LOCUS       NM_001159908            3180 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus zinc finger, AN1-type domain 2A (Zfand2a), transcript
            variant 2, mRNA.
ACCESSION   NM_001159908
VERSION     NM_001159908.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3180)
  AUTHORS   Sukenik,S., Braunstein,I. and Stanhill,A.
  TITLE     An Arsenite Relay between PSMD14 and AIRAP Enables Revival of
            Proteasomal DUB Activity
  JOURNAL   Biomolecules 11 (9), 1317 (2021)
   PUBMED   34572530
  REMARK    GeneRIF: An Arsenite Relay between PSMD14 and AIRAP Enables Revival
            of Proteasomal DUB Activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3180)
  AUTHORS   Zach,L., Braunstein,I. and Stanhill,A.
  TITLE     Stress-induced start codon fidelity regulates arsenite-inducible
            regulatory particle-associated protein (AIRAP) translation
  JOURNAL   J Biol Chem 289 (30), 20706-20716 (2014)
   PUBMED   24898249
  REMARK    GeneRIF: arsenite- inducible regulatory particle-associated protein
            (AIRAP) transcript to be translationally induced during arsenite
            stress conditions.
REFERENCE   3  (bases 1 to 3180)
  AUTHORS   Li,H., Bishop,K.M. and O'Leary,D.D.
  TITLE     Potential target genes of EMX2 include Odz/Ten-M and other gene
            families with implications for cortical patterning
  JOURNAL   Mol Cell Neurosci 33 (2), 136-149 (2006)
   PUBMED   16919471
REFERENCE   4  (bases 1 to 3180)
  AUTHORS   Stanhill,A., Haynes,C.M., Zhang,Y., Min,G., Steele,M.C.,
            Kalinina,J., Martinez,E., Pickart,C.M., Kong,X.P. and Ron,D.
  TITLE     An arsenite-inducible 19S regulatory particle-associated protein
            adapts proteasomes to proteotoxicity
  JOURNAL   Mol Cell 23 (6), 875-885 (2006)
   PUBMED   16973439
  REMARK    GeneRIF: AIRAP adapts the cell's core protein degradation machinery
            to counteract proteotoxicity induced by an environmental toxin.
REFERENCE   5  (bases 1 to 3180)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 3180)
  AUTHORS   Sok,J., Calfon,M., Lu,J., Lichtlen,P., Clark,S.G. and Ron,D.
  TITLE     Arsenite-inducible RNA-associated protein (AIRAP) protects cells
            from arsenite toxicity
  JOURNAL   Cell Stress Chaperones 6 (1), 6-15 (2001)
   PUBMED   11525245
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ083782.1, CJ148035.1, AF224494.1, BU840945.1 and BC058780.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF224494.1, SRR1660813.241447.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                CJ083782.1         59-156
            99-103              CJ148035.1         105-109
            104-1236            AF224494.1         1-1133
            1237-1240           BU840945.1         607-610
            1241-3180           BC058780.1         1176-3115
FEATURES             Location/Qualifiers
     source          1..3180
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 78.68 cM"
     gene            1..3180
                     /gene="Zfand2a"
                     /gene_synonym="Airap"
                     /note="zinc finger, AN1-type domain 2A"
                     /db_xref="GeneID:100494"
                     /db_xref="MGI:MGI:2140729"
     exon            1..215
                     /gene="Zfand2a"
                     /gene_synonym="Airap"
                     /inference="alignment:Splign:2.1.0"
     exon            216..311
                     /gene="Zfand2a"
                     /gene_synonym="Airap"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..772
                     /gene="Zfand2a"
                     /gene_synonym="Airap"
                     /note="arsenite inducible RNA associated protein"
                     /codon_start=1
                     /product="AN1-type zinc finger protein 2A"
                     /protein_id="NP_001153380.1"
                     /db_xref="CCDS:CCDS19812.1"
                     /db_xref="GeneID:100494"
                     /db_xref="MGI:MGI:2140729"
                     /translation="MEFPDLGKHCSEPTCKQLDFLPITCDACKQDFCKDHFSYVGHKC
                     PFAFKKDVQVPVCPLCNAPIPVKRGEIPDVVVGEHMDRDCTFHPGRNRNKVFTHRCSK
                     EGCRKKEMLQLACAQCHGNFCIQHRHPLDHNCQAGSSSASRGRTSTSRAAEQKPSGVS
                     WLAQRLRRTVK"
     exon            312..406
                     /gene="Zfand2a"
                     /gene_synonym="Airap"
                     /inference="alignment:Splign:2.1.0"
     exon            407..538
                     /gene="Zfand2a"
                     /gene_synonym="Airap"
                     /inference="alignment:Splign:2.1.0"
     exon            539..690
                     /gene="Zfand2a"
                     /gene_synonym="Airap"
                     /inference="alignment:Splign:2.1.0"
     exon            691..756
                     /gene="Zfand2a"
                     /gene_synonym="Airap"
                     /inference="alignment:Splign:2.1.0"
     exon            757..3095
                     /gene="Zfand2a"
                     /gene_synonym="Airap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3072..3077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfand2a"
                     /gene_synonym="Airap"
                     /note="hexamer: AATAAA"
     polyA_site      3095
                     /gene="Zfand2a"
                     /gene_synonym="Airap"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtcatca gagcgcgccg ggaacgccca ggatgtatga ctctggatct gtcggctggg
       61 gataaatggc ccaggctgct gcaggggcaa tgctacgctt tccggccttg agagaagtcg
      121 ggcgcttcgc ggcgattgga gctgcagttt ctactgcggt gtcaccggga taaccacaaa
      181 gggcaccgct tgtctgtctc cgcctctgac tacccgtgat acttaaatac atctgtgttt
      241 ttggacagca tttataatgg agtttcctga cttggggaag cactgttcag aaccaacttg
      301 caaacagcta gattttctgc caataacatg cgacgcctgt aaacaagatt tctgtaaaga
      361 ccatttttcc tacgtgggtc ataagtgtcc ctttgcgttc aagaaggatg tgcaggtgcc
      421 tgtgtgtcct ctctgcaatg cccccatccc tgtgaagaga ggtgagatcc cagatgtggt
      481 ggtcggcgag cacatggaca gagattgcac ctttcaccct gggaggaaca gaaacaaggt
      541 tttcacacat cgctgctcca aagagggatg caggaagaag gagatgctgc agctggcgtg
      601 tgctcagtgc catggcaact tctgcattca gcacaggcat cctctggacc acaattgcca
      661 ggctgggagc agctcagcca gcagagggag gacttctaca tccagagctg ctgagcagaa
      721 gccatcggga gtcagttggc tggcccagcg gctcaggcgc acagtgaagt gacagcgagt
      781 ctcctgtggg tgccacacac cagctccttc ctgttggatt ttgatcttgg gacgtgtcct
      841 ccaacacttt tcctgcttct tctgcatctg agtctttata gaagagtctc ccattgactg
      901 ttcaagttac ggtgaattga tggctcagtg gggaaagcac ttgccccaca ggcatgagga
      961 cctgagttca tccccagaac tggatgtgac tggtgtacac ttgtcatctc agcacttggg
     1021 aggtggtgag aggaaaatct ccagggcttt ctgaccagca gcctagccat attggaaagt
     1081 tccaggccag aaagacgctg cctcaaaaac caaggtggac actttctgtg gagggacatc
     1141 agaagttcac ctctggcctc acacccacac ccacacaccc acttgtgtat acacacacac
     1201 acacacacac acacacacac acacacacac acacacacac gaggctgtcc agcaacttct
     1261 tggggtgggt taggttacca tagcaaacag ctgcagggtt caaggcctga ggacttgctt
     1321 aactctcctc agtggtggct ttggcctgtg ctaaacctct ccaggacttg gtattccaga
     1381 aaattctgtc ctgtgacaga aaagaaccac cgtctgctct gtattctccc ctccatggct
     1441 tttgtaataa ggtgcctttg ggcacagtct actcatggtc cccaagaaca agagtggacg
     1501 gggtgccctt tccttacctc tggctgggga tgctatggag gaagggtgtg cacttggcct
     1561 gcagtgatgt ctccaaggtt gacttaagca accagcctca ccatgccagg actccgcatg
     1621 cctggcttca ggctgttttg tggtttgagg cagtgtctca ctgtggagcc ctggctgtca
     1681 tggaactcac cctgtagacc acactggcct tgaactcagt gatccccctg actctgcctc
     1741 ccaagcgtgg attcactttt aactcccaag aagagcacca agaaatgaga gccatttcag
     1801 aaatgtctgg ttttgccata gaagcttctc ctcttcgtgc cgaatcccca tggcagcagg
     1861 ctgagggtgt cctcagcact ttgtggagca gaaacccaga cagaagaaaa gcagtggttc
     1921 tgggccttgg ggtgcagcca ccatcactcc tgtgccacct gtgtggcctg aaccatgtct
     1981 acccccaaat ggccatggca gtgtagggga agatgcttgg ggtactctgg tgacctgtat
     2041 aagcgtttac cctcactttc caggagcttg gctattagag atgacatggg accaaccacc
     2101 cagcgggttt tgactttcgc ccttagttct gacagccttt gggacagtta actgcatgaa
     2161 ttccatacat agcagctttg tgcagggttc gtggcctcta gctgtcatgg gaggcagggg
     2221 tgggttctac tcactctgtt ctctaagcca gtgcctctcg tcacatcagt ccagctctag
     2281 actcatcggt gcactcatcc tggccccagt gcctggttag atcggggggt ggggggctgg
     2341 gggggtattt gcttttagaa caaggtctag gcagtggtgc tatgtgggga cattgagaca
     2401 aaccaatctt ttgtacttcc acttcccagc actctttcat ggtggtacac acttgaggta
     2461 tagctagcat aacaaagctt ttgattcaac ttaagtttta aaactactgg gttcaataat
     2521 taggcagtgt ttaaaagggg agttggatat atacgtctcc gtcctaacca tggtatgcaa
     2581 tagtgtttcc actgagatga ctctaagttg gaaattaaaa gcacactggg cgggctgggg
     2641 aatggtccag tgattaggag cctgaacctc tctgcagagg accagagttt ggttcccagc
     2701 accacccata ttagatggct cacaactatg tgttaacctc agctccaggg gcaaatgatg
     2761 cctctgagct ctgggccttg cactcacatg cccatgttct taaacatgaa ttcggaagta
     2821 cagtggcaaa ggttagagcc tagcgttgtg ggttaaccct tacccagagc ccaccagtga
     2881 ggagctgggg ccacaattca atagaagagc acttgccaag aacccctcgg gcctggttta
     2941 gtggagtacc tgcctgtcat gtcatcaggc ctcagattct ctccctactg caaggaagca
     3001 aaatcaccag gctttagaga caatatcaaa tgcaagacat tgtgtgttga aatatcttat
     3061 gtataatggt taataaaaat tatttatttc acccaaaaaa aaaaaaaaaa aaaaaaaaaa
     3121 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
