LOCUS       NM_011743               9137 bp    mRNA    linear   ROD 23-DEC-2022
DEFINITION  Mus musculus zinc finger protein 106 (Zfp106), mRNA.
ACCESSION   NM_011743
VERSION     NM_011743.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9137)
  AUTHORS   Kannan M, Bayam E, Wagner C, Rinaldi B, Kretz PF, Tilly P, Roos M,
            McGillewie L, Bar S, Minocha S, Chevalier C, Po C, Chelly J, Mandel
            JL, Borgatti R, Piton A, Kinnear C, Loos B, Adams DJ, Herault Y,
            Collins SC, Friant S, Godin JD and Yalcin B.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     WD40-repeat 47, a microtubule-associated protein, is essential for
            brain development and autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), E9308-E9317 (2017)
   PUBMED   29078390
REFERENCE   2  (bases 1 to 9137)
  AUTHORS   Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA,
            Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW and Black BL.
  TITLE     Suppression of C9orf72 RNA repeat-induced neurotoxicity by the
            ALS-associated RNA-binding protein Zfp106
  JOURNAL   Elife 6, e19032 (2017)
   PUBMED   28072389
  REMARK    GeneRIF: The authors identify the zinc finger protein Zfp106 as a
            specific GGGGCC RNA repeat-binding protein, and using affinity
            purification-mass spectrometry, they show that Zfp106 interacts
            with multiple other RNA binding proteins, including the amyotrophic
            lateral sclerosis-associated factors TDP-43 and FUS.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9137)
  AUTHORS   Anderson DM, Cannavino J, Li H, Anderson KM, Nelson BR, McAnally J,
            Bezprozvannaya S, Liu Y, Lin W, Liu N, Bassel-Duby R and Olson EN.
  TITLE     Severe muscle wasting and denervation in mice lacking the
            RNA-binding protein ZFP106
  JOURNAL   Proc Natl Acad Sci U S A 113 (31), E4494-E4503 (2016)
   PUBMED   27418600
  REMARK    GeneRIF: Findings indicate a central role for Zfp106 in the
            maintenance of nerve-muscle signaling.
REFERENCE   4  (bases 1 to 9137)
  AUTHORS   Joyce PI, Fratta P, Landman AS, Mcgoldrick P, Wackerhage H, Groves
            M, Busam BS, Galino J, Corrochano S, Beskina OA, Esapa C, Ryder E,
            Carter S, Stewart M, Codner G, Hilton H, Teboul L, Tucker J,
            Lionikas A, Estabel J, Ramirez-Solis R, White JK, Brandner S,
            Plagnol V, Bennet DL, Abramov AY, Greensmith L, Fisher EM and
            Acevedo-Arozena A.
  TITLE     Deficiency of the zinc finger protein ZFP106 causes motor and
            sensory neurodegeneration
  JOURNAL   Hum Mol Genet 25 (2), 291-307 (2016)
   PUBMED   26604141
  REMARK    GeneRIF: Zfp106-/- mice develop severe gait and motor abnormalities
            that deteriorate with age. The motor abnormalities exhibited by
            Zfp106-/- mice are likely due to a severe progressive adult-onset
            degenerative sensory-motor axonopathy.
REFERENCE   5  (bases 1 to 9137)
  AUTHORS   Ide S and Dejardin J.
  TITLE     End-targeting proteomics of isolated chromatin segments of a
            mammalian ribosomal RNA gene promoter
  JOURNAL   Nat Commun 6, 6674 (2015)
   PUBMED   25812914
  REMARK    GeneRIF: ZFP106 is a novel factor regulating transcription
            initiation by targeting RNA polymerase I to the promoter.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9137)
  AUTHORS   Zuberi AR, Nguyen HQ, Auman HJ, Taylor BA and Roopenian DC.
  TITLE     A genetic linkage map of mouse chromosome 2 extending from
            thrombospondin to paired box gene 1, including the H3 minor
            histocompatibility complex
  JOURNAL   Genomics 33 (1), 75-84 (1996)
   PUBMED   8617512
REFERENCE   7  (bases 1 to 9137)
  AUTHORS   Cicchetti P, Ridley AJ, Zheng Y, Cerione RA and Baltimore D.
  TITLE     3BP-1, an SH3 domain binding protein, has GAP activity for Rac and
            inhibits growth factor-induced membrane ruffling in fibroblasts
  JOURNAL   EMBO J 14 (13), 3127-3135 (1995)
   PUBMED   7621827
REFERENCE   8  (bases 1 to 9137)
  AUTHORS   Zuberi AR, Dudley ME, Christianson GJ and Roopenian DC.
  TITLE     Gene mapping in a murine cell line by immunoselection with
            cytotoxic T lymphocytes
  JOURNAL   Genomics 19 (2), 273-279 (1994)
   PUBMED   7514566
REFERENCE   9  (bases 1 to 9137)
  AUTHORS   Roopenian DC, Davis AP, Christianson GJ and Mobraaten LE.
  TITLE     The functional basis of minor histocompatibility loci
  JOURNAL   J Immunol 151 (9), 4595-4605 (1993)
   PUBMED   8409421
REFERENCE   10 (bases 1 to 9137)
  AUTHORS   Roopenian DC and Davis AP.
  TITLE     Responses against antigens encoded by the H-3 histocompatibility
            locus: antigens stimulating class I MHC- and class II
            MHC-restricted T cells are encoded by separate genes
  JOURNAL   Immunogenetics 30 (5), 335-343 (1989)
   PUBMED   2530167
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772299.10 and AL935121.9.
            
            [WARNING] On May 9, 2023 this sequence was replaced by NM_011743.4.
            
            On Jan 24, 2017 this sequence version replaced NM_011743.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.4229.1,
                                           SRR10223971.3028.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AL772299.10        53645-53817         c
            174-258             AL772299.10        45189-45273         c
            259-320             AL772299.10        35801-35862         c
            321-518             AL772299.10        29253-29450         c
            519-2687            AL772299.10        23469-25637         c
            2688-3315           AL772299.10        21553-22180         c
            3316-3385           AL772299.10        20406-20475         c
            3386-3540           AL772299.10        18433-18587         c
            3541-3601           AL772299.10        18295-18355         c
            3602-3937           AL772299.10        16707-17042         c
            3938-4697           AL772299.10        13823-14582         c
            4698-4750           AL772299.10        13479-13531         c
            4751-4896           AL772299.10        12643-12788         c
            4897-5031           AL772299.10        10369-10503         c
            5032-5148           AL772299.10        9023-9139           c
            5149-5340           AL772299.10        5872-6063           c
            5341-5403           AL772299.10        5400-5462           c
            5404-5523           AL772299.10        4101-4220           c
            5524-5595           AL772299.10        3575-3646           c
            5596-5667           AL772299.10        2661-2732           c
            5668-5814           AL935121.9         105385-105531       c
            5815-9137           AL935121.9         101718-105040       c
FEATURES             Location/Qualifiers
     source          1..9137
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.37 cM"
     gene            1..9137
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /note="zinc finger protein 106"
                     /db_xref="GeneID:20402"
                     /db_xref="MGI:MGI:1270153"
     exon            1..173
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            174..258
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..5871
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /note="SH3-domain binding protein 3; zinc finger protein
                     474; H3a minor histocompatibility antigen"
                     /codon_start=1
                     /product="zinc finger protein 106"
                     /protein_id="NP_035873.2"
                     /db_xref="CCDS:CCDS16621.1"
                     /db_xref="GeneID:20402"
                     /db_xref="MGI:MGI:1270153"
                     /translation="MVRERKCILCHIVYGSKKEMDEHMRSMLHHRELENLKGRDISHE
                     CRVCRVTEVGLSAYAKHISGQLHKDNVDAQEREDDGKEEEEEEYFDKELVQLIQERKE
                     QSRQDEPPSNSQEVNSDDRQPQWRREDRIPYQDRESYSQPPRHHRGPPQRDWKWEKDG
                     FNSTRKNSFPHSLRNSGGPRGSSVWHKGATRGSSTWFLNHSNSGGGWHSNNGMVDWNY
                     NGTGRNSSWHSEGTGGFPSWHMNNSNGNWKSSVRSTNSWNYNGPGDKFQQGRNRNPNY
                     QMEDMTKMWNKKSNKPSKYSQERCKWQRQDRDKAAKYRSPPEGYASDTFPSEGLLEFN
                     FEQRESQTTKQTDTAASKINGKNGTKARDKFRRWTPYPSQKTLDLQSALKEVIGSKSD
                     TLEKPLFNFSLITAGLRKPVDKTSNPPVIKTQKAGPPGSPSHKAISDGTAFCEVPRAC
                     PITEQSEPHQKSNKIPLLKSPLLPLPTPKSGPHKQNLKNRSKNKETKSFPSGDHSHLL
                     NTSTLEGSHGSSYTSKSRGLCPRVLKENKTVSGTQKEPDEKLNSTSQKAQDTVLQCPK
                     TLQNPLPTTPKRTENDAKESSVEESAKDSLSIESQPHSAGNSAMTSDAENHGIKSEGV
                     ASLTTEVVSCSTHTVDKEQGSQIPGTPENLSASPCNSTVLQKEAEVQVSAATSPHSGL
                     LLNLKTSLEDAQDNNLVKSDGPFETESFEDTSLDAELQKPDLNNQPPGTLLPELSKLG
                     FPASLQRDLSRHISLKSKTGTHLPEPNLNSARRIRNVSGHRKNETEKESGLKPTLRQI
                     LNASRRNVNWEQVIQQVTKKKQELGKGLPRFGIEMVPLVQNEQEVLDLDEEPDLSSLE
                     GFQWEGVSIPSSSGLARKRSLSESSVVMDRAPVYSFFTGEGTGKENEAQQSPSPNTAL
                     SAAQSQKTAMYLEQEVAPLTPSVGTGERVGNIPTQRRHSAQLPSGHIMPVMHSARDLH
                     SQERSTPLSERHAQESTGEGNSLTSNASSGHAVSSLADAATDSSCTSGAEQTDGHSIR
                     KKRRATGDGSSPELPSLERKNKRRKIKGKKERSQVDQLLTISLREEELSKSLQCMDNK
                     LLQARAALQTAYVEVQRLLVLKQQITVEMSALRTHRIQILQGLQETYEPPEHPDQAPC
                     SLISREQRNSRSQTSFETALLPAPFFPGFLDPPPSHASLPSSGNPLQITTCTLQAHGT
                     APDSSVQIKQEPMSPEQEGNMNALPQGCASNVSKELLQTNRVVDDGSSVYPAIPAVIA
                     SESTENCQEVSKDLNFSVEQGNSRSKGNSPSCQSPDLPGINRGEETAKGSSGSEACSS
                     SFLRLSFTPETPAEKETQSPADQPEQQAESTLASAETRGSKKKKKLRKKKTLRATHVP
                     ENSDTEQDVFTAKPARKVKTAKAAKGAKVTTSQTGQEQGTARDEPDSDSSLEVLEVTN
                     PQLEVVAIDTSESGDEKPDSPSKKDAWIAAEQNPIETSRSGCDEVSSTSELGTRYKDG
                     VPVSVAETQTVISIKASKHSSEISSEPGDDEEPTEGSFEGHQAAVNAIQIFGNFLYTC
                     SADTTVRVYNLVSRKCVGVFEGHTSKVNCLLVTHTSGKSSVLYTGSSDHTIRCYNIKT
                     RECMEQLQLEDRVLCLHNRWRTLYAGLANGTVVTFDIKNNKRQEIFECHGPRAVSCLA
                     TAQEGARKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTVLCMKVVNDLVFSGSSDQS
                     VHAHNIHTGELVRIYKGHNHAVTVVNILGKVMVTACLDKFVRVYELQSHDRLQVYGGH
                     KDMIMCMTIHKSVIYTGCYDGSIQAVRLNLMQNYRCWWYGCTLIFGVVDHLKQHLLTD
                     HTNPNFQTLKCRWRNCDAFFTARKGSKQDVAGHIERHAEDDSKIDS"
     exon            259..320
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            321..518
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            519..2687
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..3315
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3385
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3540
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3601
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            3602..3937
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            3938..4697
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            4698..4750
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            4751..4896
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            4897..5031
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            5032..5148
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            5149..5340
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            5341..5403
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            5404..5523
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            5524..5595
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            5596..5667
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            5668..5814
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
     exon            5815..9137
                     /gene="Zfp106"
                     /gene_synonym="Cd-1; D2Dcr28; EyeLinc12; H3a; Sh3bp3;
                     sirm; zfp-106; Znf106"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtgcgcct gcgcgcttgc gcgatggtgg tagtagcggc ggcggcggcg gcgtcagtgc
       61 ccggcgggga gcgggtcccg ggccgccgcc ggaccggagg ctaagggggc gtctgggagc
      121 tccctcgccg ggtcctcggc ggccagatgg cgtaggaagg tcgggctgtg agtgttgaca
      181 ttgagtgctt cagatctggt cactatggta cgagaacgaa aatgcatatt gtgccacatc
      241 gtgtatggct caaaaaagga gatggatgaa cacatgcgaa gcatgttgca tcacagggaa
      301 cttgagaacc tgaagggcag ggacattagt catgagtgcc gagtgtgccg ggtcacagaa
      361 gtgggtctct ctgcatatgc aaagcacatt tctggccagt tgcacaaaga taatgttgat
      421 gcccaggaaa gagaagatga tggaaaggaa gaggaagagg aagagtattt tgataaggaa
      481 cttgttcagt taatacaaga aagaaaagaa caaagtcgac aagatgaacc tcccagtaac
      541 agccaagaag taaactcaga tgacaggcag ccccagtgga gacgagaaga ccgaatccct
      601 taccaagaca gagagagcta tagtcagcca ccaagacacc atcgtggacc cccacagaga
      661 gactggaaat gggaaaagga tggctttaat agtactagaa aaaacagctt tccacattct
      721 ttgaggaata gtggtggacc aagaggaagt tctgtctggc ataaaggtgc tacaagaggc
      781 tcttcaactt ggttccttaa tcatagcaat tctggaggag gctggcattc aaacaatggg
      841 atggtagatt ggaattataa tggtacagga aggaattcca gttggcattc tgaaggaaca
      901 ggtggctttc ccagctggca catgaacaac agtaacggaa actggaaatc cagtgtacgt
      961 agtacgaata gctggaatta caatggccct ggagacaaat ttcaacaagg cagaaacaga
     1021 aatcctaact atcaaatgga agacatgacc aagatgtgga acaagaaatc taataagcca
     1081 agcaagtaca gtcaggagag atgcaagtgg cagaggcaag acagggacaa agctgccaag
     1141 tacaggagtc ctcctgaggg atacgcaagc gatacgtttc cttcagaagg cttacttgag
     1201 ttcaattttg aacagcgaga aagtcaaacc actaaacaaa cagacacggc agcctcaaaa
     1261 attaatggaa aaaatggcac caaagcaagg gacaagttcc gccgctggac accttaccct
     1321 tcccagaaga ctctagattt acagtcagcc ctgaaagaag tcattggcag caagtcagac
     1381 acactagaga agcctctctt taattttagc ttaataactg caggactgcg caaaccagtt
     1441 gataaaacaa gtaatcctcc agtgataaaa acacaaaaag caggacctcc tggatctccc
     1501 agtcacaaag ccatttctga tggcactgct ttctgtgagg tgccaagagc ttgccccatt
     1561 accgagcaat ctgagccaca tcagaagtca aataagattc cattactgaa atccccactc
     1621 cttccacttc caacccctaa atcaggtcct cataagcaaa atttaaagaa ccgctcaaaa
     1681 aataaggaga caaagtcctt tccttctgga gatcactcac atctcctgaa cacttctact
     1741 ttagaaggta gccatggttc ttcctacaca tccaaatcac gcggtttatg tcctcgtgtt
     1801 ttaaaggaga ataaaactgt atcaggcact caaaaagaac ctgacgagaa gttaaatagc
     1861 acatcacaga aagcccaaga cacagtgcta cagtgtccca aaacactgca gaatccactc
     1921 cctaccacac ccaaaaggac ggagaacgat gcaaaagaaa gtagtgtaga agagtctgcc
     1981 aaagactctc tgagcatcga gtctcagcca cactcagctg gaaacagtgc catgacatct
     2041 gatgcagaaa accatggcat aaaaagtgaa ggtgtggctt cactgaccac agaggttgtg
     2101 tcctgcagca ctcacaccgt ggataaggaa caagggagcc agatcccagg aacacccgag
     2161 aacctctccg cctccccatg taattccaca gttctccaga aagaggctga ggtacaagtg
     2221 tcagcagcga ccagtccaca ctctggctta ctgctaaact tgaagacctc tctagaagat
     2281 gcgcaggaca acaaccttgt taaatctgat ggaccttttg aaactgagag ctttgaggac
     2341 actagcctgg atgcagagct tcaaaaacct gatctcaata atcagccccc aggcacgctt
     2401 cttcccgaac taagtaaact tggttttccc gcctcgctcc agagagatct aagccgacac
     2461 atcagtttga agtccaaaac aggaacacat ctcccagagc caaacctcaa tagcgctcga
     2521 cgaattcgca atgttagtgg ccatagaaag aatgaaacag aaaaggaatc tgggcttaag
     2581 ccaaccctac gacagattct aaatgcatca aggagaaatg tcaactggga acaggtcatt
     2641 cagcaagtaa ccaagaaaaa gcaagagctg ggcaaaggct tacccaggtt tggcatagaa
     2701 atggtacctt tggttcaaaa tgaacaggaa gtcttggatt tagatgaaga gcctgatctg
     2761 tccagtctgg aaggattcca gtgggaagga gtttccattc cctcatcctc tggcttggca
     2821 agaaagcgaa gtctttctga aagcagcgtg gtcatggaca gggctcctgt gtatagcttc
     2881 tttactgggg agggtactgg taaagaaaat gaagcccagc agagtccttc acctaatact
     2941 gccctgagtg ctgcccagag tcagaagaca gccatgtatc ttgaacagga agtggcccct
     3001 ctgactccct ctgtcggaac aggtgaaagg gttggaaaca ttcctaccca gcggcgacat
     3061 agtgcacagt taccgtctgg tcacataatg cctgtcatgc attcagcccg agacctgcac
     3121 agccaggaga ggtctacccc actgtcagag cgccatgccc aggagagcac tggagaagga
     3181 aactcactca catcaaatgc atcttcaggt catgcagtct ccagcttagc agatgcagcc
     3241 actgacagca gctgtacctc tggtgctgag caaaccgatg gtcacagtat tagaaagaag
     3301 cgaagagcca ccggggatgg atcttcccct gaactaccaa gtcttgagag aaaaaataaa
     3361 cgaaggaaaa ttaaagggaa gaaagaacgt tctcaggttg accagctatt aactatttcc
     3421 ttaagagagg aagaactgag caagtctctg cagtgcatgg acaacaagct cctgcaggcg
     3481 cgggcagcac tgcagacagc gtacgttgaa gttcagaggc tactcgtgct taagcagcag
     3541 ataactgtgg agatgagtgc actgaggact cacagaatac agattctaca aggattgcaa
     3601 gaaacatatg aacctcctga gcacccagac caggctccct gtagcctcat atcacgagaa
     3661 caaaggaaca gccgatctca gacatctttt gagacagctc tgctgcctgc accctttttc
     3721 ccggggtttc tggatccacc tccttcccat gcatctctac catcctctgg aaaccctctc
     3781 caaataacca cgtgtacttt acaagcccat ggcactgccc ctgattcatc ggttcagatt
     3841 aaacaagagc ccatgtctcc tgaacaagag gggaatatga atgctttgcc acaaggctgt
     3901 gcttccaatg tgtccaagga attactgcaa actaatagag tggtcgatga cggctcttca
     3961 gtttacccag ccatccctgc agtgatagca tcagagtcaa cagagaactg ccaggaggtt
     4021 agcaaagatc tgaatttttc tgtggagcaa ggaaattcca gaagcaaagg aaactctccc
     4081 tcttgccagt ctcctgatct tcctggcata aacagaggtg aagagacagc caaaggcagc
     4141 agtggatctg aagcctgcag cagttctttt ctgagattgt ctttcactcc cgaaacgcct
     4201 gcagagaagg aaactcagtc tccagctgac cagcctgagc agcaggcaga atccacactg
     4261 gcatcagctg aaactagagg tagcaagaag aagaagaaac ttcggaagaa gaagacgctt
     4321 cgggccactc atgttcctga gaacagtgac acagagcagg atgtgttcac ggctaagcct
     4381 gcaaggaagg tcaaaactgc aaaggcagct aaaggggcga aagtgacaac cagccagact
     4441 ggtcaggagc aaggaactgc cagagatgag ccagacagcg attcttctct ggaagtcctg
     4501 gaagtcacaa atcctcagtt agaagtagtt gccattgata cttctgaatc gggagacgag
     4561 aaacctgaca gtccatcgaa aaaagatgcc tggatcgctg cagaacagaa ccccatagaa
     4621 acttctcgtt ctggttgtga tgaggttagc tctaccagtg agcttggcac ccgctacaag
     4681 gatggtgttc ctgtgagtgt ggcggaaacc cagacggtga tctccatcaa agcatctaag
     4741 cactcttcag aaatatcttc agagccggga gatgatgagg agcctacaga aggaagcttc
     4801 gaaggacacc aggctgcagt gaatgcaatt cagatatttg gaaacttcct gtatacttgt
     4861 tcagcagaca caactgtccg ggtttataat ctggtgagtc gaaagtgtgt tggtgtcttt
     4921 gagggacaca cttccaaagt gaactgcctt cttgtcactc acacctctgg gaagagttct
     4981 gtcctctaca cgggttccag tgaccacacc atccgctgct acaatattaa gacccgagag
     5041 tgtatggaac agttacagct ggaagaccgt gtcctctgcc ttcataatag atggcgaacc
     5101 ctctatgctg gactagcaaa tggcactgtg gtcacattcg acataaagaa caacaagcga
     5161 caggagatct ttgaatgcca tggccctcgg gcagtcagct gcctcgcaac agctcaggaa
     5221 ggtgcccgaa aactgctggt tgtaggatct tacgactgca ccattagtgt tcgtgatgca
     5281 cggaacggac tgctgctccg aaccctggag ggccacagca agactgttct gtgcatgaag
     5341 gtagtgaatg accttgtgtt cagtggctcc agcgaccagt cggtgcatgc tcacaacatc
     5401 catactgggg agcttgtgcg catctataaa ggccacaacc atgcagtcac tgtggtgaat
     5461 attctgggga aagtgatggt gactgcttgc ctggacaagt ttgttcgtgt ctatgagtta
     5521 cagtcccatg atcgactgca agtttatgga gggcacaaag acatgattat gtgtatgacc
     5581 atccataaga gtgtgattta cactggctgt tatgatggca gcatccaggc tgtgaggctc
     5641 aatctgatgc agaattaccg ctgttggtgg tatggctgta ctctgatatt tggcgttgtg
     5701 gatcacttga aacaacactt gctgactgac cacaccaatc ccaacttcca gacgctgaag
     5761 tgtcgatgga ggaactgcga tgcctttttt acagccagga aaggatccaa gcaggacgtt
     5821 gcaggacata ttgaacgcca cgctgaagat gacagcaaaa tagattcatg aagttttttg
     5881 cctcccacgt tgggaagtcc ttagtgaaga attctcccat gggccgttca ctgtccttct
     5941 ccaggcccct atctgtcctc caacaaagct gggagggaga aaatggttca cagccagacc
     6001 caccactagc aaagtgtgag cagtctgagg ataggttggt cacacacaac gcaggtccgc
     6061 tctagagcct gtaagtgaca tttaagcagt ttctaagaaa cctactcttc tggaacaaat
     6121 gacatacagt ggtttgtgct gctagtttat aggtgtttat taaagatgca gattttaatt
     6181 agttacccag tttgacccta atcatacata tagtttattg attcagtttg tgatttttgt
     6241 tttatgttct tatgatggct tataatagat tttttgagat cagttttaat tcctcctttt
     6301 gaaataactg ggtatttaaa tttaaagttt tctttttaaa ataattatgt gcagtgtctc
     6361 actattgatg tagctggaca aagctggcta tgagtgcgac gggaaacaca gtagtgtcct
     6421 gaagtgcctg gctgccctgc gtactgtatt ttagaattca gacattgtcc atgatcagaa
     6481 gtccctgaag acggcacttc ccagtaatca ctccagagtg ctcagtgggt gtcccctgcg
     6541 cgtctacact cctggcttct tgagtagaag gcacaaacct ttattccctt tctagctctg
     6601 gctcttggaa cctcatgaag agttgacacc ttttgcgttg ctccgttgcc agcccccatc
     6661 gttcctactg tcttgctgtg cctagagcag tggcaggcca ggcgtccagg ctgcttccac
     6721 ccactgcagg caccctagag agggagctgg gagaagcagc tcgagtcagt tgatcggcat
     6781 aggtggcagg cagagctagt gaagccggtg cctgtctcca tgctcatgcc agccgtagag
     6841 tggagtgtgg tgaagggaaa gctatcattg ggagtaccca tcttagtgga tcttagtggg
     6901 atggctttgt tcttggattt cttaaagact tgtgggtaaa actgaacaag ttttactatc
     6961 taatgctttg tttctagatt tcaaacctca gattcttcag agcgagtgga ccctcatgcc
     7021 acataccctc actttctgct actgggattg tggcctcttt ttgtccctgg cctgatcaga
     7081 cctccccata gactctccta ggaattgata gaggctgtag gcaggtcctc cctccccgca
     7141 ccccctttcc aggaaaggtt ccagtagttc ttactggatt cagaaaatgt taactaatct
     7201 aggagctgac actagctcat gcatggccac aagctgttca catgtggcct attgtgtggg
     7261 aaaaattttg atgaccacgt ggcttagatg tgaagagaac ctttgtgtga tacagaggag
     7321 atactgacag catagttatg agattaggaa ccctttccca cctctcccct ccacttcctg
     7381 taagggtgtg cagaggaggc acacttttgt ggtctgggaa gtgattgctt aggaaagttc
     7441 ctaacgagtt taatgctgac cctggatcat tccctgggtt ggtatgctaa ggaagctcac
     7501 gttccctgtt caccaaaggg aatatgcaaa gtgaggaggg gtaggacctt atgctgcaag
     7561 gaagaaggag gtaaggtgtt gaccgtggtg aggaacatgc atgcagtctg agaggattag
     7621 tacagactgc tctgagcttc ccttggtagc attgtgggca cctgcacttg gctttccttg
     7681 tttcgcaggg gttttcggaa gcagtgtgat gatgagttca agcacaggtg ggattgtttt
     7741 gggcactggg tcactgttcc ccagatgcag tgtgttctga aaatgaagag ccctgagtgt
     7801 cttggctcct caacaggagc tgcctgtagg agggagaact gtgcgtactt cttaggtcga
     7861 ccgtgacgtc tgttcaccat ctgcctccag tgccctcaga aggggcagct ctgtcttgct
     7921 gacatttgtt tgactttgtt gaagggagga aagtaactaa tacctgacaa aatgcaagac
     7981 agttcttaca agttacttaa aggtttttaa tgttcatatt taaaaaaatt ctttatgctg
     8041 attgcaacag ctcaaagcaa agaaaatctt ttaaaaatct cttgtgtata ttttcagttc
     8101 taataaaata ccaggcactt tcaattattt tgaaagtttt tactaggttc aaaacacatt
     8161 ttgacacatt ctgctagtct gtatacagga gcaaaaggag caaaaaggag caaaaacatg
     8221 tcctgacatg agcttgagac gtcatggtta gcattattac actcgttgct gtcgtgaaga
     8281 aaatgatttt cctgggagag gttgcagttg gaggtttgaa ttcatgaaca cataacagtc
     8341 tgaggctaca cttttatggt tgaagtgatt gttgccagca aaggttttgt tgttggggtt
     8401 tttttgttgt ttgtttgttt gttttcctgg tagattatca tggcacaact tgaggacatg
     8461 ggcatgtggc tgaggtgctg agtgtaggtg cacacttaaa gaatgacaca gcattctatg
     8521 gaagataatt cattgaggag gaaattgaaa tatattgtaa agtggggttg aacagtaagt
     8581 aggtttgctt aagttcacat acgtttactt agcaaatttg ttcctgttgc ttcaaggaag
     8641 gttctagaat tactataaag actgcacttg ccatacttgt ggtggtttca cccatgtcct
     8701 atcattgaga gccttgggtt tgagggagtt ggcctgatag gaaggaaagg aggaagctgt
     8761 ggtgggtctc acctggttcc atatgcagat gggtaggaaa cctctgtaaa ccaaacctac
     8821 cacttacctc cgcttcaact ccagccccag ggacatggcc cagactggcc cagaccagct
     8881 cagcccagac caggagtagc tcagtggggg cagagagtgg agaaggaaag gctgtggggg
     8941 gaagtagatg cccagagcta ccccgaacct tggtttttca atatggatta gaagaaatgt
     9001 caggtgacat ttgactgcaa agatatttct aaacagcctt cttacatttt ggtataaaag
     9061 ctgtgaactt cataactttg taagtgagat ataaagcaag tacaagaaga aaataaaata
     9121 cttttactaa gtgttca
//
