LOCUS       NM_011749               9431 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger protein 148 (Zfp148), transcript variant
            3, mRNA.
ACCESSION   NM_011749 XM_489551
VERSION     NM_011749.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9431)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 9431)
  AUTHORS   Chopp,L.B., Zhu,X., Gao,Y., Nie,J., Singh,J., Kumar,P., Young,K.Z.,
            Patel,S., Li,C., Balmaceno-Criss,M., Vacchio,M.S., Wang,M.M.,
            Livak,F., Merchant,J.L., Wang,L., Kelly,M.C., Zhu,J. and
            Bosselut,R.
  TITLE     Zfp281 and Zfp148 control CD4+ T cell thymic development and TH2
            functions
  JOURNAL   Sci Immunol 8 (89), eadi9066 (2023)
   PUBMED   37948511
  REMARK    GeneRIF: Zfp281 and Zfp148 control CD4[+] T cell thymic development
            and TH2 functions.
REFERENCE   3  (bases 1 to 9431)
  AUTHORS   Kuang,L.W., Zhang,C.C., Li,B.H., Liu,H.Z., Wang,H. and Li,G.C.
  TITLE     Identification of the MALAT1/miR-106a-5p/ZNF148 feedback loop in
            regulating HaCaT cell proliferation, migration and apoptosis
  JOURNAL   Regen Med 18 (3), 239-258 (2023)
   PUBMED   36710662
  REMARK    GeneRIF: Identification of the MALAT1/miR-106a-5p/ZNF148 feedback
            loop in regulating HaCaT cell proliferation, migration and
            apoptosis.
REFERENCE   4  (bases 1 to 9431)
  AUTHORS   Emfinger,C.H., de Klerk,E., Schueler,K.L., Rabaglia,M.E.,
            Stapleton,D.S., Simonett,S.P., Mitok,K.A., Wang,Z., Liu,X.,
            Paulo,J.A., Yu,Q., Cardone,R.L., Foster,H.R., Lewandowski,S.L.,
            Perales,J.C., Kendziorski,C.M., Gygi,S.P., Kibbey,R.G.,
            Keller,M.P., Hebrok,M., Merrins,M.J. and Attie,A.D.
  TITLE     beta Cell-specific deletion of Zfp148 improves nutrient-stimulated
            beta cell Ca2+ responses
  JOURNAL   JCI Insight 7 (10), e154198 (2022)
   PUBMED   35603790
  REMARK    GeneRIF: beta Cell-specific deletion of Zfp148 improves
            nutrient-stimulated beta cell Ca2+ responses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9431)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9431)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 9431)
  AUTHORS   Feo,S., Antona,V., Cammarata,G., Cavaleri,F., Passantino,R.,
            Rubino,P. and Giallongo,A.
  TITLE     Conserved structure and promoter sequence similarity in the mouse
            and human genes encoding the zinc finger factor
            BERF-1/BFCOL1/ZBP-89
  JOURNAL   Biochem Biophys Res Commun 283 (1), 209-218 (2001)
   PUBMED   11322790
REFERENCE   8  (bases 1 to 9431)
  AUTHORS   Passantino,R., Antona,V., Barbieri,G., Rubino,P., Melchionna,R.,
            Cossu,G., Feo,S. and Giallongo,A.
  TITLE     Negative regulation of beta enolase gene transcription in embryonic
            muscle is dependent upon a zinc finger factor that binds to the
            G-rich box within the muscle-specific enhancer
  JOURNAL   J Biol Chem 273 (1), 484-494 (1998)
   PUBMED   9417107
REFERENCE   9  (bases 1 to 9431)
  AUTHORS   Antona,V., Cammarata,G., De Gregorio,L., Dragani,T.A., Giallongo,A.
            and Feo,S.
  TITLE     The gene encoding the transcriptional repressor BERF-1 maps to a
            region of conserved synteny on mouse chromosome 16 and human
            chromosome 3 and a related pseudogene maps to mouse chromosome 8
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 90-92 (1998)
   PUBMED   9925940
REFERENCE   10 (bases 1 to 9431)
  AUTHORS   Hasegawa,T., Takeuchi,A., Miyaishi,O., Isobe,Ki. and de
            Crombrugghe,B.
  TITLE     Cloning and characterization of a transcription factor that binds
            to the proximal promoters of the two mouse type I collagen genes
  JOURNAL   J Biol Chem 272 (8), 4915-4923 (1997)
   PUBMED   9030551
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ129103.1, CK634070.1, AK146591.1 and AC127412.4.
            
            On Apr 19, 2007 this sequence version replaced NM_011749.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.116473.1,
                                           SRR1660819.91340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               CJ129103.1         2-440
            440-1070            CK634070.1         88-718
            1071-3434           AK146591.1         933-3296
            3435-9431           AC127412.4         77970-83966
FEATURES             Location/Qualifiers
     source          1..9431
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 23.93 cM"
     gene            1..9431
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /note="zinc finger protein 148"
                     /db_xref="GeneID:22661"
                     /db_xref="MGI:MGI:1332234"
     exon            1..253
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /inference="alignment:Splign:2.1.0"
     exon            254..335
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /inference="alignment:Splign:2.1.0"
     exon            336..471
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /inference="alignment:Splign:2.1.0"
     exon            472..820
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..2872
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /note="G-rich box-binding protein; transcription factor
                     BFCOL1; transcription factor ZBP-89; zinc finger
                     DNA-binding protein 89; beta enolase repressor factor 1"
                     /codon_start=1
                     /product="zinc finger protein 148"
                     /protein_id="NP_035879.1"
                     /db_xref="CCDS:CCDS28130.1"
                     /db_xref="GeneID:22661"
                     /db_xref="MGI:MGI:1332234"
                     /translation="MNIDDKLEGLFLKCGGIDEMQSSRAMVVMGGVSGQSAVSGELQE
                     SVLQDRSLPHQEILAADEVLQESEMRQQDMISHDELMVHEETVKNDEEQMDTHERLPQ
                     GLQYALNVPISVKQEITFTDVSEQLMRDKKQVREPVDLQKKKKRKQRSPAKILTINED
                     GSLGLKTPKSHVCEHCNAAFRTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHE
                     KIHTGEKPFRCDECGMRFIQKYHMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRM
                     CHENHDKKLNRCAIKGGLLTSEEDSGFSTSPKDNSLPKKKRQKTEKKSSGMDKESVLD
                     KSDLKKDKNDYLPLYSSSTKVKDEYMVAEYAVEMPHSSVGGSHLEDASGEIHPPKLVL
                     KKINSKRSLKQPLEQSQTISPLSSYEDSKVSKYAFELVDKQALLDSEGSADIDQVDNL
                     QEGPSKPVHSSTNYDDAMQFLKKKRYLQAASNNSREYALNVGTIASQPSVTQAAVASV
                     IDESTTASILDSQALNVEIKSNHDKNVIPDEVLQTLLDHYSHKPNGQHEISFSVADTE
                     VTSSISINSSDVPEVTQSENVGSSSQASSSDKANMLQEYSKFLQQALDRTSQNDAYLN
                     SPSLNFVTDNQTLPNPPAFSSIDKQVYAAMPINSFRSGMNSPLRTTPDKSHFGLIVGD
                     SQHPFPFSGDETNHASATSTADFLDQVTSQKKAEAQPVHQAYQMSSFEQPFRAPYHGS
                     RAGIATQFSTANGQVNLRGPGTSAEFSEFPLVNVNDNRAGMTSSPDATTGQTFG"
     exon            821..946
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1070
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1154
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1273
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..9431
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7762..7767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /note="hexamer: AAGAAA"
     polyA_site      7782
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /note="major polyA site"
     regulatory      7888..7893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /note="hexamer: ATTAAA"
     polyA_site      7908
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /note="major polyA site"
     regulatory      9405..9410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /note="hexamer: AATAAA"
     polyA_site      9426
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
ORIGIN      
        1 ggcgaccgcg gcgacgctct agccgcgcca tgtctgcctc tcgactgctc tgggaggagg
       61 aagagaagga ggaagaggag gaggaggagg agggggagga agaggagaaa ggcgcagggg
      121 tgggagctgt cgccggagct gccacagcaa aagttctctc ccctccccct cgccctcctc
      181 gtcgggcccg tgggaaggtc ggagccgccg ccgcctgcag tcagtgaccg cgcgcctcgg
      241 cgccagcccc gcggatagaa gagaagaatc agtggtttgg aaatttagcc aagtgatctg
      301 gcgggatggg cttatacctg acacatttta tagaggcatt ggatggcaca agtgactgag
      361 aggatcccga gagtttccgg ggcctgtgaa aggtagaaac tcaaccatga tttctttctc
      421 aactcaacag cattcccttc cttgaagtct tcgtttttac ttcagcctca ggcagttata
      481 cttaagcatg aacattgacg acaaactgga aggattgttt cttaaatgtg gcggcataga
      541 cgaaatgcag tcttccaggg caatggttgt aatgggtgga gtgtctggcc agtccgccgt
      601 gtctggagaa ctgcaggagt cagtacttca agatcgaagt ttgcctcacc aggagatcct
      661 tgctgcagac gaagtgttac aagagagtga aatgagacaa caggatatga tatcccatga
      721 tgaactcatg gtccacgagg agacagtgaa aaatgacgaa gagcagatgg acacccacga
      781 gcggcttccc caaggactgc agtatgcact caatgtccct ataagtgtaa agcaggaaat
      841 tacttttact gatgtatctg agcaactgat gagagacaaa aaacaagtca gagagccagt
      901 agacttacag aaaaagaaga agcggaaaca acgctctcct gcaaaaatcc ttacaataaa
      961 tgaggatgga tcacttggtt tgaaaacccc taaatctcac gtttgtgagc actgcaatgc
     1021 tgcctttaga acgaactatc acttacagag gcatgtcttc attcatacag gcgaaaaacc
     1081 gtttcaatgt agtcaatgtg acatgcgttt catacagaag tacctgcttc agagacacga
     1141 gaagatccat accggtgaaa aaccatttcg ctgtgatgaa tgtggtatga gattcataca
     1201 gaaatatcac atggaaaggc acaaaagaac tcacagtgga gagaagcctt atcagtgtga
     1261 atactgctta cagtattttt ccagaacaga tcgtgtattg aaacataaac gtatgtgcca
     1321 tgaaaatcac gacaaaaaac taaacagatg tgccatcaaa ggtggccttc tgacatcaga
     1381 ggaagattct ggcttttcta catcaccaaa agataattca ctgccaaaaa agaaaaggca
     1441 aaaaactgag aagaaatcgt ctgggatgga caaggagagt gtgctggaca aatctgacct
     1501 gaagaaagac aagaacgatt acctgcctct ctactcgtcg agcactaaag taaaggatga
     1561 gtacatggtg gcagagtatg ctgttgagat gccacactca tcagtgggag gctctcacct
     1621 agaagatgca tctggagaaa tacacccacc caagttggtt ctcaaaaaaa tcaatagtaa
     1681 gagaagtctg aagcagccct tggagcaaag tcaaaccatt tcacccctat ccagctatga
     1741 agacagcaaa gtttccaagt acgcttttga gcttgtggat aagcaggcgt tactggactc
     1801 agaaggcagt gctgacatcg atcaagtgga taacttgcag gagggcccca gcaaacctgt
     1861 gcacagcagt actaattacg acgatgccat gcagtttctg aagaagaagc ggtatcttca
     1921 agctgcaagt aacaacagca gggagtacgc actgaatgtg ggcaccatag cctctcagcc
     1981 ttctgtgaca caagccgccg tggccagcgt cattgatgaa agcaccacag catccatact
     2041 ggattcccag gcactgaatg tggagattaa gagcaatcat gacaaaaatg ttatcccaga
     2101 tgaggtcctg cagactctgc tggatcatta ttcccacaaa cctaatggac agcatgagat
     2161 ttccttcagc gttgcagata ctgaagtgac ttctagcata tcaatcaatt cttccgatgt
     2221 acctgaagtc acccagtcag agaatgttgg atcaagctcc caagcatcct catcagataa
     2281 agctaacatg ttgcaggaat actccaagtt tctgcagcag gctttggaca gaactagcca
     2341 aaacgatgcc tatttgaata gcccgagcct taactttgtg actgacaacc agacccttcc
     2401 aaatccgcca gcattctctt ccatagacaa gcaagtctat gcagccatgc ccatcaatag
     2461 ctttcgatca ggaatgaatt ctccactaag aacaactcca gataagtccc actttggact
     2521 aatagtcggt gactcacagc acccgtttcc cttttcaggt gacgagacaa accacgcctc
     2581 tgccacgtca acagcagact ttttggatca agtcacttct cagaagaaag ctgaggcaca
     2641 gcctgtccac caggcttacc aaatgagctc ctttgagcag cccttccgtg ctccatatca
     2701 tggatccaga gctggaatag caactcagtt tagcactgcc aatggacagg tgaaccttcg
     2761 gggaccaggg acaagtgctg aattttcaga atttcccttg gtgaatgtaa atgataatag
     2821 agctgggatg acatcttcac cagatgccac aactggccag acttttggct aaaaaaaaaa
     2881 aaaatgtgta aataatactg gcactttaga acagattact caagagtggg gttgctctgt
     2941 aaaatggagt gctgtacagt tctaagagca gtgcgttcat agcaagctga taagaatagc
     3001 aagataatcc aataactgca ttttgtttgg ttagtcagca ttccttgaac tgccttacgt
     3061 gtcgtcaccg ttagagaagc aaatgcatta cctgttttag atcagaacct tgctattcac
     3121 ccacaccaag ataaaagaaa aagactttcg cacaattgtt tcctaactga taacattgta
     3181 cattcttagg agcgtagtaa ttgtgtgaaa cttcctcata ctgtttctga gtttttcagc
     3241 atagtattgc acttcagcag ggaatccgag gatatgtcac agacagtgaa cttaaagttt
     3301 caatgtcaag agattatggc ttaaatacgt agtttgtcct atagggggga ataaaaagaa
     3361 accaccttta aaaatgatat gccatatacc cttggttttc attttgcatt attgacatgg
     3421 tttttttttt ttttgaagaa aaagtaataa aaatctgata gtctaagact ccactattta
     3481 aaagcctaat tactttttaa gtatgcatac tttcaaacct tttaccaaaa cacacaaccg
     3541 ctgaagcact cacttctcta tggaagtatg catatcggtg tcagtttctt tgtacaggta
     3601 aacttagata ttttttatga tttttcatgt gcaagtatca aggtttgaag ttttagtaaa
     3661 aaaaataaat attctgtaga ttacattccc aagaaaataa tgcttacaca aaatgtatat
     3721 tccacgtttt aaagctgaaa tgtattttat tttacacact tcagttgaca tagagcactt
     3781 agaattaatc tggtattttt tgatttctca aagttaaaat catagatttt ttaggtttga
     3841 tatggttgtg tcataatcat ctcataattg acaattttgc tttttggcaa taaaagaaag
     3901 ttgggatatc tttgaactgt aaaacctggt ttaattcttc tctttctgga ctcttgatag
     3961 attggataat taaacagtat cccaagaaac taaagaaatg ggcattttaa ttgcttactt
     4021 acgttacatt taagtgaata ctgctcacga cagttttacc aagcgaaaga gcttactgat
     4081 tccagtaact gcaatttctt tttcagctag atgagtgatg ggaaattttt tgttgcattt
     4141 caaaatctaa ataaactaca gactttatcc ttataccacg aatgtttttt ttatatatgt
     4201 atactttgtc ttaaaataat acagcatgat ataataaata gtgcttttat atatatatat
     4261 atatacacac ttttatgaag aatgatggtt tgagttacac attgaacagt tttaattttt
     4321 ggagactaac atcggctcta catctctttt atttgttcta cttttttggg ttttgtactt
     4381 tccatttccg ccatctttat cgcagtgccc cagtggtgac ctgaaaccag tacccttggg
     4441 agatgacgct ttgttaactt ccattttgac tttgctgttg accctgtaga tgcgtgcttt
     4501 gtttcagtgt tgagtatttt atccatttaa attatttttc ttttatttaa tgttatccca
     4561 agactgttct cataaagaag ggaacaaaga aatatcctcc cccagtgtcc ttcacttaca
     4621 ctcatttatt ttttaaaatg ttggtatttt tatgacaagg aatataagtt atgtttatgt
     4681 ggtttcctct acactttgtt atgaaactgc ttgaaatcat agttttccca tttgacagct
     4741 ttgctgtcag atcttcaaga actttagact tctttgaagt gactatttta agttctgcca
     4801 ttatcgatct gaagactgat gtgtgtctgt ggcgcatcac ataaccacag gaacgcttca
     4861 tcagatgagg tgtgatggac cgtgtgcacc ctagatgggt gcttgtattt ttctcatagt
     4921 acttttgaca agagcagaca tttatctcct aagttgaacc tgattaaaaa cacagtgtgg
     4981 ttccactgag cacttgatgc atttcttgta cagtgtaagg gtctgttttt aacatcacca
     5041 gcacagtttt aagaatgtga cggttgctga gcggttcagg tcagcttagg aagaaaaagc
     5101 ctttgaaaat ggaagttctg taaacagaat ttcaggtgtt gcattcctgt cttaaacaca
     5161 tttctttaaa tccacacaac ggcagacttt tctaccaggt aataagcatt cgagataact
     5221 gatagccagc ataacttact gacttaccag ttaagtatag tcatcactta ctgtgaaatt
     5281 ccagatgcct gccaggctca gcttgtatct tcatccttcg agaagcatct caacaggctg
     5341 ggtttccctg tgttggttta gaaagctttc ctgcctgggc attaaagaaa gaaagtggcc
     5401 ttgtgtgctg ctctggacag atccctggag gatatgagat accctgtcag ttcacacttc
     5461 tcatttcttc tccaagcata gctctagcac ccttcagctt ctgctcaccg ttagcctgtc
     5521 agtctgggcc cactagacaa ggcaggagct ctccagcatc cgaaagcatt gctgctgttt
     5581 gcgcttcagt tcttactgca catgtatctc attggctttg gaatagctga gtagctcctg
     5641 tggtttttat ttttgtggat ctacagtgta catgtgctac ctagtcaggt aggagtccac
     5701 catcttagct ctgactcagg gtgccagcaa tgggtcattt ctgtctctta ggaggtagaa
     5761 gaggccttgt gctcagggca agctttcatt cccacaggtg agggacactt gcaaagtgcc
     5821 agcaaggcta gatgttttgc cacttctttg atttttatta atttgggctt ttaaagggct
     5881 gtttaaaaaa aaaaaaaaaa aagcggccgg gaacctctga gtaggtgtgc tgcgtccgga
     5941 gctccctcga acctaagcta gaggtcatct tttacagtgt acttacttga agaagctcta
     6001 ttctaatcaa tgagaatcta tttgagtctg caatttaagt taaaaccttt tccgtttcaa
     6061 attgctttat ttcagggaaa taattttcca gttgtttttg ctatattctg caaataaaaa
     6121 gtgtgtgttt ccttttttcc acctaaactt tggtaggaaa cagactaaag cagacaaaca
     6181 tttcttgttg tgtttgttgc tttctttaat ccaatggata aaaaaagtaa aaccctgtaa
     6241 acattatttt atttttttat gcaataccat gctgtaaata gggttcatcg agtaaggatg
     6301 cgcctaccta tgactgaacc tttgattctg cacagttaga gtttatatat aaacgtgtct
     6361 tgacaatcaa ggacttgatg tgagtcttcc tttatgatgt ttattaatgt tatgcattcc
     6421 atttgtttga agtgagtacc aatgtgctaa tttgtattgt ctgaaagtat gtaatgtttt
     6481 tacagcttgt ttttaagact ctgtaaatat gtacaaacca gtcacagtac cgctttatgt
     6541 tagaaggcgt gtgatgttgt actgtatgta agcaataata catagcagtg ctaactttac
     6601 aagtagcatc aggaacgttc tagagaaaca tttcagagtt atccttatta gttacccttg
     6661 tttcacttaa taatgattac ctttaatcag tttttataag caaattccat tgttcctcct
     6721 gttggaacgt aacactgttt acacagcata actgacgttg caggggggac aggctagatg
     6781 tggcttcgcc tgtgctcact ctcactaagc attgaatggc cttaccactc ttgtgcaaag
     6841 atggaggaag accgctgaac ttagtgccca tcacactgaa ggaagggatg tgttttgttt
     6901 tgttttgttt tgttttcctg tttctgtacg gctacctaac tctggtttgc tttgggtttt
     6961 aatgtgtttc tgctctagat tcaagcccgc aagtgttgag gtaacttcag ttcagttgtg
     7021 aagtagatag atttcttcat atttcatagc tacatttcaa tgattctaaa ctttctactt
     7081 tgatttttag atacttattt ttcaagcttg atttctcagc tgaccagatg aatttactca
     7141 acttcaatac aaagaaagac aaacttatag cttgaagtga gtagatatta tactgtacag
     7201 agcagctctc tgaacaccca tcactgcttt agaaacgaag ccgccaattt ataaatgatt
     7261 atgacctaca ttttataggg aaaatgtttt taatgctagt catttatata atgtgctttg
     7321 aagggtttgc taggccactc ctgtcacttt ttagcacact ggtacctttt ctatgtaatg
     7381 tatgcttttt attattgtag caaagcattt cagtagaaag aattttgcaa caatatgggg
     7441 gaaatttttc attgtcgggt ttgaattata ctggatttta tctgtctagt cttacttgtc
     7501 tttattttaa tgctgtctgg aagggacctt ggtacccaaa taaagcaggt taacctcatt
     7561 gcttcaaggg catacatact gtgtagtgct gagtttcacc tggaaatctg atgactttga
     7621 aaagaaaaac acatttataa aaattgtaca gaagaaatta aatgtgtgat ggaaatcctg
     7681 atggtggagc acattggatt ttctgagaca tagtgttatt ttcctggaat cccttatgcc
     7741 ttctttgtat tccagccaat aaagaaaacc ttgttgttga aagtggtagg ctgctaggat
     7801 attctgatta tacagtattg cttttcctgt cctggtctcg gcccctctca attgctgtaa
     7861 acttttattt tctacttcct attgctaatt aaacatgtat ataatgtaga ggctgttgta
     7921 tagaactgaa tgaattggga tgctatgctt gaatgggtag ctacgtggaa atattggatg
     7981 gatactgaaa gttcctaaga tgccagagta aatttacgcg ggaaagggga tgtcttttct
     8041 tgggaaggcc acagcagatg gttcctgcac ccctaggggt cagtgggaga atcagctgca
     8101 aactcagtat cagacacaga gtggagcctc ccttcccttc ccttaaaata tgagcactaa
     8161 atttcaaaaa tctactcagg tgaacttgct ttgcagtgaa acttaaccac attgaaattt
     8221 tcactgttaa atactatatt tgtgatattt ttaaatacaa acttttacac tgcagtcagc
     8281 agcctaatga ttgaaattta gccaagatat tttaaaagta atagttatcc tccatgtata
     8341 attgttttta aacaattggg aggatttttc tgttgaaaga tttttttttt tatcatcatt
     8401 gtttaaaaaa aaagaaacca tcttgcttga gcccccattt tataccataa gtgagtcact
     8461 gagccattca agtgcagtgg tggcttgttt cacccctggc cacgggacgt gaactgacat
     8521 tacaaggttt aatgagttca tagcttttgg cacagttgtc acctcgcctc ttggagttta
     8581 taacactgtt ttgtgtattg tgatactaaa aggaagttgt tttacattat tttaaattga
     8641 attattagat taacttatat ttgcaaattc tgcattttaa atgtggacac ttggctgttt
     8701 gaaaataaaa tacagaatac aagttttatg aataattttc tagctgaatt tttcacagta
     8761 cttcgaacca aatatctact ggtaaatatg caaaaaaaat gtggtacata gttactctag
     8821 aggaagggat gtccatgtgg aattactagt tccataggtt gagtaaatat cagggccttt
     8881 actgtagttt gccgtgataa tgttactagt tctaagatct agtcagctgt taatcatcat
     8941 taactatttc agacttgaac catgttgaag catagggcta agaatatcta tatggctttt
     9001 cctttacaga taagattcca tcaacctttc tttcatcagt agcatacata gtttgttggg
     9061 tgtttttccc cctccattag tgtagataga cctgttttca gccaccagcc accttgccag
     9121 gacttcgtct tctgacagtg ggatgcattg taaaaaagca gtttgcagtt aagagtgctg
     9181 cctccgttct tgggacaaat gtcaattagt tggcccttgc aaaagtcagt gctcagagcc
     9241 tggcttattg gcacggtgct gtaaccaact gtacgtaatg gtaccactga cggtctacta
     9301 ttcattccct agatcccggt tcttgagtga tttggcttgg tggggagagg ggtggggaga
     9361 tttctacctg acacttctcc caccttctga agattctatg aaaaaataaa attgaagtca
     9421 cttgaattaa t
//
