LOCUS       NP_035879                794 aa            linear   ROD 27-APR-2025
DEFINITION  zinc finger protein 148 [Mus musculus].
ACCESSION   NP_035879 XP_489551
VERSION     NP_035879.1
DBSOURCE    REFSEQ: accession NM_011749.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 794)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 794)
  AUTHORS   Chopp,L.B., Zhu,X., Gao,Y., Nie,J., Singh,J., Kumar,P., Young,K.Z.,
            Patel,S., Li,C., Balmaceno-Criss,M., Vacchio,M.S., Wang,M.M.,
            Livak,F., Merchant,J.L., Wang,L., Kelly,M.C., Zhu,J. and
            Bosselut,R.
  TITLE     Zfp281 and Zfp148 control CD4+ T cell thymic development and TH2
            functions
  JOURNAL   Sci Immunol 8 (89), eadi9066 (2023)
   PUBMED   37948511
  REMARK    GeneRIF: Zfp281 and Zfp148 control CD4[+] T cell thymic development
            and TH2 functions.
REFERENCE   3  (residues 1 to 794)
  AUTHORS   Kuang,L.W., Zhang,C.C., Li,B.H., Liu,H.Z., Wang,H. and Li,G.C.
  TITLE     Identification of the MALAT1/miR-106a-5p/ZNF148 feedback loop in
            regulating HaCaT cell proliferation, migration and apoptosis
  JOURNAL   Regen Med 18 (3), 239-258 (2023)
   PUBMED   36710662
  REMARK    GeneRIF: Identification of the MALAT1/miR-106a-5p/ZNF148 feedback
            loop in regulating HaCaT cell proliferation, migration and
            apoptosis.
REFERENCE   4  (residues 1 to 794)
  AUTHORS   Emfinger,C.H., de Klerk,E., Schueler,K.L., Rabaglia,M.E.,
            Stapleton,D.S., Simonett,S.P., Mitok,K.A., Wang,Z., Liu,X.,
            Paulo,J.A., Yu,Q., Cardone,R.L., Foster,H.R., Lewandowski,S.L.,
            Perales,J.C., Kendziorski,C.M., Gygi,S.P., Kibbey,R.G.,
            Keller,M.P., Hebrok,M., Merrins,M.J. and Attie,A.D.
  TITLE     beta Cell-specific deletion of Zfp148 improves nutrient-stimulated
            beta cell Ca2+ responses
  JOURNAL   JCI Insight 7 (10), e154198 (2022)
   PUBMED   35603790
  REMARK    GeneRIF: beta Cell-specific deletion of Zfp148 improves
            nutrient-stimulated beta cell Ca2+ responses.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 794)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 794)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 794)
  AUTHORS   Feo,S., Antona,V., Cammarata,G., Cavaleri,F., Passantino,R.,
            Rubino,P. and Giallongo,A.
  TITLE     Conserved structure and promoter sequence similarity in the mouse
            and human genes encoding the zinc finger factor
            BERF-1/BFCOL1/ZBP-89
  JOURNAL   Biochem Biophys Res Commun 283 (1), 209-218 (2001)
   PUBMED   11322790
REFERENCE   8  (residues 1 to 794)
  AUTHORS   Passantino,R., Antona,V., Barbieri,G., Rubino,P., Melchionna,R.,
            Cossu,G., Feo,S. and Giallongo,A.
  TITLE     Negative regulation of beta enolase gene transcription in embryonic
            muscle is dependent upon a zinc finger factor that binds to the
            G-rich box within the muscle-specific enhancer
  JOURNAL   J Biol Chem 273 (1), 484-494 (1998)
   PUBMED   9417107
REFERENCE   9  (residues 1 to 794)
  AUTHORS   Antona,V., Cammarata,G., De Gregorio,L., Dragani,T.A., Giallongo,A.
            and Feo,S.
  TITLE     The gene encoding the transcriptional repressor BERF-1 maps to a
            region of conserved synteny on mouse chromosome 16 and human
            chromosome 3 and a related pseudogene maps to mouse chromosome 8
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 90-92 (1998)
   PUBMED   9925940
REFERENCE   10 (residues 1 to 794)
  AUTHORS   Hasegawa,T., Takeuchi,A., Miyaishi,O., Isobe,Ki. and de
            Crombrugghe,B.
  TITLE     Cloning and characterization of a transcription factor that binds
            to the proximal promoters of the two mouse type I collagen genes
  JOURNAL   J Biol Chem 272 (8), 4915-4923 (1997)
   PUBMED   9030551
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ129103.1, CK634070.1, AK146591.1 and AC127412.4.
            
            On Jan 18, 2005 this sequence version replaced XP_489551.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.116473.1,
                                           SRR1660819.91340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..794
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 23.93 cM"
     Protein         1..794
                     /product="zinc finger protein 148"
                     /note="G-rich box-binding protein; transcription factor
                     BFCOL1; transcription factor ZBP-89; zinc finger
                     DNA-binding protein 89; beta enolase repressor factor 1"
                     /calculated_mol_wt=88620
     Site            51
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61624.2)"
     Region          171..193
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          173..193
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(178,180,182,184..185,188..189,192,206,208,212..213,
                     216..217,220,234,236,238,240..241,244..245,248)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          185..210
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Site            194
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9UQR1; propagated from
                     UniProtKB/Swiss-Prot (Q61624.2)"
     Region          201..221
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          214..238
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          229..249
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          241..266
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Site            250
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UQR1; propagated from
                     UniProtKB/Swiss-Prot (Q61624.2)"
     Region          257..275
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          298..336
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61624.2)"
     Site            301
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61624.2)"
     Site            306
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61624.2)"
     Site            412
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UQR1; propagated from
                     UniProtKB/Swiss-Prot (Q61624.2)"
     Region          574..599
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61624.2)"
     Site            607
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9UQR1; propagated from
                     UniProtKB/Swiss-Prot (Q61624.2)"
     Site            665
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UQR1; propagated from
                     UniProtKB/Swiss-Prot (Q61624.2)"
     Site            784
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UQR1; propagated from
                     UniProtKB/Swiss-Prot (Q61624.2)"
     CDS             1..794
                     /gene="Zfp148"
                     /gene_synonym="2210405J08Rik; BERF-1; BFCOL1; ZBP-89;
                     Znf148"
                     /coded_by="NM_011749.4:488..2872"
                     /db_xref="CCDS:CCDS28130.1"
                     /db_xref="GeneID:22661"
                     /db_xref="MGI:MGI:1332234"
ORIGIN      
        1 mniddklegl flkcggidem qssramvvmg gvsgqsavsg elqesvlqdr slphqeilaa
       61 devlqesemr qqdmishdel mvheetvknd eeqmdtherl pqglqyalnv pisvkqeitf
      121 tdvseqlmrd kkqvrepvdl qkkkkrkqrs pakiltined gslglktpks hvcehcnaaf
      181 rtnyhlqrhv fihtgekpfq csqcdmrfiq kyllqrheki htgekpfrcd ecgmrfiqky
      241 hmerhkrths gekpyqceyc lqyfsrtdrv lkhkrmchen hdkklnrcai kgglltseed
      301 sgfstspkdn slpkkkrqkt ekkssgmdke svldksdlkk dkndylplys sstkvkdeym
      361 vaeyavemph ssvggshled asgeihppkl vlkkinskrs lkqpleqsqt isplssyeds
      421 kvskyafelv dkqalldseg sadidqvdnl qegpskpvhs stnyddamqf lkkkrylqaa
      481 snnsreyaln vgtiasqpsv tqaavasvid esttasilds qalnveiksn hdknvipdev
      541 lqtlldhysh kpngqheisf svadtevtss isinssdvpe vtqsenvgss sqasssdkan
      601 mlqeyskflq qaldrtsqnd aylnspslnf vtdnqtlpnp pafssidkqv yaampinsfr
      661 sgmnsplrtt pdkshfgliv gdsqhpfpfs gdetnhasat stadfldqvt sqkkaeaqpv
      721 hqayqmssfe qpfrapyhgs ragiatqfst angqvnlrgp gtsaefsefp lvnvndnrag
      781 mtsspdattg qtfg
//
