LOCUS       NM_133967               2874 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus zinc finger, DHHC domain containing 7 (Zdhhc7), mRNA.
ACCESSION   NM_133967 XM_001002092
VERSION     NM_133967.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2874)
  AUTHORS   Liu,Y., Hou,D., Chen,W., Lu,X., Komaniecki,G.P., Xu,Y., Yu,T.,
            Zhang,S.M., Linder,M.E. and Lin,H.
  TITLE     MAVS Cys508 palmitoylation promotes its aggregation on the
            mitochondrial outer membrane and antiviral innate immunity
  JOURNAL   Proc Natl Acad Sci U S A 121 (34), e2403392121 (2024)
   PUBMED   39141356
REFERENCE   2  (bases 1 to 2874)
  AUTHORS   Zhang,N., Zhang,J., Yang,Y., Shan,H., Hou,S., Fang,H., Ma,M.,
            Chen,Z., Tan,L. and Xu,D.
  TITLE     A palmitoylation-depalmitoylation relay spatiotemporally controls
            GSDMD activation in pyroptosis
  JOURNAL   Nat Cell Biol 26 (5), 757-769 (2024)
   PUBMED   38538834
REFERENCE   3  (bases 1 to 2874)
  AUTHORS   Yu,T., Hou,D., Zhao,J., Lu,X., Greentree,W.K., Zhao,Q., Yang,M.,
            Conde,D.G., Linder,M.E. and Lin,H.
  TITLE     NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome
            activation
  JOURNAL   Cell Rep 43 (4), 114070 (2024)
   PUBMED   38583156
REFERENCE   4  (bases 1 to 2874)
  AUTHORS   Jiang,Y., Xu,Y., Zhu,C., Xu,G., Xu,L., Rao,Z., Zhou,L., Jiang,P.,
            Malik,S., Fang,J., Lin,H. and Zhang,M.
  TITLE     STAT3 palmitoylation initiates a positive feedback loop that
            promotes the malignancy of hepatocellular carcinoma cells in mice
  JOURNAL   Sci Signal 16 (814), eadd2282 (2023)
   PUBMED   38051779
REFERENCE   5  (bases 1 to 2874)
  AUTHORS   Kerkenberg,N., Wachsmuth,L., Zhang,M., Schettler,C., Ponimaskin,E.,
            Faber,C., Baune,B.T., Zhang,W. and Hohoff,C.
  TITLE     Brain microstructural changes in mice persist in adulthood and are
            modulated by the palmitoyl acyltransferase ZDHHC7
  JOURNAL   Eur J Neurosci 54 (6), 5951-5967 (2021)
   PUBMED   34355442
  REMARK    GeneRIF: Brain microstructural changes in mice persist in adulthood
            and are modulated by the palmitoyl acyltransferase ZDHHC7.
            Review article
REFERENCE   6  (bases 1 to 2874)
  AUTHORS   Tsutsumi,R., Fukata,Y., Noritake,J., Iwanaga,T., Perez,F. and
            Fukata,M.
  TITLE     Identification of G protein alpha subunit-palmitoylating enzyme
  JOURNAL   Mol Cell Biol 29 (2), 435-447 (2009)
   PUBMED   19001095
REFERENCE   7  (bases 1 to 2874)
  AUTHORS   Greaves,J., Salaun,C., Fukata,Y., Fukata,M. and Chamberlain,L.H.
  TITLE     Palmitoylation and membrane interactions of the neuroprotective
            chaperone cysteine-string protein
  JOURNAL   J Biol Chem 283 (36), 25014-25026 (2008)
   PUBMED   18596047
REFERENCE   8  (bases 1 to 2874)
  AUTHORS   Fukata,M., Fukata,Y., Adesnik,H., Nicoll,R.A. and Bredt,D.S.
  TITLE     Identification of PSD-95 palmitoylating enzymes
  JOURNAL   Neuron 44 (6), 987-996 (2004)
   PUBMED   15603741
REFERENCE   9  (bases 1 to 2874)
  AUTHORS   Keller,C.A., Yuan,X., Panzanelli,P., Martin,M.L., Alldred,M.,
            Sassoe-Pognetto,M. and Luscher,B.
  TITLE     The gamma2 subunit of GABA(A) receptors is a substrate for
            palmitoylation by GODZ
  JOURNAL   J Neurosci 24 (26), 5881-5891 (2004)
   PUBMED   15229235
REFERENCE   10 (bases 1 to 2874)
  AUTHORS   Chaudhary,J. and Skinner,M.K.
  TITLE     Identification of a novel gene product, Sertoli cell gene with a
            zinc finger domain, that is important for FSH activation of
            testicular Sertoli cells
  JOURNAL   Endocrinology 143 (2), 426-435 (2002)
   PUBMED   11796495
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC075666.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_001002092.1, NM_133967.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075666.1, AK041905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2874
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 68.93 cM"
     gene            1..2874
                     /gene="Zdhhc7"
                     /gene_synonym="Gramp2"
                     /note="zinc finger, DHHC domain containing 7"
                     /db_xref="GeneID:102193"
                     /db_xref="MGI:MGI:2142662"
     exon            1..381
                     /gene="Zdhhc7"
                     /gene_synonym="Gramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..466
                     /gene="Zdhhc7"
                     /gene_synonym="Gramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..797
                     /gene="Zdhhc7"
                     /gene_synonym="Gramp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..1409
                     /gene="Zdhhc7"
                     /gene_synonym="Gramp2"
                     /EC_number="2.3.1.225"
                     /note="GABA-A receptor-associated membrane protein 2;
                     DHHC-7; zinc finger DHHC domain-containing protein 7;
                     SERZ-beta; acyltransferase ZDHHC7"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC7"
                     /protein_id="NP_598728.1"
                     /db_xref="CCDS:CCDS22715.1"
                     /db_xref="GeneID:102193"
                     /db_xref="MGI:MGI:2142662"
                     /translation="MQPSGHRLRDIEHHPLLTDNDNYDSASSSSSETDMADRVWFIRD
                     GCGMVCAVMTWLLVVYADFVVTFVMLLPSKDFWYSVVNGVLFNCLAVLALSSHLRTML
                     TDPGAVPKGNATKEYMESLQLKPGEVIYKCPKCCCIKPERAHHCSICKRCIRKMDHHC
                     PWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGLQFISCVRGQWTECSDFSPPITVI
                     LLVFLCLEGLLFFTFTAVMFGTQIHSICNDETEIERLKSEKPTWERRLRWEGMKSVFG
                     GPPSLLWMNPFVGFRLRRLQMRTRKGGPEFSV"
     exon            798..922
                     /gene="Zdhhc7"
                     /gene_synonym="Gramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1019
                     /gene="Zdhhc7"
                     /gene_synonym="Gramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1101
                     /gene="Zdhhc7"
                     /gene_synonym="Gramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1232
                     /gene="Zdhhc7"
                     /gene_synonym="Gramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..2854
                     /gene="Zdhhc7"
                     /gene_synonym="Gramp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctgcctc tcctccaaga accgccgagt tcttggaagc ccggtcttgg atgaaatcgc
       61 cagagcctcc ccgcgatccg cctcccggaa gccccgggcg gcgcgaccgg aaggacgcag
      121 gcgcagcgtc ttgacctcgg cctggtccag ttccggggtc gttcggctcg gctgtgccag
      181 ttcggcgtcg ggctcccgct tctgctgggg ctgctgcctc tcgcccaccg gcccggccgg
      241 cccgagcagc gcggaaccga gccggatccg ggtccacccg gcccggccat gagcgctgcc
      301 gcatgatgcg tcgccgcccg cgccgttgca gccgccggcc accaggagcc tcagcactgg
      361 gcgaccccgc ccgggcctcg ggccacatca cacaggacag catgcggctt acagtcctga
      421 aaaaaaggca caagtgctcc catgatgctt aaaagcaact tgtaagggtg tttcagggaa
      481 tcatgcagcc gtcgggacac aggctccggg acatcgagca ccatcctctc ctgactgaca
      541 atgacaatta cgactcagca tcctcttcgt cctccgagac tgacatggca gacagggtgt
      601 ggttcatccg agatggctgt ggcatggtct gtgctgtcat gacgtggctt ctcgtcgtct
      661 atgcagactt cgtggtgacc tttgtcatgc tgctgccttc caaagacttc tggtactccg
      721 tggtgaacgg agtcctcttc aactgcttgg cggtgctcgc gctgtcctcc cacctgagaa
      781 ccatgctcac tgacccgggt gctgtcccca aaggcaacgc cacgaaggag tacatggaga
      841 gcttgcagct gaagccaggc gaggtgatct acaagtgccc caagtgttgc tgcatcaagc
      901 cggaacgtgc ccaccactgc agtatttgca agagatgcat tcgaaagatg gaccatcact
      961 gcccgtgggt gaacaactgc gtcggggaga agaatcagag gttcttcgtg cttttcacca
     1021 tgtacatagc tctgtcttcg gttcatgctc tgattctctg tgggcttcag ttcatctcct
     1081 gcgtccgagg gcagtggaca gagtgcagcg acttctctcc tcccataact gtaatcctgt
     1141 tggtcttcct gtgccttgag ggcctcctgt tcttcacctt caccgcagtc atgttcggca
     1201 cccagatcca ctcgatatgc aatgatgaaa cagagatcga gaggctgaag agcgagaagc
     1261 ccacgtggga gcgcaggctg cggtgggaag gaatgaagtc tgtcttcggg ggccctccct
     1321 ccctcctctg gatgaacccc ttcgttggct tccgactcag gcggctgcag atgaggacca
     1381 ggaaaggagg ccccgagttc tctgtctgag ccttcagggt gggaatgtct gcagacatcc
     1441 gtgctcagtg gcctgcgtgc acagcagcct tgtgggcaga tggagcgggc cagctgacgg
     1501 ggccatgagc ggcttcatgg accacaggcc acaggcactt gtcatttctc ttgtgtactg
     1561 ccaggagaag catgcagtcc cgggaggcca tcgtctcacc atcctgaccc ttgggatgtc
     1621 gcgtgggcac ccacgggtgg agttgcttct cagtcatgaa gaaagccagc acagcagcgc
     1681 tgggagtcct gctggcccat ccccagcgca cccccttacc cgaaagaagg ggttccacag
     1741 agactctgcc ttggaggcct ctgacaccca gcactgaaca gtgaaagcag cttccagaac
     1801 actccctgct gccccggaac gggcatcctt tgacccttcc agcaagtctg tgtgtgctca
     1861 tccttgtgtg tctgtgtggt gtgtgtgtgt gtgtgtgtgt gagcatgtgt cagagtcagc
     1921 agtgtcgttg aggcacgtat gtggtagaca agctgtcttt cagactccag tgtttcaggg
     1981 aagtgggacg cactgctggc ccttgctggc ctactatgaa tgtatcctac agtgtccaga
     2041 tccaaagaac aggcatgcct gtgcatgggc ccggcctcct gcttttattt cactgaaaat
     2101 ttagtgtttg agggcgtgga gctgaggttt tgttgttcca gccaaactgc aactgcaaca
     2161 gtctctcaac agggagagtg gtagcccatg ctgaggccca gcgctttggg gcaggggcca
     2221 tgaggagctc agcgtgagaa gccacctagg gccccttggg gcaggtgctg cagggtgaga
     2281 cagcctggtg cctgagctgt cagagtggtg atatgtgact atttctctac ccatggcacc
     2341 gcagtcagtg gagccttggt gcgggcttag aatcccgtca gtacacaaac agctcccctc
     2401 aggggatttg ccttaaccgc tggttgttgc tttgctgctg ggtgagagca gtctgacaga
     2461 gtctggggac ttcctgagag tcttctccca tgcagacacc agtgtttccc ttctgggacc
     2521 agctgccttt ctgtccctgg gacaccatga ctgttctttc ggtgtcagtt gcttgtgccc
     2581 tgccctcatc tgggctcctg tgctactgag gtgaccccca gggacctgag ccgagccctc
     2641 atgcagcgag caatctctgg ggcccaagtc cctgcagagg gacatcgagg cctcagattg
     2701 tctctgcgtt cctttgcaca cgtgtctggg catgtaggct ctggcggtct caccctccag
     2761 tgtggagtct gtgcggtgaa cccaagctga gtatacttga cttttcaatt cctcagtgtg
     2821 attttatatg aaataaagta acccgtccac agttaaaaaa aaaaaaaaaa aaaa
//
