LOCUS       NM_001374618            3009 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus zinc finger protein 143 (Zfp143), transcript variant
            1, mRNA.
ACCESSION   NM_001374618 XM_006507532
VERSION     NM_001374618.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3009)
  AUTHORS   Dong,Y., Hu,M., Tan,K. and Dai,R.
  TITLE     ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic
            fatty liver disease by targeting increased lncRNA NEAT1 expression
            to activate ROCK2 pathway
  JOURNAL   Epigenetics 18 (1), 2239592 (2023)
   PUBMED   37566742
  REMARK    GeneRIF: ZNF143 inhibits hepatocyte mitophagy and promotes
            non-alcoholic fatty liver disease by targeting increased lncRNA
            NEAT1 expression to activate ROCK2 pathway.
REFERENCE   2  (bases 1 to 3009)
  AUTHORS   Chern,T., Achilleos,A., Tong,X., Hill,M.C., Saltzman,A.B.,
            Reineke,L.C., Chaudhury,A., Dasgupta,S.K., Redhead,Y., Watkins,D.,
            Neilson,J.R., Thiagarajan,P., Green,J.B.A., Malovannaya,A.,
            Martin,J.F., Rosenblatt,D.S. and Poche,R.A.
  TITLE     Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin
            metabolism and ribosomopathy
  JOURNAL   Nat Commun 13 (1), 134 (2022)
   PUBMED   35013307
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3009)
  AUTHORS   Zhou,Q., Yu,M., Tirado-Magallanes,R., Li,B., Kong,L., Guo,M.,
            Tan,Z.H., Lee,S., Chai,L., Numata,A., Benoukraf,T., Fullwood,M.J.,
            Osato,M., Ren,B. and Tenen,D.G.
  TITLE     ZNF143 mediates CTCF-bound promoter-enhancer loops required for
            murine hematopoietic stem and progenitor cell function
  JOURNAL   Nat Commun 12 (1), 43 (2021)
   PUBMED   33397967
  REMARK    GeneRIF: ZNF143 mediates CTCF-bound promoter-enhancer loops
            required for murine hematopoietic stem and progenitor cell
            function.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3009)
  AUTHORS   Ngondo-Mbongo,R.P., Myslinski,E., Aster,J.C. and Carbon,P.
  TITLE     Modulation of gene expression via overlapping binding sites exerted
            by ZNF143, Notch1 and THAP11
  JOURNAL   Nucleic Acids Res 41 (7), 4000-4014 (2013)
   PUBMED   23408857
REFERENCE   5  (bases 1 to 3009)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   6  (bases 1 to 3009)
  AUTHORS   Adachi,K., Tanaka,T., Saito,H. and Oka,T.
  TITLE     Hormonal induction of mouse selenocysteine transfer ribonucleic
            acid (tRNA) gene transcription-activating factor and its functional
            importance in the selenocysteine tRNA gene transcription in mouse
            mammary gland
  JOURNAL   Endocrinology 140 (2), 618-623 (1999)
   PUBMED   9927285
REFERENCE   7  (bases 1 to 3009)
  AUTHORS   Adachi,K., Saito,H., Tanaka,T. and Oka,T.
  TITLE     Molecular cloning and characterization of the murine staf cDNA
            encoding a transcription activating factor for the selenocysteine
            tRNA gene in mouse mammary gland
  JOURNAL   J Biol Chem 273 (15), 8598-8606 (1998)
   PUBMED   9535833
REFERENCE   8  (bases 1 to 3009)
  AUTHORS   Marine,J.C., Gilbert,D.J., Bellefroid,E.J., Martial,J.A.,
            Ihle,J.N., Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of fifteen unique mouse KRAB-containing zinc
            finger loci
  JOURNAL   Mamm Genome 7 (6), 413-416 (1996)
   PUBMED   8662221
REFERENCE   9  (bases 1 to 3009)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Matera,A.G., Bourguignon,C.,
            Desai,T., Healy,K.C., Bray-Ward,P., Martial,J.A., Ihle,J.N. and
            Ward,D.C.
  TITLE     Emergence of the ZNF91 Kruppel-associated box-containing zinc
            finger gene family in the last common ancestor of anthropoidea
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10757-10761 (1995)
   PUBMED   7479878
REFERENCE   10 (bases 1 to 3009)
  AUTHORS   Ihle,J.N., Smith-White,B., Sisson,B., Parker,D., Blair,D.G.,
            Schultz,A., Kozak,C., Lunsford,R.D., Askew,D., Weinstein,Y. et al.
  TITLE     Activation of the c-H-ras proto-oncogene by retrovirus insertion
            and chromosomal rearrangement in a Moloney leukemia virus-induced
            T-cell leukemia
  JOURNAL   J Virol 63 (7), 2959-2966 (1989)
   PUBMED   2542606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121995.2 and AC147244.2.
            
            On Oct 7, 2019 this sequence version replaced XM_006507532.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC121995.2         119508-119572
            66-184              AC147244.2         153158-153276       c
            185-277             AC147244.2         152190-152282       c
            278-361             AC147244.2         151305-151388       c
            362-445             AC147244.2         150558-150641       c
            446-642             AC147244.2         148496-148692       c
            643-717             AC147244.2         147045-147119       c
            718-837             AC147244.2         145584-145703       c
            838-913             AC147244.2         142417-142492       c
            914-1039            AC147244.2         140843-140968       c
            1040-1219           AC147244.2         139390-139569       c
            1220-1447           AC147244.2         136420-136647       c
            1448-1596           AC147244.2         133884-134032       c
            1597-1758           AC147244.2         130834-130995       c
            1759-1905           AC147244.2         129544-129690       c
            1906-3009           AC147244.2         127366-128469       c
FEATURES             Location/Qualifiers
     source          1..3009
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.7 cM"
     gene            1..3009
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /note="zinc finger protein 143"
                     /db_xref="GeneID:20841"
                     /db_xref="MGI:MGI:1277969"
     exon            1..65
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     exon            66..184
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1989
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mStaf; zfp-143; selenocysteine tRNA gene
                     transcription-activating factor; zinc finger protein 80,
                     related sequence 1"
                     /codon_start=1
                     /product="zinc finger protein 143 isoform 1"
                     /protein_id="NP_001361547.1"
                     /db_xref="CCDS:CCDS90307.1"
                     /db_xref="GeneID:20841"
                     /db_xref="MGI:MGI:1277969"
                     /translation="MLLAQINRDSQGMTEFPGGGMEAQHVTLCLTEAVTVADGDNLEN
                     MEGVSLQAVTLADGSTAYIQHNSKDGRLIDGQVIQLEDGSAAYVQHVPIPKSTGDSLR
                     LEDGQAVQLEDGTTAFIHHTSKDSYDQSSLQAVQLEDGTTAYIHHAVQVPQSDTILAI
                     QADGTVAGLHTGDATIDPDTISALEQYAAKVSIDGSDGVTSTGMIGENEQEKKMQIVL
                     QGHATRVTPKSQQSGEKAFRCKYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHSGCGK
                     AFATGYGLKSHFRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHTGERPFKCPIEGC
                     GRSFTTSNIRKVHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVP
                     GCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQISTLAMHKRTAHNDTEPIEEEQ
                     EAFFEPPPGQGDDVLKGSQITYVTGVDGEDIVSTQVATVTQSGLSQQVTLISQDGTQH
                     VNISQADMQAIGNTITMVTQDGTPITVPTHDAVISSAGTHSVAMVTAEGTEGQQVAIV
                     AQDLAAFHTASSEMGHQQHSHHLVTTETRPLTLVATSNGTQIAVQLGEQPSLEEAIRI
                     ASRIQQGETPGLDD"
     exon            185..277
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     exon            278..361
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     exon            362..445
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     exon            446..642
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     exon            643..717
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     exon            718..837
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     exon            838..913
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1039
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1219
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1447
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1596
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1758
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1905
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..3009
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2393..2398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /note="hexamer: AATAAA"
     polyA_site      2425
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
     regulatory      2988..2993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /note="hexamer: AATACA"
     polyA_site      3009
                     /gene="Zfp143"
                     /gene_synonym="D7Ertd805e; KRAB14; pHZ-1; SBF; Staf;
                     Zfp79; Zfp80-rs1; Znf143"
                     /note="major polyA site"
ORIGIN      
        1 gcggctgttt cctgtcctgg tgcatggtgg tcggacgaag gaattgttgg aaaattttct
       61 cggaggtaga aaatgttgtt agcacaaata aatcgggatt ctcagggaat gacagaattt
      121 cctggaggag gaatggaggc tcaacatgtt accctgtgcc tgacggaggc agtaaccgtg
      181 gcagatggtg acaatttaga aaatatggaa ggtgtgagtt tacaagctgt gacactcgca
      241 gacggctcta ctgcttacat acagcataat tctaaagacg ggagactcat tgatggccag
      301 gtcattcagc tggaagatgg ttctgctgcc tatgttcagc atgtccccat acctaaaagt
      361 acaggggaca gtttgcggct ggaggatggg caagcagtgc agctagaaga cgggaccact
      421 gcatttatcc accacacctc gaaagacagt tatgaccaga gctcacttca ggccgttcag
      481 ttagaagatg ggacaacagc ttatatccac catgcagtgc aagtcccaca gtctgatacc
      541 atcttggcaa ttcaggctga tgggacagtg gcagggctgc acactgggga tgccacaatt
      601 gacccagata ccattagtgc tttggagcag tacgcagcaa aggtatccat tgatggcagt
      661 gacggtgtaa caagtacagg aatgattgga gagaatgagc aagagaaaaa aatgcagatt
      721 gtcttacaag gccatgctac tcgggtaact cctaaatctc agcagagtgg agaaaaggca
      781 tttcggtgca aatacgacgg ctgtgggaaa ctctatacaa cagctcatca ccttaaggtc
      841 catgagcgct cacacacagg agaccggcct taccagtgtg agcattcagg ctgtgggaaa
      901 gcatttgcaa caggttatgg attaaaaagt catttcagaa ctcatactgg agaaaagcca
      961 tatcggtgtt cagaagataa ttgtacaaag tctttcaaaa cttcaggaga tctacagaag
     1021 cacatcagaa cccatacagg agaaaggccc tttaagtgtc ctattgaagg ctgtggtcgg
     1081 tcctttacca catcaaatat cagaaaagtg cacattagga cacacacagg agaaagacct
     1141 tattactgca cagaacctgg atgtgggagg gcatttgcca gcgcaactaa ttataaaaac
     1201 catgtgagga tacacacagg agaaaagcca tatgtctgta cagttcctgg gtgtgacaaa
     1261 cggtttacag aatattccag tttgtataaa caccatgtcg ttcacactca ctctaaacca
     1321 tacaactgta accactgtgg gaagacgtac aaacagattt ccacactggc catgcacaaa
     1381 cggacagccc acaacgacac agagcccatt gaggaggagc aggaagcctt cttcgagcct
     1441 cccccaggtc aaggtgatga tgttcttaaa gggtcccaga tcacatatgt tacaggtgta
     1501 gatggagagg acattgtatc tacacaagta gccacagtaa cccagtctgg gctgagtcaa
     1561 caagtcacac tcatatcaca ggatgggact caacatgtca acatatctca agctgacatg
     1621 caggccattg gcaacaccat caccatggta acacaggatg gcacacccat cacggtcccc
     1681 actcacgatg cagtcatctc ctcagcagga acacattctg ttgctatggt taccgcggag
     1741 ggcacagaag gacagcaggt cgcaattgta gctcaagatc tggcagcgtt ccatacagca
     1801 tcttcagaga tgggacacca acaacatagc catcacctag taactacaga aaccagacct
     1861 ctgaccttag tggcaacatc caacggcacc cagatcgcag ttcagcttgg agagcagccg
     1921 tctctggaag aagctatcag aatagcatcg aggatccaac aaggggagac gccagggttg
     1981 gatgattaac actcggaatt acagagcaat aaaacaggag gaggagcctt tcatctctgg
     2041 cggcagaatc cctgaagccc tgcccggcag agcagaagtt ccattcctga agcactggac
     2101 acatttttat gcaagagtag agaacatttt cttcttgaca cttttgtgta catagccccg
     2161 gaatgaaatc ccaacgtgat tcattgtgta cgaggaagaa tgaaatgagg gctctgcagc
     2221 agttcttcat gctactcttg accacatggc aaattcctga aatccaccca taagatcagc
     2281 agggtctgaa cacagtcaag atgcgctttt aacttactgt gaaaaacacg gctgtatcta
     2341 atgtgctgaa ggttctacat gtgaaacaat cataactcca aagccatcac agaataaagg
     2401 atgcaagcct tcagctgtcc ctccagttaa tgtctggatt gtttgtccta atacacaccc
     2461 atgtttactt ggatttcaag gtttgaagac ctcatttata gagccccatc cctgttatat
     2521 aacacttctt caagctaaaa tgctgattat tttagcatta cattggatta tgtataaaat
     2581 tacaaagttt ggttatttta aattaaaaca ttaaatccag tgtttgaagc tgggaatggc
     2641 agcttgtgcc tgtaatccca gcattaaagt cctgatgcag gaggagaaca taaatgtgag
     2701 actaacctgg gctgtgtagt gaattccagg ctaatctgag ctactctcaa aaaacaagat
     2761 atatccatta tttgggttgt taaaatcagc cttttgattt tttgctactg ttttttatga
     2821 taatcaacta tgagagtttc ccacgggtct ggcctaggct tatagttcta tggctgagaa
     2881 tgaatttact ccaaaaaact gggttagtga gttgtgtaaa ttatttattt ttgctcctaa
     2941 tcttttgttt taaagcttat ttaccttaaa gtttattatt gactttgaat acagcagttt
     3001 ttaaaacaa
//
