LOCUS       NM_172465               2995 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus zinc finger, DHHC domain containing 9 (Zdhhc9), mRNA.
ACCESSION   NM_172465 XM_910670 XM_921724 XM_921730 XM_921740 XM_921749
            XM_921756 XM_921763
VERSION     NM_172465.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2995)
  AUTHORS   Yu,T., Hou,D., Zhao,J., Lu,X., Greentree,W.K., Zhao,Q., Yang,M.,
            Conde,D.G., Linder,M.E. and Lin,H.
  TITLE     NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome
            activation
  JOURNAL   Cell Rep 43 (4), 114070 (2024)
   PUBMED   38583156
REFERENCE   2  (bases 1 to 2995)
  AUTHORS   Balasubramanian,A., Hsu,A.Y., Ghimire,L., Tahir,M., Devant,P.,
            Fontana,P., Du,G., Liu,X., Fabin,D., Kambara,H., Xie,X., Liu,F.,
            Hasegawa,T., Xu,R., Yu,H., Chen,M., Kolakowski,S., Trauger,S.,
            Larsen,M.R., Wei,W., Wu,H., Kagan,J.C., Lieberman,J. and Luo,H.R.
  TITLE     The palmitoylation of gasdermin D directs its membrane
            translocation and pore formation during pyroptosis
  JOURNAL   Sci Immunol 9 (94), eadn1452 (2024)
   PUBMED   38530158
REFERENCE   3  (bases 1 to 2995)
  AUTHORS   Gu,M., Jiang,H., Tan,M., Yu,L., Xu,N., Li,Y., Wu,H., Hou,Q. and
            Dai,C.
  TITLE     Palmitoyltransferase DHHC9 and acyl protein thioesterase APT1
            modulate renal fibrosis through regulating beta-catenin
            palmitoylation
  JOURNAL   Nat Commun 14 (1), 6682 (2023)
   PUBMED   37865665
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2995)
  AUTHORS   Wild,A.R., Hogg,P.W., Flibotte,S., Nasseri,G.G., Hollman,R.B.,
            Abazari,D., Haas,K. and Bamji,S.X.
  TITLE     Exploring the expression patterns of palmitoylating and
            de-palmitoylating enzymes in the mouse brain using the curated
            RNA-seq database BrainPalmSeq
  JOURNAL   Elife 11, e75804 (2022)
   PUBMED   35819139
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2995)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2995)
  AUTHORS   Shimell,J.J., Shah,B.S., Cain,S.M., Thouta,S., Kuhlmann,N.,
            Tatarnikov,I., Jovellar,D.B., Brigidi,G.S., Kass,J.,
            Milnerwood,A.J., Snutch,T.P. and Bamji,S.X.
  TITLE     The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for
            Dendrite Outgrowth and Inhibitory Synapse Formation
  JOURNAL   Cell Rep 29 (8), 2422-2437 (2019)
   PUBMED   31747610
  REMARK    GeneRIF: The X-Linked Intellectual Disability Gene Zdhhc9 Is
            Essential for Dendrite Outgrowth and Inhibitory Synapse Formation.
REFERENCE   7  (bases 1 to 2995)
  AUTHORS   Kouskou,M., Thomson,D.M., Brett,R.R., Wheeler,L., Tate,R.J.,
            Pratt,J.A. and Chamberlain,L.H.
  TITLE     Disruption of the Zdhhc9 intellectual disability gene leads to
            behavioural abnormalities in a mouse model
  JOURNAL   Exp Neurol 308, 35-46 (2018)
   PUBMED   29944857
  REMARK    GeneRIF: this study highlights a key role for zDHHC9 in brain
            development and behaviour
REFERENCE   8  (bases 1 to 2995)
  AUTHORS   Liu,P., Jiao,B., Zhang,R., Zhao,H., Zhang,C., Wu,M., Li,D.,
            Zhao,X., Qiu,Q., Li,J. and Ren,R.
  TITLE     Palmitoylacyltransferase Zdhhc9 inactivation mitigates leukemogenic
            potential of oncogenic Nras
  JOURNAL   Leukemia 30 (5), 1225-1228 (2016)
   PUBMED   26493479
REFERENCE   9  (bases 1 to 2995)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672274.7.
            
            On Oct 25, 2007 this sequence version replaced NM_172465.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032233.1, BC042618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AL672274.7         184142-184364       c
            224-513             AL672274.7         182330-182619       c
            514-674             AL672274.7         170222-170382       c
            675-833             AL672274.7         166883-167041       c
            834-971             AL672274.7         158683-158820       c
            972-1020            AL672274.7         157761-157809       c
            1021-1123           AL672274.7         156909-157011       c
            1124-1227           AL672274.7         154171-154274       c
            1228-1324           AL672274.7         153702-153798       c
            1325-2995           AL672274.7         147633-149303       c
FEATURES             Location/Qualifiers
     source          1..2995
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 25.55 cM"
     gene            1..2995
                     /gene="Zdhhc9"
                     /gene_synonym="6430508G22; 9530098M12Rik"
                     /note="zinc finger, DHHC domain containing 9"
                     /db_xref="GeneID:208884"
                     /db_xref="MGI:MGI:2444393"
     exon            1..223
                     /gene="Zdhhc9"
                     /gene_synonym="6430508G22; 9530098M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            224..513
                     /gene="Zdhhc9"
                     /gene_synonym="6430508G22; 9530098M12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..1441
                     /gene="Zdhhc9"
                     /gene_synonym="6430508G22; 9530098M12Rik"
                     /EC_number="2.3.1.225"
                     /note="DHHC9; DHHC-9; zinc finger DHHC domain-containing
                     protein 9"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC9"
                     /protein_id="NP_766053.1"
                     /db_xref="CCDS:CCDS40960.1"
                     /db_xref="GeneID:208884"
                     /db_xref="MGI:MGI:2444393"
                     /translation="MSVMVVRKKVTRKWEKLPGRNTFCCDGRVMMARQKGIFYLTLFL
                     ILGTCTLFFAFECRYLAVQLSPAIPVFAAMLFLFSMATLLRTSFSDPGVIPRALPDEA
                     AFIEMEIEATNGAVPQGQRPPPRIKNFQINNQIVKLKYCYTCKIFRPPRASHCSICDN
                     CVERFDHHCPWVGNCVGKRNYRYFYLFILSLSLLTIYVFAFNIVYVALKSLKIGFLET
                     LKETPGTVLEVLICFFTLWSVVGLTGFHTFLVALNQTTNEDIKGSWTGKNRVQNPYSH
                     GNIVKNCCEVLCGPLPPSVLDRRGILPLEESGSRPPSTQETSSSLLPQSPASTEHMNS
                     NEMAEDTSIPEEMPPPEPPEPPQEASEAEK"
     exon            514..674
                     /gene="Zdhhc9"
                     /gene_synonym="6430508G22; 9530098M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            675..833
                     /gene="Zdhhc9"
                     /gene_synonym="6430508G22; 9530098M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            834..971
                     /gene="Zdhhc9"
                     /gene_synonym="6430508G22; 9530098M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1020
                     /gene="Zdhhc9"
                     /gene_synonym="6430508G22; 9530098M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1123
                     /gene="Zdhhc9"
                     /gene_synonym="6430508G22; 9530098M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1227
                     /gene="Zdhhc9"
                     /gene_synonym="6430508G22; 9530098M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1324
                     /gene="Zdhhc9"
                     /gene_synonym="6430508G22; 9530098M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..2995
                     /gene="Zdhhc9"
                     /gene_synonym="6430508G22; 9530098M12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2977..2982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc9"
                     /gene_synonym="6430508G22; 9530098M12Rik"
     polyA_site      2995
                     /gene="Zdhhc9"
                     /gene_synonym="6430508G22; 9530098M12Rik"
ORIGIN      
        1 actactggag cgacctggtg acgtgaggag cgttccattc cgccagcggt gggcggttgc
       61 cacagctggt ttagggcccc gactattggg gccccttgtc aggaggaggc accctccctg
      121 tcagggagaa gtcgctacca cctctggctg ctgacgagat cccccgggac agtgtgcact
      181 ttctgccccc agttgccggc cgagttcagt gtcccttgtt cagggctctt gataatgttt
      241 gacccagtgg caacactagt agacgacctg attttaaagc tgacctcagc ctctgcatct
      301 tctctcgagt agtcccaaag cccatcttgg accaggaact gtaatcatgt ctgtgatggt
      361 ggtaagaaag aaggtgacac ggaaatggga gaaactccca ggcaggaaca ccttctgctg
      421 tgatggccgc gtcatgatgg cccggcaaaa gggcatcttc tacctgaccc tcttcctcat
      481 cctggggaca tgtacactct tctttgcctt cgagtgtcgc tacctggctg ttcagctgtc
      541 tcctgccatt cctgtgtttg ccgctatgct ctttcttttc tccatggcca cgctgttgag
      601 gacaagtttc agtgaccctg gagtgattcc tcgagcacta ccagatgaag cagctttcat
      661 agaaatggaa atagaagcca ccaatggtgc cgtgccacag ggccagcgac cacctcctcg
      721 tattaagaat ttccagataa acaaccagat tgtgaaactg aaatactgtt atacatgcaa
      781 gatcttccgg cctcccaggg cctcccattg tagcatctgt gacaactgtg tggagcgctt
      841 cgaccatcac tgcccctggg tgggaaactg tgttggaaag aggaactacc gctacttcta
      901 cctcttcatc ctctctctct ccctcctcac aatttatgtc ttcgccttta acatcgtcta
      961 tgtggccctc aaatccttga aaattggctt cctggagaca ctgaaagaaa cgcctggaac
     1021 tgttctggaa gtactcattt gcttcttcac tctctggtct gttgtggggc tgactggatt
     1081 tcacacattc cttgtggctc tcaatcagac caccaatgaa gacatcaaag gatcatggac
     1141 agggaagaat cgtgtgcaga atccgtacag ccacggcaac attgtgaaga actgctgtga
     1201 agtgctttgt ggccccttgc cccccagtgt cctggatcga aggggtattt tgccactgga
     1261 ggaaagtgga agtcgacctc caagtactca agagaccagc agtagcctgt tgccacagag
     1321 cccagcctcc acagagcata tgaactctaa tgagatggca gaggacacca gcattcctga
     1381 agagatgcca cctccagaac ccccagagcc accacaggag gcatccgaag ctgagaagta
     1441 gcctctctat ggaagagact tttgtttgtg tttcattagg gctatgagag atttcagggg
     1501 agacaaccac ctgagacaga gaacaaatga gctgtccctt attactattt ttctttggtc
     1561 tttagtcacc caattaccgg catcttcttg ctgcaaactt ttttttttta atgtttgaac
     1621 ttaagacagt ggcagaagat gccagtcaca tctggcaact ggacaaatgg gtctcttggg
     1681 acatggcact ggttggtttc ccattgtctc agccacaagg tatccttgga ctcccctcct
     1741 cttccctcca gatcctagct cccctgctgg gggtcattgg tctctttctg gggctaaaga
     1801 gtctcaagac tgactccagt cctttccagc tgctgcatgt cccgagtcca gaggcagtca
     1861 cagagacctc tggccaggga attctaactg ggctcttgac tccttcagaa ctaaggattg
     1921 gagagggacg ctggaggatt ctcctggctc caaagtgcca gcattgccag ccaatccttt
     1981 taggaatagg gcaggtacct tccacttgta tttatttctg tagcttctct tttctccccc
     2041 cccatctact ctctaacatc caaatcccac tctttccccc attagatgct atacgtaagt
     2101 agtcatggta gagataatac atttctccta cgttctccag aaacttcaat gcctgtgcta
     2161 ttctcaataa gcattgatga gatgccaaca acacagcccc tcacactctc tgtctcatct
     2221 cccctctttg ctcatgagtc cactttcatt ttctcctttt gactcctgct tcagccggga
     2281 gcaggactag cagtaataaa agtctgcact ttgctggttt cttttcctca ggggaagcct
     2341 gagtgctcac ttaaacacta cccctcagac ttcttgtgta aggcctacag aggccgtgaa
     2401 tgcacaaatg gggaagccaa ggcacagaga ggctctcctc tcctctcctc tcctctcctc
     2461 tcctctcctc tcctctcctc tcctctcctc tcctctcctc tcctctcctc tcctctcctc
     2521 tcctctcctc tcttctcccc acctctcccc tcccctccct catcatcccc tcaaaacaaa
     2581 agagagagaa aaaaaagact aatcagtact tccattaagc cttggctgag tgagggaaag
     2641 cccagcactg ctgccccacc ctccgggtat cccgctccaa ggcctcagcc cacctctggc
     2701 aacggtaacc acaccagggg cttcatctaa gcccctgctc ttccagcact tccaccggca
     2761 gagtcccaga gccacttgat cctgggggtg gactgcagcc ccccaggcag ctctgctcgg
     2821 gacctgcact atttcaggga agaagaacta tgtattatat gtggctatat ttcctagagc
     2881 acctgtgttt ttctctttct aagccagggt cttgtctgga tgacttacgg ggacagggag
     2941 gggtgcaaac cacgactttt aatctatttg aaggcgatta aactgtgtct aatgc
//
