LOCUS       NM_178395               3398 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus zinc finger, DHHC domain containing 2 (Zdhhc2),
            transcript variant 1, mRNA.
ACCESSION   NM_178395
VERSION     NM_178395.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3398)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3398)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3398)
  AUTHORS   Zhou,B., Yang,W., Li,W., He,L., Lu,L., Zhang,L., Liu,Z., Wang,Y.,
            Chao,T., Huang,R., Gu,Y., Jia,T., Liu,Q., Tian,S., Pierre,P.,
            Maeda,T., Liang,Y. and Kong,E.
  TITLE     Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated
            Inflammatory Response in Psoriasis
  JOURNAL   Front Immunol 11, 607442 (2021)
   PUBMED   33488612
  REMARK    GeneRIF: Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells
            Mediated Inflammatory Response in Psoriasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3398)
  AUTHORS   Zhao,R., Zhang,H., Zhang,Y., Li,D., Huang,C. and Li,F.
  TITLE     In vivo Screen Identifies Zdhhc2 as a Critical Regulator of
            Germinal Center B Cell Differentiation
  JOURNAL   Front Immunol 11, 1025 (2020)
   PUBMED   32587588
  REMARK    GeneRIF: In vivo Screen Identifies Zdhhc2 as a Critical Regulator
            of Germinal Center B Cell Differentiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3398)
  AUTHORS   Greaves,J., Munro,K.R., Davidson,S.C., Riviere,M., Wojno,J.,
            Smith,T.K., Tomkinson,N.C. and Chamberlain,L.H.
  TITLE     Molecular basis of fatty acid selectivity in the zDHHC family of
            S-acyltransferases revealed by click chemistry
  JOURNAL   Proc Natl Acad Sci U S A 114 (8), E1365-E1374 (2017)
   PUBMED   28167757
REFERENCE   6  (bases 1 to 3398)
  AUTHORS   Woolfrey,K.M., Sanderson,J.L. and Dell'Acqua,M.L.
  TITLE     The palmitoyl acyltransferase DHHC2 regulates recycling endosome
            exocytosis and synaptic potentiation through palmitoylation of
            AKAP79/150
  JOURNAL   J Neurosci 35 (2), 442-456 (2015)
   PUBMED   25589740
REFERENCE   7  (bases 1 to 3398)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   8  (bases 1 to 3398)
  AUTHORS   Greaves,J., Carmichael,J.A. and Chamberlain,L.H.
  TITLE     The palmitoyl transferase DHHC2 targets a dynamic membrane cycling
            pathway: regulation by a C-terminal domain
  JOURNAL   Mol Biol Cell 22 (11), 1887-1895 (2011)
   PUBMED   21471008
REFERENCE   9  (bases 1 to 3398)
  AUTHORS   Jia,L., Linder,M.E. and Blumer,K.J.
  TITLE     Gi/o signaling and the palmitoyltransferase DHHC2 regulate
            palmitate cycling and shuttling of RGS7 family-binding protein
  JOURNAL   J Biol Chem 286 (15), 13695-13703 (2011)
   PUBMED   21343290
REFERENCE   10 (bases 1 to 3398)
  AUTHORS   Fukata,M., Fukata,Y., Adesnik,H., Nicoll,R.A. and Bredt,D.S.
  TITLE     Identification of PSD-95 palmitoylating enzymes
  JOURNAL   Neuron 44 (6), 987-996 (2004)
   PUBMED   15603741
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030662.1, AK017566.1 and BE989599.1.
            
            On Oct 24, 2017 this sequence version replaced NM_178395.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046533.1, SRR1660819.157633.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2424              AK030662.1         2-2425
            2425-3103           AK017566.1         765-1443
            3104-3398           BE989599.1         1-295               c
FEATURES             Location/Qualifiers
     source          1..3398
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.89 cM"
     gene            1..3398
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /note="zinc finger, DHHC domain containing 2"
                     /db_xref="GeneID:70546"
                     /db_xref="MGI:MGI:1923452"
     exon            1..355
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            356..382
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..477
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..598
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..668
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            669..701
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            702..822
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            823..955
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1082
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1175
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1288
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1361
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..3382
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1595..1600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /note="hexamer: ATTAAA"
     polyA_site      1622
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /note="major polyA site"
     regulatory      3351..3356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /note="hexamer: AATAAA"
     polyA_site      3382
                     /gene="Zdhhc2"
                     /gene_synonym="5730415P04Rik; 6430583A19Rik; DHHC-2"
                     /note="major polyA site"
ORIGIN      
        1 ctactctgag ccgccgcctc agcccggcag agcagcggga gtccgcggcg cccgctcgct
       61 gccgcgggat ggggagctag cgccacggcg gccgcggtgg ccgcagcaca gccagccgcc
      121 gcccccgggc ctgtcccgtc gggtgctccg ggagccccga gcccggcccc gagccaggcc
      181 cacgggcggc ggcggcggca gagctgggca ggtgtctgcg gctggaagat ggcgccctcg
      241 ggctcgggcg gcgtgaggcg gcggtgccgg cgggtgctct actggatccc ggtggtgttc
      301 atcagcttgc tgctgggctg gtcctactac gcctacgcca tccagctgtg catagtgtcc
      361 atggaaaaca ttggtgaaca agttgtgtgc ctcatggctt atcatctact ttttgcaatg
      421 tttgtctggt catactggaa aaccattttt acattgccca tgaatccttc aaaagaattc
      481 catctctctt atgcagagaa agaattgctg gagagagagc caagaggaga agcccatcag
      541 gaagttctga ggcgagcagc caaagacctt cccatctaca ccaggaccat gtccggcgca
      601 atccgatatt gtgacagatg ccaacttata aaaccagacc gctgtcatca ttgttccgtc
      661 tgtgataaat gtattttgaa gatggatcat cattgcccat gggtgaacaa ttgtgttgga
      721 ttttcaaact acaaattctt ccttcttttc ttggcttact ctctgctgta ctgccttttc
      781 attgctgcta ccgatttaca gtattttatc agattttgga caaatggtct gcctgatact
      841 caagccaagt tccatattat gtttttattc tttgctgcag ctatgttttc tgtcagcttg
      901 tcctctctgt ttggttatca ttgctggcta gtcagcaaaa ataaatctac tttagaggca
      961 ttcagaaatc cagtatttag acacggaaca gataagaacg gattcagctt gggtttcagt
     1021 aaaaacatga gacaagtgtt tggtgatgag aagaaatact ggctgttacc agtattttca
     1081 agtcaaggtg atggctgttc ctttccaact tgccttgtta accaggatcc tgaacaacct
     1141 tctactcctg cgggactaaa ttcaacagtg aaaaatcctg aaaaccacca gtttcctgca
     1201 aagcctctga gagagtccca gagccatctc cttaaggatt ctcagacctg gacagagagc
     1261 agcgcaaacc ctgggaaggg caaagccggt atgagcaacc ctgcattaac tatggagaac
     1321 gagacttagt tctacaatca aaataaaacc actcttgtaa agtaccagtg ctgtggagga
     1381 atggaacaac cttccgattg gaaggcacca tttgccaatt gtccctatat ccctttgact
     1441 agatatgcaa attttgtctt cagtgatggg gatcaaacac agcagtatga agagtttcaa
     1501 gtaatcacca aactgatgct taaaacagaa cactgtttat tccaatatat aaacttctgt
     1561 aactaataca aattactatt aacctttaaa agttattaaa agggaaccat tttctgccaa
     1621 aacccgagat taagtttatg ggcccatgtt cattcgaata attgggttgt acaacttatc
     1681 tcataatccc attattcatt tgatattctg ttttagaaaa tttaggttaa tcttaagatt
     1741 taataaattt caaatcatgt tattatgcaa aactgtattt gagagcaggt aagaaatcat
     1801 ccttgatttt ttttttctga tgtgagatta gcttccgatg agagagctgc attgactatg
     1861 aactcattac ggaggccatg tagcctatag ctggaggtca tttatcccct tgtgccaggt
     1921 ttcaattccc attctagact ttgtctccca ttggaagatt caaatacaaa tactgaagct
     1981 cgagttcaaa gcaattggat aaaaactttt gtttgactta atatgatgtc ttgacaagga
     2041 acttacatca gaaatgtact ttcatgtctt ctcatttgaa atcagaggga acacatgcta
     2101 attctcttga agattgcctg gcaacactct tttgctggtt tggatgttaa ccaatctgtt
     2161 tttttttttt aactacttgc tcagtgttat tgtgaaaaga ctgagtttct aagcatttct
     2221 gatagatcaa tggattattc ctccatgtgc acctgtgtat catctctgtc ttttcatcaa
     2281 aactacaatt gtcaatagat atttttcctc aaatgcctat ccagattaaa ttatgcaaat
     2341 catttaaaaa tgaggaagtt tagtttacca tgaactaaac atcgtgctgt ttagaaatgt
     2401 agtttagggt aaattacgat aatgtgtttg ttgatgccaa aatgtttggc ctcagtaagt
     2461 atactcacag aagttcttgt gccttgtatg cactatttac aaaaaggaaa aaaaaatctc
     2521 atttttcaaa aaatctggga agtaagtttt ataaattaat cttagaatgt taagctgtgc
     2581 cattggttcc tttggtacta attttgaaaa tttcaagtag attagctttt tttaaaaaaa
     2641 aaatggctaa ataattgatg taagcaagaa ttcactacaa actgaaagac ctggagagaa
     2701 tagaataatg aaagatcctt gcaatcactc attcttgcta aagcgttttt gagttttgtt
     2761 tgtttgtttg tttttttcga gacagggttt ctctgtgtag tcctggctgt cctggaactc
     2821 actctgtaga ccatgctggc ctcgaacttt tgagagtgtt tagggagagc agacatccgc
     2881 acaattcatt gtgggatcca ggcgggtgcg gttctgtgga tgagggcaat gattgcttcc
     2941 tcgtctctca cgcttgagcg ttggatctga caatctactt cacaagactc agaagatgaa
     3001 ggatgctctc ccctttgtct ttaagcatgt tttgatcatt tgtcattacc ggaagtgcca
     3061 gactggagct catagctcct gctagaagtc ttttgggcag cagcatgtgg tgtatttgaa
     3121 gatctatgca gcagattttc tgatagcaca ttgctccctt atctgttttc cagggcagga
     3181 gtctattagg catgtccttt tatcaaagtg gtagctggtg gggctggggg aggatttacg
     3241 gtttaccctg gtaggatgct gttatttctg ctctctttag gtcgtttatt tacttatttt
     3301 aaatacctaa gtccatacac cttagagaca aaatggaaaa aagattaaga aataaaattt
     3361 tttcagtatg ttgtaatggt taaaaaaaaa aaaaaaaa
//
