LOCUS       NM_144887               4740 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus zinc finger, DHHC domain containing 5 (Zdhhc5), mRNA.
ACCESSION   NM_144887
VERSION     NM_144887.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4740)
  AUTHORS   Balasubramanian,A., Hsu,A.Y., Ghimire,L., Tahir,M., Devant,P.,
            Fontana,P., Du,G., Liu,X., Fabin,D., Kambara,H., Xie,X., Liu,F.,
            Hasegawa,T., Xu,R., Yu,H., Chen,M., Kolakowski,S., Trauger,S.,
            Larsen,M.R., Wei,W., Wu,H., Kagan,J.C., Lieberman,J. and Luo,H.R.
  TITLE     The palmitoylation of gasdermin D directs its membrane
            translocation and pore formation during pyroptosis
  JOURNAL   Sci Immunol 9 (94), eadn1452 (2024)
   PUBMED   38530158
REFERENCE   2  (bases 1 to 4740)
  AUTHORS   Zhou,Y., Yue,S., Li,L., Zhang,J., Chen,L. and Chen,J.
  TITLE     SMPDL3B is palmitoylated and stabilized by ZDHHC5, and its
            silencing aggravates diabetic retinopathy of db/db mice: Activation
            of NLRP3/NF-kappaB pathway
  JOURNAL   Cell Signal 116, 111064 (2024)
   PUBMED   38266744
  REMARK    GeneRIF: SMPDL3B is palmitoylated and stabilized by ZDHHC5, and its
            silencing aggravates diabetic retinopathy of db/db mice: Activation
            of NLRP3/NF-kappaB pathway.
REFERENCE   3  (bases 1 to 4740)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4740)
  AUTHORS   Zheng,S., Que,X., Wang,S., Zhou,Q., Xing,X., Chen,L., Hou,C.,
            Ma,J., An,P., Peng,Y., Yao,Y., Song,Q., Li,J., Zhang,P. and Pei,H.
  TITLE     ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7
            interaction and inflammasome activation
  JOURNAL   Mol Cell 83 (24), 4570-4585 (2023)
   PUBMED   38092000
  REMARK    GeneRIF: ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7
            interaction and inflammasome activation.
REFERENCE   5  (bases 1 to 4740)
  AUTHORS   Yan,P., Liu,H., Zhou,T., Sun,P., Wang,Y., Wang,X., Zhang,L.,
            Wang,T., Dong,J., Zhu,J., Lv,L., Li,W., Qi,S., Liang,Y. and Kong,E.
  TITLE     Crosstalk of Synapsin1 palmitoylation and phosphorylation controls
            the dynamicity of synaptic vesicles in neurons
  JOURNAL   Cell Death Dis 13 (9), 786 (2022)
   PUBMED   36097267
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4740)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 4740)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 4740)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 4740)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4740)
  AUTHORS   Nagaya,M., Inohaya,K., Imai,Y. and Kudo,A.
  TITLE     Expression of zisp, a DHHC zinc finger gene, in somites and lens
            during zebrafish embryogenesis
  JOURNAL   Mech Dev 119 Suppl 1, S311-S314 (2002)
   PUBMED   14516702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW491606.1, AY894891.1, BC065155.1 and AK173251.1.
            
            On Nov 22, 2008 this sequence version replaced NM_144887.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173251.1, AK145086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AW491606.1         1-8
            9-1949              AY894891.1         1-1941
            1950-4690           BC065155.1         1820-4560
            4691-4740           AK173251.1         4648-4697
FEATURES             Location/Qualifiers
     source          1..4740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     gene            1..4740
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /note="zinc finger, DHHC domain containing 5"
                     /db_xref="GeneID:228136"
                     /db_xref="MGI:MGI:1923573"
     exon            1..182
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /inference="alignment:Splign:2.1.0"
     exon            183..1337
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /inference="alignment:Splign:2.1.0"
     CDS             1234..3381
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /EC_number="2.3.1.225"
                     /note="probable palmitoyltransferase ZDHHC5; DHHC-5; zinc
                     finger DHHC domain-containing protein 5"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC5"
                     /protein_id="NP_659136.1"
                     /db_xref="CCDS:CCDS16190.1"
                     /db_xref="GeneID:228136"
                     /db_xref="MGI:MGI:1923573"
                     /translation="MPAESGKRFKPSKYVPVSAAAIFLVGATTLFFAFTCPGLSLNVS
                     PAVPIYNAIMFLFVLANFSMATFMDPGIFPRAEEDEDKEDDFRAPLYKTVEIKGIQVR
                     MKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLLSLTAHI
                     MGVFGFGLLYVLYHIEELSGVRTAVTMAVMCVAGLFFIPVAGLTGFHVVLVARGRTTN
                     EQVTGKFRGGVNPFTNGCCNNVSRVLCSSPAPRYLGRPKKEKTIVIRPPFLRPEVSDG
                     QITVKIMDNGIQGELRRTKSKGSLEITESQSADAEPPPPPKPDLSRYTGLRTHLSLAT
                     NEDSSLLGKDSPPTPTMYKYRPGYSSSSTSAAMPHSSSAKLSRGDSLKEPTSIADSSR
                     HPSYRSEPSLEPESFRSPTFGKSFHFDPLSSGSRSSSLKSAQGTGFELGQLQSIRSEG
                     TTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEPDPPLGYTSPFLSARLAQ
                     QREAERHPRLLPTGPPHREPSPVRYDNLSRHIVASLQEREKLLRQSPPLAGREEEPGL
                     GDSGIQSTPGSGHAPRTSSSSDDSKRSPLSKTPLGRPAVPRFGKPDGLRSRGLGSPEP
                     GTTAPYLGRSISYSSQKAPSGVSETEEVALQPLLTPKDEVQLKTTYSKSNGQPKSIGS
                     ASPGPGQPPLSSPTRGGVKKVSGVGGTTYEISV"
     exon            1338..1459
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1617
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1790
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1893
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1985
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2118
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2242
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2355
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..3215
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..4740
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4503..4508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /note="hexamer: AATAAA"
     polyA_site      4519
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /note="major polyA site"
     regulatory      4627..4632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /note="hexamer: ATTAAA"
     regulatory      4671..4676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /note="hexamer: AATACA"
     polyA_site      4672
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
     polyA_site      4690
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
     regulatory      4721..4726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
                     /note="hexamer: AGTAAA"
     polyA_site      4740
                     /gene="Zdhhc5"
                     /gene_synonym="1110032A17Rik; Zisp"
ORIGIN      
        1 cggccgcgcg ccggccgcac agaggcgagc gtcggccgtc gggagcgcgc ggcggcgggg
       61 cgggcgtgga gcgtgcgggg gccgcgcgct gcctctcaga ggccagacgg cactgctggg
      121 aggcggcggc gacaacgacg gcggtgacaa cgacggcggc ggtgacgggc gccgcgccgg
      181 gggtaaagca ccatatccca tctgcatcca ggaagcccaa gattgaagac aaaagatcag
      241 agacattgac taacctggaa acagggacat ctttggaact ttatctacag taatctttta
      301 aactgtcatc aggtgaaatc aacttcatct tattctgctt attgaaaagg acatggcttc
      361 ttcaaggatt ttaaatttcc ttttagtttt ttgtgaactt tatgggaaac agagccctta
      421 aaaggcttgg gaataacaag aagagattga aaacaggcaa tactgctgtc tgtttttttc
      481 tccccattca aagaaaagga tttacaactc aaccctgtaa cagctgttat ccaactttgt
      541 ccatcaagag agacataaat aaaattaaat caccattgcc agccagccag ccctggtgaa
      601 gttaaggtgt gagagtggtg gcattgagaa gacggccgga aagagacgag gactgcagtt
      661 aaaataaatc agcttctctt taagctggaa gagaccccaa gttccttctc ggattaaact
      721 agaaacccag ggcacacctt ttaggtgctg ctcctagtgt ggtgttgtgg aggggctctt
      781 gtatctcctc agaagagtta aagcttcctg ccctccccac cccctgatac ttctgtcctc
      841 ccttttgaag acctgccttc atccatgagc tataccttga tctgcctgac tctgcatggt
      901 ttccacctgc aactgtttgc atgcatacag cctactgttt gtcttcacgt tttaaactgt
      961 acaagttgtg tttcttaatc tccttttctg ctctattctg gggaggtggt ttttaatcag
     1021 ttgaaatcac ctttccccct cccatgtgct ttccttcatt tgagatcttt tgaccttcat
     1081 ttttatttgg gagggggaag ggtgataatt atacattttc tgttttcccc agtttctttc
     1141 ctctctgttt ccctcatccc attttcttgt ctgttctgcc gctgtgtggg cctgggctat
     1201 gcggcagggc acatctttca tcagagctcc aacatgcccg cagagtctgg aaagaggttc
     1261 aaacccagca agtatgtacc ggtctcagca gccgccatat ttctagtggg agctacaaca
     1321 ctcttctttg cctttacgtg tccaggacta agcctgaatg tgtcacctgc agtgcccatt
     1381 tacaatgcaa ttatgtttct ctttgtgctg gccaacttta gcatggccac ctttatggac
     1441 ccaggaattt ttccccgagc cgaggaagat gaagacaaag aagatgactt ccgagctccc
     1501 ctttacaaaa cagtggagat caagggtatc caggtgcgaa tgaaatggtg tgccacctgc
     1561 cgcttttacc gccctcctag atgctcccac tgcagtgtct gtgacaactg tgtggaggaa
     1621 tttgaccatc actgcccttg ggtaaacaac tgtattggtc gcaggaacta cagatacttc
     1681 ttccttttcc tcctttccct gacagctcac atcatgggtg tgtttggctt tggcctcctt
     1741 tatgtcctct atcacataga ggaactctca ggggtccgca ctgctgtcac catggcagtg
     1801 atgtgtgtgg ctggcttatt tttcatccct gtagctggcc tcacaggatt tcatgtggtg
     1861 ctggtggcta ggggacgcac aaccaatgaa caggttacag gtaaattccg gggaggtgtg
     1921 aatcccttca ccaatggctg ctgtaacaac gttagccgtg tcctctgcag ttctccagca
     1981 cccaggtatt tggggagacc aaagaaagag aagacaattg taatcagacc tcctttcctt
     2041 cgaccagaag tgtcagatgg gcagataact gtgaagatca tggataatgg catccaggga
     2101 gaattgagga ggactaagtc taaaggaagc ctagagataa cagagagcca gtctgcagat
     2161 gcagaacctc cacctcctcc taagccggac ctcagccgat acacggggct tcgaacacac
     2221 ctcagcctgg ctactaatga ggatagcagt ctcttgggca aggacagtcc ccctacacct
     2281 accatgtaca agtatcgacc aggttacagc agcagtagca catcagccgc catgcctcat
     2341 tcctccagcg ccaagttgag tcgtggagac agcttaaagg agccaacttc aattgcagat
     2401 agcagccgcc atcccagcta ccgctcagaa cccagcttgg agccagagag cttccggtct
     2461 cctacttttg gcaaaagctt tcattttgat ccattgtcca gtggctcacg atcctccagc
     2521 ctcaagtcag ctcagggcac gggctttgag ctgggccagt tgcagtccat tcgttcagag
     2581 ggcaccacct ccacctccta taagagcctg gccaatcaga cacgcaatgg aagtctatct
     2641 tatgacagcc tactcactcc ttcagacagc cctgattttg agtcagtaca ggcagggcct
     2701 gagccagacc cacctttagg ctacacctct cccttcctgt cagcccggct ggcccagcaa
     2761 cgggaagccg agaggcatcc acgtttgctg ccaactggcc caccacaccg agaaccctca
     2821 ccagtccgtt atgacaatct gtctcgccac attgtggcct ccctccagga acgagagaag
     2881 ctgctacgac agtcacctcc acttgcaggc cgtgaggaag aaccaggctt gggagactca
     2941 ggcattcagt caacaccagg ctcaggccat gccccccgta ctagttcctc ctcagatgat
     3001 tccaagagat cacccttgag taagactcca ctgggacgcc cagctgttcc ccgttttggc
     3061 aaaccagatg ggctaagaag ccggggacta gggtcccctg aaccaggcac aactgccccc
     3121 tacctgggcc gatcaatatc ctatagcagc caaaaagccc catctggtgt ctcagagaca
     3181 gaggaagtag cattgcagcc attactgaca cccaaagatg aagtacagct caagaccacc
     3241 tacagcaaat ccaatgggca gcccaagagt ataggctcag cttcccctgg cccaggccag
     3301 ccacctctca gtagccccac aaggggagga gtcaagaagg tgtcaggggt gggtggcacc
     3361 acttatgaga tttctgtgtg aatcttggcg cctcccttcc cccacacctc tgcacctaca
     3421 ccaaagggcc tcaggtggcc accttccttc cttcaagggg ctccccttct ttgcatggac
     3481 atttttaaaa tcaccgactc catgaggatg aggtttgttt tacaaaatgc catgaggtta
     3541 aggagagttg ggaccctgag actggagtgg cacctccccc tcctttgatc ttttaagacc
     3601 ttcccttcct tgatccctgg accagactca gtggacattt gtgcaattgc tcgccctgga
     3661 gggaaccaga tcatttttaa accagaaata atttttttta ttattgttac ggattctatt
     3721 tttttcctct tctccgttac caggtgtgtg tgtacatata tatatatata tatattataa
     3781 atatcaaaga aattatatat ctatcctggg atgggaaaac aagggaggga tatatagata
     3841 tatatatata tatatacata aggaggggga ttttattctt ccctttcctt agaccagcag
     3901 gaaaagagag acattaaagt cttccttttc tcaatggttc cctctctttt gtcccagtta
     3961 ccaactaagg aagtagcact ctctgctggt gctaagagat taggaaagaa acctgggtac
     4021 atctggggtt ctcagataaa agaacttggg agagtttttt aggctccttc acatctagtt
     4081 tccccaggaa aggggtcagt tacatgacgg tggtgggaga tcaggaagag agcttggcct
     4141 aatttaagaa acaccaggca accctgccct ccattcttgg gagacaggga ctgtgttggg
     4201 cttcagtgag ccccttcaat gcttccctat aatcagaaaa atcttaaaat ccaaggccag
     4261 gagagaagaa tccaaaaagc aatatttttc atcacatgcc aaaaatggga tagagagaag
     4321 gagtggcagg cctaggcccc tccgagtgtc ccttggggtt taccccttag cccatctcaa
     4381 tatggtgctg ggtagagggg gtagctgggt tctaaccttt aaacagggaa gactccagcc
     4441 tctatacaga gaccctttaa tttttttatt ctgattagcc attttaaacc aacaaggaat
     4501 aaaataaatc ctgatctaac cagtcccccc tgacttgtgt tttgtctggt taaggcaggg
     4561 tgaatggtct tagggagtca aaagagaaac ctcattctct ggttctgttt ttattctggc
     4621 tatccaatta aatgccctgc tgggtgagaa aaacctagct tttcataaca aatacatcct
     4681 ctctgttgaa tctcttgcta ttcctttgtt tccttttgaa agtaaaaaca gctaagcatg
//
