LOCUS       NM_001080943            3610 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus zinc finger, DHHC-type containing 22 (Zdhhc22),
            transcript variant 1, mRNA.
ACCESSION   NM_001080943 XM_006515851 XM_138102 XM_977454 XM_994649
VERSION     NM_001080943.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3610)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3610)
  AUTHORS   Kim,Y., Yang,H., Min,J.K., Park,Y.J., Jeong,S.H., Jang,S.W. and
            Shim,S.
  TITLE     CCN3 secretion is regulated by palmitoylation via ZDHHC22
  JOURNAL   Biochem Biophys Res Commun 495 (4), 2573-2578 (2018)
   PUBMED   29287726
  REMARK    GeneRIF: Taken together, our results suggest that palmitoylation by
            ZDHHC22 at C241 in the CCN3 TSP1 domain may be required for the
            secretion of CCN3. Aberrant palmitoylation induces intracellular
            accumulation of CCN3, inhibiting neuronal axon growth.
REFERENCE   3  (bases 1 to 3610)
  AUTHORS   Tian,L., McClafferty,H., Knaus,H.G., Ruth,P. and Shipston,M.J.
  TITLE     Distinct acyl protein transferases and thioesterases control
            surface expression of calcium-activated potassium channels
  JOURNAL   J Biol Chem 287 (18), 14718-14725 (2012)
   PUBMED   22399288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153147.7.
            
            On or before Dec 10, 2019 this sequence version replaced
            XM_006515851.3, NM_001080943.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662773.2648483.1,
                                           SRR7974084.25492.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AC153147.7         116899-117084       c
            187-726             AC153147.7         114657-115196       c
            727-3610            AC153147.7         107269-110152       c
FEATURES             Location/Qualifiers
     source          1..3610
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 41.17 cM"
     gene            1..3610
                     /gene="Zdhhc22"
                     /gene_synonym="Gm262"
                     /note="zinc finger, DHHC-type containing 22"
                     /db_xref="GeneID:238331"
                     /db_xref="MGI:MGI:2685108"
     exon            1..186
                     /gene="Zdhhc22"
                     /gene_synonym="Gm262"
                     /inference="alignment:Splign:2.1.0"
     exon            187..726
                     /gene="Zdhhc22"
                     /gene_synonym="Gm262"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..992
                     /gene="Zdhhc22"
                     /gene_synonym="Gm262"
                     /EC_number="2.3.1.225"
                     /note="putative palmitoyltransferase ZDHHC22; DHHC-22;
                     zinc finger DHHC domain-containing protein 22"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC22"
                     /protein_id="NP_001074412.1"
                     /db_xref="CCDS:CCDS36500.1"
                     /db_xref="GeneID:238331"
                     /db_xref="MGI:MGI:2685108"
                     /translation="MLALRLLNVVAPAYFLCISLVTFVLQLFLFLPSMREDPTATPLF
                     SPAVLHGALFLFLSANALGNYVLVIQNSPDDLGTCQGTMSQRPQCPPPSTHFCRVCSR
                     VTLRHDHHCFFTGNCIGSRNMRNFILFCLYTSLACLYSMVAGVAYISAVLSISFAHPL
                     AFLTLLPTSISQFFSGAVLGSDMFVILMLYLWFAVGLACAGFCCHQLLLILRGQTRYQ
                     VRKGMAVRARPWRKNLQEVFGKRWLLGLLVPMFNVGTESSKQQDK"
     exon            727..3610
                     /gene="Zdhhc22"
                     /gene_synonym="Gm262"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3572..3577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc22"
                     /gene_synonym="Gm262"
                     /note="hexamer: AATAAA"
     regulatory      3585..3590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc22"
                     /gene_synonym="Gm262"
                     /note="hexamer: AATAAA"
     polyA_site      3591
                     /gene="Zdhhc22"
                     /gene_synonym="Gm262"
     polyA_site      3610
                     /gene="Zdhhc22"
                     /gene_synonym="Gm262"
                     /note="major polyA site"
ORIGIN      
        1 actctctggc acccaagtag gagggcggca gctgcccgct ccctcctccc acacccccgc
       61 tacctgccca gtccccgaag cgaagcgtga ggaggctgcg agccagtcgg gcgagcccac
      121 aactttgcag cctcggggaa gaccagggtt ggcgtccggg gctcctcctg tcgcgactag
      181 agctcggaat gtgatccagg atgctggcct tgcggctgct caacgtggta gcccccgcct
      241 actttctttg catttccctg gtgaccttcg tactgcagct cttcctcttc ctgcccagca
      301 tgcgtgagga ccccacagcc accccgctct tctcgcctgc tgtgcttcac ggggcgctct
      361 tcctgttcct ctcagccaat gccctgggca attacgtcct ggtcatccag aactccccag
      421 acgacctggg cacctgccag gggaccatgt cccagagacc tcagtgccca ccgcccagca
      481 cccacttctg ccgagtgtgt tcccgagtca cgctgaggca cgaccatcac tgtttcttca
      541 ccggcaactg catcggcagc agaaacatgc gcaacttcat cctgttctgc ctctacacct
      601 ctctggcctg cctttactcc atggtggctg gagtggccta catctcagct gtcctttcca
      661 tctccttcgc ccaccccctg gccttcctta cgctcctgcc cacttcaatc agccagttct
      721 tctccggagc tgtcctcggt tctgacatgt tcgtcatcct catgctctac ctctggtttg
      781 ctgtcggcct ggcctgcgcc ggtttctgct gccaccaact gctgttgatc ctccgggggc
      841 aaacccgcta ccaggttcga aaggggatgg ctgtaagagc ccgaccctgg cgcaagaact
      901 tacaggaggt cttcggaaag aggtggctgc ttggcttgct ggtacccatg ttcaatgtcg
      961 gcaccgaaag ctcgaagcag caggacaaat agctggcagg cacttctgcc gtttctgtgt
     1021 ctcagtttct cctgaccaca cagcaccctt gtcttcacct gtgacacacc acaccctccc
     1081 ctaggaagag cctcatatcc accccaggtc ttcaatcctc agaggatata ttaacaggtg
     1141 catcccgaca cggaagggaa gtggctacct gggcaccact aggctgctcc aggtccagcc
     1201 aggtagggag ctactaaatc gttaaggtgt ttctacttca agtttttttt tttttttttt
     1261 ttttttggtt ttttgttttt ctgggaagcc cttctctgcc cctacctggc ctttccactc
     1321 ctgtgtctca ggtcattgct gcttttgcta aagcccttct cttgtgttga tagtggagac
     1381 tgcattcttg ctgctagcag gagattccac agaaccgaga ggctggtaaa tggtagctac
     1441 catgaatgag aagcagtcaa gcaagctttg ccaactgcta gtgagaatgg gaaggggtgg
     1501 agagccaccc tcatccactg tgagggatag tcaatagtat ttgtgttggg gaggggggtg
     1561 cacaggcact tgctgctcag cccaagtaca aggccttttc cctagagaca gcaatcaatg
     1621 gcctgatgtt cttcaatgct gttctctgtc caacctgccc catctagcca gcccagccca
     1681 gcccaggagt tagctgaata gttcttttct ctggaatttc tctggtcttt ccctttggtc
     1741 tccagccttc agattttttg ctagctattg agaagggaag aagggagaga caagagggag
     1801 ttacttaccc gtaagtaata agagaagtgt gcttcttata tagccttata taatcgtgtg
     1861 tgtgtgtgtg tatatgtgtg agtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtaagag
     1921 ggggcggagg tgaagagtgt tgttatgagc acagagagag agtgagtatt ggaggagaag
     1981 gagagagagg caaatgggtt aactcttttg cagccaaagc cagccagtga ttgaatttta
     2041 cctggagtga gtgctggccc ctggaggtat tttgacagga tctaggcagt tatctacaag
     2101 aagagatttt ttttttgtac tactttgttc tagatgaact tagagatccc tttccactcc
     2161 ttgattccag tgtcttcttt gatactgctg gtgccagaga caaggtcttt agaaactaga
     2221 tcttaggctg gagagatggc tcaggggtta agagcattaa cttcttgctc ttccagaggt
     2281 cccgagttca attctcagca accacatggt ggctcacaac catctgtaat aggatctgat
     2341 gtcctcttct ggtgtgtctg aagagagtaa agtatattga catacataaa gtaaataaat
     2401 ctttaggaaa agggagaaag aaagatcttt agagacaaga tctttacctg ctttcatggg
     2461 gcgggaggta ggataaccat ggaaagggtc taaaaatcat aacacgggct ttctgcacac
     2521 agtccagcca tccaggagac ttcctgatgt tagcagtagc tgagaggagg ccggcagtgg
     2581 aggacagaga ggtataacta tgttcgggcc aggttggtgc agttagctgt aaggagagag
     2641 aagcctggaa gccatgctca gccctgagga gtttgtggga atgacagaat attggggtgc
     2701 agttgccagt ccattcctgc cagtttggct agctctagat agggatcctg ccttgtatcc
     2761 tgagacccag aggaccagac agacccttgg ggcatatgaa ggggtgggag ccacacaaaa
     2821 ccatctcctg agttggtccc agggcccata caacatctat acaggcactg aggctggtct
     2881 gtgctctgca gtatctagtg ggtggctaca gtgaccccaa ccactgccca agaagagcgt
     2941 gaattgttga acagagcacg ggaggatatt actcaggccc gactttggcg ccccccagag
     3001 ggctaatgta gtaatggcgt tcctgctcac aagtctccct tcagcaggta ttcttttggg
     3061 ccctgttcgc tcctactcta tccgttcatc ctagctatct gtatccagca cagcccatgg
     3121 gctgagtctc agtcactggc aatccagatg cccacatcag gggcagatga cgcctaccac
     3181 cattgcgctc tgctttcttg acagtcagtg cagctggcct cttggagaca gaatgatgcg
     3241 gcagggctga aggggagccc aggcttcctc agtggaagag ccattcgagg tatctctgct
     3301 cacagttctg ggcacccttt agcagcatga agaaacaaga gaggggagat gtctggatag
     3361 ttcaggcctt ggggctctct tgaccctaga gttcaaactc gaaagccagc cctacgttgt
     3421 ccaggctcag gaccacggaa cccgacatcc cagaggggaa agggagtact tccggtggcc
     3481 agctctttaa acaggtcagg gacgaatggc tgtagggaga ttgccaggtg tggtacttga
     3541 gtagcatttg aacacacggc cctctgttgt taataaagaa aatcaataaa atacgtggtt
     3601 ttcaactgta
//
