORS   Davies,W., Isles,A., Smith,R., Karunadasa,D., Burrmann,D.,
            Humby,T., Ojarikre,O., Biggin,C., Skuse,D., Burgoyne,P. and
            Wilkinson,L.
  TITLE     Xlr3b is a new imprinted candidate for X-linked parent-of-origin
            effects on cognitive function in mice
  JOURNAL   Nat Genet 37 (6), 625-629 (2005)
   PUBMED   15908950
REFERENCE   8  (bases 1 to 3557)
  AUTHORS   Mallon,A.M., Platzer,M., Bate,R., Gloeckner,G., Botcherby,M.R.,
            Nordsiek,G., Strivens,M.A., Kioschis,P., Dangel,A., Cunningham,D.,
            Straw,R.N., Weston,P., Gilbert,M., Fernando,S., Goodall,K.,
            Hunter,G., Greystrong,J.S., Clarke,D., Kimberley,C., Goerdes,M.,
            Blechschmidt,K., Rump,A., Hinzmann,B., Mundy,C.R., Miller,W.,
            Poustka,A., Herman,G.E., Rhodes,M., Denny,P., Rosenthal,A. and
            Brown,S.D.
  TITLE     Comparative genome sequence analysis of the Bpa/Str region in mouse
            and Man
  JOURNAL   Genome Res 10 (6), 758-775 (2000)
   PUBMED   10854409
REFERENCE   9  (bases 1 to 3557)
  AUTHORS   Heiss,N.S., Gloeckner,G., Bachner,D., Kioschis,P., Klauck,S.M.,
            Hinzmann,B., Rosenthal,A., Herman,G.E. and Poustka,A.
  TITLE     Genomic structure of a novel LIM domain gene (ZNF185) in Xq28 and
            comparisons with the orthologous murine transcript
  JOURNAL   Genomics 43 (3), 329-338 (1997)
   PUBMED   9268636
REFERENCE   10 (bases 1 to 3557)
  AUTHORS   Levin,M.L., Chatterjee,A., Pragliola,A., Worley,K.C., Wehnert,M.,
            Zhuchenko,O., Smith,R.F., Lee,C.C. and Herman,G.E.
  TITLE     A comparative transcription map of the murine bare patches (Bpa)
            and striated (Str) critical regions and human Xq28
  JOURNAL   Genome Res 6 (6), 465-477 (1996)
   PUBMED   8828036
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB663121.1, BB648025.1, AK048188.1, U46687.1, AK014497.1 and
            BM934903.1.
            
            On Oct 3, 2007 this sequence version replaced NM_009549.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF494744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-594               BB663121.1         1-594
            595-631             BB648025.1         575-611
            632-670             AK048188.1         613-651
            671-933             U46687.1           497-759
            934-963             AK048188.1         912-941
            964-1168            U46687.1           790-994
            1169-1813           AK014497.1         217-861
            1814-2800           AK048188.1         1792-2778
            2801-3177           BM934903.1         229-605
            3178-3557           AK048188.1         3156-3535
FEATURES             Location/Qualifiers
     source          1..3557
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.29 cM"
     gene            1..3557
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /note="zinc finger protein 185"
                     /db_xref="GeneID:22673"
                     /db_xref="MGI:MGI:108095"
     exon            1..181
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            182..259
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1686
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /note="isoform a is encoded by transcript variant 1; P1-A;
                     LIM domain protein Zfp185"
                     /codon_start=1
                     /product="zinc finger protein 185 isoform a"
                     /protein_id="NP_033575.3"
                     /db_xref="CCDS:CCDS30191.2"
                     /db_xref="GeneID:22673"
                     /db_xref="MGI:MGI:108095"
                     /translation="MSISSLGSIGKGRTVPSGEEERNNILRQMKVRTTLKGDQSWITK
                     HDDSEDHTIEPLSRHNRATSFSSVRDESNARSPNARAPAGYIIRGVFTRTIDSSSHSQ
                     HRPSKTNGAPRSASGQLGAANSGHPLQSSGYKMTTEDYKKLAPYNIRRSSISGTEEEE
                     VPFTPDEQKRRSQAALGVLRKTAPREHSYVLSAAKKTTSSPTQELQSPFLAKRVDVVD
                     EDVLPEKNQEPPALARPDPGRSSSTTEKIAHRQITPPTAELHLVAPDLEALSTPDSCE
                     ENNAAPKIIKEIPGTLQDGQSDPTVASQQLADLSILEPQGSPSGAEQQIKAEDCTNML
                     MSPSSCMVTVTISDTSEQSQLCVPGVSSKVDSSSTIKGILFVKEYMNTSEVSSGKPVS
                     SHCDSPSSIEDSLDLAKKAPHEGTPSERPTEGVCTYCSHEIQDCPKITLEHLGICCHE
                     YCFKCGICNKPMGDLLDQIFIHRDTIHCGKCYEKLF"
     exon            260..383
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            384..449
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            450..488
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            489..566
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            567..653
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            654..737
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            738..821
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            822..863
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            864..947
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1034
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1223
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1334
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1415
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1484
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1587
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1686
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..3557
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3508..3513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /note="hexamer: AATAAA"
     polyA_site      3526
                     /gene="Zfp185"
                     /gene_synonym="P1; Znf185"
                     /note="major polyA site"
ORIGIN      
        1 gttctcgggc gggcggagcc cagtccgtgc ctcttcgttg ccccgcgcgc ttcccactgc
       61 gtaccgcttc ccgcgcccgc tgacgcggcc cggctgggtt cagtgctgcc cacccgaggg
      121 agcccgcgca ccacgcctgt ccgaccctct gcccgtcaca caagccgggc acctgtacca
      181 ggagctcact gaatccacta attaaagagc tgaaagataa acatcatgag tatttcttcc
      241 ttaggaagta ttgggaaagg gagaactgta ccatctggtg aagaggagcg caataatatc
      301 ctaagacaga tgaaagtacg gactacacta aagggtgacc agagctggat caccaagcat
      361 gatgactctg aggatcatac catagagcca ctctcacgtc acaaccgagc cacatccttc
      421 tcatcagtca gagacgaatc aaatgccagg tctccaaacg caagggctcc agctggttac
      481 ataatccggg gagtgttcac ccgaacaata gatagctctt ctcactccca gcatcgcccc
      541 tctaagacca acggagctcc aagaagtgct tctgggcagc tgggagcagc taattctggt
      601 catcctcttc agtcgtctgg ctataagatg actacggaag attataagaa actagcaccg
      661 tacaacatca ggcgcagctc catatcaggg actgaggaag aggaggtgcc attcacccca
      721 gatgagcaga aacggaggtc ccaggctgca cttggtgttc tgaggaagac agccccccgg
      781 gagcactctt acgtcctctc agcagctaag aagaccacta gcagtccgac ccaggagctg
      841 cagtcgccat tccttgcaaa aagggttgat gtggtagatg aggacgtcct tcctgagaaa
      901 aaccaggaac cacctgctct ggcaagacct gatcctggcc gaagcagctc gacaaccgag
      961 aagattgccc atcggcagat tacacccccc acagcagaac tccacctggt ggccccagac
     1021 ctggaagccc tgagcactcc agattcttgt gaggagaaca atgcagcccc caagatcatc
     1081 aaggaaatac ctggcaccct acaagatgga caaagtgacc caactgtggc ttctcagcaa
     1141 cttgcagatc tcagcatcct agagccacag ggtagcccca gtggagccga gcagcaaatc
     1201 aaagccgagg actgtactaa catgctgatg agcccttcaa gctgcatggt cactgttacc
     1261 atctctgaca cctctgaaca atctcaattg tgtgttcctg gtgtctcaag caaggtggac
     1321 tccagctcaa ctatcaaagg gattctcttc gtgaaggagt acatgaatac cagtgaagtg
     1381 tcttctggga agccagtgtc ttcacactgt gacagtccca gcagcattga agactcattg
     1441 gatctggcaa agaaagcccc acatgaaggt actccttctg agagaccaac cgaaggggtc
     1501 tgtacttact gtagccatga gatccaagat tgtccgaaga ttacccttga acatcttggc
     1561 atctgctgcc atgagtattg ttttaagtgc gggatttgca ataaaccgat gggtgatctc
     1621 ctagatcaga tcttcattca ccgtgacacc atccactgtg ggaaatgcta tgagaagctc
     1681 ttctaggctg aacagaagct gatgatcccc agctgtattt ggctgtccag ttgacccaaa
     1741 ttgttggctc ctcgtcactt acatcctcca tggttccact gtacttctgc ctaccttgtg
     1801 cggaaggagc atacatctaa gattgtgtag ccatgatgtt atgattttgt gtagcctttt
     1861 ataccttagg aatatctcag ttccttgctt ccaggatgaa tgagtccact ttgacctccc
     1921 tgagacatgt tttctaatga gtgcagatga cctagtatgt tagacatggg tacaagtcta
     1981 ggtatcagcg tatgcagact ttctgaggct tctgagagcc caagccaaaa aactgttgac
     2041 gatccctggt agggaaatta caggcattaa atactaaggg ttggcaatag gctactgttt
     2101 agcttgtcta ttcactttgt gtgtatgtgt gtgtgtgttt aaatttctca cattttaaaa
     2161 atagttaatt ttttgattga attacatagc agatttaaat tacctccttc cattctcctt
     2221 tggtttttcc agtaaggtat gtcagcacat gttggaaagt ttacccaggt ttaaatttga
     2281 taagatacaa tattaggagg cttctaccaa agggatatct gtgtctgttt gaattttgtt
     2341 agttagttaa aatctttacc ctcagtattg ctgaactttt atcctctgaa cagcttttaa
     2401 tgtgtgtaaa tcagggtaaa gaaaacagat acggtttctt gagacttctg ttcctactgt
     2461 gaaatatttc cctgaagcgt agtgttagaa atggctttga aaagtgtgaa attcacccca
     2521 tctctgggct tcttgggtcc ctccttgaaa cactacggta atttaattgc tccctttccc
     2581 tctcctccag agtctttcac ccagagacga atttggctta tgtaacttct caaagaaaag
     2641 cttgctatcc agtgaaacgt caagtaggct ctctgccctg atcgtgcagc attttgtgac
     2701 ctgttttcta gtcctgaatc tgtctcaaac taacatcaac ttctaggttc ccaggtactc
     2761 aaaacactac cagttgatgt ctggcacagc agaggcaggt tcgtccctgc agtttgctaa
     2821 tatgctgctc taagtcaacc tcactctgct gcctttgggc tcagcattaa attggaagct
     2881 ccttgaaagg aaaaaaatag tcctcaagac ttgggaatgc aaaattgagg cttctttgtt
     2941 ggattgactt agaagatagc tcttcactct ctgcagactt tgaatgggct tgttcttcct
     3001 accaggtaac cagagaagaa cattctattt atttgactat ttatctgtta cctgaactct
     3061 gaagggaaga aggagtacat tgtgccacac cccaatacta attatgaact agttctttct
     3121 caagttcagc tctaggatgg gacttagcag agagtggcca ataacatatg tgtgccaaat
     3181 gaattagtaa gagaaaacta agtcagtccc ttaattatct aggcatttca gtgcaggcct
     3241 catagacaag agtaaaaggc tctaaatcgg atggcttccc cacttaaagg tgtactctgc
     3301 catttaagga gttttagaaa tataaaatat actcaaagac agcttgtaag gctagtattg
     3361 atttgaatcc aaaacagccc ttttgtgtct tagacacaaa attctgcagc taacaaagag
     3421 agatggtttt gcattgattt gcttcttttt aattgctttc cgtttttaat tatccttgct
     3481 taatccacat taatgtacac aaattataat aaatgttaag atgttacaca gcagtattat
     3541 aacttctttt ttaaacc
//
