LOCUS       NM_001355290            9228 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus zinc finger E-box binding homeobox 2 (Zeb2),
            transcript variant 6, mRNA.
ACCESSION   NM_001355290 XM_017318065
VERSION     NM_001355290.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9228)
  AUTHORS   Thiruppathy,M., Teubner,L., Roberts,R.R., Lasser,M.C.,
            Moscatello,A., Chen,Y.W., Hochstim,C., Ruffins,S., Sarkar,A.,
            Tassey,J., Evseenko,D., Lozito,T.P., Willsey,H.R., Gillis,J.A. and
            Crump,J.G.
  TITLE     Repurposing of a gill gene regulatory program for outer-ear
            evolution
  JOURNAL   Nature (2025) In press
   PUBMED   39788155
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 9228)
  AUTHORS   Gladka,M.M., Kohela,A., de Leeuw,A.E., Molenaar,B., Versteeg,D.,
            Kooijman,L., van Geldorp,M., van Ham,W.B., Caliandro,R.,
            Haigh,J.J., van Veen,T.A.B. and van Rooij,E.
  TITLE     Hypoxia-responsive zinc finger E-box-binding homeobox 2 (ZEB2)
            regulates a network of calcium-handling genes in the injured heart
  JOURNAL   Cardiovasc Res 120 (15), 1869-1883 (2024)
   PUBMED   39308239
REFERENCE   3  (bases 1 to 9228)
  AUTHORS   Cai,Y., Zhou,J., Xu,A., Huang,J., Zhang,H., Xie,G., Zhong,K.,
            Wu,Y., Ye,P., Wang,H. and Niu,H.
  TITLE     N6-methyladenosine triggers renal fibrosis via enhancing
            translation and stability of ZEB2 mRNA
  JOURNAL   J Biol Chem 300 (9), 107598 (2024)
   PUBMED   39059495
  REMARK    GeneRIF: N6-methyladenosine triggers renal fibrosis via enhancing
            translation and stability of ZEB2 mRNA.
REFERENCE   4  (bases 1 to 9228)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   5  (bases 1 to 9228)
  AUTHORS   Knox,J.J. and Cancro,M.P.
  TITLE     ABCs begin with ZEB2
  JOURNAL   Immunol Cell Biol 102 (4), 229-231 (2024)
   PUBMED   38525813
  REMARK    GeneRIF: ABCs begin with ZEB2.
REFERENCE   6  (bases 1 to 9228)
  AUTHORS   Yamada,K., Yamada,Y., Nomura,N., Miura,K., Wakako,R., Hayakawa,C.,
            Matsumoto,A., Kumagai,T., Yoshimura,I., Miyazaki,S., Kato,K.,
            Sonta,S., Ono,H., Yamanaka,T., Nagaya,M. and Wakamatsu,N.
  TITLE     Nonsense and frameshift mutations in ZFHX1B, encoding
            Smad-interacting protein 1, cause a complex developmental disorder
            with a great variety of clinical features
  JOURNAL   Am J Hum Genet 69 (6), 1178-1185 (2001)
   PUBMED   11592033
REFERENCE   7  (bases 1 to 9228)
  AUTHORS   Tylzanowski,P., Verschueren,K., Huylebroeck,D. and Luyten,F.P.
  TITLE     Smad-interacting protein 1 is a repressor of liver/bone/kidney
            alkaline phosphatase transcription in bone morphogenetic
            protein-induced osteogenic differentiation of C2C12 cells
  JOURNAL   J Biol Chem 276 (43), 40001-40007 (2001)
   PUBMED   11477103
REFERENCE   8  (bases 1 to 9228)
  AUTHORS   Cacheux,V., Dastot-Le Moal,F., Kaariainen,H., Bondurand,N.,
            Rintala,R., Boissier,B., Wilson,M., Mowat,D. and Goossens,M.
  TITLE     Loss-of-function mutations in SIP1 Smad interacting protein 1
            result in a syndromic Hirschsprung disease
  JOURNAL   Hum Mol Genet 10 (14), 1503-1510 (2001)
   PUBMED   11448942
REFERENCE   9  (bases 1 to 9228)
  AUTHORS   Zwijsen,A., van Grunsven,L.A., Bosman,E.A., Collart,C., Nelles,L.,
            Umans,L., Van de Putte,T., Wuytens,G., Huylebroeck,D. and
            Verschueren,K.
  TITLE     Transforming growth factor beta signalling in vitro and in vivo:
            activin ligand-receptor interaction, Smad5 in vasculogenesis, and
            repression of target genes by the deltaEF1/ZEB-related SIP1 in the
            vertebrate embryo
  JOURNAL   Mol Cell Endocrinol 180 (1-2), 13-24 (2001)
   PUBMED   11451567
  REMARK    Review article
REFERENCE   10 (bases 1 to 9228)
  AUTHORS   Verschueren,K., Remacle,J.E., Collart,C., Kraft,H., Baker,B.S.,
            Tylzanowski,P., Nelles,L., Wuytens,G., Su,M.T., Bodmer,R.,
            Smith,J.C. and Huylebroeck,D.
  TITLE     SIP1, a novel zinc finger/homeodomain repressor, interacts with
            Smad proteins and binds to 5'-CACCT sequences in candidate target
            genes
  JOURNAL   J Biol Chem 274 (29), 20489-20498 (1999)
   PUBMED   10400677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935127.9 and AL929120.7.
            
            On Oct 29, 2022 this sequence version replaced NM_001355290.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.196355.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AL935127.9         26418-26445         c
            29-298              AL935127.9         26005-26274         c
            299-449             AL935127.9         24202-24352         c
            450-591             AL935127.9         23198-23339         c
            592-849             AL929120.7         112546-112803       c
            850-921             AL929120.7         107096-107167       c
            922-1110            AL929120.7         92215-92403         c
            1111-1325           AL929120.7         91299-91513         c
            1326-1434           AL929120.7         88583-88691         c
            1435-3404           AL929120.7         85725-87694         c
            3405-3585           AL929120.7         84178-84358         c
            3586-9228           AL929120.7         73210-78852         c
FEATURES             Location/Qualifiers
     source          1..9228
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 27.31 cM"
     gene            1..9228
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /note="zinc finger E-box binding homeobox 2"
                     /db_xref="GeneID:24136"
                     /db_xref="MGI:MGI:1344407"
     exon            1..28
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /inference="alignment:Splign:2.1.0"
     exon            29..298
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /inference="alignment:Splign:2.1.0"
     exon            299..449
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /inference="alignment:Splign:2.1.0"
     exon            450..591
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             519..4166
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /note="smad-interacting protein 1; zinc finger homeobox
                     protein 1b"
                     /codon_start=1
                     /product="zinc finger E-box-binding homeobox 2"
                     /protein_id="NP_001342219.1"
                     /db_xref="CCDS:CCDS16020.1"
                     /db_xref="GeneID:24136"
                     /db_xref="MGI:MGI:1344407"
                     /translation="MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDAGSETDEEDKL
                     HIAEDDSLANPLDQDTSPASMPNHESSPHMSQGLLPREEEEEELRESVVEHSWHSGEI
                     LQASVAGPEEMKEDYDAMGPEATIQTTINNGTVKNANCTSDFEEYFAKRKLEERDGHA
                     VSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDR
                     GYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQG
                     AGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKC
                     IGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKT
                     EPLDFNDYKVLMATHGFSGSSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGF
                     PTMNSNLSEVQKVLQIVDNTVSRQKMDCKTEDISKLKGYHMKDPCSQPEEQGVTSPNI
                     PPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLV
                     TDDKMIENHSISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNK
                     AGVFVDNKALLLSSVLSEKGLTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVG
                     LPQEFVKEWFEQRKVYQYSNSRSPSLERTSKPLAPNSNPTTKDSLLPRSPVKPMDSIT
                     SPSIAELHNSVTSCDPPLRLTKSSHFTNIKAVDKLDHSRSNTPSPLNLSSTSSKNSHS
                     SSYTPNSFSSEELQAEPLDLSLPKQMREPKGIIATKNKTKATSINLDHNSVSSSSENS
                     DEPLNLTFIKKEFSNSNNLDNKSNNPVFGMNPFSAKPLYTPLPPQSAFPPATFMPPVQ
                     TSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGDLLDGAQDY
                     MSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQ
                     ICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEER
                     EAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEE
                     GYGKLRRRDGDEEEEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSD
                     HEEDNMEDGME"
     exon            592..849
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /inference="alignment:Splign:2.1.0"
     exon            850..921
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1110
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1325
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1434
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..3404
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3405..3585
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..9228
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5222..5227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /note="hexamer: AATATA"
     polyA_site      5248
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /note="major polyA site"
     regulatory      5597..5602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /note="hexamer: AATAAA"
     polyA_site      5618
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /note="major polyA site"
     regulatory      8909..8914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /note="hexamer: AGTAAA"
     regulatory      8927..8932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /note="hexamer: AACAAA"
     polyA_site      8932
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
     polyA_site      8946
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
     regulatory      9010..9015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /note="hexamer: AATAAA"
     polyA_site      9037
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
     regulatory      9080..9085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /note="hexamer: AATAAA"
     polyA_site      9103
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
     regulatory      9205..9210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
                     /note="hexamer: AAGAAA"
     polyA_site      9228
                     /gene="Zeb2"
                     /gene_synonym="9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b;
                     Zfx1b; Zfxh1b"
ORIGIN      
        1 ccactaaagc gtttgcggag acttcaagaa aagaaaaaga aaaaaatgtc attagaagag
       61 gcgtaacacg tcagtccgtc cccaggtttg tgtttcctgg agtggccgaa aagagatcag
      121 ttctaacctg ctcggcagga ataacggtcc tgcctccaga cactcttggc gaggttttgt
      181 tcagtttgct ccgggagctg tttcttcgcc tccacctttt tctcccccac acttcgcggc
      241 ttcttcatgc tttttcttct caccatttct ggccaaaact acaaacaaga cttcacagcc
      301 cgctgtttaa actaatcctc gaggcacagc gtcttcccac cccgcggagt ttcagggctc
      361 tcctcttctc cggcctgcct ccgaggttcc ccttctccaa gttttgacag tttgagctga
      421 aagaatgcag cgcctccctc gatttttaga tcgagcctgc gtgctgccga agcagggcgc
      481 cgagtccatg cgaactgcca tctgatccgc tcttatcaat gaagcagccg atcatggcgg
      541 atggcccccg gtgcaagagg cgcaaacaag ccaatcccag gaggaaaaac gtggtgaact
      601 atgacaacgt agtggacgca ggctcggaga cagatgaaga ggacaagctt cacattgctg
      661 aagatgatag ccttgcaaac cctctggacc aggacaccag cccagctagc atgcccaacc
      721 atgagtcctc cccacacatg agccaagggc tgctaccaag agaggaagaa gaggaggagc
      781 taagggagag tgttgtggag cacagctggc acagtggcga gattctgcaa gcctctgtag
      841 ccggtccaga agaaatgaag gaagattatg atgcaatggg gccagaagcc acgatccaga
      901 ccacaattaa caatggtaca gttaagaatg caaattgcac atcagacttt gaggaatact
      961 ttgccaaaag aaaactggag gaaagagatg gccacgcagt gagcatcgaa gagtaccttc
     1021 agcgaagcga cacggccatt atttacccag aagcccctga ggagctgtct cgccttggca
     1081 cgccagaggc caacgggcaa gaagaaaatg acctgccacc tggaactcca gatgcttttg
     1141 cccaactgct gacctgcccc tactgcgacc gcggctacaa gcgcttgaca tcgctgaagg
     1201 agcacatcaa gtaccgccac gagaagaatg aagagaactt ttcctgccct ctttgtagct
     1261 acacgttcgc ctaccgcacc cagctcgaga ggcatatggt gacgcacaag ccagggacag
     1321 atcagcacca aatgctaacc caaggagcag gtaaccgcaa gttcaagtgc acggagtgtg
     1381 gcaaggcctt caagtacaag caccacctga aagaacacct gagaattcac agtggtgaaa
     1441 aaccttacga atgcccaaac tgcaagaaac gcttctctca ttctgggtcc tacagttcac
     1501 atatcagcag caagaaatgt attggtttaa tatcagtaaa tggccgaatg agaaacaata
     1561 tcaagacggg ttcttcccct aattctgttt cttcttctcc tactaactca gccattactc
     1621 agttaaggaa caagttggaa aatggaaaac cacttagcat gtctgagcag acaggcttac
     1681 ttaagattaa aacagaacca ctagacttca atgactataa agttcttatg gcaacacatg
     1741 ggtttagtgg cagcagtccc tttatgaacg gtgggcttgg agccaccagc cctttaggtg
     1801 tacacccatc tgctcagagt ccaatgcagc acttaggtgt agggatggaa gcccctttac
     1861 ttggatttcc cactatgaat agtaacttga gtgaggtaca aaaggttcta cagattgtgg
     1921 acaatacggt ttctaggcaa aagatggact gcaagacgga agacatttca aagttgaaag
     1981 gttatcacat gaaggatcca tgttctcagc cagaagaaca aggggtaact tctcccaata
     2041 ttccccctgt cggtcttcca gtagtgagtc ataacggtgc cactaaaagt attattgact
     2101 ataccttaga gaaagtcaat gaagccaaag cttgcctcca gagcttgacc accgactcaa
     2161 ggagacagat cagtaacata aagaaagaga agttgcgtac tttgatagat ttggtcactg
     2221 atgataaaat gattgagaac cacagcatat ccactccatt ttcatgccag ttctgtaaag
     2281 aaagcttccc gggccctatt cccctgcatc agcatgaacg atacctgtgt aagatgaatg
     2341 aagagatcaa ggcagtcctg caacctcatg aaaacatagt ccccaacaaa gctggagttt
     2401 ttgttgataa taaagccctc ctcttgtcat ctgtactttc cgagaaagga ctgacaagcc
     2461 ccatcaaccc atacaaggac cacatgtctg tactgaaagc atactatgct atgaacatgg
     2521 agcccaactc tgatgaactg ctgaaaatct ccattgctgt gggccttcct caggaatttg
     2581 tgaaggaatg gtttgagcaa agaaaagtct accagtattc gaattccagg tcaccatcac
     2641 tggaaaggac ctccaagccg ttagctccca acagtaaccc caccacaaaa gactctttgt
     2701 tacccaggtc tcctgtaaaa cctatggact ccatcacatc gccatctata gcagaactcc
     2761 acaacagtgt tacgagttgt gatcctcctc tcaggctaac aaaatcttcc catttcacca
     2821 atattaaagc agttgataaa ctggaccact cgaggagtaa tactccttct cctttaaatc
     2881 tttcctccac atcttctaaa aactcccaca gtagctcgta cactccaaat agcttctctt
     2941 ccgaggagct gcaggctgag ccgttggacc tgtcattacc aaaacaaatg agagaaccca
     3001 aaggtattat agccacaaag aacaaaacaa aagctactag cataaactta gaccacaaca
     3061 gtgtttcttc atcgtctgag aattcagatg agcctctgaa tttgactttt atcaagaaag
     3121 agttttcaaa ttctaataac ctggacaata aaagcaacaa ccctgtgttc ggcatgaacc
     3181 catttagtgc caagccttta tacacccctc ttccaccaca gagcgcattt ccccctgcca
     3241 ctttcatgcc accagtccag accagcatcc ccgggctacg accataccca ggactggatc
     3301 agatgagctt cctaccgcat atggcctata cctacccaac gggagcagct acctttgctg
     3361 atatgcagca aaggaggaaa taccagagga aacaaggatt tcagggagac ttgctggatg
     3421 gagcacaaga ctacatgtca ggcctagatg acatgacaga ctccgattcc tgtctgtctc
     3481 gaaagaagat aaagaagaca gaaagtggca tgtatgcatg tgacttatgt gacaagacat
     3541 tccagaaaag cagttccctt ctgcgacata aatacgaaca cacaggaaag agaccacacc
     3601 agtgtcagat ttgtaagaaa gcgttcaaac acaaacacca ccttatcgag cactcgaggc
     3661 tgcactcggg cgagaagccc tatcagtgtg acaaatgtgg caagcgcttc tcacactcgg
     3721 gctcctactc gcagcacatg aatcacaggt actcctactg caagcgggag gcggaggagc
     3781 gggaagcagc cgagcgcgag gcgcgagaga aagggcactt ggaacccacc gagctgctga
     3841 tgaaccgggc ttacctgcag agcatcaccc ctcaggggta ctctgactcg gaggagaggg
     3901 agagcatgcc gagggatggc gagagcgaga aggagcacga gaaggagggc gaggagggtt
     3961 atgggaagct gcggagaagg gacggcgacg aggaggaaga ggaggaagag gaagaaagtg
     4021 aaaataaaag tatggatacg gatcccgaaa cgatacggga tgaggaagag actggggatc
     4081 actcgatgga cgacagttca gaggatggga aaatggaaac caaatcagac cacgaggaag
     4141 acaatatgga agatggcatg gaataaacta ctgcatttta agcttcctat tttttttttc
     4201 cagtagtatt gttacctgct tgaaaacact gctgtgttaa gctgttcatg cacgtgcctg
     4261 acgcttccag gaagctgtag agagggacag aaggggcagt tcagccaaga cagagttaga
     4321 tggagttgga tattgtttaa aaaaaaaaaa actgcattat gcaaaaattt tgtacagtgt
     4381 taaggcctaa aaactgtgtg gttcagagac taattcctgt gtttaatagc atttatactt
     4441 taagcacaac tagaaaattc taagaattgc actctacgta tgtatcacta caaacttaaa
     4501 aaaaattatg tctaatttat attaatacat tttaaaaggt gcccgcacta ccatacatca
     4561 gtattttatt attattatta ttgttattcc tgtttaattt aatgtgcccg cactacagtg
     4621 catcagtatt acgattcctc aacactttcc tttcgctatt catgaatttc ccattgtttt
     4681 acagcctaag taaccacaca cttttaggcc tcaatttttt attttttatt tttttctgtg
     4741 aaggaacttg aagtgatgca tgtgtgaatt taagataccg aagtcttaaa gtgacctgga
     4801 tgtgaaggaa aaagtaagat gagaagtaaa gaaagccttt gtaaggtggt tttaaaagcc
     4861 ttatgcaaac cttttaatct gtgtctctgc aagtgccatc cttgtacagt gttcagaggg
     4921 taacgagggt tacctttgca ccagcttcag tgttaagctc accgtgttct ttgaagcacc
     4981 cgtgtcagta ttagacgact aggcagcagt tccttagttt acatatgttt gtgcaattat
     5041 tttctgtact tttttgttca ttaattttgt cagtattaca ccaaactttt tttgcaacaa
     5101 aaaaaaattt ttttttgcat tcatttaatt ttaggtcaaa taacatttta tttatgtggc
     5161 tcattttata tttcctaatt ttatttattt catactgtag tgtacagtat tatagttctt
     5221 caatatatag atatatttta gtaaaaaagg aacatgacgt tgatcatttg ggcaaatttt
     5281 acgtaaagag aagagcattt attgtgtttt ggaacattaa ttgtgagatg ggatttttca
     5341 attttattat tttatttttg tttttgtttt tccaattact ggagattcca aatttggaaa
     5401 cttttgatac aatcttgtga aaacactgta ttttcgactg aaaattccac tttcttcatc
     5461 ttgtttttta gctaacctca agagggactg ttaaatacaa tgtatgatac catgacaaaa
     5521 atctttcctg aattgtcttt gtaaaagtat tattgaattt tcaatttgta atttcttttg
     5581 aaaatgacca tgctcgaata aaaatgtagc caaactaaga atgtagttaa tgagttctgt
     5641 acttttagag agctttcctt caatgaccat taacatgtaa catgcttatg cttataataa
     5701 tgctaattat gtttttcaat ataattttag tttagcaata attttgactg gtaccaataa
     5761 ctgtttttta aaattccata cttatgtaca gcaattttac agcttttctc aactgatcct
     5821 gattccagat tgtgtatttt ttatgtgagg ttatattatt caaatttagt ctatttactt
     5881 tacagacatt tctacttttg cattacaagt atttagagat tatgtgttaa aaactcactt
     5941 ttctgtccaa ggggtctttg tgatttattc agaaaagtct aatttcaaaa agacagctat
     6001 tattcaatgt tatttataat atgtaacttt ttttctaaga gttgggataa tttatctcac
     6061 tttttgaaat gcagactgta gcttatcctt tatctaagat tataaaatgg ggggtgggtg
     6121 ggaaaacaaa gctaaaggca catgctaaca aaaataacct tcattttcca agacagtctt
     6181 tcagttttta caagacgacc ctaatagtca gtatatgaat gtattcatag gtttttacac
     6241 aatgattttt tttatcagaa accagattct aattcctaaa tctaataaca aagtcagaat
     6301 aataatacaa aagcagatta ccttatgaaa tttacagctc ttgaatatac gtaactataa
     6361 tatagtagct gtccacatat tttttctact ttagaatcaa aaaacaaaag catgattttg
     6421 ctattgaatt tgctaaaact ttaagtgtga cacctcaagt tggcaagaaa aacatatttt
     6481 tattatttag ccattttcct aaatttcata aacattgttc cttgaaatga cacacacaca
     6541 cacacacaca cacacacaca cacatacatg ccccaagaga gagaaaagat gtaatgacta
     6601 tacagaggca attgagcaga tacttgtaga aagcatattt tcagctctat cttcaagcct
     6661 ggtgaggact ggcattagga gagatggcat aaagcattct gctcctgtca tcgctatacc
     6721 agagtttgca tgtttggaaa gtttacagca ttctttccct atttctcctt ctttcaatgg
     6781 cacaaataaa tacactacat agaaattttc ccgattttaa aggctctagg cgatatcttt
     6841 attaattcaa cctgaaaata tcaagccatt aaattttgtc tgggtagaat aaatccctgt
     6901 ggcctccttt aaagcaatgt aggtctctgc tgcccatggg gcatatctgt gtccctaccc
     6961 acaagagaca ggaccaacaa agaacacatg agcaacatac tctttctccc cagaaagaag
     7021 aaagcatgca tgagaaggag caaaggggag cacagagtct ccctcccctc ctgaaatccc
     7081 tctttccacc attgttttta caaattactt ttcacaggaa ggctcagaat acctgagtct
     7141 gcaaggatca ggttaacact tgtaaattgt gacaatcact acaatgtcct atatcttaag
     7201 gtttctttcc tttttaaaaa tgcaatttag ccactaatag tattgcacat tagagctgca
     7261 taatcttcca actccaggga agactaaaac attggactta tcctaggatt cctttccaag
     7321 gtcataaaca agaaagccct ccaaatcatg acacataatc tccttttctt atcgaatact
     7381 cttcccttgt tctagtctta agtattaccc tttacccctg aggatagggg ctgggaaaag
     7441 gtgatgaaat cctggaactg aacaccccgc ccattttctc aagagccttt tgtattctag
     7501 cagatctggg aggttctttc ttttttgcac atgacactgt aggcttagtt ctgagaaact
     7561 gggcaagaga gatgagattt ctcagccaga actaacagcg ttcatctccc ttagcatgaa
     7621 cttgagcttg cagtggagtg ggagggcctg aaggaggaag gagagaaggg actatatttg
     7681 aataggtatt aataaattta ttagatactt ttcacaatca gataacttta aaatgttatt
     7741 ttttatcttc taaggacata agccttaaca acatcaaaat ttagtcataa atttgaagat
     7801 attccccaat aataagttta tatatataca tatatatata tttgaaataa aaaattgtta
     7861 gccatgtttt tttgctccag gatgtgtggc catgccaggc tgtgagccct ggatatgcac
     7921 acaaacaagt gtgtgtgctc tgaagccccc gcacattgta ataaacacag ctgcatttat
     7981 ttgagtatgt gttcccgtgt acatgtaaaa acatccaaac aaacacactc agcagattta
     8041 tttcatgtgc aatggggcaa ttattcaaat aaatatgctc aatacaatta tttgagtctc
     8101 gcatttgcat gctcatcact cacagaacta atactaaaag agggggaaac accaaagaat
     8161 ttacgtgggg gaaaatatat gtgaaagcaa tgttattgta gatgttataa ggtagccaaa
     8221 gctatggctc ccttcttaac tgaaacacaa tgattttgta ttcagtggca tttgtttcta
     8281 acgatgaata gttatttcac tcacttgatc attacatcag aaggactgca gtgtttagat
     8341 tcatataata gcaaacttta aggacctgaa gcagataagg atgagacatc tctatatttc
     8401 aaaagcagaa tagttctttc tacatacttt acatcaaagg aacactgata aattattatg
     8461 gctcacatac gtaactataa atttaaaatg ttatacatat agaaaaacat tcctacattt
     8521 taaaacatta aaaagtcaca gatgactcgt gtgatcattt tatatattaa taaatactac
     8581 aatatatatg tgaacacatt acaaatcata ttggtgaaca aagaggctgt aaagcctctc
     8641 ttcagtatac tgacataacc taatatacta aaatgggaag gggcttttag tcactgaata
     8701 tgcatcgtga aacaaagatg aagaaactac atggcttgtg cccatcacga aaaagattca
     8761 tactgaaggc ttagctttgg tttttattca attaaattgt caaactgtgc acagtgaact
     8821 tttttttttt tttagaactt gagacatttg tgatgttggc tgtttaaatc tttgttacct
     8881 tcgctgtgaa ttgaaattgt acatatttag taaatcatgc aaacaaaaca aactttttag
     8941 acaatatttt tattggagag ttttcttttc ctgtatccat gtttaaaaaa aaaagacctc
     9001 ctttcccaaa ataaaaaatg tcaatactaa atttaaagaa gtataaagga ataattgctt
     9061 cctttagagc aaatatttaa ataaacatgg agagaattgg caacatgttc ttttggggct
     9121 aataggctgt gttcaatttt ttgggttaaa gttccagagg gcctctgttt cacattcaaa
     9181 gataatatat taatctctga attaaagaaa tgctcttagg taacagga
//
