LOCUS       NM_001159905            1206 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus zinc finger, AN1 type domain 2B (Zfand2b), transcript
            variant 2, mRNA.
ACCESSION   NM_001159905
VERSION     NM_001159905.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1206)
  AUTHORS   Rahighi,S., Braunstein,I., Ternette,N., Kessler,B., Kawasaki,M.,
            Kato,R., Matsui,T., Weiss,T.M., Stanhill,A. and Wakatsuki,S.
  TITLE     Selective Binding of AIRAPL Tandem UIMs to Lys48-Linked
            Tri-Ubiquitin Chains
  JOURNAL   Structure 24 (3), 412-422 (2016)
   PUBMED   26876100
  REMARK    GeneRIF: Study demonstrates specificity of AIRAPL for Lys48-linked
            tri-ubiquitin chains triggered by intrinsic selectivity of its
            double-sided UIM (UIM2) for Lys48 linkage and a flexible inter-UIM
            linker that results in an overall conformation which confers
            simultaneous binding of tUIMs to three consecutive ubiquitin
            moieties in a Lys48-linked chain.
REFERENCE   2  (bases 1 to 1206)
  AUTHORS   Osorio,F.G., Soria-Valles,C., Santiago-Fernandez,O., Bernal,T.,
            Mittelbrunn,M., Colado,E., Rodriguez,F., Bonzon-Kulichenko,E.,
            Vazquez,J., Porta-de-la-Riva,M., Ceron,J., Fueyo,A., Li,J.,
            Green,A.R., Freije,J.M. and Lopez-Otin,C.
  TITLE     Loss of the proteostasis factor AIRAPL causes myeloid
            transformation by deregulating IGF-1 signaling
  JOURNAL   Nat Med 22 (1), 91-96 (2016)
   PUBMED   26692333
  REMARK    GeneRIF: AIRAPL-deficient mice develop a fully-penetrant
            myeloproliferative neoplastic process via dysregulation of
            IGF1/IGF1R.
REFERENCE   3  (bases 1 to 1206)
  AUTHORS   Glinka,T., Alter,J., Braunstein,I., Tzach,L., Wei Sheng,C.,
            Geifman,S., Edelmann,M.J., Kessler,B.M. and Stanhill,A.
  TITLE     Signal-peptide-mediated translocation is regulated by a p97-AIRAPL
            complex
  JOURNAL   Biochem J 457 (2), 253-261 (2014)
   PUBMED   24160817
REFERENCE   4  (bases 1 to 1206)
  AUTHORS   Yun,C., Stanhill,A., Yang,Y., Zhang,Y., Haynes,C.M., Xu,C.F.,
            Neubert,T.A., Mor,A., Philips,M.R. and Ron,D.
  TITLE     Proteasomal adaptation to environmental stress links resistance to
            proteotoxicity with longevity in Caenorhabditis elegans
  JOURNAL   Proc Natl Acad Sci U S A 105 (19), 7094-7099 (2008)
   PUBMED   18467495
REFERENCE   5  (bases 1 to 1206)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX217579.1, AK151430.1 and BX633014.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three transcripts encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI414235.1, BI415741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-682               CX217579.1         4-685
            683-1199            AK151430.1         719-1235
            1200-1206           BX633014.1         1-7                 c
FEATURES             Location/Qualifiers
     source          1..1206
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.61 cM"
     gene            1..1206
                     /gene="Zfand2b"
                     /gene_synonym="1110060O18Rik"
                     /note="zinc finger, AN1 type domain 2B"
                     /db_xref="GeneID:68818"
                     /db_xref="MGI:MGI:1916068"
     exon            1..62
                     /gene="Zfand2b"
                     /gene_synonym="1110060O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            63..138
                     /gene="Zfand2b"
                     /gene_synonym="1110060O18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..857
                     /gene="Zfand2b"
                     /gene_synonym="1110060O18Rik"
                     /note="AIRAP-like protein; arsenite-inducible
                     RNA-associated protein-like protein"
                     /codon_start=1
                     /product="AN1-type zinc finger protein 2B"
                     /protein_id="NP_001153377.1"
                     /db_xref="CCDS:CCDS15064.1"
                     /db_xref="GeneID:68818"
                     /db_xref="MGI:MGI:1916068"
                     /translation="MEFPDLGAHCSEPSCQRLDFLPLKCDACSGIFCADHVAYAQHHC
                     GSAYQKDIQVPVCPLCNVPVPVARGEPPDRAVGEHIDRDCRSDPAQQKRKIFTNKCER
                     SGCRQREMMKLTCDRCGRNFCIKHRHPLDHECSGEGHQTSRAGLAAISRAQGLASTST
                     APSPSRTLPSSSSPSRATPQLPTRTASPVIALQNGLSEDEALQRALELSLAEAKPQVL
                     SSQEEDDLALAQALSASEAEYQQQQAQSRSLKPSNCSLC"
     exon            139..233
                     /gene="Zfand2b"
                     /gene_synonym="1110060O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            234..365
                     /gene="Zfand2b"
                     /gene_synonym="1110060O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            366..517
                     /gene="Zfand2b"
                     /gene_synonym="1110060O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            518..610
                     /gene="Zfand2b"
                     /gene_synonym="1110060O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            611..671
                     /gene="Zfand2b"
                     /gene_synonym="1110060O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            672..739
                     /gene="Zfand2b"
                     /gene_synonym="1110060O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            740..812
                     /gene="Zfand2b"
                     /gene_synonym="1110060O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1203
                     /gene="Zfand2b"
                     /gene_synonym="1110060O18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1180..1185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfand2b"
                     /gene_synonym="1110060O18Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      1201
                     /gene="Zfand2b"
                     /gene_synonym="1110060O18Rik"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcgcg agccctcggg aggaggagta ggggctgcgg gccggcggac gctcaggctt
       61 cgcaggcccc gcacggccag gcgatggagt ttccggacct cggggctcac tgttccgagc
      121 cgagctgtca gcgcttggat tttttgccac tcaagtgcga tgcctgctcg ggcatcttct
      181 gcgcagacca tgtggcctac gcccagcatc actgtggatc agcttaccaa aaggatatcc
      241 aggtacctgt gtgccctctc tgtaatgtgc ctgtgccggt ggccagagga gagcctcctg
      301 accgtgctgt gggagagcac attgacagag actgtcgttc tgacccagca cagcaaaaac
      361 gcaagatctt caccaataag tgtgaacgtt ctggctgccg gcagcgggag atgatgaaac
      421 tgacttgtga tcgctgtggc cgaaacttct gcatcaagca ccgtcatccc ctggaccatg
      481 aatgctctgg ggaaggtcat cagaccagca gggcagggct tgctgctatt tctagagcac
      541 aaggtctggc ttctacaagc accgccccca gtccaagccg gaccttgcct tcatcatcct
      601 ccccaagcag agctacaccc cagcttccaa ccaggacagc ctctcctgtt attgctttgc
      661 agaatggctt gagtgaggat gaggccctgc agcgtgccct ggaactgtcc cttgcggagg
      721 ctaaacccca ggttctaagt tctcaggagg aagacgactt ggcgttagca caggcactgt
      781 cagccagtga ggcagaatac caacagcagc aggcgcagag tcgtagcttg aagccgtcca
      841 actgcagcct gtgctagggc cctgggcttg gggagagagg ctcacccaag gactgtgacc
      901 ctcacatctc cagggtccac agggaaagga agcacagaga agcctggaca gcagtgccaa
      961 gcaggagtga cgtggaggac gctccatgga gcccggagag gaaggacact catgcagcta
     1021 agctagctct gctgctgcag aagagggtgg ccgggaagtg ctctctggtt ggggccttgg
     1081 taggtgctaa ccagactcaa tccctacagc ctttttcatc atgttactcc cttttccctg
     1141 gggctgccac atgtagcaga cagggagagg gccgggaaga gtaaagactg gcaatcagta
     1201 agaaaa
//
