LOCUS       NM_022981               3600 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus zinc finger protein 110 (Zfp110), transcript variant
            2, mRNA.
ACCESSION   NM_022981
VERSION     NM_022981.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3600)
  AUTHORS   Liang,Y., Huimei Hong,F., Ganesan,P., Jiang,S., Jauch,R.,
            Stanton,L.W. and Kolatkar,P.R.
  TITLE     Structural analysis and dimerization profile of the SCAN domain of
            the pluripotency factor Zfp206
  JOURNAL   Nucleic Acids Res 40 (17), 8721-8732 (2012)
   PUBMED   22735705
REFERENCE   2  (bases 1 to 3600)
  AUTHORS   Taher,L., Collette,N.M., Murugesh,D., Maxwell,E., Ovcharenko,I. and
            Loots,G.G.
  TITLE     Global gene expression analysis of murine limb development
  JOURNAL   PLoS One 6 (12), e28358 (2011)
   PUBMED   22174793
REFERENCE   3  (bases 1 to 3600)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   4  (bases 1 to 3600)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 3600)
  AUTHORS   Korade,Z., Kenchappa,R.S., Mirnics,K. and Carter,B.D.
  TITLE     NRIF is a regulator of neuronal cholesterol biosynthesis genes
  JOURNAL   J Mol Neurosci 38 (2), 152-158 (2009)
   PUBMED   18677445
  REMARK    GeneRIF: Data show that in vitro down regulation of NRIF expression
            decreased the mRNA for two main cholesterogenic enzymes,
            3-hydroxy-3-methylglutaryl-coenzyme A reductase and
            7-dehydrocholesterol reductase.
REFERENCE   6  (bases 1 to 3600)
  AUTHORS   Kendall,S.E., Ryczko,M.C., Mehan,M. and Verdi,J.M.
  TITLE     Characterization of NADE, NRIF and SC-1 gene expression during
            mouse neurogenesis
  JOURNAL   Brain Res Dev Brain Res 144 (2), 151-158 (2003)
   PUBMED   12935912
  REMARK    GeneRIF: NRIF gene expression gradually decreassedas development
            progressed.
REFERENCE   7  (bases 1 to 3600)
  AUTHORS   Benzel,I., Barde,Y.A. and Casademunt,E.
  TITLE     Strain-specific complementation between NRIF1 and NRIF2, two zinc
            finger proteins sharing structural and biochemical properties
  JOURNAL   Gene 281 (1-2), 19-30 (2001)
   PUBMED   11750124
REFERENCE   8  (bases 1 to 3600)
  AUTHORS   Collins,T., Stone,J.R. and Williams,A.J.
  TITLE     All in the family: the BTB/POZ, KRAB, and SCAN domains
  JOURNAL   Mol Cell Biol 21 (11), 3609-3615 (2001)
   PUBMED   11340155
  REMARK    Review article
REFERENCE   9  (bases 1 to 3600)
  AUTHORS   Honer,C., Chen,P., Toth,M.J. and Schumacher,C.
  TITLE     Identification of SCAN dimerization domains in four gene families
  JOURNAL   Biochim Biophys Acta 1517 (3), 441-448 (2001)
   PUBMED   11342224
REFERENCE   10 (bases 1 to 3600)
  AUTHORS   Casademunt,E., Carter,B.D., Benzel,I., Frade,J.M., Dechant,G. and
            Barde,Y.A.
  TITLE     The zinc finger protein NRIF interacts with the neurotrophin
            receptor p75(NTR) and participates in programmed cell death
  JOURNAL   EMBO J 18 (21), 6050-6061 (1999)
   PUBMED   10545116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN707582.1, AK013583.1 and AC107704.8.
            
            On Feb 7, 2018 this sequence version replaced NM_022981.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006657.1, AJ242914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               CN707582.1         1-246
            247-2971            AK013583.1         4-2728
            2972-3600           AC107704.8         68928-69556
FEATURES             Location/Qualifiers
     source          1..3600
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 7.66 cM"
     gene            1..3600
                     /gene="Zfp110"
                     /gene_synonym="2900024E01Rik; NRIF; Nrif1"
                     /note="zinc finger protein 110"
                     /db_xref="GeneID:65020"
                     /db_xref="MGI:MGI:1890378"
     exon            1..404
                     /gene="Zfp110"
                     /gene_synonym="2900024E01Rik; NRIF; Nrif1"
                     /inference="alignment:Splign:2.1.0"
     exon            405..485
                     /gene="Zfp110"
                     /gene_synonym="2900024E01Rik; NRIF; Nrif1"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..2939
                     /gene="Zfp110"
                     /gene_synonym="2900024E01Rik; NRIF; Nrif1"
                     /note="neurotrophin receptor interacting factor"
                     /codon_start=1
                     /product="neurotrophin receptor-interacting factor 1"
                     /protein_id="NP_075357.4"
                     /db_xref="CCDS:CCDS20814.1"
                     /db_xref="GeneID:65020"
                     /db_xref="MGI:MGI:1890378"
                     /translation="MEDSMASTLPTTWPHESVKFEDVSLTFTEEEWAQLDFQQKCLYR
                     EIMMENYSNMISVEHHFSKPNVISQLEKAEDCWPMQREIPQDTLPECSWPSPDPGMNS
                     FPSKSPLMKIEVVEVLTLNKDVAGPRNALIQSLYPEDLNPGNLKPAQQPSKRLTDTEA
                     SRQKFRHFQYEESAGPQKAMSQLRKLCHQWLQPNTRSKKQILELLVLEQFLNALPEKF
                     RVWVESQHPEDCKAVVALLENMTSVSKDDASLACSSEATDQLKEKRKGVATLPVTFAA
                     EVPAEEPVTFQDVAVDFNEEEWRLLGPTQKTEYHDVMLETLGNLVSVGWEPTLGNREL
                     TPDSPIPVVKPIHDPNTKDLSRNGTQSTVFESILEDGVKEMHTIESNQVGNLQEKGHP
                     QKKFSESSKSQDQTSRHKSQGSLNEVLPRKYVKVKQKGTGKRKGRTNTISMTRGLRIR
                     KQQKDSVEWQGRSGSTPVTHGSSIKNQQQGSEQGKPGTSRDPITLTVPAKVYQKATGS
                     KESILMDSSDAMVSDVPPKIHQKGPEWHKVGESNNSMLQGSSVQNHQMESGAGRASDN
                     SLLTHALPVKSHQKGYKEGNVQGNRNSWKHIKPHQKGSKGERVEELSTSEKHVPYVKN
                     HLKTSERGKDREINASIKCDPYIKTYYRGSDVGRLRRANNCRKAFSLHAQQISFIKIH
                     KGSQVCRCSECGKLFRNARYFSVHKKIHTGERPYMCMACGKAFVQSSSLTQHLRIHSG
                     ERPFECSECGRTFNDRSAISQHLRTHTGAKPYHCERCGKAFRQSSHLTRHERTHTGER
                     PYVCIKCGKAFTQSSHLIGHQKTHGIKFKKQPKL"
     exon            486..612
                     /gene="Zfp110"
                     /gene_synonym="2900024E01Rik; NRIF; Nrif1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..708
                     /gene="Zfp110"
                     /gene_synonym="2900024E01Rik; NRIF; Nrif1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..1182
                     /gene="Zfp110"
                     /gene_synonym="2900024E01Rik; NRIF; Nrif1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1283
                     /gene="Zfp110"
                     /gene_synonym="2900024E01Rik; NRIF; Nrif1"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1410
                     /gene="Zfp110"
                     /gene_synonym="2900024E01Rik; NRIF; Nrif1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..3600
                     /gene="Zfp110"
                     /gene_synonym="2900024E01Rik; NRIF; Nrif1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3319..3324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp110"
                     /gene_synonym="2900024E01Rik; NRIF; Nrif1"
                     /note="hexamer: ATTAAA"
     polyA_site      3339
                     /gene="Zfp110"
                     /gene_synonym="2900024E01Rik; NRIF; Nrif1"
     regulatory      3572..3577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp110"
                     /gene_synonym="2900024E01Rik; NRIF; Nrif1"
                     /note="hexamer: AATAAA"
     polyA_site      3594
                     /gene="Zfp110"
                     /gene_synonym="2900024E01Rik; NRIF; Nrif1"
                     /note="major polyA site"
ORIGIN      
        1 gttcttttgc tcctgttagt gggttcgatt ctctcctagc ctcggtctct gtccacagag
       61 gtactggtgc tcagcgtctt agtatccttc ttcaaaagct gcatcctagt tctttagcag
      121 tcaataacac acttttcgga cttcggcttc gcccgccaac aggacaaacg ccgcctaact
      181 gctgccgctc gacgtccgcg ggggcgtctg ggagttgtag tccggactcg tgagctggcg
      241 cagttcggga caagaccgac gggcgagcgc cattgtgtct ttccgcaatc gtagcgctgc
      301 gtgaaagccc gtcgggggca gcacccatct tctgttttat ttgcaacctc tggaacccag
      361 tgtcggcttc gtttgtggcg ccacttctac ggacccggga gaaggtttcg tcagcattct
      421 gcctactcct gggagagaac atggaggaca gtatggcttc cacgcttcca acaacctggc
      481 cccatgagtc tgtgaagttt gaagatgtat ctctgacgtt taccgaggaa gagtgggcac
      541 agctggactt ccaacagaag tgcctgtaca gggagatcat gatggagaac tacagcaaca
      601 tgatttcagt ggagcatcac ttttcaaagc caaatgtgat atctcagcta gaaaaagccg
      661 aagactgctg gccaatgcag agagaaattc ctcaagatac tcttccagaa tgttcttggc
      721 cttctccaga ccctggaatg aattcctttc cttctaagag tcccctgatg aagatcgagg
      781 ttgttgaggt ccttacattg aacaaggatg tggctggtcc tcggaatgcc ctgattcaat
      841 ccctctatcc agaagacttg aacccaggta acctcaagcc agctcaacag ccaagcaagc
      901 gtttgactga cactgaagct tctcgccaga agttccgaca tttccagtat gaagagtcag
      961 ctggtcccca gaaggctatg tcccagcttc gtaagctgtg tcaccagtgg ctgcagccca
     1021 atacacgttc aaagaagcag atcctagagt tgctggtgct cgagcagttc ctgaatgcac
     1081 tgcctgagaa gtttcgggta tgggtagagt cgcagcaccc agaagattgc aaagcagtgg
     1141 tggctttgtt ggagaatatg acctcggtgt ctaaggacga tgcttcgctt gcctgctcca
     1201 gtgaggccac tgatcaacta aaggagaaaa ggaagggtgt ggccacctta ccagttactt
     1261 ttgcagctga ggttccagct gaggagccgg tgactttcca ggatgtggct gtagacttca
     1321 atgaggagga gtggcggcta ctaggtccaa cgcagaagac tgagtatcat gatgtgatgc
     1381 tagagacctt gggcaacttg gtctctgtgg ggtgggagcc tacattggga aacagagagt
     1441 taactccaga ctctcccatt cctgtggtaa aaccaattca tgacccaaac acaaaagatc
     1501 tctcaaggaa tggtacccag tctactgtct ttgaaagtat cttagaagat ggggtcaaag
     1561 aaatgcacac catagaatca aatcaagtgg ggaatctaca ggaaaaaggc catcctcaga
     1621 agaagttctc tgaaagctcc aagtctcaag accaaactag tcgtcacaaa agccagggct
     1681 cactcaatga agttcttcct agaaagtatg taaaagttaa gcagaagggc actggaaaga
     1741 ggaaaggcag gacaaacacc atttccatga cacgaggttt acgcataaga aaacagcaga
     1801 aggactctgt ggagtggcaa ggcaggagtg gcagcactcc tgtgacacat ggctcctcca
     1861 taaaaaacca gcaacagggt tctgagcagg gaaaacctgg gaccagtaga gatcccatta
     1921 cacttactgt gcctgcaaaa gtttaccaga aagccactgg ctctaaagag agtatactta
     1981 tggacagtag cgatgccatg gtgtctgatg tacctccaaa gattcaccag aaaggccctg
     2041 aatggcataa agttggggaa agtaacaatt ccatgttaca aggttcatct gtacaaaatc
     2101 accagatgga gtctggggca gggagagcca gtgacaacag tctcttgaca catgccttac
     2161 ctgtaaaaag tcatcagaaa ggctataaag aaggaaacgt ccaagggaac aggaattcct
     2221 ggaaacatat aaaacctcac cagaagggtt ctaaagggga aagagtcgag gaacttagca
     2281 cttctgaaaa acatgtcccc tatgtaaaaa atcacctaaa gacctcggaa agaggaaaag
     2341 acagggaaat caatgcttcc ataaaatgtg atccctatat aaaaacttac tatagaggtt
     2401 ctgatgtggg aaggctcagg agagccaaca attgtaggaa agccttcagc ctgcatgctc
     2461 agcagatatc ctttataaaa attcacaagg ggagccaagt ttgccgatgt agtgaatgtg
     2521 gtaaactgtt ccggaatgct aggtatttct ctgtccataa gaagatccac acaggagagc
     2581 ggccatatat gtgtatggcc tgtgggaaag catttgttca gagctcctcc ctcacacagc
     2641 atcttagaat tcatagtgga gagagaccat ttgagtgttc agagtgtggg aggaccttca
     2701 acgaccgctc agccatctct cagcacctga gaactcatac tggagctaag ccctaccact
     2761 gtgagcgctg tgggaaagct ttccgtcaga gttcccacct taccaggcat gagagaactc
     2821 atactggtga gagaccatat gtgtgcatca agtgtgggaa ggcattcaca cagagctcac
     2881 accttattgg gcatcagaaa acacatggga taaaattcaa gaagcagccc aaattgtagc
     2941 ctttgtgcct ttcaaagcac tatttttttt tcagccttga gatgtactat gcagacactc
     3001 agtatgacag ataggctttg actaaggaga gccccacacc ttaaggacag ctcaggacac
     3061 cacctagcag gcagtgagtg aaaccatcag ggagttctta attgcttcat ttatcctcaa
     3121 aaggaaataa aatatctgaa aatgcatcta agtttaagaa gtcaagtacc aaaaattgca
     3181 ctgatatttc tatacaggat aaaatgtgta agtgaaaaaa aactaaaagt atatagctaa
     3241 ataagctatt atatttgtgt ggaacttttt tttctgctgt gatagctatt ttttgttatc
     3301 agtttgacta caactggaat taaactgatt taagctgaat atacctttga ggaatttttt
     3361 tcttaatctg gattgcacct tctactggca acctatataa aggacatgga agaaagaagc
     3421 ttgccctctt tgcctgtttg ctctcactag ctagtctatt ctttcacttg cattagagct
     3481 tacatacggg ttctggcatc tatcacctga gacatcctgc ctcgtgaact gaacaactac
     3541 tggatttttg gggattctta gaccttccac taataaacag ccattgtcgt actagctgga
//
