LOCUS       NM_030708              13874 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger homeodomain 4 (Zfhx4), transcript variant
            2, mRNA.
ACCESSION   NM_030708
VERSION     NM_030708.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 13874)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 13874)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 13874)
  AUTHORS   Liau,E.S., Jin,S., Chen,Y.C., Liu,W.S., Calon,M., Nedelec,S.,
            Nie,Q. and Chen,J.A.
  TITLE     Single-cell transcriptomic analysis reveals diversity within
            mammalian spinal motor neurons
  JOURNAL   Nat Commun 14 (1), 46 (2023)
   PUBMED   36596814
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13874)
  AUTHORS   Wang,W., Cho,H., Lee,J.W. and Lee,S.K.
  TITLE     The histone demethylase Kdm6b regulates subtype diversification of
            mouse spinal motor neurons during development
  JOURNAL   Nat Commun 13 (1), 958 (2022)
   PUBMED   35177643
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 13874)
  AUTHORS   Nakamura,E., Hata,K., Takahata,Y., Kurosaka,H., Abe,M., Abe,T.,
            Kihara,M., Komori,T., Kobayashi,S., Murakami,T., Inubushi,T.,
            Yamashiro,T., Yamamoto,S., Akiyama,H., Kawaguchi,M., Sakata,N. and
            Nishimura,R.
  TITLE     Zfhx4 regulates endochondral ossification as the transcriptional
            platform of Osterix in mice
  JOURNAL   Commun Biol 4 (1), 1258 (2021)
   PUBMED   34732852
  REMARK    GeneRIF: Zfhx4 regulates endochondral ossification as the
            transcriptional platform of Osterix in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 13874)
  AUTHORS   Ding,S., Wu,X., Li,G., Han,M., Zhuang,Y. and Xu,T.
  TITLE     Efficient transposition of the piggyBac (PB) transposon in
            mammalian cells and mice
  JOURNAL   Cell 122 (3), 473-483 (2005)
   PUBMED   16096065
REFERENCE   7  (bases 1 to 13874)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 13874)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   9  (bases 1 to 13874)
  AUTHORS   Sakata,N., Hemmi,K., Kawaguchi,M., Miura,Y., Noguchi,S., Ma,D.,
            Sasahara,M., Kato,T., Hori,M. and Tamaoki,T.
  TITLE     The mouse ZFH-4 protein contains four homeodomains and twenty-two
            zinc fingers
  JOURNAL   Biochem Biophys Res Commun 273 (2), 686-693 (2000)
   PUBMED   10873665
REFERENCE   10 (bases 1 to 13874)
  AUTHORS   Kostich,W.A. and Sanes,J.R.
  TITLE     Expression of zfh-4, a new member of the zinc finger-homeodomain
            family, in developing brain and muscle
  JOURNAL   Dev Dyn 202 (2), 145-152 (1995)
   PUBMED   7537552
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061199.1, AC115031.11, BI988177.1 and AC118246.15.
            
            On Feb 13, 2007 this sequence version replaced NM_030708.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1437              BC061199.1         1-1437
            1438-3004           AC115031.11        65578-67144
            3005-3429           AC115031.11        68066-68490
            3430-3661           AC115031.11        152280-152511
            3662-3897           BI988177.1         365-600
            3898-3978           AC118246.15        59350-59430
            3979-4179           AC118246.15        59629-59829
            4180-4297           AC118246.15        60407-60524
            4298-9700           AC118246.15        61390-66792
            9701-13874          AC118246.15        74411-78584
FEATURES             Location/Qualifiers
     source          1..13874
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 1.96 cM"
     gene            1..13874
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /note="zinc finger homeodomain 4"
                     /db_xref="GeneID:80892"
                     /db_xref="MGI:MGI:2137668"
     exon            1..374
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /inference="alignment:Splign:2.1.0"
     exon            375..3004
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /inference="alignment:Splign:2.1.0"
     CDS             421..11166
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger homeobox protein 4; zinc finger homeodomain protein
                     4"
                     /codon_start=1
                     /product="zinc finger homeobox protein 4 isoform 2"
                     /protein_id="NP_109633.2"
                     /db_xref="CCDS:CCDS38382.1"
                     /db_xref="GeneID:80892"
                     /db_xref="MGI:MGI:2137668"
                     /translation="METCDSPPISRQENGQSTSKLCGMTQLDNEVPEKVAGIEPDREN
                     SSSHDNLKTDERKSEVLLGFSIENAAATQVTSAKEIPCNECATSFPSLQKYMEHHCPN
                     ARLPVLKDDESETSELEDSDVENLTGEIVYQPDGSAYIIEDSKESGQNAQTGANSKLF
                     STAMFLDSLASAGEKSDQSSTAPVSFYPQIINTFHIASSLGKPFTADPAFPNTSALAG
                     VGPVLHSFRVYDLRHKREKDYLTSDGSAKNSCVSKDVPNNVDLSKFDGCVSDGKRKPV
                     LMCFLCKLSFGYIRSFVTHAVHDHRMTLNDEEQRLLSNKCVSAIIQGIGKDKEPLISF
                     LEPKKSTSVYPNFSTTNLIGPDPTFRGLWSAFHVENGDSLQAGFAFLKGSASPSSSAE
                     QPLGITHMPKAEVNLGGLSSLVVNTPITSVSLSHLSSESSKMSESKDQENNCERPKES
                     TILHPNVGCPVKSEPTEPGDEDEEDAYSNELDDEEVLGELTDSIGNKDFPLLNQSISP
                     LSSSVLKFIEKGTSSSSGTIAEDTEKKKQAAAAGRSNGNVTNSYSIGGKDFADGSISR
                     DGTTAAPSETTHGDEDSSTTHQHGFTPSTPGTPGPGGDGSPGNGIECPKCDTVLGSSR
                     SLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKTGQPHP
                     RLARGESYTCGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNVQNLQNGNGEQVFGHS
                     APTPNTSLSGCGTPSPSKPKQKPTWRCEVCDYETNVARNLRIHMTSEKHMHNMMLLQQ
                     NMKQIQHNLHLGLAPAEAELYQYYLAQNIGLTGMKLENPAETQLLLNPFQFDSATAAA
                     LAPGLGELSPYISDPALKLFQCAVCNKFTSDSLEALSVHVNSERSLPEEEWRAVIGDI
                     YQCKLCNYNTQLKANFQLHCKTDKHMQKYQLVAHIKEGGKSNEWRLKCIAIGNPVHLK
                     CNACDYYTNSVDKLRLHTTNHRHEAALKLYKHLQKQEGAVNSESCYYYCAVCDYSSKI
                     KLNLVQHVRSVKHQQTEGLRKLQLHQQGLPSEEDNLSEIFFVKECPANELETASLGAR
                     NGEDELIEQQLKAASEEPSEDAGDPLKPPTVAEDDEKEAHKRDNSEGKISTKDPEVIV
                     PEKELKVVTGATQPLLLAKEDNTGTKRSKPTEDNKFCPEQFYQCPYCNYNSRDQSRIQ
                     MHVLSQHSVQPVICCPLCQDVLSNKMHLQLHLTHLHSVSPDCVEKLLMTVPVPDVMMP
                     NSMLLPAAAPEKSEQDPPTALTAEGSGKYSGDSPVDDKSMSGLEDSKVGVEIKNEEQK
                     PAKEPVEASEWNKTSSKDVNISDALQDQLNEQQKRQPLSVSDRHVYKYRCNHCSLAFK
                     TMQKLQIHSQYHAIRAATMCTLCQRSFRTFQALKKHLEAGHPELSEAELQQLYASLPM
                     NGELWAESETMTQDDHGIDQEMEREYEVDHEGKASPVESDSSSIPDDLGLEPKRTLPF
                     RKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLKKVLQEASSPVP
                     QEANSSTDNKPYKCSTCSVAYSQSSTLEIHMRSVLHQTKARAAKLEPSRHLPSGHSIT
                     AAVNSPGQGMLESMSLASVNSKDTHLDAKELNKKQTPELISAQPTHHPPPRSPAQIQM
                     QLQHELQQQAAFFQPQFLNPAFLPHFPMTPEALLQFQQPQFLFPFYIPGAEFSLGPDL
                     GLPTSTTFGVPGMTGMAGSLLEDLKQQIQTQHHVGQTQLQFLQQAQQYQAVQPQLQPQ
                     NQQPPLPQQQQPQQQPSKLLKQEQGSLASTDCQLMKDMPSYKEAEEVTEKQEKPKQEF
                     INDTEGLKDSKDIKKQKSLEPCIPPPRIASGARGNAAKALLENFGFELVIQYNENRQK
                     VQKKGKSGEGENSDKLECGICGKLFSNVLILKSHQEHVHGQFFPYGALEKFARQYREA
                     YDKLYPISPSSPETPPPPPPPPPLPPAPPQPSTLGPVKIPNTVSAPLQAPPPTPPPPP
                     PPPPPPPPPPPPPPPPSAPQQVQLPVSLDLPLFPSIMMQPVQHPALPPQLALQLPQMD
                     TLSADLTQLCQQQLGIDPNFLRHSQFKRPRTRITDDQLKILRAYFDINNSPSEEQIQE
                     MAEKSGLSQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITVLEDIRIDPQPTSLEHYK
                     SDAAFSKRSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNLPTRVIVVWFQNA
                     RQKARKSYENQAEAKDNEKRELTNERYIRTSNMQYQCKKCNVVFPRIFDLITHQKKQC
                     YKDEDDDAQDESQTEDSMDATDQVLYKHCMVSGQTDTAKSTATLVASSGSGTSTPLIP
                     SPKPEPEKNSPKTEYPGEKTKQSDPSLPQGTKSAPSSVLTSSEPQQASIPQPPTQPPK
                     QPQLIGRPPSASQTPIPSSPLQISMTSLQNSLPPQLLQYPCDQCTIAFPTLELWKEHQ
                     HMHFLAAQNQFLHSPFLERPMDMPYMIFDPNNPLMTGQLLGSSLTQMPPQTSTAHTTA
                     PASVAASLKRKLEDKEDNNCSEKEGGNSGEDQHRDKRLRTTITPEQLEILYEKYLLDS
                     NPTRKMLDHIAREVGLKKRVVQVWFQNTRARERKGQFRAVGPAQSHKRCPFCRALFKA
                     KSALESHIRSRHWNEGKQAGYSLPPSPLISTEDGGESPQKYIYFDYPSLPLTKIDLST
                     ENELASTVSTPVSKTAELSPKNLLSPSSFKAECPEDVENLNAPSADAGYDQSKTDFDE
                     TSSINTAISDATTGDEGAADMENTGGSGEVKPALSPKETKTLDSLQKPATTPTTEVCD
                     DKFLFSLTSPSIHFNDKDGDHDQSFYITDDPDDNADRSETSSIADPSSPNPFGSSNPF
                     KSKSNDRPGHKRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWF
                     QNARAKEKKFKINIGKPFMINQSGTDGTKPECTLCGVKYSARLSIRDHIFSKQHISKV
                     RETVGSQLDREKDYLAPTTVRQLMAQQELDRIKKASDVLGLTVQQQGITDNCSLHGIS
                     LQAAYPGLPGLPPVILPGMNGPSSLPGFPQNSNTLTSPGTGMLGFPSSATSSPALSLS
                     SGPTKSLLQTPPPPPPPPPPPSSLSGQQTEPQNKESEKKQTKPNKVKKIKEEESEAIK
                     PEKHPKKEEKISSALTVLGKVVGETHMDPTQLQALQNAIAGDPASFIGGQFLPYFIPG
                     FASYFSPQLPGTVQGGYLPPICGMESLFPYGPAVPQTLAGLSPGALLQQYQQYQQSLQ
                     DSLQKQQKQQQEQQQKPVPAKTAKGEGDQPQSSNEASETKEEKSTAPESTKEEVQLDS
                     KSAEFSDTCIVPFVKYEFVCRKCQMMFTDEDATVNHQKSFCYFGQPLIDPQETVLRIP
                     VSKYQCLACDLALSGNEALSQHLQSSLHKEKTIKQAMRNAKEHVRLLPHSVCSPPPNT
                     SSTSPSAASSNNTYPHLSCFSMKSWPNILFQASARKAASSPSSPPSLSLPSTVTSSLC
                     STSGVQTSLPTESCSDESDSELSQKLQDLDNSLEVKAKPASGLDGNFNSVRMDMFSV"
     exon            3005..3429
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..3661
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /inference="alignment:Splign:2.1.0"
     exon            3662..3730
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /inference="alignment:Splign:2.1.0"
     exon            3731..3847
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /inference="alignment:Splign:2.1.0"
     exon            3848..3978
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4179
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /inference="alignment:Splign:2.1.0"
     exon            4180..4297
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /inference="alignment:Splign:2.1.0"
     exon            4298..9700
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /inference="alignment:Splign:2.1.0"
     exon            9701..13874
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13856..13861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /note="hexamer: ATTAAA"
     polyA_site      13874
                     /gene="Zfhx4"
                     /gene_synonym="A930021B15; C130041O22Rik; Zfh-4; Zfh4"
                     /note="major polyA site"
ORIGIN      
        1 acacaaagac atgcgcactc aacttaatca gccatttttt ttaaacaggg ctaaaacgat
       61 aataattagc agaataaaga catatcggat tttcatttcc tttcctcctt ttcccaaccc
      121 cttcacaagc aaacagcgag accgcggtcg gcacatgctt taactcctcc cggaaccccg
      181 aggaccgctc cgtgctcccc actttttgct ccagcgtttt tattttcacc caataaagtt
      241 cgaggattat ttttttattt tttattcttt ttaatgaacc ctctcgtttt acttggatgt
      301 gatcagctgt acgtaaaata aaagcaaaac aaaaaagagg cgaagatcga gtaggaactg
      361 cagggaaatg gaaagtccct gacaggctgg atgaaatgag atccccatgt agcaattgcc
      421 atggaaacct gtgactctcc tcctatctca aggcaggaaa atgggcagag cacatcaaag
      481 ctatgtggaa tgacacaact tgataatgag gtgccagaga aagttgcagg gatagagcct
      541 gacagggaaa acagctcctc acatgacaac ctgaaaacgg atgagcgcaa aagtgaagtc
      601 ttgctgggtt tcagcattga gaatgcagct gccactcagg tcacctcagc aaaggaaata
      661 ccctgcaacg aatgtgccac ttcttttccc agtttacaga aatatatgga acaccactgc
      721 cctaatgccc gccttcctgt cctgaaggat gacgagagtg agaccagcga gttagaggac
      781 agtgatgtgg aaaacttaac aggggagata gtttaccagc ctgatggatc agcgtatata
      841 attgaggact ccaaagaaag tggacagaat gcacagactg gggcaaacag caaactcttt
      901 tcaacagcaa tgtttctgga ctccctggca tctgctggag agaagagtga tcagtcttct
      961 acggcccctg tgtcattcta cccacagatc atcaacactt ttcatattgc ttcatccctc
     1021 gggaaaccat ttacagccga tccggctttc ccaaatacct cagcattagc aggagttggt
     1081 cctgtgttgc acagtttccg tgtctatgat ctccgacaca agagagagaa agactatcta
     1141 accagtgatg gctcagccaa aaactcctgt gtgtccaaag atgtccctaa caatgtggac
     1201 ttgtccaaat tcgatggttg tgttagtgat gggaagagga aacctgtctt aatgtgtttc
     1261 ttgtgcaaat tgtcttttgg ctatatcagg tcatttgtaa cccatgctgt acatgatcat
     1321 cggatgactc tcaatgatga ggagcagagg ctcctcagta ataaatgcgt ctccgccata
     1381 atacagggga ttggcaaaga caaagaacct cttataagct ttctggaacc aaaaaaatcc
     1441 acttctgttt atcccaattt ttctactaca aacctcatag gacctgatcc aaccttccgc
     1501 ggtttatgga gcgcttttca tgttgaaaac ggtgactctt tgcaggctgg ctttgccttc
     1561 ttgaagggaa gtgcaagccc ttccagctca gcagaacagc cgctggggat cacccacatg
     1621 ccaaaggctg aagtgaacct gggggggctg tctagtttag tagtgaacac cccaattacc
     1681 tccgtctccc tcagccactt atcatctgag tctagcaaga tgtcagagag caaagaccaa
     1741 gagaacaact gtgaaaggcc aaaagaaagt accatcttac acccgaatgt ggggtgccct
     1801 gtcaaaagtg aacccactga gccgggagat gaggatgaag aggatgcata ttccaatgaa
     1861 ctcgatgacg aggaagtatt aggtgaactc acagatagta ttggtaataa agatttccct
     1921 ctcttaaacc aaagcatttc tcctttatca tccagtgtgc taaaatttat tgaaaaaggt
     1981 acctcgtcct cctcggggac tattgctgaa gacactgaga agaaaaaaca ggccgccgct
     2041 gctggaagaa gcaatggcaa cgttactaat agctatagca ttggtggcaa ggactttgca
     2101 gacggaagta tcagtagaga tggcaccaca gcagctccta gtgaaacgac ccatggagac
     2161 gaggacagtt caacaacaca ccagcatggc ttcaccccga gcacacctgg tacaccaggt
     2221 cctggaggag atggctcccc aggcaatggc attgagtgtc caaaatgtga cacggttttg
     2281 gggtcttcaa ggtctcttgg tggtcacatg actatgatgc actcaaggaa ctcatgtaaa
     2341 accctgaaat gtcccaaatg taactggcac tacaaatatc agcagactct ggaggcccat
     2401 atgaaggaga agcacccgga gccaggtggc tcttgtgttt attgtaagac tggacaacct
     2461 catcccaggc ttgcccgggg agagagttac acgtgtggct ataaaccctt ccgttgtgag
     2521 gtttgtaact actctaccac taccaaaggc aacctcagta ttcatatgca gtcagacaag
     2581 cacctgaaca atgttcagaa tcttcaaaat ggcaatggcg agcaggtgtt tggccactct
     2641 gctccaaccc ctaacactag cctcagtggc tgtggaacac cctccccatc caaacccaaa
     2701 cagaaaccca cctggcggtg tgaagtctgt gactatgaga ccaacgtggc gaggaacctc
     2761 cggattcaca tgaccagtga gaagcacatg cacaacatga tgcttctgca gcagaacatg
     2821 aaacagattc agcacaatct gcacctgggc ctcgccccgg ccgaggccga gctctaccag
     2881 tactacctgg ctcagaacat cggcctgaca gggatgaagc tggaaaatcc tgccgagact
     2941 cagctcctgc ttaacccttt ccagttcgac tccgccacag cagcggctct ggcaccagga
     3001 cttggagagc tgtcacctta tatcagtgac ccggcgctga agctattcca gtgtgctgtt
     3061 tgcaacaaat tcacctctga cagcctggag gctctaagtg tgcatgtgaa cagcgagcgc
     3121 tctctccctg aagaggaatg gagagctgta attggagata tctaccagtg caagctctgc
     3181 aactacaaca cacagctcaa agccaacttc cagctccact gcaagactga taagcatatg
     3241 cagaagtacc agctggtggc ccacatcaag gaagggggca aaagcaatga gtggaggctg
     3301 aagtgcattg ccattggcaa ccctgttcac ctaaagtgta acgcctgtga ctactacacc
     3361 aacagtgtgg ataaattacg tctgcatact accaatcaca ggcacgaggc ggccctgaaa
     3421 ctctacaagc acttgcagaa gcaagagggt gcggtgaatt ctgagtcctg ttattactac
     3481 tgtgcggtgt gtgattactc ctccaagatc aagttaaacc tagtccaaca tgttcggtcg
     3541 gtgaagcatc agcagactga ggggctgcga aagcttcagc tgcaccagca aggcctgcca
     3601 tcagaggagg acaacctcag tgagatattt tttgtgaagg aatgtccagc gaatgagctt
     3661 gaaacagcat ctttgggagc caggaatggt gaggacgaac ttatagagca gcaattgaag
     3721 gcggcctcag aagaacccag tgaagatgca ggagaccctc tgaagcctcc cacagtggct
     3781 gaggatgatg agaaagaggc acacaagaga gacaacagtg aaggcaaaat ctctactaaa
     3841 gaccctgaag taatcgtccc agagaaagag ctgaaagttg tgacaggggc cacacagcca
     3901 ctcctgctgg ccaaagaaga caacacagga accaaaaggt caaaacctac agaggataat
     3961 aaattttgtc ctgaacagtt ctatcagtgt ccttattgta actacaacag tagggaccaa
     4021 agtcggatcc agatgcatgt cctgtcacag cactctgtac agccagtcat ctgctgtcca
     4081 ctctgccagg atgttctcag caacaagatg cacctgcagc tgcatctgac ccatttgcac
     4141 agtgtgtctc cagactgtgt ggagaagctg cttatgacag tgcctgtccc tgatgtaatg
     4201 atgccaaaca gtatgctact accagcagct gcccctgaga aatcagagca ggacccacct
     4261 acagccttga cagcagaggg ttctgggaaa tattcaggtg acagcccagt ggatgacaaa
     4321 agcatgtcag ggcttgagga ctccaaggtg ggtgtggaaa taaagaatga ggaacagaag
     4381 ccagcaaagg agcctgtgga ggcatcagaa tggaataaaa ccagcagtaa ggatgtgaac
     4441 atctcagatg ctctacaaga tcaactgaat gaacaacaaa aaaggcagcc cttgtcagtc
     4501 tccgaccgcc atgtttataa gtaccgttgt aaccactgta gcttggcttt taaaactatg
     4561 cagaagcttc agatacattc ccagtatcat gcaatccggg cggctacaat gtgtaccctc
     4621 tgccagcgga gtttccgtac attccaggct ttaaagaaac acttggaagc aggccatcct
     4681 gaactgagtg aagctgaact gcagcagctc tatgcctcct tgccaatgaa tggtgagctc
     4741 tgggcagaga gtgagacaat gacccaggat gaccatggca tagatcagga aatggagaga
     4801 gaatatgagg tggaccatga agggaaggca agtcctgtag agagcgacag cagctctatc
     4861 ccagatgatc tgggcttgga accaaagcgg accttacctt ttagaaaagg acccaacttt
     4921 acaatggaaa aattcctcga tccatctcgt ccttacaagt gtacagtgtg taaagagtca
     4981 tttacccaaa agaacattct cttggtccat tataattcag tgtctcactt gcataagttg
     5041 aaaaaggttt tgcaagaagc ctccagtcct gtcccccagg aagccaatag cagcacagat
     5101 aataagccct acaagtgcag cacctgcagt gttgcataca gccaaagctc gaccttggag
     5161 atccacatga gatcagtgct ccaccagaca aaggccaggg ctgcaaagct ggaaccaagt
     5221 agacacctac ccagtggtca tagcatcaca gctgctgtga atagccctgg ccaagggatg
     5281 ttagagtcca tgagcttagc ttcagtcaac agcaaagata cccacttaga tgccaaagaa
     5341 ttaaataaaa agcaaactcc cgaattaatc tctgcacaac ccacccatca cccaccacct
     5401 aggtcaccag cacaaatcca gatgcaactt cagcacgagt tgcagcagca ggctgcattc
     5461 tttcagccac agtttctaaa cccagctttt ttgcctcatt ttccaatgac cccagaggca
     5521 ctgctccagt ttcagcaacc ccagtttctc tttccattct atatacctgg ggcagagttt
     5581 agcttggggc cagatctggg cttgcccacc tccaccacat ttggggtgcc aggtatgact
     5641 ggcatggctg gttccttgct tgaagatctg aagcaacaga ttcaaacaca acatcatgtt
     5701 ggccaaactc agctccaatt tttacaacaa gcacaacagt accaagctgt acagccccag
     5761 ctgcagcctc aaaatcaaca gcctccccta ccacaacagc agcaacctca acagcaacca
     5821 agcaaactgt tgaaacaaga gcaaggtagc ctggcaagta cagactgcca actcatgaag
     5881 gacatgccat cttacaagga ggcagaagag gtgactgaaa agcaagaaaa accaaagcaa
     5941 gaatttataa atgataccga aggactcaaa gacagcaaag acataaagaa gcaaaagtct
     6001 ttagaacctt gtattcctcc accccgaata gcctcagggg ccaggggaaa tgcagccaaa
     6061 gcattactgg agaactttgg ttttgaactg gttattcagt ataatgagaa caggcagaag
     6121 gtccagaaaa agggtaaaag tggagaaggc gaaaactctg acaagctgga gtgcggaatc
     6181 tgtggtaaat tgttctcaaa tgttcttatt ttaaaaagtc accaagaaca tgtgcatggg
     6241 caatttttcc catatggagc actagaaaaa tttgctcgtc aatacaggga ggcctatgac
     6301 aagctttatc caatttctcc ttcttcccca gaaacaccac cgcctccacc tccacctcct
     6361 cccctgccac ctgcaccccc acagccttct actttggggc ctgtgaaaat cccaaacaca
     6421 gtatctgctc ctctgcaagc tccaccaccc actcctccac cgcctccacc tcctcctcct
     6481 cctcctccac cacctccacc cccacctcct cccccatctg caccacaaca ggtccaattg
     6541 cctgtttccc ttgacctccc cctctttcct tccattatga tgcagccagt gcagcaccct
     6601 gcacttcccc cacagctggc cctgcagctg ccccagatgg acaccctctc agcagatctc
     6661 actcagcttt gtcaacagca gctggggata gaccctaact tcttgagaca ttctcaattc
     6721 aaacggccac ggacccggat tacagatgat cagctaaaaa ttctgagagc ttattttgac
     6781 atcaataatt ctccaagtga agaacagatc caagaaatgg ctgagaaatc tggcctctct
     6841 caaaaagtca tcaaacactg gtttcgaaat acactcttta aggaacgaca gagaaataaa
     6901 gattctccat acaacttcag taaccctcct ataactgttt tagaagatat tcgaattgat
     6961 ccgcaaccta catctttaga acattacaaa tcagatgccg cattcagcaa aagatcatcc
     7021 aggacaaggt ttactgacta ccagcttagg gttcttcaag actttttcga cacaaatgct
     7081 tatccaaaag acgatgaaat agaacagctg tcgactgttc tcaacctccc cacccgggtt
     7141 attgttgtat ggttccagaa tgctcggcag aaagcaagga agagctatga gaaccaagca
     7201 gaagctaaag ataatgaaaa aagagaactc accaatgaac gctacattag aacaagcaac
     7261 atgcaatacc aatgcaaaaa gtgcaatgtg gttttcccca ggatctttga cttgatcaca
     7321 catcagaaaa agcagtgtta taaagatgaa gatgatgatg cccaagatga aagccaaacg
     7381 gaagactcca tggatgccac tgatcaagtg ttgtacaagc attgcatggt gtctggacaa
     7441 acagatacag ccaaaagcac tgcaacccta gtagccagtt caggctctgg gactagcacg
     7501 cccctgattc cttctcctaa accagaacct gagaagaatt ctccaaaaac tgaatatcct
     7561 ggagaaaaga caaagcagag tgacccctct cttcctcaag gcaccaagtc agctccctca
     7621 tcagtactga cttcttcaga gccacagcag gcgtccatac cccagcctcc aacacagccg
     7681 cccaagcaac cccaactgat tggaagacct ccctcagcgt cacaaactcc aatcccttcc
     7741 agcccactgc aaatttccat gacttctctt cagaacagtc tacctccaca gttactccag
     7801 tacccatgtg atcagtgtac catagccttc ccaaccctgg aactttggaa ggaacaccaa
     7861 cacatgcact tcctcgctgc tcaaaaccaa ttcctccact ctccattctt ggaaagaccc
     7921 atggacatgc cctacatgat atttgacccc aacaatccac tgatgactgg acagctcctg
     7981 gggagctctc tcactcaaat gccaccacag accagtactg cccacactac cgcccctgcg
     8041 agtgtcgctg cttcccttaa aaggaaattg gaggataaag aagataataa ttgcagtgag
     8101 aaggagggcg ggaatagcgg tgaagatcaa caccgtgata aacgcttgag aaccaccatc
     8161 acgcctgagc aactcgaaat actctatgaa aagtacttgc tggattctaa tcctacccga
     8221 aaaatgcttg atcacattgc acgggaagtg gggctgaaga aaagagtggt ccaagtctgg
     8281 ttccagaaca ctcgggctcg agaaaggaaa gggcagttcc gtgcagtggg tcctgcccag
     8341 tctcataaac ggtgtccatt ctgcagagct ctatttaaag caaaatcagc cttagaaagc
     8401 cacattcgct ctcgccactg gaatgagggg aagcaggcag gttatagctt gccaccaagc
     8461 cctttaatat ccacagagga tgggggagag agtccacaga aatacattta ttttgattac
     8521 ccatctttgc cattgactaa aattgatcta tctactgaga atgaattggc ctccacagtc
     8581 tctacgcctg ttagtaaaac agcagaactg tcacccaaaa atcttttaag tccttcttct
     8641 ttcaaagcag aatgtccaga ggatgtagag aatctaaatg ccccttcggc tgatgctggg
     8701 tatgatcaga gtaaaactga ctttgatgag acctcatcta ttaatacggc catcagtgat
     8761 gcaaccacag gagatgaggg agcagcagat atggaaaaca cgggaggttc tggggaggtg
     8821 aaaccagctt tgtcccctaa agaaaccaaa actcttgact ctttgcaaaa accagcaacc
     8881 acacccacca cagaggtctg tgatgacaaa tttctctttt ctctcacaag tccatcaatc
     8941 cacttcaatg acaaagatgg tgaccatgac caaagctttt acatcacgga tgaccctgac
     9001 gacaatgctg accgcagtga aacatctagc atagctgatc ccagttcacc aaatccattt
     9061 gggtctagca acccctttaa gtccaaaagc aatgatcggc ctggtcacaa gcgcttcaga
     9121 acccagatga gcaatcttca actaaaggtc ctcaaggctt gcttcagtga ctatcggact
     9181 ccaaccatgc aagaatgtga aatgctgggc aatgagattg gtctgcccaa acgagtggtg
     9241 caggtgtggt ttcagaatgc tagggcaaag gaaaagaagt ttaaaattaa tataggaaag
     9301 ccgttcatga tcaatcaaag tggaacagat ggtactaagc cagagtgtac cctctgtggg
     9361 gtgaagtact ctgcccgctt gtccatccga gatcatattt tttccaaaca gcatatttcc
     9421 aaagtgaggg agactgtggg cagtcagctt gaccgggaga aagattacct tgctcctacc
     9481 accgttcgac agctaatggc ccaacaagaa ctggaccgta taaagaaagc ttctgatgtg
     9541 ctgggcctaa cagtacagca gcaaggcatc accgataact gctcgctgca tggtatcagc
     9601 ttgcaagcag cctaccctgg gctccctggc cttcctccag tcattcttcc tggaatgaat
     9661 ggcccttcct ccttgccagg atttccacaa aattcaaaca cattaacatc tccgggtaca
     9721 ggtatgcttg ggtttcctag ttcagctact tcgtctcctg ccctgtctct cagcagtggc
     9781 cccaccaaat ctttgctgca gactccacca cctccaccac cacctcctcc tcctccatcc
     9841 tctctgtcag gacagcagac cgagccacag aacaaagaat cggagaaaaa gcaaactaag
     9901 ccaaacaagg tgaaaaaaat caaggaggag gaatcggagg ctatcaaacc cgaaaagcac
     9961 cccaaaaagg aggaaaaaat ctcatctgct cttacagtgt tgggcaaagt ggtaggggaa
    10021 acacacatgg atcctactca gctgcaggcc ttgcagaatg caattgctgg ggacccagca
    10081 tcctttatag gagggcagtt cttgccatac tttatccctg ggtttgcatc ctacttttca
    10141 cctcagctcc ctggaacagt gcagggaggc tacctgccac caatctgtgg catggagagt
    10201 ctctttccct atggtcctgc agtacctcag acactggcgg gcctgtcccc aggggcgctt
    10261 ctacagcagt accaacagta tcagcagagc ctgcaagatt ccctacagaa acagcaaaag
    10321 caacagcaag aacagcagca gaaaccagtt cctgccaaga cagccaaagg cgagggcgac
    10381 cagccgcaga gctccaacga ggcttcggaa accaaggaag agaaaagtac tgctcccgaa
    10441 agcacaaaag aagaagtcca gttagattcc aagagtgcag agttttcaga tacttgtatt
    10501 gttccatttg tcaagtatga gtttgtatgc agaaagtgcc agatgatgtt tactgacgaa
    10561 gatgccacag taaaccatca aaagtccttc tgttatttcg gtcagccatt gattgaccct
    10621 caagaaacag tgcttcgcat cccagtcagc aaatatcagt gtcttgcctg tgacctggct
    10681 ctcagtggga atgaagcact tagtcaacac ctccagtcaa gcttgcacaa agagaaaaca
    10741 atcaaacaag caatgagaaa tgccaaagag catgttagat tattacctca ctcagtctgc
    10801 tcccctcctc ctaacacctc atctacctcg ccgtctgcag cttcttctaa taacacctac
    10861 cctcatctct cttgcttctc catgaagtcc tggcctaata tccttttcca agcatccgcc
    10921 aggaaagctg cttcgtcccc ctcttctcct ccctccctct ccttgccttc aacggttacc
    10981 tcaagtttgt gcagcacctc aggggttcaa acctcactac ccacagaaag ttgttcagat
    11041 gagtctgaca gtgagctgag ccagaagcta caagacttag ataattcttt ggaagtgaaa
    11101 gctaaacctg cttctggcct agatggtaat ttcaatagtg tccgaatgga tatgttcagt
    11161 gtgtaggagt gaagacagga tcccgtgctt aaaaaaaaat ttaaaaataa aaaattttta
    11221 aaaaaagact ttaactgcag ttccaaagct tctctaaccc aaaaattaca gtaccaaatg
    11281 attgactcag gattgttttt cccatattga tatgctggca atataggatg gtatgtggtg
    11341 aagaagacta atgcaggtgg ttgaatgcgc ttgtaatata tgctaaaata tggaaaagga
    11401 aaaaaatatc tcacaagttc tttgggaact tgtttcaagc caaaaactct caagacagaa
    11461 aattgcacct cagctgggtt gatttcaaaa tgccagcatg gacagtatgg gaggacgatc
    11521 cggatgtgtc aaagagaact tctcttagtt tagttaggtg taattcagta gctttaaatt
    11581 ctcaggtcag aacataacat ttctcatttg ttaaaagcag caagaagcct ggtaaaactg
    11641 tgacttttcc ccaaatgtca atctttatta gaaagcattt tctaggtgtg tttagtgtgc
    11701 aaagaaactt tctaaccctt accggacacc gcacagcttc ctgcactcaa gccgcagggt
    11761 agtacagttt taccacagag ggactcttga gcaatggagt cacgtgtctg ccctgtgtat
    11821 tgcagtttgt cttgacacaa gctgttttta caccagtgtc atccctttct tgtagaatat
    11881 actaataatc tgtgccaact ctaccttccc acttttacct ctgacatcat tctttttttc
    11941 tgaaaggggt aataattcta gttttgatag actctgagga tcatatgaac aggacatttt
    12001 tcatttgtga atttaatgct atcttgtcaa ggtacttgct tgtgtctgaa ctctagtgca
    12061 cttatcattt tgtagaccat gtggaattta ataagatact tttccccact cctttctttg
    12121 tgtgtagtgc agcaacagtt tggtctgcat ttgttagaag tgtaactcct aacaacccaa
    12181 agacctattt aataattggt gcataaatga aagtagtact gtatacttga aactgtttaa
    12241 gtacaagttg aacaaaaatt atgaaaaggt atatttgctt ctcgggaaag caaagaagct
    12301 gctttaagaa aattaaaagg ggactaaaaa tttgttttgt ataaagagga tagccctgcg
    12361 cacgtaggac tgaattcagt gatatcccta tacactgcca attagtggat aggttattgt
    12421 acttccattc atactctggg cacttgtgtt aaattgttct gttacacact tttgtctaac
    12481 ctgttttgtt ttttatcata tatgcattaa aagtattatg tttatcaaca tttgctgcta
    12541 ttgtgttaac atttttgttt tgcttgccat gaggccccat ttccacctcc cagtaaactg
    12601 acttataaat tgctatactt ttcctgtttt ttctgttgct gtggaactta aagaatgtga
    12661 aagctgtcaa agggtgtttt cggaatcact tttgtgtttc gtatagtaaa acaatgtgat
    12721 tcattccaaa gtaacagaag gctatttgta agaaagataa aggcttgtga acaaagaaag
    12781 ctaagctgtt gtacatattg tagttggctg tgcatggtac aaatttatta atatgaagaa
    12841 atgcaaaatg tattgctttt gatatttcta ttctgagatg aaccagtagc atgtaatgca
    12901 actgtttgac agtttaactc aattcatgct tcaaactgtt ttaatcatca aaccaagtca
    12961 ctgttcattt tcatcttctt gtacagtttt tgtttgggta atgatcacag caatccttac
    13021 acattttatg taaactcttt aatgtcttta atttggattt ttgtttctta gaactttaac
    13081 atttatttta atcctgaaga cacttttttg attgtgtttc gtaagagaca acatggcctc
    13141 ctaaggtgca atcctgccgc tatagtgagc taatgtcctg aatccaaagg cttcagaaaa
    13201 ttgcttttgc ctttttcatg aatgttaagc agcagcattg tgagatcgat ctgtcctggc
    13261 agttaacaca atgtgcaaca gtgtgttagc atggaacaga acgcctctca caaaacaaag
    13321 gaccgtttta caaaggatga tccgacagtg tgtcgacata aacttttaca actgcacagc
    13381 agccaaaaaa gaaaaaaaag aaaaaaaaaa actttaactg gacggacgtt gttagggtga
    13441 gaaataaaag gacagcctcc aaaggttgag agcaagaatt gtttttttct tggatatcaa
    13501 agggattatc acagcgcaat cattgtctac aacaacgtgt acactcaatg cctgggttac
    13561 ataggaaatg caccctgagg ttttaataaa gcccctatgg ctataacttt aaataaacta
    13621 aaccaaaaat gttattgatg ttttatatag agagtaggat cattagtttt tgttactgta
    13681 atgtttgatg tctcaaatgc accgtattac ggtaataaca tggtttcgaa aactttctgt
    13741 ttttattttg tcacagagct gttgtcatag ttgaaatgat gtttattgta gatggtattt
    13801 gaacttattc ttctggaaat agttcatcaa gtatgtttgt tgctcattgt gatacattaa
    13861 aaactgtatc tgca
//
