LOCUS       NM_001017968            2847 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus zinc finger, DHHC domain containing 18 (Zdhhc18),
            mRNA.
ACCESSION   NM_001017968 XM_620106
VERSION     NM_001017968.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2847)
  AUTHORS   Shi,C., Yang,X., Liu,Y., Li,H., Chu,H., Li,G. and Yin,H.
  TITLE     ZDHHC18 negatively regulates cGAS-mediated innate immunity through
            palmitoylation
  JOURNAL   EMBO J 41 (11), e109272 (2022)
   PUBMED   35438208
  REMARK    GeneRIF: ZDHHC18 negatively regulates cGAS-mediated innate immunity
            through palmitoylation.
REFERENCE   2  (bases 1 to 2847)
  AUTHORS   Nakahara,M., Tateyama,H., Araki,M., Nakagata,N., Yamamura,K. and
            Araki,K.
  TITLE     Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from
            MSM/Ms mice
  JOURNAL   Mamm Genome 24 (5-6), 228-239 (2013)
   PUBMED   23604909
REFERENCE   3  (bases 1 to 2847)
  AUTHORS   Kuo,B.Y., Chen,Y., Bohacec,S., Johansson,O., Wasserman,W.W. and
            Simpson,E.M.
  TITLE     SAGE2Splice: unmapped SAGE tags reveal novel splice junctions
  JOURNAL   PLoS Comput Biol 2 (4), e34 (2006)
   PUBMED   16683015
REFERENCE   4  (bases 1 to 2847)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   5  (bases 1 to 2847)
  AUTHORS   Fukata,M., Fukata,Y., Adesnik,H., Nicoll,R.A. and Bredt,D.S.
  TITLE     Identification of PSD-95 palmitoylating enzymes
  JOURNAL   Neuron 44 (6), 987-996 (2004)
   PUBMED   15603741
REFERENCE   6  (bases 1 to 2847)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2847)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX537327.7, CJ049628.1, AY668950.1 and AL627228.31.
            
            On Sep 14, 2006 this sequence version replaced NM_001017968.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849377, SAMN00849381
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               BX537327.7         17181-17531         c
            352-421             CJ049628.1         230-299
            422-1183            AY668950.1         1-762
            1184-2847           AL627228.31        182907-184570       c
FEATURES             Location/Qualifiers
     source          1..2847
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.25 cM"
     gene            1..2847
                     /gene="Zdhhc18"
                     /gene_synonym="DHHC-18"
                     /note="zinc finger, DHHC domain containing 18"
                     /db_xref="GeneID:503610"
                     /db_xref="MGI:MGI:3527792"
     exon            1..351
                     /gene="Zdhhc18"
                     /gene_synonym="DHHC-18"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1183
                     /gene="Zdhhc18"
                     /gene_synonym="DHHC-18"
                     /EC_number="2.3.1.225"
                     /note="zinc finger DHHC domain-containing protein 18; DHHC
                     domain-containing cysteine-rich protein 18"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC18"
                     /protein_id="NP_001017968.2"
                     /db_xref="CCDS:CCDS38906.1"
                     /db_xref="GeneID:503610"
                     /db_xref="MGI:MGI:3527792"
                     /translation="MKDCEYQQISPGAAPPPASPGARRPGPAAPPAPSPGPAPGAPRW
                     SGSGSGSGSLGRRPRRKWEVFPGRNRFYCGGRLMLAGHGGVFALTLLLILSTTILFFV
                     FDCPYLARTLTLAIPIIAAILFFFVMSCLLQTSFTDPGILPRATICEAAALEKQIDNT
                     GSSTYRPPPRTREVMINGQTVKLKYCFTCKMFRPPRTSHCSVCDNCVERFDHHCPWVG
                     NCVGRRNYRFFYAFILSLSFLTAFIFACVVTHLTLLSQGSNFLSALKKTPASVLELVI
                     CFFSIWSILGLSGFHTYLVASNLTTNEDIKGSWSSKRGGEASVNPYSHKSIITNCCAV
                     LCGPLPPSLIDRRGFVQSDTALPSPIRSDDPACGAKPDASMVGGHP"
     exon            352..512
                     /gene="Zdhhc18"
                     /gene_synonym="DHHC-18"
                     /inference="alignment:Splign:2.1.0"
     exon            513..662
                     /gene="Zdhhc18"
                     /gene_synonym="DHHC-18"
                     /inference="alignment:Splign:2.1.0"
     exon            663..800
                     /gene="Zdhhc18"
                     /gene_synonym="DHHC-18"
                     /inference="alignment:Splign:2.1.0"
     exon            801..849
                     /gene="Zdhhc18"
                     /gene_synonym="DHHC-18"
                     /inference="alignment:Splign:2.1.0"
     exon            850..952
                     /gene="Zdhhc18"
                     /gene_synonym="DHHC-18"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1065
                     /gene="Zdhhc18"
                     /gene_synonym="DHHC-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..2847
                     /gene="Zdhhc18"
                     /gene_synonym="DHHC-18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2822..2827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc18"
                     /gene_synonym="DHHC-18"
                     /note="hexamer: AATAAA"
     polyA_site      2847
                     /gene="Zdhhc18"
                     /gene_synonym="DHHC-18"
                     /note="major polyA site"
ORIGIN      
        1 ggagcggccg ggcgcggagc cgaggcccgc ggccggccgc atgaaggact gcgagtacca
       61 gcagataagc cccggggccg ccccgccgcc cgcctccccc ggggcgcgtc gccccggccc
      121 cgccgcgccc cctgctccaa gccccgggcc cgcgcctggc gcgccgcgct ggagcggcag
      181 cggcagcggc agcgggagcc tgggccgccg gccccggcgt aagtgggagg tgttcccggg
      241 ccgcaaccgc ttctactgcg gaggccggct catgctggcc ggccacggcg gcgtcttcgc
      301 gctcacgctg ctgctcatcc tcagcaccac catcctcttc ttcgtcttcg actgtcccta
      361 cctggcccgc acactgaccc tggccattcc tatcatcgct gccatcctct tcttcttcgt
      421 catgagctgt ctcctgcaga ccagtttcac ggaccctggc atcctgcccc gggccaccat
      481 ctgtgaggcc gctgccctgg agaagcagat cgataacaca ggcagctcca cataccgacc
      541 gccccctcgg actcgggagg tgatgatcaa cgggcagaca gtgaaactca agtattgctt
      601 cacctgtaag atgtttcggc ctccccggac ctcgcactgc agtgtctgcg acaactgtgt
      661 ggaacggttt gaccatcact gcccttgggt gggcaactgt gtggggagac ggaactaccg
      721 cttcttttat gcgtttattc tctccctctc cttcttgacg gccttcatct tcgcctgcgt
      781 ggtcacccac ctgacccttc tttctcaagg aagcaacttc ctctccgctc tgaaaaagac
      841 accagcaagt gtgctggagt tggtcatctg cttcttctca atctggtcca tcctgggcct
      901 ctcagggttc cacacgtacc tcgtggcctc caacctgaca actaacgaag atatcaaagg
      961 gtcttggtcc agcaagaggg gtggcgaggc ctctgtcaac ccctacagcc ataaaagtat
     1021 tatcaccaac tgctgtgctg tgctctgtgg cccactgcct cccagcctga ttgaccggcg
     1081 aggattcgtg cagtctgata ccgcgttgcc ctcgcccatc agaagtgatg acccggcctg
     1141 tggagccaag ccagacgcca gcatggtagg aggccacccc tgaatgtgct tgccacctgc
     1201 cgtcctccac acctgcgggg accctcccca tgccatctga gggaagcaga gccgccagag
     1261 ctgccagtct tttcctattt atttcccacc ctgcgtggtt ttctttgaac tgtcccatag
     1321 ctgtgccctc tgctccccaa acctaggttc ccacagttta ggccttaggc cccctagctg
     1381 gtcagtggca ggagaggaga gtcacagcct ctggaggcca ctaaggagac catgccaagt
     1441 cactgcctgt gggagggaga cccagcctga gtgagggcat gaactgaatg gtggcctcct
     1501 agctggaggc gtgcttggac cttggtgagc cagggcctgc tgagtagctg gctctgaacc
     1561 acaggcgaca agtggggacc ctctctggga ctgctgtggt ttggggctcc tacattccat
     1621 ctgtgataac cactgggatg gttttttggg aggggttata tggagctagc cagtagagct
     1681 ggggtccagt agagagagca agcaggggtg ggaagcagcc tgtgtcaggg gaagccaaac
     1741 aagccatcca ggcccgcaga acctcagctc ctgtagagtc ctgggcagca cagtagggat
     1801 ggggacgtgg ctttccccct gcccacagag actctctaaa ggatcctttc ctgtgccccc
     1861 cagcccctct tccaggtcag ggctagaggt gggtgggtta gctcatgctg gtaatacttg
     1921 aaacgggttt attaatgctg ggtattttgc acaattttat agtcttcttt tttacatagc
     1981 cttttaaaaa taggagttaa tgtgttacta tccgtgtagt gccaagtcaa gggttttcag
     2041 aaggttaggt agtttaatac atttattaca gcagatgtag ccgtgagggg ttgtgtgtat
     2101 gcgcacatgt gtgtccatgc atgcggtgta cagatacagc tgactcccat gtcctcccct
     2161 ggactgttcc ctttccccat tgccctgggt tcagaagcag cctgaggtat gggggactgg
     2221 gtgggaggct gtgttagtca caggagagag accacccgct ccggcccttt agacgccacc
     2281 acccagcccc caggttaggc tcccagctgt gacctgcccc gacaggctga ggttaggtgt
     2341 ggtgggtggg gtggtggctc agggagcggc tgccagtctg caagccacac cccctcccag
     2401 gtgttctgct ttgagtgtag gcctcagtgc tagggacgag gacaccgagt ttctgctaat
     2461 caggaccgga ggcaggggca gagtggaccc ggaggcccgt gtgggttgtc cagaacctta
     2521 tagtgcagcc tcctgctgct gggagctgta gtttctaatc aaaatagtct cgttctcctc
     2581 ggcccttcag gtgggctgaa gtccttggat cataacatag aaagtcacta ctgagtcctc
     2641 tccttgttcc agagcccagt gggtcccaga caaagctggg aagtggtggg tgccaggggc
     2701 cactgggaga tggcttcaga gccccaggcc accccgagtg gccctgggag gtagatagga
     2761 aggggctgga gggctccctg acccgccttt cgttcgagcc agtatctttg ttcccgtttg
     2821 taataaagct tctgttttaa gagctga
//
