LOCUS       NM_001302548            3185 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus zinc finger protein 131 (Zfp131), transcript variant
            2, mRNA.
ACCESSION   NM_001302548
VERSION     NM_001302548.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3185)
  AUTHORS   Yin,G., Jia,S., Zhang,Y., Xian,Y., Guo,Y. and Liu,Q.
  TITLE     YAP1-activated ZNF131 promotes hepatocellular carcinoma cell
            proliferation through transcriptional regulation of PAIP1
  JOURNAL   Arch Biochem Biophys 754, 109921 (2024)
   PUBMED   38341068
  REMARK    GeneRIF: YAP1-activated ZNF131 promotes hepatocellular carcinoma
            cell proliferation through transcriptional regulation of PAIP1.
REFERENCE   2  (bases 1 to 3185)
  AUTHORS   Garipler,G., Lu,C., Morrissey,A., Lopez-Zepeda,L.S., Pei,Y.,
            Vidal,S.E., Zen Petisco Fiore,A.P., Aydin,B., Stadtfeld,M.,
            Ohler,U., Mahony,S., Sanjana,N.E. and Mazzoni,E.O.
  TITLE     The BTB transcription factors ZBTB11 and ZFP131 maintain
            pluripotency by repressing pro-differentiation genes
  JOURNAL   Cell Rep 38 (11), 110524 (2022)
   PUBMED   35294876
  REMARK    GeneRIF: The BTB transcription factors ZBTB11 and ZFP131 maintain
            pluripotency by repressing pro-differentiation genes.
REFERENCE   3  (bases 1 to 3185)
  AUTHORS   Iguchi,T., Miyauchi,E., Watanabe,S., Masai,H. and Miyatake,S.
  TITLE     A BTB-ZF protein, ZNF131, is required for early B cell development
  JOURNAL   Biochem Biophys Res Commun 501 (2), 570-575 (2018)
   PUBMED   29750959
  REMARK    GeneRIF: ZNF131 suppresses expression of Cdk inhibitor, p21(cip1),
            and that of pro-apoptotic factors, Bax and Puma, targets of p53, to
            facilitate cell cycle progression and suppress unnecessary
            apoptosis, respectively, of pro-B cells.
REFERENCE   4  (bases 1 to 3185)
  AUTHORS   Robinson,S.C., Donaldson-Kabwe,N.S., Dvorkin-Gheva,A., Longo,J.,
            He,L. and Daniel,J.M.
  TITLE     The POZ-ZF transcription factor Znf131 is implicated as a regulator
            of Kaiso-mediated biological processes
  JOURNAL   Biochem Biophys Res Commun 493 (1), 416-421 (2017)
   PUBMED   28882591
  REMARK    GeneRIF: We also demonstrate that Kaiso inhibits Znf131 expression,
            raising the possibility that Kaiso and Znf131 act to fine-tune
            target gene expression. Together, our findings implicate Znf131 as
            a co-regulator of Kaiso-mediated biological processes.
REFERENCE   5  (bases 1 to 3185)
  AUTHORS   Iguchi,T., Aoki,K., Ikawa,T., Taoka,M., Taya,C., Yoshitani,H.,
            Toma-Hirano,M., Koiwai,O., Isobe,T., Kawamoto,H., Masai,H. and
            Miyatake,S.
  TITLE     BTB-ZF Protein Znf131 Regulates Cell Growth of Developing and
            Mature T Cells
  JOURNAL   J Immunol 195 (3), 982-993 (2015)
   PUBMED   26136427
  REMARK    GeneRIF: Znf131 is critical for T cell development during
            double-negative to double-positive stage, with which significant
            cell expansion triggered by the pre-TCR signal is coupled.
REFERENCE   6  (bases 1 to 3185)
  AUTHORS   Donaldson,N.S., Nordgaard,C.L., Pierre,C.C., Kelly,K.F.,
            Robinson,S.C., Swystun,L., Henriquez,R., Graham,M. and Daniel,J.M.
  TITLE     Kaiso regulates Znf131-mediated transcriptional activation
  JOURNAL   Exp Cell Res 316 (10), 1692-1705 (2010)
   PUBMED   20303951
  REMARK    GeneRIF: Znf131 is a transcriptional activator, a less common
            function of POZ-ZF proteins, that is negatively regulated by its
            heterodimerization partner Kaiso.
REFERENCE   7  (bases 1 to 3185)
  AUTHORS   Donaldson,N.S., Daniel,Y., Kelly,K.F., Graham,M. and Daniel,J.M.
  TITLE     Nuclear trafficking of the POZ-ZF protein Znf131
  JOURNAL   Biochim Biophys Acta 1773 (4), 546-555 (2007)
   PUBMED   17306895
  REMARK    GeneRIF: The mechanism of Znf131 nuclear localization, is reported.
REFERENCE   8  (bases 1 to 3185)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   9  (bases 1 to 3185)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   10 (bases 1 to 3185)
  AUTHORS   Trappe,R., Buddenberg,P., Uedelhoven,J., Glaser,B., Buck,A.,
            Engel,W. and Burfeind,P.
  TITLE     The murine BTB/POZ zinc finger gene Znf131: predominant expression
            in the developing central nervous system, in adult brain, testis,
            and thymus
  JOURNAL   Biochem Biophys Res Commun 296 (2), 319-327 (2002)
   PUBMED   12163020
  REMARK    GeneRIF: Results suggest that Znf131/ZNF131 plays a role during
            development and organogenesis as well as in the function of the
            adult central nervous system.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK030398.1, AK162903.1,
            AK011832.1, AK135723.1 and BP765660.1.
            
            Summary: This gene encodes a member of the BTB/POZ family of
            transcription factors. This protein has been found to act as a
            transcriptional activator and may regulate estrogen receptor
            signaling. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Oct
            2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an in-frame portion of the 5' coding region compared to
            variant 1. Variants 2 and 5 encode the same isoform (2, also known
            as the short isoform), which is shorter than isoform 1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849382
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AK030398.1         1-120
            121-167             AK162903.1         128-174
            168-2561            AK030398.1         169-2562
            2562-2950           AK011832.1         2364-2752
            2951-3165           AK135723.1         2839-3053
            3166-3185           BP765660.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..3185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13"
     gene            1..3185
                     /gene="Zfp131"
                     /gene_synonym="2610109I01Rik; Znf131"
                     /note="zinc finger protein 131"
                     /db_xref="GeneID:72465"
                     /db_xref="MGI:MGI:1919715"
     exon            1..228
                     /gene="Zfp131"
                     /gene_synonym="2610109I01Rik; Znf131"
                     /inference="alignment:Splign:2.1.0"
     exon            229..367
                     /gene="Zfp131"
                     /gene_synonym="2610109I01Rik; Znf131"
                     /inference="alignment:Splign:2.1.0"
     exon            368..469
                     /gene="Zfp131"
                     /gene_synonym="2610109I01Rik; Znf131"
                     /inference="alignment:Splign:2.1.0"
     exon            470..614
                     /gene="Zfp131"
                     /gene_synonym="2610109I01Rik; Znf131"
                     /inference="alignment:Splign:2.1.0"
     exon            615..972
                     /gene="Zfp131"
                     /gene_synonym="2610109I01Rik; Znf131"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1195
                     /gene="Zfp131"
                     /gene_synonym="2610109I01Rik; Znf131"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1326
                     /gene="Zfp131"
                     /gene_synonym="2610109I01Rik; Znf131"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..3167
                     /gene="Zfp131"
                     /gene_synonym="2610109I01Rik; Znf131"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3065..3070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp131"
                     /gene_synonym="2610109I01Rik; Znf131"
                     /note="hexamer: AATAAA"
     polyA_site      3088
                     /gene="Zfp131"
                     /gene_synonym="2610109I01Rik; Znf131"
                     /note="major polyA site"
     regulatory      3144..3149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp131"
                     /gene_synonym="2610109I01Rik; Znf131"
                     /note="hexamer: AGTAAA"
     polyA_site      3167
                     /gene="Zfp131"
                     /gene_synonym="2610109I01Rik; Znf131"
ORIGIN      
        1 gggagaggcg ccggagggag aggcgacccg gggagtcgtt gtgggccgcg ggccggaccg
       61 gggccggggc cgccgcagcc tgggccgggc ggaaggctcg gcgggccgtt gggaggccgc
      121 cgaggctgtt cggggtcctc cccggccgga cttgcgctcc cgggcgtccc tgagcctccc
      181 ggcactgtgc ccaccccgct ccagctcgcg tctccaggct ccgattagag caccccgacg
      241 gccatggagg ctgaagagac gatggaatgc cttcaggagt ttcctgaaca tcataaaatg
      301 atcttggacc gattgaatga acaacgggag caggaccggt ttacggacat caccctgatt
      361 gtcgacggac accattttaa ggcccacaag gctgttttgg ctgcctgcag taagttcttc
      421 tacaaattct tccaggagtt tactcaagag cctttggttg aaattgaagg tgttagtaaa
      481 atggcttttc gccacttaat tgagttcaca tacacagcaa aactaatgat acaaggggaa
      541 gaagaagcca atgatgtgtg gaaagcagca gagtttctac aaatgctgga agctattaaa
      601 gcacttgaag tcaggaacaa agaaaactca gctccattag aggaaaacac tacaggaaaa
      661 aatgaggcaa aaaaaagaaa gattgcagaa acttcaaatg ttatcactga atcattacca
      721 tctgcagaat cagaacctgt ggaaattgag gtggagattg ctgagggcac aattgaagta
      781 gaagatgaag gcatcgaagc tttggaggaa atggcttctg ccaagcagtc tataaagtac
      841 atacagagca caggctcctc cgatgattcc gctctggcgt tgttggcaga tatcaccagc
      901 aagtaccgtc aaggtgaaag caaaggacag attagcgaag atgactgtgc atctgacccc
      961 ataagcaaac aggaacacat gaaatcacac tccactgaga gtttcaagtg tgaaatatgc
     1021 aataaaaggt atcttcgaga gagtgcgtgg aaacagcacc ttaactgtta ccaccttgaa
     1081 gaaggtggag taagtaagaa gcaaagaact gggaaaaaaa ttcacatatg ccagtactgt
     1141 gacaaacagt ttgaccactt tggacacttt aaagaacacc ttcgaaaaca tacaggtgaa
     1201 aaaccttttg aatgttcaaa ttgtcacgag cggtttgcta gaaatagcac tctcaaatgt
     1261 cacctcactg catgccaaac tggagtagga gcaaaaaagg gcaggaagaa gctttatgaa
     1321 tgccaggtct gtaacagtgt atttaacagc tgggaccagt tcaaagatca cttggtaata
     1381 cacactggag ataaacccaa ccattgtact ctgtgtgact tgtggtttat gcaaggaaat
     1441 gaattacgga ggcatcttag tgatgctcac aatatttcag agcgtatagt aactgaagaa
     1501 gtcctttcag tagaaacaca tttacaaacc gagccagtga catcaatgac tattatagag
     1561 caagttggga aagtgcatgt gttgccactg cttcaggtcc aagtggattc cgcacaagta
     1621 actgtggaac aagttcatcc agatctgctc caggacagcc aagtgcatga ttcacaaatg
     1681 accgggcttc cagagcaggt ccaagtgagt tatctggaag tgggccgaat tcagactgaa
     1741 gaaggcactg aagtacatgt tgaagagctt cacgttgaac gggtaaatca gatgccagtt
     1801 gaagtacaga ctgagcttct agaagctgac ttggatcaca tgacccctga aatcatgagc
     1861 caagaggaga gagagcctaa ccatgcagat gctgccatgg aagaacacga agatgctgag
     1921 gggttagaga ccaaaccaag cgagtattcc caagctagaa aaacagagaa tgacaggaca
     1981 tctctgccgg ttttagaatg aaataacagt tatattttta aatttacatt tgtggtaaac
     2041 tgatgggcag tgtgacctta agctatcaaa taagtggacc aaagttaaac tatttctgtt
     2101 gtgctgaact gtttctatgg aaacaggctg atgtccttcc agttaatgcc acagagtggg
     2161 aatattcctc ataatgagtg gaagctttga gaagtatatt tctgttaact taaatgaatt
     2221 atattcttat tatatagttg ggtacgaatg catctatttt cattgtggta agggtctctg
     2281 tatcctcttc cccaggtcat gtctttcctt aaattctttg catattataa aatcatactt
     2341 aaaaccatta gaatacgtac atttgtattc taatgcatgt taaaaagttg agtatgtagg
     2401 caacacaagg ctgcatgagg gaagtgcatt gttacgtgca gttaatagtt gggggctggc
     2461 tttattttga acaacattct tgtctatcca gtggctacaa atgttgtccc cacaacagaa
     2521 acggtggtgg cagaatttct agaatgttaa aaaacaaaaa caaaacaaaa aaaaaaaaac
     2581 caccctgtgc cttttcaaag ccaacaaaac ttcagaaaaa cacctctggt tctttcaaag
     2641 tttgtgtttt aaagtgctct ggtacttggt attttttgct aaaatgacaa ctaccaattc
     2701 tttttccttt aagttacatt gaaatttttt catttaacgg cagctgaagg gccattttca
     2761 attggaaaag ttcacttcca tctgtggtaa actttatttt gatgagaagt tgcactagta
     2821 ttttaccacc agatggaaaa aatattaggt gagcatcatt tttaaattaa tgtatttaaa
     2881 ataaagtaca gaggatatgt acatgtatat aatatatcag gcttttgttt tgagtggaat
     2941 cttttccccc caattcttaa tgtaaagatt ttgtgctata acttttaaag ccatacaaat
     3001 aagagtgcta aactgtggac ttaaaagtag ttgtgtaaat atttttaatc agtattactt
     3061 ggaaaataaa aataacaacc acgtaaaatc aatattgcta ttttctttac ctgttaaata
     3121 ctgggagata atttacgttt taaagtaaac tttaaaatta tgtgttaaaa aaaaaaaaaa
     3181 aaaaa
//
