LOCUS       NM_009551               7385 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus zinc finger, AN1-type domain 5 (Zfand5), mRNA.
ACCESSION   NM_009551 XM_916405 XM_924251 XM_924253
VERSION     NM_009551.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7385)
  AUTHORS   Lee,D., Zhu,Y., Colson,L., Wang,X., Chen,S., Tkacik,E., Huang,L.,
            Ouyang,Q., Goldberg,A.L. and Lu,Y.
  TITLE     Molecular mechanism for activation of the 26S proteasome by ZFAND5
  JOURNAL   Mol Cell 83 (16), 2959-2975 (2023)
   PUBMED   37595557
  REMARK    GeneRIF: Molecular mechanism for activation of the 26S proteasome
            by ZFAND5.
REFERENCE   2  (bases 1 to 7385)
  AUTHORS   Lee,D., Takayama,S. and Goldberg,A.L.
  TITLE     ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates
            overall protein degradation
  JOURNAL   Proc Natl Acad Sci U S A 115 (41), E9550-E9559 (2018)
   PUBMED   30254168
  REMARK    GeneRIF: Unlike other proteasome regulators, ZFAND5 enhances
            multiple 26S activities and overall cellular protein breakdown.
            Erratum:[Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1458. doi:
            10.1073/pnas.1822050116.. PMID: 30642959]
REFERENCE   3  (bases 1 to 7385)
  AUTHORS   Li,A., Ma,S., Smith,S.M., Lee,M.K., Fischer,A., Borok,Z.,
            Bellusci,S., Li,C. and Minoo,P.
  TITLE     Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast
            cell fate
  JOURNAL   BMC Biol 14, 19 (2016)
   PUBMED   26984772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7385)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   5  (bases 1 to 7385)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7385)
  AUTHORS   Hishiya,A., Iemura,S., Natsume,T., Takayama,S., Ikeda,K. and
            Watanabe,K.
  TITLE     A novel ubiquitin-binding protein ZNF216 functioning in muscle
            atrophy
  JOURNAL   EMBO J 25 (3), 554-564 (2006)
   PUBMED   16424905
  REMARK    GeneRIF: ZNF216 functions in protein degradation via the UPS and
            plays a crucial role in muscle atrophy.
REFERENCE   7  (bases 1 to 7385)
  AUTHORS   Choi,P., Xanthaki,D., Rose,S.J., Haywood,M., Reiser,H. and
            Morley,B.J.
  TITLE     Linkage analysis of the genetic determinants of T-cell IL-4
            secretion, and identification of Flj20274 as a putative candidate
            gene
  JOURNAL   Genes Immun 6 (4), 290-297 (2005)
   PUBMED   15815685
REFERENCE   8  (bases 1 to 7385)
  AUTHORS   Hishiya,A., Ikeda,K. and Watanabe,K.
  TITLE     A RANKL-inducible gene Znf216 in osteoclast differentiation
  JOURNAL   J Recept Signal Transduct Res 25 (3), 199-216 (2005)
   PUBMED   16194934
  REMARK    GeneRIF: ZNF216 is a potent inhibitory factor for osteoclast
            differentiation and the mechanism is unlikely due to direct
            attenuation of the NF-kappa B pathway
REFERENCE   9  (bases 1 to 7385)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 7385)
  AUTHORS   Scott,D.A., Greinwald,J.H. Jr., Marietta,J.R., Drury,S.,
            Swiderski,R.E., Vinas,A., DeAngelis,M.M., Carmi,R., Ramesh,A.,
            Kraft,M.L., Elbedour,K., Skworak,A.B., Friedman,R.A., Srikumari
            Srisailapathy,C.R., Verhoeven,K., Van Gamp,G., Lovett,M.,
            Deininger,P.L., Batzer,M.A., Morton,C.C., Keats,B.J., Smith,R.J.
            and Sheffield,V.C.
  TITLE     Identification and mutation analysis of a cochlear-expressed, zinc
            finger protein gene at the DFNB7/11 and dn hearing-loss loci on
            human chromosome 9q and mouse chromosome 19
  JOURNAL   Gene 215 (2), 461-469 (1998)
   PUBMED   9758550
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103947.20.
            
            On Jul 14, 2011 this sequence version replaced NM_009551.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076397.1, BC080270.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-465               AC103947.20        101692-102156
            466-625             AC103947.20        105840-105999
            626-737             AC103947.20        106392-106503
            738-841             AC103947.20        107069-107172
            842-967             AC103947.20        109039-109164
            968-7385            AC103947.20        109837-116254
FEATURES             Location/Qualifiers
     source          1..7385
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 14.32 cM"
     gene            1..7385
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
                     /note="zinc finger, AN1-type domain 5"
                     /db_xref="GeneID:22682"
                     /db_xref="MGI:MGI:1278334"
     exon            1..465
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
                     /inference="alignment:Splign:2.1.0"
     exon            466..625
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
                     /inference="alignment:Splign:2.1.0"
     CDS             475..1116
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
                     /note="zinc finger, A20 domain containing 2; zinc finger
                     protein 216; zinc finger A20 domain-containing protein 2"
                     /codon_start=1
                     /product="AN1-type zinc finger protein 5"
                     /protein_id="NP_033577.1"
                     /db_xref="CCDS:CCDS29697.1"
                     /db_xref="GeneID:22682"
                     /db_xref="MGI:MGI:1278334"
                     /translation="MAQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQNS
                     GRMSPMGTASGSNSPTSDSASVQRADAGLNNCEGAAGSTSEKSRNVPVAALPVTQQMT
                     EMSISREDKITTPKTEVSEPVVTQPSPSVSQPSSSQSEEKAPELPKPKKNRCFMCRKK
                     VGLTGFDCRCGNLFCGLHRYSDKHNCPYDYKAEAAAKIRKENPVVVAEKIQRI"
     exon            626..737
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
                     /inference="alignment:Splign:2.1.0"
     exon            738..841
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
                     /inference="alignment:Splign:2.1.0"
     exon            842..967
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
                     /inference="alignment:Splign:2.1.0"
     exon            968..7385
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2550..2555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
                     /note="hexamer: AATAAA"
     polyA_site      2572
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
                     /note="major polyA site"
     regulatory      4291..4296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
                     /note="hexamer: ATTAAA"
     polyA_site      4311
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
     regulatory      6976..6981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
                     /note="hexamer: AATAAA"
     polyA_site      6994
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
     regulatory      7150..7155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
                     /note="hexamer: AATAAA"
     polyA_site      7176
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
     regulatory      7261..7266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
                     /note="hexamer: ATTAAA"
     polyA_site      7281
                     /gene="Zfand5"
                     /gene_synonym="2310057A04Rik; 5830475F03Rik; Za20d2;
                     Zfp216"
ORIGIN      
        1 agagccagag cgtcagtcgt cgggatcgct gagcggtgtg catctggtca ggcgtccgct
       61 cgctgcccgg agtcgcgcag agtctctggc gaacgcggaa gcccgaagag cgcagtcctc
      121 gggccccgtc ggcgctcagg cctctccgcg cgcctcctca ctcggccggg acgtcgctgt
      181 ggaggcgtga ggtgccggcg gccgggcgcc tggagcggcg ctagccccgc ggcctgcggt
      241 tcttctcctc ccccgccgcc ctcccacccg agctgcggcg gggctcggcc gcctcggcgc
      301 ttctgcacga acaaaggagg cctccgcggc gccagcgcag ctccgcctgc gctccgctcc
      361 gctccggccc gcggcggccg ctagccagcc cttcccggag gcctcagccc ggcccaccgc
      421 ccggcgtcgc gcgccagctc gctagtgcat ccgggccccc gcaggaagaa aaatatggct
      481 caggagacta accagacccc agggcccatg ctgtgtagta caggatgtgg cttttatggg
      541 aatcctagga caaatggaat gtgttctgtt tgctacaaag aacatcttca gagacagcag
      601 aatagtggca gaatgagccc aatggggaca gctagtggtt ccaacagtcc tacctcagat
      661 tctgcatctg tacagagagc agatgctggt ttaaacaact gtgaaggtgc tgctggcagc
      721 acatctgaaa aatcaagaaa tgtgcctgtg gctgccttgc ctgtaactca acaaatgaca
      781 gaaatgagca tttcaagaga ggacaaaata actaccccga aaacagaggt gtcagagcca
      841 gttgtcactc agcccagtcc atcagtttct cagcccagtt cttctcaaag tgaagaaaaa
      901 gctcctgagt tgcccaaacc aaagaagaac agatgtttta tgtgtagaaa gaaagttggc
      961 cttacagggt ttgactgccg atgtggaaat ttgttttgtg gacttcaccg ttactctgac
     1021 aagcacaact gtccatatga ttacaaagca gaagctgcag caaaaatcag aaaagaaaat
     1081 ccagttgttg tggctgaaaa aatccagaga atataaaatt actacatgtg aagagactga
     1141 aactttgttt ttattttaat atatcgtagg aaaacattaa agagcagatg catggccatt
     1201 ttcctttgat gttctccaga gttttgcttt atacttgtct gtcatataat tgatctttta
     1261 ggatgtttgg gtgtttgtta caggcagaat tggatagata cagccctaca aatgtatatg
     1321 ccctcccctc agtaaaattg gacaaaaata tgcacaacaa attgaaatac acatatacta
     1381 ggaacaaaat ttagttccac gtgccaaact aaaggaatga aatctctgca tgtttgcagc
     1441 atatctgcct tttgggaatg taatcaaggt ataatctttg gctagtgtta tgtgcctgta
     1501 cttaaaaaaa aaaaaatggt acaccagaaa aggactggca gtctactacc atagtcaaac
     1561 ttcaccttaa tttcgacatg acttttggaa gcaggaagaa agctacaaaa ctggtatttg
     1621 gtaccatgtg tgagcctggt taaattggtc ttctaaaagc tgtcaattag gacattctgc
     1681 gaaaggtaac atcacaactg gttctaagtc aaaccatcaa gtcaacagca gggtgcctga
     1741 gataatcttg gaagcttatt gtgctggcct gcaccagaag atatctgcat tctcattact
     1801 aaaattgtag cacagaactg cactaggatt tgtttacaag gagaaattaa actctgtttg
     1861 gttttcacat atagcagctc tgttaaataa catgcatctg aattttaagt tgcaaaggta
     1921 tctgaacagt taatttttca tgtgcatctt ttgttgaatg ttttggttca agaaagaatg
     1981 tttaaagctt tttaaagact tcagttctta atgtaactgt acccttctgc atggaaaatc
     2041 ataaccaaca tggctgcagt agacttcttt agtggtatcc agcaccactt gcagagggct
     2101 gctttatcat attgtacttg ggtgtaggac tctagtgttc ttgggtgtat tgcatgggct
     2161 gcattatcta cagcattgta caataacaac tagaaaaggc ggtatacttc actgatgctt
     2221 gtctggtaat atcacttctg tgttaaaatg gaaggttttt tgtgatgtat gaaacttgtg
     2281 ttttttatat ataaatgagt atagttagat tagtgttgtg gtaatgcctg ttttcatctg
     2341 taaatagtta agtatgtaca caacaaggca ctacttctga tttttgcagt gttcagtcct
     2401 agtttttctt tattaaaaca ttgagttttg cttcaatttt atgtacctta gttctaagtt
     2461 agatttgcag atgtgtacag atagttcata tttatgtatt gcacataatc atgctattca
     2521 gcattgatgc tatattgtat tatgtaaata ataaaagcag tgtacagagg gagacttctt
     2581 gtttattggg tttttaagtc ttagacacct aaatagggaa aataggaaag ttttcatatt
     2641 caaatttatt tcatatagct ttgtattgca gttgttttgc atgatcattc ttgagttcag
     2701 tcatgggaat gccatgagct ggtcatgaat cttaagtgtg gcatatgata ggcaaatttt
     2761 gaagagtgag taggcaccat taatatgaag tggtcctaaa atatgaaaaa ggaatgaaat
     2821 ttaaataatg ctttaccccg ctcctatgtt gtgtttgtct ggttaaataa tcctgaatga
     2881 gaatgtaggt agttttgttt taaacagcag cagttacttt attctgtagg gttttggata
     2941 tgatgtagag aggagaaaac ctaattcaat gcaggtattg tgcttagatg aaatattaaa
     3001 tgctccagac cacctaaagt caagaataga accattgctt ttcagaggtg actttagagc
     3061 agaaataatg tgattcgtgt ccacccactc ttgaatacaa ttaaatgaag tataaatgtt
     3121 tgacaaaatc catgtattga acagtagtaa cccccctcag tctgcggggt attgcattgg
     3181 ttgagttgaa aatgaggcgt tttaaagaaa acttgtttta aaatgactac tgtccacagg
     3241 tgtcaacaaa tgcttgatgc tttactgttt ttttgtttgt tggactgaac caaaagtctc
     3301 atgcatgcta aaggaagtgc tcttttgagt gtcgtgtggg agttaatggt agactcttgc
     3361 tctctcctca gtgtgtgaac gcttcagtat acaatagtga ttgtataatc atattttggg
     3421 gcagagagtg atgttggggt cctaacccta gttcacagtg cagcctaagt taccctattc
     3481 cttgtgatcc tgccttagct tgcagagtcc taaagttata ggaatgagct cttgactata
     3541 caaacacaca cacaggattt ggctttacat aatttgtcag gaacgttcac cagggagaat
     3601 aatttcagtg tgtaaggcac caggggagat ttgagttctt cctagactct tggacttaga
     3661 aagtgtgtct cattccagac tgagttagct gctatgcaca ttgaaattaa gtgttaggta
     3721 aatagggagg tctttgcatg taatctagtg ggtctcacct ggaaagcttg ggcttctaaa
     3781 gcagtgaatg gttagcaaaa ctaggctggc tttgtttttt gtggtgctaa ggatcctaaa
     3841 ccacactgcc ctgcttcaga taacacctaa ttcaggaata tcaagaaagc acttaaaatg
     3901 gttctgctac cataccacta cttgctagtt actttctcag gatgagtctt agaacttgaa
     3961 tgaaacaatg aatttggttg cctgaagcta ccttagaggc caagatctgt agctttgttt
     4021 ttgatcttga aatggactcc ctttgtaccc taggctggtc ttgaactggt ggtaatcatg
     4081 tttgagactg ccaactgtag ttgtaacagc caggctgtct tagactccca ccatcagcat
     4141 tttaagtgtt gagttacaga tgtgagctgc catgcctcac ttaagatctc taactttcac
     4201 ataaagtaat tggaggtgtt cttctgagtt aggttttctt gaaagatgtc tacattaaag
     4261 ttcctgttaa ctctggacag ggaaatgcca attaaaatag caaaatgcta atcatctggc
     4321 tttgttttta tatgttctta gggtttcaat atggatatat gaaatttcag tttgtcccat
     4381 atccaccacg tgaaatgtgt gtattttagt tctttattct ctgtaaatac ctgcttatta
     4441 tgtacaaatt catgtgtctt catttgaaat aattcttaaa gtgggtgcca tctgtagtat
     4501 taggtcttag ctttggagag gtaactcagc aactggctgt gcttggtgct cttccttagg
     4561 aactcctaac acttaggaca cactacacat ggctgccacc aagcctaacc tggacttgat
     4621 ccccaggacc cagagaactg cttatccttt gacttgtatg caagcattca caatataaaa
     4681 ctaaaacttg cgagtcctgt ttttatattc ccttagacta catttctttc tgtccaagta
     4741 aaaatgagtt ttgtagagta aatgtaaatc catcttgatc atggcagcta ggtgcgcttc
     4801 tttttagaag agatgcattc ttcacatgtc aggtttgagg cagggtccac atatactcat
     4861 ggctgtcctg gacctgtcca tgtaagctgg gctattaatt ttgagattag aatggtgagt
     4921 gctggaatta aaggtgcggg ccacatgaga tacttattag taccaagctg aagaaaattt
     4981 taaattactt ttaagaaaat tgatactctt gaatatttcc ttcagatttt gtttgcaaaa
     5041 agaatttcta ggttttagct aggcatctag ggctttgacc ttctaattcc tgcactccag
     5101 aatgaggatg gcagcaagtt tcaagccagc ctggtttgtt gtaggaagcc tttatgattt
     5161 ggggttattt gtatctgggg tggcgaaaca tacaaaagca gttccatagt taatttgcta
     5221 gtttactcag aattaatagg aaatctttct agtatatttc aaagttcagt caagggcagg
     5281 aactgttaat caaagtctcc gagtgtgtgt gtgtgtcagc actggctcaa actgaatttc
     5341 tcaagcagcc tgtgtgtaaa acccatggca aatttaagtt cactggcctt tattgcacac
     5401 ttgtgttttc ttgttcctcc atcactaaag attgattcaa acatataggt gatgacaatg
     5461 cttgaggctg tctgttgtgt cacatttttg tagttttatg aaagccttag gttttggttt
     5521 tggttttaat tctttgtcca caccgatgag aaaagtactt caccagaatg gtatttctcg
     5581 aggaagcccc acctaggact tagggcatat atctaatata actatataaa ctatatagtg
     5641 tactaagtgg cttctgacat taagctttgg ggttattgtt actgtaaagc cattctgcag
     5701 tagaaacgta ttaaagaatg gttactctgc tatttgtgtt acacattata cagaggtaaa
     5761 ctagatactt ttagagtgcc atctttagtt attcagttaa cataaatatt agattgtgtt
     5821 gaatatctag ggtcacaaca gttttaacac tcctagatat atatcagaaa tatgagaaaa
     5881 aattgtcagg tgatacctat ttgaaacatg ttcaatctac atattgtggt gttggcatgg
     5941 cttttaagca ttgggttgat caagagaata aggctttgcg gtgaattaaa gagtagctta
     6001 tcaattgtta cttaataaat tgagatctgt aattagcagg cagcctgcat tataactggt
     6061 gttcctgctg tgtaaaacat aaggactatg taattcaata ctaagaggat tatacaagta
     6121 aatactagat gaaaaattat aaaagagggt tatactatta cattcctgga gtgctagaac
     6181 caggatatga aatagaaagg tcaaagtaag attgccttta tttaatcaac cctcatctgg
     6241 ctctatctcc cctcaaattt tgttcagaat tttcttaaaa ggttttctgt ggttttaatc
     6301 agaatactag taatttaaat tttttccatg ttaaagccat ggttgttttt taatttggtt
     6361 cttccaacac aatttattca attttactta acttctacca ggtctggttt aggcttagca
     6421 aaatgcagtg tgttgaagca aaacttagaa atggtgggaa tttgcttacc ctagggaaca
     6481 ggtcatgttc agactagagc acccagcact gcatgagttc agttgatgct tttaaaggcc
     6541 gtaccttctt ggaagggatg ataatgcatg gccatagcca tgccatgagc tacagttact
     6601 gaaaacatca ggagcaagtt ggttaggctg acttcccact atctagcagg gaacaaatgc
     6661 tgtggtgtct aagtgctgag gtagcctaaa ttatattcta gccaaactag agtttttctg
     6721 accatcttct ggagtaggga gggtgttttt aaaaagatct ctattaaagt ataccaggag
     6781 ggacactata tttattatat acttatggtt attatagggc taataaccaa aaaaaagaac
     6841 attttaaaat ttacttactc aatatactgt taactgagaa ggtttgtaca atgtttttaa
     6901 ttccttatac aggtgctgaa atagaaattt aagtatatat gtaactttaa atttcttgat
     6961 aaccacatcc taaataataa aaagggtgaa attagttttt gtgtattttt acttagccca
     7021 gtatatccaa agtcatatca gtatcccagc acttgggaga cagtaggcag atctcttgtc
     7081 tgtttgaggc catcttggtt tatatgagtc ccaggccagg ctgagctgca cagtgagatt
     7141 ttacctaaaa ataaagcctg tgactgctta acttaagtta cttcctcttt tgcaccttag
     7201 tgccttcatc tgtatagatt aagtgatggt gtggttaatg ggttgagtag caaacgcact
     7261 attaaatgta gttaaaatgt agtaagaatt tactatgtct ctttaaaatt gacataaaca
     7321 cacacataca tatatttgtc tgtgtttgtg tgggtatata ttatgttcaa gtgtactcag
     7381 aggcc
//
