LOCUS       NM_001039198            8738 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger homeobox 2 (Zfhx2), mRNA.
ACCESSION   NM_001039198 XM_989828
VERSION     NM_001039198.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8738)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8738)
  AUTHORS   van de Haar,L.L., Riga,D., Boer,J.E., Garritsen,O., Adolfs,Y.,
            Sieburgh,T.E., van Dijk,R.E., Watanabe,K., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Posthuma,D., Meye,F.J., Basak,O. and
            Pasterkamp,R.J.
  TITLE     Molecular signatures and cellular diversity during mouse habenula
            development
  JOURNAL   Cell Rep 40 (1), 111029 (2022)
   PUBMED   35793630
REFERENCE   3  (bases 1 to 8738)
  AUTHORS   Habib,A.M., Matsuyama,A., Okorokov,A.L., Santana-Varela,S.,
            Bras,J.T., Aloisi,A.M., Emery,E.C., Bogdanov,Y.D., Follenfant,M.,
            Gossage,S.J., Gras,M., Humphrey,J., Kolesnikov,A., Le Cann,K.,
            Li,S., Minett,M.S., Pereira,V., Ponsolles,C., Sikandar,S.,
            Torres,J.M., Yamaoka,K., Zhao,J., Komine,Y., Yamamori,T.,
            Maniatis,N., Panov,K.I., Houlden,H., Ramirez,J.D., Bennett,D.L.H.,
            Marsili,L., Bachiocco,V., Wood,J.N. and Cox,J.J.
  TITLE     A novel human pain insensitivity disorder caused by a point
            mutation in ZFHX2
  JOURNAL   Brain 141 (2), 365-376 (2018)
   PUBMED   29253101
REFERENCE   4  (bases 1 to 8738)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   5  (bases 1 to 8738)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 8738)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8738)
  AUTHORS   Komine,Y., Takao,K., Miyakawa,T. and Yamamori,T.
  TITLE     Behavioral abnormalities observed in Zfhx2-deficient mice
  JOURNAL   PLoS One 7 (12), e53114 (2012)
   PUBMED   23300874
  REMARK    GeneRIF: Homozygous Zfhx2-deficient mice showed several behavioral
            abnormalities, namely, hyperactivity, enhanced depression-like
            behaviors, and an aberrantly altered anxiety-like phenotype
REFERENCE   8  (bases 1 to 8738)
  AUTHORS   Chung,Y.C., Tsai,Y.J., Shiu,T.Y., Sun,Y.Y., Wang,P.F. and Chen,C.L.
  TITLE     Screening large numbers of expression patterns of transcription
            factors in late stages of the mouse thymus
  JOURNAL   Gene Expr Patterns 11 (1-2), 84-92 (2011)
   PUBMED   20932939
REFERENCE   9  (bases 1 to 8738)
  AUTHORS   Komine,Y., Nakamura,K., Katsuki,M. and Yamamori,T.
  TITLE     Novel transcription factor zfh-5 is negatively regulated by its own
            antisense RNA in mouse brain
  JOURNAL   Mol Cell Neurosci 31 (2), 273-283 (2006)
   PUBMED   16257534
  REMARK    GeneRIF: Results report features of zfh-5 isolated from the mouse
            brain; in addition to the mRNA, the antisense strand of zfh-5 is
            also expressed in the developing brain, in a manner complementary
            to the expression of zfh-5 mRNA.
REFERENCE   10 (bases 1 to 8738)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB190186.1.
            
            On May 4, 2006 this sequence version replaced XM_989828.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164141
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..8738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.05 cM"
     gene            1..8738
                     /gene="Zfhx2"
                     /gene_synonym="ZFH-5"
                     /note="zinc finger homeobox 2"
                     /db_xref="GeneID:239102"
                     /db_xref="MGI:MGI:2686934"
     exon            1..41
                     /gene="Zfhx2"
                     /gene_synonym="ZFH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            42..2113
                     /gene="Zfhx2"
                     /gene_synonym="ZFH-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..7779
                     /gene="Zfhx2"
                     /gene_synonym="ZFH-5"
                     /note="zinc finger homeodomain protein 5"
                     /codon_start=1
                     /product="zinc finger homeobox protein 2"
                     /protein_id="NP_001034287.1"
                     /db_xref="CCDS:CCDS27107.1"
                     /db_xref="GeneID:239102"
                     /db_xref="MGI:MGI:2686934"
                     /translation="MATLNSASPSGTVPSPGHNVRSPPPETSSSSTSDPVTKDPPDAP
                     STSESIRSSEPGGERLESGSDLDPPKEIGEPQEEPGCGHIPPKDLGVAKEEEEILPLD
                     LSSHLFFAAGGQAYLLANLPLPRGSELSLPKGFPWDEASAKEEPSLPLLTHFPSSHLT
                     TLHIQHGFDPIQGFSSSDQMLSHDTSAPSLAACERRDGSFWSYQLVPNPTEDPKDGPL
                     GSRREDHRAMFWICLLCRLGFGRLQTFIGHTLSHGVKLSPAHHQGLLGSPAVLQEGHD
                     GGMALLSFLEPKFLTRPSPEVPDTSTVTVKTNGAQAEDGPPEADGQALVLPAEEVIAL
                     SPPSPPTALATWDPSPTQAKDSPVPRGEAGPDWFPEGQEEDGGLCLPLNQSSPTSKEV
                     AVLPAPAGSPEDTSDPPPSCRLADDYTPAPAAFQGLSLSSHMSLLHSRNSCKTLKCPK
                     CNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNCGYKPYRCDVCNY
                     STTTKGNLSIHMQSDKHLANLQGFQAGPGGQASPPEASLPPTSVGDKEPKTKSSWQCK
                     VCSYETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLVGPGPPPPPGAAPTNPPE
                     LFQYFGPQALGQPQTPMPGPGLRPDKPLEAQLLLNGFHHLGAPARKFPTAAPGSLSPE
                     THLPPSQLLGSSSDGLPTSPSPDDSPALKVFRCLVCQAFSTDSLELLLYHCSIGRSLP
                     EAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHTQKYQLAAHLREGGGAMGTPSL
                     LALGDGASYGSISPLHLRCNICDFESNSKEKMQLHTRGSAHEENSQIYKFLLEMEGAE
                     AGPEPGLYHCLLCAWDTPSRLALLQHLRTPAHRDAQAQRRLQLLQNGPAAEEGLSALQ
                     SILSFSHGRLQTPGKASDTPLAQPPTSEKDAQNKTEQQASEVTEDRSGPPRDSANQIT
                     VFCCPYCSFLSPECDQVRVHTLSQHAVQPKYRCPLCQEQLVGRPALHFHLSHLHNVVP
                     ECVEKLLLVATTVEMTFATKMLPGPTLNPVEDGLDHPAPGAEPTPNRDQVAESSNLAP
                     EVSPDPPLEPPLAPVEGSREPSESPDQPPSPAPSPAPRLDAQVEELAPLPTMSEEEEG
                     AMGEPRSAEPTPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVHY
                     NSVSHLHKMKKAAIDPSGPARGEAGIPPPAATASDKPFKCTVCRVSYNQSSTLEIHMR
                     SVLHQTRSRGAKIDARAEGAERGQEEFKEGETEGEAGTEKKGPDPGGFMSGLPFLSPP
                     PPPLDLHRFSAPLFTPPVLPPFPLVPESLLKLQQQQLLLPFYLHDLKVGPKLALASPT
                     PMLSLPAANPPPLPAPPKAELAEQEWERPLMAEEGTEAGPSSPTHTSPNEAARTAAKA
                     LLENFGFELVIQYNEGKQAVPPPPTPPPPESLGGGDKLACGACGKLFSNMLILKTHEE
                     HVHRRFLPFEALSRYAAQFRKSYDSLYPPPVEPPKPPDGCLESPPQLGPPFVVPEPEV
                     GGIHTSEERSLSGGGPWPSEEEEGSRGSLPPAVPVGRRFSRTKFTEFQTQALQSFFET
                     SAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNACEGGPVTAGGASGGASGCRR
                     CHATFACVFELVRHLKKCYDDQPPEEEEEAERGEEEEEVEEEEAEERNLEPAAARPGG
                     PSPEHADGEDLSQTEPTRPESKESEGKAPPSPPVYACDQCAASFPSQDLLTTHHRLHL
                     LPSVQPSAPPPSQLLDLPLLVFGERNPVVSGTSSVTGTPLKRKHDDGSLSPTGSEAGG
                     GGEGEPPKDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQ
                     NTRARERKGQFRSTPGGVAGPAVKPTVPPSPAPFPKFNLLLSKIEDETGKEAPKRDAP
                     AFPYPTVTPAVGPLPFLPPGKEAAVPTPEPPPPLPPPALSEDEGPEEPSKASPESEAC
                     SPSAGDLSDSSASSLAEPESPGAGGTSGGPGGGTGVPDSMGQRRYRTQMSSLQLKIMK
                     ACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGTAPPGSGGSSEG
                     TSAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPET
                     PLAPKGPPATTPASSVPLGASPTLPRLAPVLLPGPTLAQPPLGSIASFNSGPAASSGL
                     LGLATSVLPATTVVQTAGPGRPLPQRPVSNQTNSSTDPTPGPATEPSGDKVSGERKPV
                     ATLPNSSTDALKNLKALKATVPALLGGQFLPFPLPPAGGAAPPAVFGPQLQGAYFQQL
                     YGMKKGLFPMNPVIPQTLIGLLPNALLQQPPQAPEPTATAPPKPPELPASGEGESSEA
                     DELLTGSTGISTVDVTHRYLCRQCKMAFDGEAPATAHQRSFCFFGRGSGASMPAPLRV
                     PICTYHCLACEVLLSGREALASHLRSSAHRRKAAPPPGGPPITVTNSATAVPAAVAFA
                     KEEARLPHTDPNPKTTTTSTLLAL"
     exon            2114..2631
                     /gene="Zfhx2"
                     /gene_synonym="ZFH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2872
                     /gene="Zfhx2"
                     /gene_synonym="ZFH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2947
                     /gene="Zfhx2"
                     /gene_synonym="ZFH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3006
                     /gene="Zfhx2"
                     /gene_synonym="ZFH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3007..3207
                     /gene="Zfhx2"
                     /gene_synonym="ZFH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3334
                     /gene="Zfhx2"
                     /gene_synonym="ZFH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..6811
                     /gene="Zfhx2"
                     /gene_synonym="ZFH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            6812..8725
                     /gene="Zfhx2"
                     /gene_synonym="ZFH-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgcgg ttcgactccc gtccctgctt ccagctgagg tggtactggc tgtcacgctg
       61 aaatgaaccc tcagcagtcc tccgtctacc atggctaccc ttaactcagc ctctccctcc
      121 ggaaccgttc cttcccctgg gcacaatgtt cggtcaccac ctccagagac ctcctcctcc
      181 agcacctctg atcctgtcac caaagatccc cctgatgccc cctccacctc tgagagcata
      241 aggtcctcag agccgggggg agagcgtctg gagtcaggca gtgaccttga cccaccaaag
      301 gagattggag agccccaaga agagcctggc tgtggccaca tcccaccaaa ggaccttggg
      361 gtggcaaagg aggaggaaga gatccttcct ttggacctca gcagccactt attcttcgca
      421 gctggaggcc aggcctacct actggccaac ctgcccctgc ctaggggcag tgaactctcg
      481 ttaccaaagg gcttcccctg ggatgaggca agcgccaagg aagagcccag cctgcccctc
      541 ctcacccact tcccctcctc acaccttacc acccttcaca tccaacatgg cttcgaccca
      601 atccaaggct ttagctcttc tgaccaaatg ttgtcccacg atacctcagc gccgtctctg
      661 gctgcctgtg agagaaggga tggatccttc tggagctacc agctggttcc aaacccaacc
      721 gaagatccca aagatggccc cctggggagc cgacgggaag accacagggc gatgttttgg
      781 atctgccttc tctgccgcct gggtttcggc aggctccaga ccttcatagg tcacacactt
      841 tctcatggag tgaagctgag ccctgcccac caccagggcc tgctgggcag cccagccgta
      901 cttcaggagg gtcatgatgg cggcatggcc ctcctaagct ttctggaacc aaaatttctt
      961 acccgtcctt ctcccgaagt accggacacc agcacagtga ctgtgaagac aaatggagcc
     1021 caggctgagg acggcccccc agaggcagat ggtcaagccc ttgttctccc cgctgaagag
     1081 gttatagccc tcagcccacc atccccaccc acagccctag ccacctggga ccccagccca
     1141 acccaagcca aagattcgcc agtaccaaga ggcgaggcgg ggccagactg gttccctgag
     1201 gggcaggaag aggatggagg gctctgcctc ccgctcaacc aaagctcacc cacctctaag
     1261 gaggtggccg tgctcccagc tccagcaggc tctcccgaag ataccagtga cccacctccg
     1321 tcctgtcgcc tggccgatga ctacactcca gcccctgccg ccttccaggg cctcagcctg
     1381 tccagtcaca tgtccctgct acactcacgc aattcctgca agactctcaa gtgtcccaag
     1441 tgcaactggc actacaagta ccagcagacc ctggacgtgc acatgcggga gaagcacccc
     1501 gagagcaaca gccactgcag ctactgtagc gccgggggcg cccacccccg cctggcccgc
     1561 ggagagagct acaactgcgg ctacaagccc taccgctgcg atgtctgcaa ctactccacc
     1621 accaccaaag gcaacctcag catccacatg cagtccgaca agcacctggc caacctgcag
     1681 ggcttccagg cagggcctgg cgggcaggcg agtcccccgg aggcatccct cccacccacc
     1741 tctgtcgggg ataaagagcc caagaccaag tcatcctggc agtgcaaagt gtgcagctac
     1801 gaaaccaaca tctcccgaaa cctgcgcatc cacatgactt ctgagaaaca catgcagaac
     1861 gtcctgatgt tgcaccaggg gctgccactt ggcctgccac cagggctggt ggggccagga
     1921 cctcctcccc caccaggggc tgcccccacc aaccctcctg aactcttcca gtactttggg
     1981 ccccaggccc taggacagcc tcagacaccc atgcctgggc ccgggctgag gccagacaag
     2041 ccccttgaag cccagctact cctaaatggt ttccaccacc ttggagcgcc tgcccgcaag
     2101 ttccccacag ctgcccctgg cagcctctcc cctgagaccc atctgccacc aagtcagctc
     2161 ctgggctcct catctgatgg gctgcccact tcgccatccc cagatgacag cccagccctg
     2221 aaggtgttcc gctgcctggt gtgccaggct ttcagcacag acagcctgga gctgctgctg
     2281 taccactgca gcattggccg gagcctgccg gaggccgaat ggaaggaggt agctggggat
     2341 acccaccgct gcaagctctg ctgctatggc acccagctca aggccaactt ccagctccac
     2401 ctcaagaccg acaaacacac tcagaaatac cagctagcag cccacctccg ggaggggggc
     2461 ggagccatgg gcaccccttc cctactggcc ctgggggatg gggcttctta cggctccatc
     2521 tccccacttc acctgcgctg caacatctgt gacttcgagt ccaacagcaa ggagaagatg
     2581 cagctgcaca cccggggttc agcccacgaa gaaaacagcc agatctataa gtttctgctg
     2641 gaaatggagg gagcagaggc agggccggag cccgggcttt accactgcct gttgtgcgcc
     2701 tgggacacgc cctcccgcct agccttgctg caacacctac gcacgcctgc ccaccgggac
     2761 gcccaggccc agaggcggct gcagctgctg cagaacggcc cagccgctga agaaggactc
     2821 tcagctctcc agagtattct gagcttcagc catgggcggc ttcaaactcc tgggaaggct
     2881 tctgacaccc ccttagctca accacccacc tctgagaaag atgcccagaa caagacggaa
     2941 caacaggctt ccgaagtgac agaggacaga agcggccctc ccagagatag tgccaaccag
     3001 atcacggtct tctgctgtcc ctactgtagc ttcctgagcc cagagtgtga ccaggtgagg
     3061 gtccatacac tctcccagca tgccgtgcag cccaagtaca ggtgcccact ctgccaggag
     3121 cagctggtgg gccggcctgc cttgcacttc cacctcagcc accttcacaa tgtggtgccc
     3181 gagtgcgtcg agaagctgct gcttgtggcc acaactgtag agatgacctt cgcaaccaaa
     3241 atgcttcctg gacccacatt aaaccctgtg gaggatggcc tagaccaccc agctcctgga
     3301 gcagagccca ctcccaacag agaccaagta gcagaaagct ctaacctggc cccagaagtc
     3361 agcccagatc ctcctcttga gcctcccctg gcgccagtcg agggctccag ggagccctca
     3421 gaaagccctg atcagccgcc ttctccagcc ccatctccag cccctcggct tgatgcccag
     3481 gttgaagaat tggctcctct acccaccatg tctgaagagg aagagggagc tatgggggag
     3541 ccccgctctg cagaaccaac cccagctgac tcccgccacc ctctaaccta tcggaagacc
     3601 acaaactttg ccctggacaa gtttcttgac cctgctcggc cctataagtg cactgtgtgt
     3661 aaggagtcct tcacccagaa gaacatcctg ttggttcatt acaactccgt ctctcacctt
     3721 cataagatga agaaggcagc cattgaccca tcgggccctg cccgaggcga ggcgggcatc
     3781 ccaccgcccg ccgccactgc gtcagacaag ccctttaagt gcacagtctg ccgagtgtcc
     3841 tataaccaga gctccacact ggagattcac atgcgatcag ttctgcacca gacacgctcg
     3901 aggggggcca agatcgacgc cagggctgaa ggagcagagc ggggccaaga agagttcaag
     3961 gaaggcgaga ctgagggcga ggcaggtact gagaagaaag gccctgaccc tggtggcttc
     4021 atgtctggac tgcctttctt gtccccacca cctcctccct tggatctaca ccgattctca
     4081 gcccctctct tcaccccacc agtcctgccc ccgttccccc tggttccaga atcactactc
     4141 aagctccagc aacaacagct gcttcttccc ttctacctcc atgacctcaa ggtggggccc
     4201 aagctggcac tggctagccc tacgcccatg ctgtccctgc ccgctgccaa cccacctcct
     4261 ctccctgcac cccccaaggc tgagctggct gagcaggaat gggaacggcc cctcatggct
     4321 gaagagggga ctgaagcggg gccttcttca ccaacccaca catcacccaa tgaagctgcc
     4381 cgcacagcag ccaaagccct tctagaaaat tttggctttg agttagtgat tcagtacaac
     4441 gaagggaagc aggcagtgcc ccctccccca actcctccgc ctccagagtc tctggggggc
     4501 ggagacaagc tggcctgtgg ggcctgtggg aaactcttct ccaacatgct catcctcaag
     4561 actcatgagg aacatgtcca ccgccgcttt ctgccctttg aggctctgag ccgttacgcc
     4621 gctcagtttc gaaagagcta tgatagccta tacccacccc cagtagagcc ccccaaacct
     4681 ccagacgggt gcctggagtc acctccccag ctaggcccac ctttcgtggt cccagaacct
     4741 gaagtagggg ggatccacac ttctgaagag cggagcctgt caggaggagg accctggccc
     4801 tctgaggaag aagaaggctc tagagggagt cttcctcccg cagtacctgt gggccgccgg
     4861 ttctctagaa ccaagtttac agagttccag acccaggctc tacagtcttt ctttgagacc
     4921 agtgcctacc ccaaggacgg ggaggtggag cgcctggcaa gcctcttggg tctggctagc
     4981 cgcgtggtgg tagtgtggtt ccagaatgcc cgccagaaag cccgtaaaaa tgcctgtgag
     5041 ggtgggcctg tgacagccgg aggagcctct ggaggggcct ctggctgcag gcgctgccac
     5101 gccaccttcg cctgtgtttt tgagttagtt aggcacctca agaagtgcta tgatgaccag
     5161 cctcctgagg aggaggagga ggcagagagg ggggaagagg aggaagaggt ggaggaagag
     5221 gaggcggagg aacggaacct ggaacccgca gcagcaagac ctggcggccc atcaccagaa
     5281 catgcagatg gggaagactt gagccaaacg gagccaacaa ggccagaaag caaagagtct
     5341 gaagggaagg caccgccctc acctcccgtc tatgcctgtg accagtgtgc cgcttctttc
     5401 cccagccagg acctcctgac cactcaccat cgactccatt tgctaccatc tgtgcagccc
     5461 agcgccccgc caccgtccca gctcctagat ctacccttgc tggtgtttgg ggagcggaac
     5521 ccagtagtat cgggcacctc atcagtgacc gggacacccc tcaagcggaa gcacgatgac
     5581 ggcagtctgt ctcccacagg cagtgaagca ggaggcggag gagagggtga accccccaaa
     5641 gacaaacgcc tgcgcactac catcctgcct gagcagctgg agatcctgta ccgctggtac
     5701 atgcaggact ccaaccccac acggaagatg ctcgactgta tctctgagga agtgggactc
     5761 aaaaaacgag tagtacaggt ctggttccag aataccagag cccgggagag gaaaggtcag
     5821 tttcgaagca cccctggggg agttgccggt ccagcagtca agcccactgt accgccctcc
     5881 ccagctccct tccccaaatt caacctcctg ttgagcaaga ttgaagacga aacggggaag
     5941 gaagccccaa agagagacgc acctgccttt ccctacccca cagtcacccc tgctgttggg
     6001 cctctgccat tcctaccacc tgggaaagag gccgctgtac caacaccaga gcccccacca
     6061 cccctcccgc ccccagcact cagtgaggac gagggtccag aggaaccatc taaagcgtct
     6121 ccagaaagcg aggcttgcag tccatcggca ggagacctaa gtgattcatc tgcttccagc
     6181 ctggctgaac cagaatcccc tggggccggg gggaccagtg ggggaccagg cggtgggacc
     6241 ggagttccag atagcatggg gcagcggcga tatcggaccc aaatgagcag ccttcagctg
     6301 aagatcatga aagcctgcta tgaagcctac cgcaccccta ctatgcagga gtgtgaagtc
     6361 ctcggggagg aaattggact gcccaagaga gtcattcagg tctggttcca gaatgcccgt
     6421 gccaaggaaa aaaaagccaa actgcaggga acagcaccac cagggagcgg gggcagcagt
     6481 gagggcacct cggcagccca gcgcaccgac tgtccctact gtgacgttaa gtatgacttc
     6541 tacgtctcct gcagaggcca cctcttctct cggcagcacc ttgccaagct caaggaggca
     6601 gtccgagccc agctgaagag cgaaagcaaa tgctatgact tagctcccgc acccgagacc
     6661 ccactggccc ccaaagggcc acctgccacc acacctgcct cctccgtgcc cttgggggct
     6721 tccccaacct tgcctcgcct ggctccagtc ctcttgcctg gcccaactct ggcccagcca
     6781 ccacttggaa gcatagcttc tttcaattca ggccctgcag cctcctcagg ccttcttggc
     6841 cttgccactt cggtcctgcc tgctaccaca gtggtccaga ctgctggtcc aggccgcccc
     6901 ttacctcaga gacctgtatc taaccaaacc aacagttcta ctgaccctac ccctggccca
     6961 gctactgagc cctcaggaga caaagtctct ggtgagcgaa agccagttgc aacccttccc
     7021 aactcttcca ctgatgccct caagaacctg aaagcattga aagccactgt cccagccctg
     7081 ttggggggcc aattcctgcc cttcccattg ccccctgcag gcggggcagc accaccagct
     7141 gtctttggtc ctcagttaca gggggcatac ttccaacagc tttacggcat gaagaagggg
     7201 ctatttccca tgaacccggt gatacctcag acccttattg ggctgctccc caatgccctc
     7261 ctccagcaac caccccaagc ccccgagcct acagccacag cccctccaaa gccccccgag
     7321 ctgccggctt cgggggaagg ggaaagtagt gaggctgatg agctgctgac aggcagcact
     7381 ggcatctcca ccgtggatgt gactcaccgc tacttgtgcc gccagtgcaa gatggcattt
     7441 gacggcgagg ccccagctac tgcccaccag agatccttct gcttctttgg gcggggctct
     7501 ggggcctcca tgcccgcccc attgcgggtg cctatctgca cctaccactg cctggcctgc
     7561 gaggtgctgc tgagtgggcg tgaagcccta gcctcccatc tgcgctcctc agcccacagg
     7621 cgcaaggcag ccccgccccc aggaggccct cccatcaccg ttaccaacag cgccactgct
     7681 gtcccggctg ctgtggcttt tgccaaagag gaagcaagat tacctcacac ggaccccaac
     7741 ccaaaaacta ctactacctc tacacttcta gctttataaa cagataaacc aagatgggga
     7801 caagagaggg cctcagggtt ccctcacccc aaccttcagc tctgcccacc tcatgggagt
     7861 ctgtcaattc ccaccttccg tgggcttcac acaccccacc tccagcagag tcctgcctcc
     7921 tccccgcccc acaaacacac tgaccctcat tctcagcccc ttgcagatgc acccccactc
     7981 tggcatacat gtctgctttg ttcccccatt tcccccattg aattcccagc cctcttcctt
     8041 cccttgtaaa cacatacctt ttccatacta ctatattgac tgagaaaaca ccaaaagaaa
     8101 gaaaaaaaga aaagaaaacc caaggcaaaa aagtgggggt ggaaaatcaa ctttgccacc
     8161 cccttcttcc tgtcccttgt ccagagcaca gaccgctcac aaactccaaa aacccagttg
     8221 gttcctatgg ttggagcctg gggtgggcaa ggagcccata aaactaacca aacgggaggc
     8281 tggggggcgg ggggagaagc acccctgctc ccctccctcc tgccctctcc tcacctggtg
     8341 ggacccctag cagcctggac tcctggggaa gcggctgcca gaaagccctc taccaaccca
     8401 cacccctccc ctggaaactg cagtaacttt tttttctcaa aggctttaaa cacagaggcc
     8461 ctctcagcag ccatgggcct gcccctcgcc ctagccttgc taagggcagt ccagcctccg
     8521 gggatcagcg ttgcccacca atggcaaatc caaagttctt taaaaaaaaa aaaaaagaaa
     8581 gaaacacacc aaaataaaca agagcaagag agagtgtgca cagacacaaa aagagagatg
     8641 gagagaccag aggaatgaag taaagaaaaa cataaacttt gaatatacat agagagagag
     8701 aaaaaaaaag aaaactctca tcaaaaaaaa aaaaaaaa
//
