LOCUS       NM_011546               5806 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus zinc finger E-box binding homeobox 1 (Zeb1),
            transcript variant 1, mRNA.
ACCESSION   NM_011546
VERSION     NM_011546.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5806)
  AUTHORS   Ohyama,K., Shinohara,H.M., Takayama,N., Ogawa,R., Omura,S.,
            Hayashida,M. and Takahashi,T.
  TITLE     Differentiation stage-specific expression of transcriptional
            regulators for epithelial mesenchymal transition in dentate granule
            progenitors
  JOURNAL   Front Neurosci 18, 1425849 (2024)
   PUBMED   39268037
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5806)
  AUTHORS   Menche,C., Schuhwerk,H., Armstark,I., Gupta,P., Fuchs,K., van
            Roey,R., Mosa,M.H., Hartebrodt,A., Hajjaj,Y., Clavel Ezquerra,A.,
            Selvaraju,M.K., Geppert,C.I., Barthel,S., Saur,D., Greten,F.R.,
            Brabletz,S., Blumenthal,D.B., Weigert,A., Brabletz,T., Farin,H.F.
            and Stemmler,M.P.
  TITLE     ZEB1-mediated fibroblast polarization controls inflammation and
            sensitivity to immunotherapy in colorectal cancer
  JOURNAL   EMBO Rep 25 (8), 3406-3431 (2024)
   PUBMED   38937629
REFERENCE   3  (bases 1 to 5806)
  AUTHORS   Li,T., Wei,L., Zhang,X., Fu,B., Zhou,Y., Yang,M., Cao,M., Chen,Y.,
            Tan,Y., Shi,Y., Wu,L., Xuan,C., Du,Q. and Hu,R.
  TITLE     Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis
            via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition
  JOURNAL   Mol Cancer Res 22 (6), 538-554 (2024)
   PUBMED   38381131
  REMARK    GeneRIF: Serotonin Receptor HTR2B Facilitates Colorectal Cancer
            Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal
            Transition.
REFERENCE   4  (bases 1 to 5806)
  AUTHORS   Huang,Q., Zheng,S., Gu,H., Yang,Z., Lu,Y., Yu,X. and Guo,G.
  TITLE     The deubiquitinase BRCC3 increases the stability of ZEB1 and
            promotes the proliferation and metastasis of triple-negative breast
            cancer cells
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (4), 564-575 (2024)
   PUBMED   38449391
  REMARK    GeneRIF: The deubiquitinase BRCC3 increases the stability of ZEB1
            and promotes the proliferation and metastasis of triple-negative
            breast cancer cells.
REFERENCE   5  (bases 1 to 5806)
  AUTHORS   Do,K.K., Wang,F., Sun,X., Zhang,Y., Liang,W., Liu,J.Y., Jiang,D.Y.,
            Lu,X., Wang,W., Zhang,L., Dean,D.C. and Liu,Y.
  TITLE     Conditional deletion of Zeb1 in Csf1r+ cells reduces inflammatory
            response of the cornea to alkali burn
  JOURNAL   iScience 27 (5), 109694 (2024)
   PUBMED   38660397
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5806)
  AUTHORS   Williams,T.M., Montoya,G., Wu,Y., Eddy,R.L., Byers,M.G. and
            Shows,T.B.
  TITLE     The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on
            human chromosome 10p11.2
  JOURNAL   Genomics 14 (1), 194-196 (1992)
   PUBMED   1427828
REFERENCE   7  (bases 1 to 5806)
  AUTHORS   Lane,P.W. and Eicher,E.M.
  TITLE     Location of plucked (pk) on chromosome 18 of the mouse
  JOURNAL   J Hered 76 (6), 476-477 (1985)
   PUBMED   4086792
REFERENCE   8  (bases 1 to 5806)
  AUTHORS   Michalides,R., Verstraeten,R., Shen,F.W. and Hilgers,J.
  TITLE     Characterization and chromosomal distribution of endogenous mouse
            mammary tumor viruses of European mouse strains STS/A and GR/A
  JOURNAL   Virology 142 (2), 278-290 (1985)
   PUBMED   2997987
REFERENCE   9  (bases 1 to 5806)
  AUTHORS   Sidman,R.L., Conover,C.S. and Carson,J.H.
  TITLE     Shiverer gene maps near the distal end of chromosome 18 in the
            house mouse
  JOURNAL   Cytogenet Cell Genet 39 (4), 241-245 (1985)
   PUBMED   2414073
REFERENCE   10 (bases 1 to 5806)
  AUTHORS   Lane,P.W., Searle,A.G., Beechey,C.V. and Eicher,E.
  TITLE     Chromosome 18 of the house mouse
  JOURNAL   J Hered 72 (6), 409-412 (1981)
   PUBMED   6949984
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127028.18, BC139769.1, AK034821.1 and BE852657.1.
            
            On Nov 16, 2011 this sequence version replaced NM_011546.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U26259.1, BC139769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC127028.18        64026-64056
            32-4842             BC139769.1         1-4811
            4843-5800           AK034821.1         1546-2503
            5801-5806           BE852657.1         1-6                 c
FEATURES             Location/Qualifiers
     source          1..5806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.42 cM"
     gene            1..5806
                     /gene="Zeb1"
                     /gene_synonym="3110032K11Rik; AREB6; BZP; MEB1; Nil2;
                     TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
                     [delta]EF1"
                     /note="zinc finger E-box binding homeobox 1"
                     /db_xref="GeneID:21417"
                     /db_xref="MGI:MGI:1344313"
     exon            1..108
                     /gene="Zeb1"
                     /gene_synonym="3110032K11Rik; AREB6; BZP; MEB1; Nil2;
                     TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
                     [delta]EF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..3404
                     /gene="Zeb1"
                     /gene_synonym="3110032K11Rik; AREB6; BZP; MEB1; Nil2;
                     TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
                     [delta]EF1"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger homeobox protein 1a; transcription factor 8;
                     twirler"
                     /codon_start=1
                     /product="zinc finger E-box-binding homeobox 1 isoform 1"
                     /protein_id="NP_035676.1"
                     /db_xref="CCDS:CCDS29039.1"
                     /db_xref="GeneID:21417"
                     /db_xref="MGI:MGI:1344313"
                     /translation="MADGPRCKRRKQANPRRNNVTNYNTVVEANSDSDDEDKLHIVEE
                     ESITDAADCEGGMPDDELPADQTVLPGGSDRGGGAKNCWQDNVKDNECDSDAENEQNH
                     DPNVEEFLQQQDTAVIYPEAPEEDQRQGTPEASSHDENGTPDAFSQLLTCPYCDRGYK
                     RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGREQRHVTQSGGNR
                     KFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLM
                     PVNGRPRSGLKTSQCSSPSLSTSPGSPTRPQIRQKIENKPLQEPLSVNQIKTEPVDYE
                     FKPIVVASGINCSTPLQNGVFSSGGQLQATSSPQGVVQAVVLPTVGLVSPISINLSDI
                     QNVLKVAVDGNVIRQVLETNQASLASKEQEAVSASPIQQGGHSVISAISLPLVDQDGT
                     TKIIINYSLEQPSQLQVVPQNLKKEIPAPTNSCKSEKLPEDLTVKSETDKSFEGARDD
                     STCLLCEDCPGDLNALPELKHYDPECPAQPPPPAPATEKPESSASSAGNGDLSPSQPP
                     LKNLLSLLKAYYALNAQPSTEELSKIADSVNLPLDGVKKWFEKMQAGQIPGQSPDPPS
                     PGTGSVNIPTKTDEQPQPADGNEPQEDSTRGQSPVKIRSSPVLPVGSAMNGSRSCTSS
                     PSPLNLCSARNPQGYSCVAEGAQEEPQVEPLDLSLPKQQGELLERSTVSSVYQNSVYS
                     VQEEPLNLSCAKKEPQKDSCVTDSEPVVNVVPPSANPINIAIPTVTAQLPTIVAIADQ
                     NSVPCLRALAANKQTILIPQVAYTYSATVSPAVQEPPVKVIQPNGNQDERQDTSSEGV
                     STVEDQNDSDSTPPKKKTRKTENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGI
                     CRKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKRGAEDRD
                     AMEQEDAGPEVLPEVLATEHVGARASPSQADSDERESLTREEDEDSEKEEEEEDKEME
                     ELQEGKECENPQGEEEEEEEEEEEEEEEEEEEVEADEAEHEAAAKTDGTVEVGAAQQA
                     GSLEQKASESEMESESESEQLSEEKTNEA"
     exon            109..309
                     /gene="Zeb1"
                     /gene_synonym="3110032K11Rik; AREB6; BZP; MEB1; Nil2;
                     TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
                     [delta]EF1"
                     /inference="alignment:Splign:2.1.0"
     exon            310..471
                     /gene="Zeb1"
                     /gene_synonym="3110032K11Rik; AREB6; BZP; MEB1; Nil2;
                     TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
                     [delta]EF1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..674
                     /gene="Zeb1"
                     /gene_synonym="3110032K11Rik; AREB6; BZP; MEB1; Nil2;
                     TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
                     [delta]EF1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..780
                     /gene="Zeb1"
                     /gene_synonym="3110032K11Rik; AREB6; BZP; MEB1; Nil2;
                     TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
                     [delta]EF1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..2585
                     /gene="Zeb1"
                     /gene_synonym="3110032K11Rik; AREB6; BZP; MEB1; Nil2;
                     TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
                     [delta]EF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2766
                     /gene="Zeb1"
                     /gene_synonym="3110032K11Rik; AREB6; BZP; MEB1; Nil2;
                     TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
                     [delta]EF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..5806
                     /gene="Zeb1"
                     /gene_synonym="3110032K11Rik; AREB6; BZP; MEB1; Nil2;
                     TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
                     [delta]EF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5227..5232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zeb1"
                     /gene_synonym="3110032K11Rik; AREB6; BZP; MEB1; Nil2;
                     TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
                     [delta]EF1"
                     /note="hexamer: AATAAA"
     polyA_site      5249
                     /gene="Zeb1"
                     /gene_synonym="3110032K11Rik; AREB6; BZP; MEB1; Nil2;
                     TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
                     [delta]EF1"
                     /note="major polyA site"
     regulatory      5782..5787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zeb1"
                     /gene_synonym="3110032K11Rik; AREB6; BZP; MEB1; Nil2;
                     TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
                     [delta]EF1"
                     /note="hexamer: AATAAA"
     polyA_site      5806
                     /gene="Zeb1"
                     /gene_synonym="3110032K11Rik; AREB6; BZP; MEB1; Nil2;
                     TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
                     [delta]EF1"
ORIGIN      
        1 gggagggagg gaggaggtga ctcgagcatt tagacacaag cgagaggatc atggcggatg
       61 gccccaggtg taagcgcaga aagcaggcga acccgcggcg caataacgtt acaaattata
      121 atactgtggt agaagcaaat tcagattccg atgatgaaga caaactccat attgtggaag
      181 aagaaagtat tacagatgca gctgactgtg aaggtggcat gccagatgat gaactgccag
      241 cagaccagac agtattacca ggaggcagtg acaggggggg cggtgccaag aactgctggc
      301 aagacaacgt gaaagacaac gagtgtgact cagatgcaga aaatgagcaa aaccatgatc
      361 cgaatgtgga agaatttctg cagcaacaag acaccgccgt catttatcct gaggcgcccg
      421 aggaagacca gcggcagggc acaccagaag ccagcagtca tgatgaaaac ggaacaccag
      481 atgcattttc ccagttgctc acctgcccgt attgtgatag aggctacaag cgctttacct
      541 ctttgaaaga acacattaag taccgccatg agaagaacga ggacaacttc agctgctccc
      601 tgtgcagtta cacctttgca tacagaaccc agcttgaacg tcatatgaca tcacataagt
      661 caggaagaga gcaaagacat gtgacacagt ctgggggaaa ccgcaagttc aagtgcactg
      721 aatgcgggaa ggccttcaag tacaaacacc acctgaaaga gcacttacgg attcacagtg
      781 gagagaagcc atacgaatgc ccgaactgca agaaacggtt ttcccattct ggctcctata
      841 gctcacatat aagcagtaag aagtgtatta gcttgatgcc tgtgaatggc aggcctagat
      901 caggactcaa gacatctcag tgttcctcgc catctctttc gacatcacca ggcagtccca
      961 cacgcccaca gatacgacag aagatagaga ataaacccct tcaagaaccg ctttctgtaa
     1021 accaaatcaa aactgaacct gtggattatg agttcaaacc catagtggtt gcttcaggaa
     1081 tcaactgttc aaccccttta caaaatgggg tttttagcag tggtggccaa ttgcaggcaa
     1141 ccagttctcc tcagggtgtg gtgcaagccg ttgttctgcc aacagttggt ttggtatctc
     1201 ccataagtat caacttaagt gacattcaga atgtacttaa agtggctgta gatggtaacg
     1261 taatacgaca agtcttggag actaatcaag ccagtcttgc atccaaagag caagaagcag
     1321 tgagtgcttc gcccatccag cagggtggcc attctgtcat ttctgccatc agtcttcctt
     1381 tagttgatca ggatggaaca accaaaatca tcatcaacta cagtcttgag cagcccagtc
     1441 aacttcaggt tgttccccag aatttaaaga aagaaatccc agcccctaca aacagctgca
     1501 aaagtgagaa gttaccagaa gaccttactg tcaaatcaga aacggacaaa agctttgagg
     1561 gggccaggga tgatagcact tgccttctgt gtgaggactg cccaggggac ctcaatgcac
     1621 ttccagaact aaagcactat gacccagagt gccctgctca gcctccaccc cctgccccag
     1681 ccaccgagaa gccagagtcc tctgcttcat cagctggaaa cggagatttg tctcccagtc
     1741 agccaccttt aaagaacctt ctgtcactct tgaaagccta ctatgctctg aacgcgcagc
     1801 caagcacaga agagctctca aagatcgccg attctgtgaa cctaccgctg gatggagtta
     1861 aaaagtggtt tgaaaagatg caagctggac agattccagg acagtctcct gacccccctt
     1921 ctcctggaac cgggtcagta aacataccta caaaaaccga tgagcagcct caacctgcgg
     1981 atggaaatga gccccaggaa gacagcacac gcggacagag tcctgtcaag ataaggagct
     2041 ctccggtttt acctgtagga tcagccatga acggttccag aagctgcaca tcatccccat
     2101 cccctctaaa cctttgctca gccaggaacc cgcagggtta ctcttgtgtg gcagagggtg
     2161 cccaggagga gccccaagta gaacctcttg atctctcact accaaagcaa cagggagagt
     2221 tactggaaag gtcgacagtc agtagcgttt accagaacag tgtttattct gtccaggaag
     2281 aacccttgaa cttgtcttgt gcaaaaaagg aaccacaaaa ggacagctgt gttacagact
     2341 cagaaccagt tgtaaatgta gtcccaccaa gtgccaaccc cataaacatt gctattccta
     2401 cagtcactgc ccagttaccc acaatcgtgg ccattgctga ccagaacagt gttccatgtt
     2461 taagagcact ggccgccaac aagcagacta ttctgattcc ccaagtggca tatacatatt
     2521 cagctactgt gagccctgcc gtgcaggagc cgccagtgaa ggtgatccag ccaaacggaa
     2581 accaggatga aagacaagac actagctcag aaggagtctc cactgtggag gaccagaatg
     2641 actctgactc cacgccaccc aaaaagaaaa ctcggaagac agagaatgga atgtatgcat
     2701 gtgacctgtg tgacaagata tttcagaaga gcagctcact gttgagacac aaatatgagc
     2761 acacaggtaa gaggcctcac gagtgtggaa tctgtagaaa ggcatttaaa cacaagcatc
     2821 atttgattga gcacatgcgg ctgcactctg gggaaaagcc ctatcaatgt gacaagtgtg
     2881 gcaagcgctt ctcacactcc ggctcctact ctcaacacat gaatcaccgc tactcctact
     2941 gcaagagagg agctgaagac agagatgcta tggagcagga agacgctggg cccgaagtcc
     3001 tgccggaagt cctggcgact gagcatgttg gtgcccgggc gtctccctca caggctgact
     3061 cggacgagag agaaagtctg acaagggaag aagatgaaga cagtgaaaag gaggaggagg
     3121 aggaagataa agagatggaa gaattacagg aaggaaagga atgtgagaac ccacaggggg
     3181 aggaggagga ggaggaggag gaggaagagg aggaagaaga ggaggaagag gaggaagtgg
     3241 aagcggatga agccgagcat gaggcagcag ccaagactga tggtacagtg gaggttggag
     3301 ctgcacagca ggcaggcagc ttagagcaga aggccagcga gagcgagatg gagagcgaaa
     3361 gcgagagtga gcagctgtct gaagagaaga caaatgaagc ttaggagttc ttctaaaagg
     3421 aaattctact tggtaatgaa atttgctcta tattacccac gcttttcatg gaaacatggc
     3481 tccatggctc ctgtgctatg gttcctgctc actactgtgt aatgtcagaa ctgaaaaaaa
     3541 aaaaattccg ggtgtgcctg aacctcaaac ctagtaattt ttcatgcagt tttcaaagtt
     3601 aggaacaaat ttataacatg aagcagctta gaaaacatta atgactcaga aaacaaaggt
     3661 ttctcagcag gttacaggag gctggatggg cgtccggcat ggctagcagt attatcactc
     3721 ttacgttggc tcattcttaa gctctacaat gggagaaatt ttataatttt tttattggta
     3781 aacatatgct aaatccgctt cagtatttta ttatgttttt taaaatgtga gaacttctgc
     3841 actacagaat tcccttcaca gagcagtaga aagcagttca aaccgtgctg gctacctgct
     3901 gctacccagt cagtcaggag ataggacctc tgacgttaga tgccgtgttg ccatctaaca
     3961 tgtattgcta gccttaagga agcagccaga gaagagctgg agtttcttac tcgtgtgatt
     4021 tttaaatgga gttcaaaggt tgtcgttgag tcctgactcc agggacgacc agtgttgatg
     4081 tggcaaggcc ggcagaggcg gcagaatcag tgttcgtgat tgtttgcgta cgttagcaac
     4141 catgaaggat ctataggaag caagcgctgt gtccctttgg ccttaagcaa gacctgtgct
     4201 ctaagtgcca ttctcagtat tgcaaggctc tgacagcctt cccgcagtgt ggcctatatt
     4261 aactagcagt tgttgattcg tttgttgtgt caaaattccc aaacaaaact caaaaccact
     4321 gactgtgaga gaagctgaag cactggggca tctcacactt ttgttcctca gtagtcattt
     4381 catgttgatt gactctcaga agtctctaca gaaataaaag ggaaattctc caaactactt
     4441 aatccatgta cttgcgtgtc aggcatggat acgctattgg tttttggttc acagccgttt
     4501 tccaaatgtt agttattacg gacccaggtg atgaacaaca gcagctgatt tttacctacc
     4561 agtattattt tatttctttt agtttataga tctgtgcaac atttttgtac tgtatgtctt
     4621 taagcctggc agtattaata cccttcttac tgacacgtac ttttagtttt agaaaacttt
     4681 tatatttatg tgtcttattt ttatatttct ttatttatta cacagtgtag tgtataatac
     4741 tgtagtttgt attaatacaa taatatattt tagtatgaaa ttttggaaag ttgctaagat
     4801 ttacagtaga gatgcagttg gttcccgtgc gttgagattt gatttaacag tgttctgtta
     4861 acatttatac ttgcctccga ctgtagacca gcctttaaat gggaaggtat tagttttaca
     4921 actacaatca agtcattctc cctttcccca gtttttaata ggaaactctt acactttgac
     4981 actcactgtg tgcgactcat agcatgccgc tctgcagtct tctgttaaga gttggcccag
     5041 ccataactca ttcccttagc aagccaaatt agaattgcct tctgtaaaca gtgttgggaa
     5101 caatgtttaa catgtgccaa tttgttcctg tatccatgta tgtaagctac caatctgact
     5161 cttcctttta agttccttgt tacaccatgg tcattttcta gttttttacc agactcccca
     5221 gctcacaata aacgcatcaa caaacctgac ctgctgtcgt tctttggatc atcaaatttc
     5281 ctttggaaaa ttgtctatga agtgggcatt acatcctaga gcttcattca tcttgagctg
     5341 agtttgttga cacaaagtat ttgagacact tagcacaaag aatgcctttt cctgtggggg
     5401 aaattccctg aggaagccct ctgcacaggt tgtcccttct tccaaaaccc acagagcaag
     5461 agccttcccc tcagggaaca tcagggctgt gcaagcttaa gatgcttttt gcttgtactc
     5521 tgccactctt tgaacccttc tcattcagct caaggactgt cactgatgtt cctccccatg
     5581 tcatggtcat gcctcatgtg ccccctgccc atgaactgcc tctcaacaga cattcattga
     5641 atgaacacag aaactgcaca tttgcagagc ttagctgtgc tcactgtttt gcctctaatc
     5701 tgaaagttca taaggtaaat gattcccata atgtgccggt ggtcttgttt gagtcttata
     5761 ggcacttacc ataggagatg taataaatga ctgccttgga agctgc
//
