LOCUS       NM_172151               4887 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus zinc finger, DHHC domain containing 8 (Zdhhc8),
            transcript variant 1, mRNA.
ACCESSION   NM_172151 XM_286749 XM_358776 XM_489766
VERSION     NM_172151.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4887)
  AUTHORS   Tamura,M., Spellman,T.J., Rosen,A.M., Gogos,J.A. and Gordon,J.A.
  TITLE     Hippocampal-prefrontal theta-gamma coupling during performance of a
            spatial working memory task
  JOURNAL   Nat Commun 8 (1), 2182 (2017)
   PUBMED   29259151
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4887)
  AUTHORS   Paronett,E.M., Meechan,D.W., Karpinski,B.A., LaMantia,A.S. and
            Maynard,T.M.
  TITLE     Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a
            Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical
            Projection Neuron Generation
  JOURNAL   Cereb Cortex 25 (10), 3977-3993 (2015)
   PUBMED   25452572
REFERENCE   3  (bases 1 to 4887)
  AUTHORS   Mukai,J., Tamura,M., Fenelon,K., Rosen,A.M., Spellman,T.J.,
            Kang,R., MacDermott,A.B., Karayiorgou,M., Gordon,J.A. and
            Gogos,J.A.
  TITLE     Molecular substrates of altered axonal growth and brain
            connectivity in a mouse model of schizophrenia
  JOURNAL   Neuron 86 (3), 680-695 (2015)
   PUBMED   25913858
REFERENCE   4  (bases 1 to 4887)
  AUTHORS   He,M., Abdi,K.M. and Bennett,V.
  TITLE     Ankyrin-G palmitoylation and betaII-spectrin binding to
            phosphoinositide lipids drive lateral membrane assembly
  JOURNAL   J Cell Biol 206 (2), 273-288 (2014)
   PUBMED   25049274
REFERENCE   5  (bases 1 to 4887)
  AUTHORS   Karpinski,B.A., Maynard,T.M., Fralish,M.S., Nuwayhid,S., Zohn,I.E.,
            Moody,S.A. and LaMantia,A.S.
  TITLE     Dysphagia and disrupted cranial nerve development in a mouse model
            of DiGeorge (22q11) deletion syndrome
  JOURNAL   Dis Model Mech 7 (2), 245-257 (2014)
   PUBMED   24357327
REFERENCE   6  (bases 1 to 4887)
  AUTHORS   Mukai,J., Liu,H., Burt,R.A., Swor,D.E., Lai,W.S., Karayiorgou,M.
            and Gogos,J.A.
  TITLE     Evidence that the gene encoding ZDHHC8 contributes to the risk of
            schizophrenia
  JOURNAL   Nat Genet 36 (7), 725-731 (2004)
   PUBMED   15184899
REFERENCE   7  (bases 1 to 4887)
  AUTHORS   Maynard,T.M., Haskell,G.T., Peters,A.Z., Sikich,L., Lieberman,J.A.
            and LaMantia,A.S.
  TITLE     A comprehensive analysis of 22q11 gene expression in the developing
            and adult brain
  JOURNAL   Proc Natl Acad Sci U S A 100 (24), 14433-14438 (2003)
   PUBMED   14614146
REFERENCE   8  (bases 1 to 4887)
  AUTHORS   Puech,A., Saint-Jore,B., Merscher,S., Russell,R.G., Cherif,D.,
            Sirotkin,H., Xu,H., Factor,S., Kucherlapati,R. and Skoultchi,A.I.
  TITLE     Normal cardiovascular development in mice deficient for 16 genes in
            550 kb of the velocardiofacial/DiGeorge syndrome region
  JOURNAL   Proc Natl Acad Sci U S A 97 (18), 10090-10095 (2000)
   PUBMED   10963672
REFERENCE   9  (bases 1 to 4887)
  AUTHORS   Lund,J., Chen,F., Hua,A., Roe,B., Budarf,M., Emanuel,B.S. and
            Reeves,R.H.
  TITLE     Comparative sequence analysis of 634 kb of the mouse chromosome 16
            region of conserved synteny with the human velocardiofacial
            syndrome region on chromosome 22q11.2
  JOURNAL   Genomics 63 (3), 374-383 (2000)
   PUBMED   10704284
REFERENCE   10 (bases 1 to 4887)
  AUTHORS   Lund,J., Roe,B., Chen,F., Budarf,M., Galili,N., Riblet,R.,
            Miller,R.D., Emanuel,B.S. and Reeves,R.H.
  TITLE     Sequence-ready physical map of the mouse chromosome 16 region with
            conserved synteny to the human velocardiofacial syndrome region on
            22q11.2
  JOURNAL   Mamm Genome 10 (5), 438-443 (1999)
   PUBMED   10337614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY894892.1 and AY668947.1.
            
            On Sep 7, 2007 this sequence version replaced NM_172151.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY894892.1, AY668947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1378              AY894892.1         1-1378
            1379-2415           AY668947.1         1253-2289
            2416-4887           AY894892.1         2416-4887
FEATURES             Location/Qualifiers
     source          1..4887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.29 cM"
     gene            1..4887
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /note="zinc finger, DHHC domain containing 8"
                     /db_xref="GeneID:27801"
                     /db_xref="MGI:MGI:1338012"
     exon            1..230
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2415
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /EC_number="2.3.1.225"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable palmitoyltransferase ZDHHC8; DHHC-containing
                     protein 8; zinc finger DHHC domain-containing protein 8"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC8 isoform 1"
                     /protein_id="NP_742163.4"
                     /db_xref="CCDS:CCDS28017.1"
                     /db_xref="GeneID:27801"
                     /db_xref="MGI:MGI:1338012"
                     /translation="MPRSPGTRLKPAKYIPVATAAALLVGSSTLFFVFTCPWLTRAVS
                     PAIPVYNGILFLFVLANFSMATFMDPGVFPRADEDEDKEDDFRAPLYKNVDVRGIQVR
                     MKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVNNCIGRRNYRYFFLFLLSLSAHM
                     VGVVAFGLLYVLNHSEGLGAAHTTITMAVMCVAGLFFIPVIGLTGFHVVLVTRGRTTN
                     EQVTGKFRGGVNPFTRGCYGNVEHVLCSPLAPRYVVEPPRMPLSVSLKPPFLRPELLE
                     RAVPLKVKLSDNGLKAGRSKSKGSLDQLDEKPLDLGPPLPPKIEAGTFGRDLKTPRPG
                     SAESALSVQRTSPPTPAMYKFRPAFSTGPKTPFCGPNEQVPGPDSLTLADDSTHSLDF
                     VSEPSLDLPDHGPGGLRPPYPPSPPLNTTDAFSGALRSLSLKAASRRGGDHMTLQPLR
                     SEGGPPTPHRSLFAPHALPNRNGSLSYDSLLNPGSPSGHACPTHPSVGIASYHSPYLH
                     PGPSDPPRPPPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQT
                     DSLFGDSGVYDTPSSYSLQQASVLTEGPRGSVLRYGSRDDLVAGPGFGGARNPALQTS
                     LSSLSSSMSRAPRTSSSSLQADQANNNAPGPRPGSGSHRSPARQGLPSPPGTPRSPSY
                     TGSKAVAFIHTDLPDRQPSLAMQRDHPQLKTPPSKLNGQSPGMARLGPAASPMGPNAS
                     PARHTLVKKVSGVGGTTYEISV"
     exon            231..352
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..510
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..683
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..786
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..878
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1014
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1135
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1245
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..2243
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..4868
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3374..3379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /note="hexamer: ATTAAA"
     polyA_site      3393
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /note="major polyA site"
     regulatory      4842..4847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
                     /note="hexamer: AATAAA"
     polyA_site      4868
                     /gene="Zdhhc8"
                     /gene_synonym="D16H22S1738E; DHHC-8; E330009O14Rik;
                     Op53c05; ZDHHCL1"
ORIGIN      
        1 gggatttcct ccactgccgc tgcggcggat cctgcgccgc gtccagcccg cgcgcccgac
       61 cccggcccga cccggccggc cccgcccgcc cggcccgggg agggatgcgg cggcgcggcg
      121 cccaggatgc cccgcagccc cgggacgcgc ctcaaacccg ccaagtacat cccggtggcc
      181 acggccgccg cgctgttggt tggttccagc acactcttct tcgtattcac gtgcccatgg
      241 ttgacaagag ctgtgtctcc agctattcct gtctacaatg gcatcctctt cctctttgtc
      301 ctggccaact tcagtatggc taccttcatg gaccctggag tcttcccccg agcggacgag
      361 gacgaggaca aggaggatga cttccgggcc ccactgtaca agaatgtgga tgtgcggggc
      421 atccaggtcc gcatgaagtg gtgtgcaacg tgccactttt accgtccacc gcgctgctca
      481 cactgcagtg tctgtgacaa ctgtgtggag gactttgacc atcactgccc ctgggtcaac
      541 aactgcattg gacgccgcaa ctaccgttac ttcttcctgt tcctgctgtc actcagcgcg
      601 cacatggtgg gggtggtggc cttcggcctg ctctatgtgc tcaatcactc ggaggggctg
      661 ggagccgccc acaccaccat caccatggct gtcatgtgtg tggctggcct tttcttcatt
      721 cctgtcatcg gcctcactgg ctttcacgtg gtactggtca cgcggggccg caccaccaat
      781 gagcaggtga ctgggaagtt ccgcgggggt gtgaatccct tcacccgagg ctgctatggg
      841 aacgtggagc acgtgttatg cagtcccctg gcgccccggt atgtggtgga accccccagg
      901 atgccgctct cagtgagcct caagccaccc ttcctgagac ctgagctcct ggaacgagct
      961 gtgcccctca aggtcaaact tagcgacaat gggctgaaag ctggccgcag caagtccaag
     1021 ggcagtctag accagctgga tgagaaacct ctggacctgg gacctccact gccccccaag
     1081 atagaggctg gtacctttgg aagagatctg aagaccccaa gacctggcag tgctgagagt
     1141 gccctatcag tacagaggac cagcccccca acacctgcca tgtataagtt ccggccagcc
     1201 ttctccactg gtcccaagac acccttttgt ggacctaatg agcaggtccc aggtcctgac
     1261 tcccttactc tggcagatga cagcacccac agtctagact ttgtgtctga gcccagcctg
     1321 gatctcccag accacgggcc gggtggtctg cgtcctccct acccgccctc cccacccctc
     1381 aacaccactg atgccttctc aggtgccttg cgctccctga gtctcaaggc tgccagtcgg
     1441 aggggtgggg accacatgac cttacagcca ctgcgctctg aaggtgggcc ccctacacct
     1501 caccgtagtc tctttgctcc tcatgcactg cccaatcgaa atggcagcct gtcatatgac
     1561 agcctactta accctggctc acccagtggc cacgcatgcc ccacacaccc ctctgttggt
     1621 atagccagct accattcacc ctacctgcac cctgggccat cagatccacc gcggccccca
     1681 ccccgcagct tcagccctgt gctgggtccc cggcctaggg aaccctctcc tgtgcgctat
     1741 gacaacctgt ctcggaccat catggcctct atccaggagc gcaaggacag ggaagagcgt
     1801 gaacggctgc tgcgctccca gactgactca ctctttggcg actctggtgt ctatgataca
     1861 cccagctcct acagcctgca acaggccagt gtgttaacgg aaggcccccg tggctctgtc
     1921 ctgcgttacg gctccaggga tgacctcgtg gccgggcctg gctttggtgg tgcccgcaat
     1981 cctgccctgc agacgtcatt gtcctcgctg tccagctcca tgagtcgggc acctcggaca
     2041 tcttcctcct ccctgcaggc tgaccaggcc aacaacaatg ccccaggacc ccggcctggc
     2101 agtggttcac ataggtcacc tgcccgtcag ggcctgcctt ccccaccagg caccccccga
     2161 tcgccctcct acacgggctc caaggccgtc gccttcatcc acacagacct cccggaccgg
     2221 cagccctcac tggctatgca gagggatcac cctcagctga agaccccccc aagtaagctt
     2281 aacgggcagt ccccaggcat ggcccgtctg gggcctgctg ccagccccat ggggcccaac
     2341 gccagccctg cccggcacac gctggttaag aaggtgtccg gcgtgggtgg gactacgtat
     2401 gaaatctcgg tgtgagaact gaccaccact catctgctgt gatgccacgg ggaccaggac
     2461 cccccgcagt agctccccaa ccctatcaag ttctctgccc cagggaggag gctccccaag
     2521 cctgctgtgg acacatcaac aggaaagaca gccttgcctc cacaagcttg agctccggcc
     2581 tctgcctgtt catctactta cctagtactc acagggcaga tgggtccaag gctgtgggct
     2641 gtgatgggca cctggactgc ctccttcatc agccaagctc agccctgcat cctattgccc
     2701 tcattcccta aggccagtcc ccagcagtcc catgggccca cccactcctg tctggatggg
     2761 ttgctcagcc ctgttctcca gctgctccta actcacggcc tttcactgac aaagctggtc
     2821 gcttgttgct tggcaaggcc tgtgctttgc agggagcata accctggcct gctccgggtt
     2881 gggatgcata gatgaacgta cggacagata cttgagcggt agcaggggtc ccagctccct
     2941 ctgttcgtgt cttgcctggc tggtgggttc gtgtccctgt gtctgtatgc tgtgctgccg
     3001 tgccacgtct gatgtgttag tgctcggctg ccactgttct ttcatcaaag ccttaacttc
     3061 tgctttatgc tcttgtggga ggtgatgggg ggtggggtcg gccagagcag agagggggcc
     3121 agatgctgcc cgggagacca gtggggccga gagccccctc cctctctctc gggccttccc
     3181 tgccaaactg gagaatcctc accccaaagc atcccgggtt cccagcactg gcttggccag
     3241 cacagctgga aagcacatca gggcgggtcc attcgtcccc tggcgtcagg ggcctgagta
     3301 agcacatggc agcgtccgct tgcatcgtgt ctgttctatg tttttatatt tacatctata
     3361 tatctataat tttattaaaa aaaggaaaaa tcattttgag cctttccttg ggcaaggctg
     3421 tggctgtggg tacaggggtg tctcaggaaa ggggttggcc agctggtgca gggtggcatg
     3481 ttcctcttgg acagctctgc tggcattgcc aagtcaggcc tagttggtaa cgaatggact
     3541 tctgctggtg agttgcaaag gtgtcttact cccagtctgt gtcatgccgg acggaagggt
     3601 gtttggtgaa aggctaggac ctcagctgcc tcctgggact ctgaggtacc aaagggcttg
     3661 gagcagctat atagtggagg ctgcacatga ggccaatgcc tggccgagaa acctacagat
     3721 actactatac ttcttccctg ccatatgcca agggaggaat tagggagtgt caggaagaac
     3781 tcagagcagg gctggaaagg gctagggtag gtccagagtt tcaagaaggg gaggtgtcca
     3841 gagcctgggg ccccttagtt ctacccactg ctgacttcca cctttctgct tctctctcat
     3901 ggatatcggc caacaggggg cgcattggca gctgtagccg tggatggggg tggcgtggta
     3961 cgcctagggg gactcctggc ctccacctat gccaccttgg ccaccctgag gatcacccgc
     4021 cgctgcgggc cccctggagc gtggctgctg gggcagcccc ccgtgggacc atttgtcggc
     4081 tacattctgc tgcatccagc cttttcccca gcctctcagg tccctaacag gacactagta
     4141 ggtggctcta gggccatgga cagtcttctg gggacccaga agacgaggtt gctgtagagc
     4201 tttggagttg ggctggatgt agcctggaga tccctacccc gttccccgtc aaccagccac
     4261 atcttgactg atcagtctgc cagggtccac gaccctgtct ccaggtgacc tcaggaagtc
     4321 cccccacctg ctgcaggggt ccagtgcccc aatgggggtg gcctcagagc tactgggaac
     4381 cagcatgacc tttaccccaa cctccttacc ccttccaagc actttaagcc acttcctcta
     4441 gggagcccag gcctctgtgg gttgggctgg ggtgggggtc tcaggtcacc gcaggttact
     4501 gcactcctcc actcaacccc aagcccctga acagatgcct taaagtcctg gagctgccag
     4561 ccagcttggt gcaccatgaa cctggtccac ccgtctctgc ctcttgcctg ctctgaccca
     4621 cctgggtctt ctgcagccaa gggtgatacc tctgggaata cccaagcctg tgggcctgga
     4681 tacccctggg aggagtcaga acagaacccc tgccaactcc tcttttcaca caggggctgt
     4741 gtcctggggg ctacttctgg gcagcagtta tgtgtctccc atatggggac agatcacaaa
     4801 ctgttttctg ttgtatagga tttccctccc tcaacttccc taataaattt tttttttgtt
     4861 cacctccaaa aaaaaaaaaa aaaaaaa
//
