LOCUS       NM_025883               2257 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus zinc finger, DHHC domain containing 6 (Zdhhc6),
            transcript variant 2, mRNA.
ACCESSION   NM_025883
VERSION     NM_025883.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2257)
  AUTHORS   Yu,T., Hou,D., Zhao,J., Lu,X., Greentree,W.K., Zhao,Q., Yang,M.,
            Conde,D.G., Linder,M.E. and Lin,H.
  TITLE     NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome
            activation
  JOURNAL   Cell Rep 43 (4), 114070 (2024)
   PUBMED   38583156
REFERENCE   2  (bases 1 to 2257)
  AUTHORS   Komaniecki,G., Camarena,M.D.C., Gelsleichter,E., Mendoza,R.,
            Subler,M., Windle,J.J., Dozmorov,M.G., Lai,Z., Sarkar,D. and Lin,H.
  TITLE     Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6
            Regulates Its Biological Activity
  JOURNAL   Biochemistry 62 (2), 543-553 (2023)
   PUBMED   36548985
  REMARK    GeneRIF: Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6
            Regulates Its Biological Activity.
REFERENCE   3  (bases 1 to 2257)
  AUTHORS   Fukata,Y., Murakami,T., Yokoi,N. and Fukata,M.
  TITLE     Local Palmitoylation Cycles and Specialized Membrane Domain
            Organization
  JOURNAL   Curr Top Membr 77, 97-141 (2016)
   PUBMED   26781831
  REMARK    Review article
REFERENCE   4  (bases 1 to 2257)
  AUTHORS   Fredericks,G.J., Hoffmann,F.W., Rose,A.H., Osterheld,H.J.,
            Hess,F.M., Mercier,F. and Hoffmann,P.R.
  TITLE     Stable expression and function of the inositol 1,4,5-triphosphate
            receptor requires palmitoylation by a DHHC6/selenoprotein K complex
  JOURNAL   Proc Natl Acad Sci U S A 111 (46), 16478-16483 (2014)
   PUBMED   25368151
REFERENCE   5  (bases 1 to 2257)
  AUTHORS   Blaskovic,S., Adibekian,A., Blanc,M. and van der Goot,G.F.
  TITLE     Mechanistic effects of protein palmitoylation and the cellular
            consequences thereof
  JOURNAL   Chem Phys Lipids 180, 44-52 (2014)
   PUBMED   24534427
REFERENCE   6  (bases 1 to 2257)
  AUTHORS   Chamberlain,L.H., Lemonidis,K., Sanchez-Perez,M., Werno,M.W.,
            Gorleku,O.A. and Greaves,J.
  TITLE     Palmitoylation and the trafficking of peripheral membrane proteins
  JOURNAL   Biochem Soc Trans 41 (1), 62-66 (2013)
   PUBMED   23356259
REFERENCE   7  (bases 1 to 2257)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2257)
  AUTHORS   Conibear,E. and Davis,N.G.
  TITLE     Palmitoylation and depalmitoylation dynamics at a glance
  JOURNAL   J Cell Sci 123 (Pt 23), 4007-4010 (2010)
   PUBMED   21084560
REFERENCE   9  (bases 1 to 2257)
  AUTHORS   Lu,J., Qian,J., Izvolsky,K.I. and Cardoso,W.V.
  TITLE     Global analysis of genes differentially expressed in branching and
            non-branching regions of the mouse embryonic lung
  JOURNAL   Dev Biol 273 (2), 418-435 (2004)
   PUBMED   15328023
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133100.5 and AK159304.1.
            
            On Feb 8, 2018 this sequence version replaced NM_025883.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033317.1, AK154741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC133100.5         12790-12798
            10-2172             AK159304.1         7-2169
            2173-2257           AC133100.5         30526-30610
FEATURES             Location/Qualifiers
     source          1..2257
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.33 cM"
     gene            1..2257
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /note="zinc finger, DHHC domain containing 6"
                     /db_xref="GeneID:66980"
                     /db_xref="MGI:MGI:1914230"
     exon            1..241
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            242..713
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             447..1688
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /EC_number="2.3.1.225"
                     /note="isoform 1 is encoded by transcript variant 2; H4
                     homolog; zinc finger DHHC domain-containing protein 6;
                     palmitoyltransferase ZDHHC6; stearoyltransferase ZDHHC6"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC6 isoform 1"
                     /protein_id="NP_080159.3"
                     /db_xref="CCDS:CCDS29909.1"
                     /db_xref="GeneID:66980"
                     /db_xref="MGI:MGI:1914230"
                     /translation="MGIFCSVIKFENLQDLRRLCHWGPIIALGVIAICSTMAMIDSVL
                     WYWPLHTTGGSVNFIMLINWTVMILYNYFNAMFAGPGFVPRGWKPEKSQDSMYLQYCK
                     VCQAYKAPRSHHCRKCNRCVMKMDHHCPWINNCCGHQNHASFTLFLLLAPLGCTHAAF
                     IFVMTMYTQLYNRLSFGWNTVKIDMSAARRDPPPIVPFGLAAFAATLFALGLALGTTI
                     AVGMLFFIQIKIILRNKTSIESWIEEKAKDRIQYYQLDEVFIFPYDMGSKWKNFKQVF
                     TWSGVPEGDGLEWPIREGCDQYSLTIEQLKQKADKRVRSVRYKVIEDYNGACCPLNRG
                     VRTFFTSPCTEEPRIRLQKGEFILATRGLRYWLYGDKILDDSFIEGTSRVRGWFPRNC
                     VEKCPCDGDSDPAPEGEKKNR"
     exon            714..805
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            806..965
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1127
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1181
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1349
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1391
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1537
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1584
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..2257
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2130..2135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /note="hexamer: AATAAA"
     regulatory      2158..2163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /note="hexamer: ATTATA"
     polyA_site      2158
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /note="major polyA site"
     polyA_site      2177
                     /gene="Zdhhc6"
                     /gene_synonym="2400007G07Rik; 5930409M18Rik; DHHC-6"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtggct gtggcggagc ttgcgccgag gacccgagcg ggaggctcac ggcggccgcg
       61 tgaaccagag acgcgcgggt ccgagttccc cgcgcaggtc tcgccgtcag ggttcgcatt
      121 cggcttgctc agactgaagc gctcatgaca gagctataag gaggagaaaa tctgttccgc
      181 tgagcccggg ccgtcccgga aatgcgatgg ctgtggagcg ggcaccggag accagactga
      241 ggctgtgttt caaatcaacc tatattctcc tgtgagatac agagttctgg aggccacaac
      301 tgaaaatgac ataccccacc tcagtgaccc ttcagccaaa ggcatgacag ctcaggcaca
      361 cacatggact tgttgcacac agaaatgtgt gcacaggaaa aggagatctc tagttcttta
      421 gaagaaagaa gtcattcttc accaagatgg gcatattctg ctcagtaatc aagtttgaaa
      481 atcttcaaga cttaaggaga ctgtgtcatt ggggtcccat catagccctg ggtgttatag
      541 caatatgttc cacaatggcc atgatcgact ctgtcttgtg gtattggccc ttacatacaa
      601 ctggaggaag tgtgaacttc atcatgttga taaattggac cgtcatgatt ctttataatt
      661 acttcaatgc catgtttgct ggtcctggct tcgtccctcg ggggtggaaa ccggaaaagt
      721 ctcaggatag catgtatctc cagtattgta aagtctgcca agcatacaag gcgccacgtt
      781 cacaccattg cagaaagtgt aacagatgtg taatgaagat ggaccaccac tgcccctgga
      841 tcaacaactg ctgtggtcac cagaaccacg cctcgttcac gctcttcctc ctgttggccc
      901 ctctgggctg cactcatgct gctttcatct tcgtgatgac aatgtacaca cagctttata
      961 atcggctctc ctttgggtgg aacacagtca agattgacat gagtgcagcc aggagagatc
     1021 cacctccaat tgttcccttc ggattggctg cgtttgccgc caccttgttt gccttgggat
     1081 tggctttggg aacaaccata gctgttggga tgttgttttt catacagata aaaattattc
     1141 tcagaaacaa aacttctatt gaatcatgga ttgaagaaaa ggctaaagat cgcattcagt
     1201 attaccaact ggatgaagtc ttcatttttc cttatgatat gggaagtaag tggaagaact
     1261 ttaaacaggt gtttacatgg tcgggagttc ctgaaggaga tggacttgag tggccaatac
     1321 gagagggctg tgaccagtac agcctcacaa tagaacagtt gaagcaaaag gcagacaaga
     1381 gagtcagaag tgttcgctat aaagtcatag aagattacaa tggtgcctgc tgccctttga
     1441 atagaggagt gagaaccttc tttacgagcc cctgcactga ggagcctcgg atccggctgc
     1501 agaaaggaga gttcatctta gcaacgagag ggctgcgata ctggttgtat ggagacaaaa
     1561 ttcttgatga ttccttcata gaaggtactt caagagtaag agggtggttt cctagaaact
     1621 gtgtggaaaa gtgtccctgt gatggtgact cagatccagc cccagagggg gagaagaaga
     1681 acagatagcc actgttaaag tgagatcact aagtcttcat tacttgaaaa tccacatgta
     1741 gtacctgaga attatgcaac gagcctactc tgcttaaggt attcttttcc tcaaagatgc
     1801 cctagtgcca tgacttcaga aatgtttatt accgttttga aacagaagcc attctgcata
     1861 tgcctttgaa ttcctgccgt ctttccactt cttcctactg aagcaaggcc gttccagccc
     1921 agtgagcaac ttgccctttc tgtgtgctgc acatctgact tcccctgcag gtctaattcc
     1981 ccactggaca ggagcatctt gcatgtggtt actctgtttc ttcctcagtt gacatttcct
     2041 tcataatctt ctagagactg taaaacttgt cagattcaat ataaactcaa atttggttac
     2101 ttttaataat acagattttt gtcaaatcca ataaaggtca atggatgttc tgtaaaaatt
     2161 atagttttca ccaaaaagca ttgtttttag tttgcttttt ggtttggtgg tggtggtggt
     2221 ggtttatttt gtcttctgag taaaaaggtt tctctga
//
