LOCUS       NM_172554               4563 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus zinc finger, DHHC domain containing 17 (Zdhhc17),
            transcript variant 1, mRNA.
ACCESSION   NM_172554 NM_177085
VERSION     NM_172554.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4563)
  AUTHORS   Gupta,J.P. and Jenkins,P.M.
  TITLE     Ankyrin-B is lipid-modified by S-palmitoylation to promote
            dendritic membrane scaffolding of voltage-gated sodium channel
            NaV1.2 in neurons
  JOURNAL   Front Physiol 14, 959660 (2023)
   PUBMED   37064897
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4563)
  AUTHORS   Butler,L., Locatelli,C., Allagioti,D., Lousa,I., Lemonidis,K.,
            Tomkinson,N.C.O., Salaun,C. and Chamberlain,L.H.
  TITLE     S-acylation of Sprouty and SPRED proteins by the S-acyltransferase
            zDHHC17 involves a novel mode of enzyme-substrate interaction
  JOURNAL   J Biol Chem 299 (1), 102754 (2023)
   PUBMED   36442513
  REMARK    GeneRIF: S-acylation of Sprouty and SPRED proteins by the
            S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate
            interaction.
REFERENCE   3  (bases 1 to 4563)
  AUTHORS   Niu,J., Sanders,S.S., Jeong,H.K., Holland,S.M., Sun,Y.,
            Collura,K.M., Hernandez,L.M., Huang,H., Hayden,M.R., Smith,G.M.,
            Hu,Y., Jin,Y. and Thomas,G.M.
  TITLE     Coupled Control of Distal Axon Integrity and Somal Responses to
            Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17
  JOURNAL   Cell Rep 33 (7), 108365 (2020)
   PUBMED   33207199
  REMARK    GeneRIF: Coupled Control of Distal Axon Integrity and Somal
            Responses to Axonal Damage by the Palmitoyl Acyltransferase
            ZDHHC17.
REFERENCE   4  (bases 1 to 4563)
  AUTHORS   Kang,R., Wang,L., Sanders,S.S., Zuo,K., Hayden,M.R. and
            Raymond,L.A.
  TITLE     Altered Regulation of Striatal Neuronal N-Methyl-D-Aspartate
            Receptor Trafficking by Palmitoylation in Huntington Disease Mouse
            Model
  JOURNAL   Front Synaptic Neurosci 11, 3 (2019)
   PUBMED   30846936
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4563)
  AUTHORS   Greaves,J., Munro,K.R., Davidson,S.C., Riviere,M., Wojno,J.,
            Smith,T.K., Tomkinson,N.C. and Chamberlain,L.H.
  TITLE     Molecular basis of fatty acid selectivity in the zDHHC family of
            S-acyltransferases revealed by click chemistry
  JOURNAL   Proc Natl Acad Sci U S A 114 (8), E1365-E1374 (2017)
   PUBMED   28167757
REFERENCE   6  (bases 1 to 4563)
  AUTHORS   Fukata,M., Fukata,Y., Adesnik,H., Nicoll,R.A. and Bredt,D.S.
  TITLE     Identification of PSD-95 palmitoylating enzymes
  JOURNAL   Neuron 44 (6), 987-996 (2004)
   PUBMED   15603741
REFERENCE   7  (bases 1 to 4563)
  AUTHORS   Huang,K., Yanai,A., Kang,R., Arstikaitis,P., Singaraja,R.R.,
            Metzler,M., Mullard,A., Haigh,B., Gauthier-Campbell,C.,
            Gutekunst,C.A., Hayden,M.R. and El-Husseini,A.
  TITLE     Huntingtin-interacting protein HIP14 is a palmitoyl transferase
            involved in palmitoylation and trafficking of multiple neuronal
            proteins
  JOURNAL   Neuron 44 (6), 977-986 (2004)
   PUBMED   15603740
REFERENCE   8  (bases 1 to 4563)
  AUTHORS   Ducker,C.E., Stettler,E.M., French,K.J., Upson,J.J. and Smith,C.D.
  TITLE     Huntingtin interacting protein 14 is an oncogenic human protein:
            palmitoyl acyltransferase
  JOURNAL   Oncogene 23 (57), 9230-9237 (2004)
   PUBMED   15489887
REFERENCE   9  (bases 1 to 4563)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   10 (bases 1 to 4563)
  AUTHORS   Singaraja,R.R., Hadano,S., Metzler,M., Givan,S., Wellington,C.L.,
            Warby,S., Yanai,A., Gutekunst,C.A., Leavitt,B.R., Yi,H.,
            Fichter,K., Gan,L., McCutcheon,K., Chopra,V., Michel,J.,
            Hersch,S.M., Ikeda,J.E. and Hayden,M.R.
  TITLE     HIP14, a novel ankyrin domain-containing protein, links huntingtin
            to intracellular trafficking and endocytosis
  JOURNAL   Hum Mol Genet 11 (23), 2815-2828 (2002)
   PUBMED   12393793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK039575.1, AK046891.1, BC027101.1, AW911453.1 and BC051527.1.
            
            On Jan 14, 2010 this sequence version replaced NM_172554.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.174534.1,
                                           SRR1660819.45859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1226              AK039575.1         2-1227
            1227-3291           AK046891.1         1169-3233
            3292-3750           BC027101.1         3180-3638
            3751-4133           AW911453.1         82-464
            4134-4563           BC051527.1         349-778
FEATURES             Location/Qualifiers
     source          1..4563
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 57.86 cM"
     gene            1..4563
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /note="zinc finger, DHHC domain containing 17"
                     /db_xref="GeneID:320150"
                     /db_xref="MGI:MGI:2445110"
     exon            1..129
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1935
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /EC_number="2.3.1.225"
                     /note="isoform 1 is encoded by transcript variant 1;
                     huntingtin interacting protein 14; palmitoyltransferase
                     ZDHHC17; zinc finger DHHC domain-containing protein 17;
                     acyltransferase ZDHHC7; acyltransferase ZDHHC17; DHHC
                     domain-containing cysteine-rich protein 17"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC17 isoform 1"
                     /protein_id="NP_766142.2"
                     /db_xref="CCDS:CCDS56748.1"
                     /db_xref="GeneID:320150"
                     /db_xref="MGI:MGI:2445110"
                     /translation="MQREEGFNTKMADGPDEYETETGCVPLLHPEEIKPQSHYNHGYG
                     EPLGRKTHIDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNR
                     IDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSC
                     IHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVN
                     LGDKYHKNTALHWAVLAGNTTVISLLLEAGGNVDAQNVKGESALDLAKQRKNVWMINH
                     LQEARQAKGYDNPSFLRKLKADKEFRQKVMLGTPFLVIWLVGFIADLDIDSWLIKGLM
                     YGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFL
                     ANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRS
                     KHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIYGCVSYWGLHC
                     ETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFLWVAVLLMCQLYQITCLGITTNER
                     MNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQI
                     SGSGYQLV"
     exon            130..233
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            234..356
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            357..434
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            435..579
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            580..644
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            645..807
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            808..933
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1076
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1177
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1302
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1365
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1459
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1543
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1701
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1796
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..4549
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4530..4535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /note="hexamer: AATAAA"
     polyA_site      4549
                     /gene="Zdhhc17"
                     /gene_synonym="A230053P19Rik; D130071N24Rik; DHHC-17;
                     Hip14"
                     /note="major polyA site"
ORIGIN      
        1 gccgagcccc gcgaggctga aacgctttct cccagcatgc agcgggagga gggatttaac
       61 accaagatgg cggacggccc ggatgagtac gagaccgaaa cgggctgcgt gccccttctc
      121 cacccggagg aaatcaaacc acagagccac tataaccatg gctatggaga acctcttggt
      181 cggaaaactc atattgatga ctatagcaca tgggacatcg tcaaggcgac acaatatgga
      241 atatatgaac gctgccgaga attggtggaa gcgggttacg atgtacggca accagacaaa
      301 gaaaatgtta cacttcttca ttgggctgcc atcaataaca gaatagattt agtcaaatac
      361 tatatttcga aaggtgctat tgtggatcaa cttggaggag acctgaattc aactccgttg
      421 cactgggcca caagacaagg ccatttatcc atggttgtac aactaatgaa atatggtgca
      481 gacccctcct taattgatgg ggaaggatgc agctgtatcc acttggctgc tcagttcgga
      541 catacctcaa ttgttgctta tcttatagca aaaggacagg atgtagatat gatggatcag
      601 aatggaatga cccctttaat gtgggcagct tatagaacac atagtgtgga tccaactaga
      661 ttgcttttaa cattcaatgt ttcagttaac cttggtgaca agtatcacaa aaacactgct
      721 ctgcactggg cagtcctagc agggaacacc acagtcatta gtcttcttct ggaagccgga
      781 ggcaatgtgg acgcccagaa cgtcaagggt gagtcagcac ttgatttggc aaagcaaaga
      841 aaaaacgtgt ggatgatcaa ccatttgcag gaggcaaggc aagcgaaagg gtatgacaac
      901 ccatccttcc tcagaaagct gaaggctgac aaggaatttc ggcagaaagt aatgctggga
      961 accccattcc tggtgatctg gctggtcggg tttatagcag acctagacat tgattcttgg
     1021 ctcattaaag ggttaatgta tggtggcgtt tgggctacag tgcaatttct ttccaagtcc
     1081 ttctttgacc attcaatgca cagcgcattg ccccttggga tatatttggc aaccaaattc
     1141 tggatgtatg tgacatggtt cttctggttc tggaatgatc tcaacttcct gttcatccac
     1201 ctccccttcc ttgccaacag cgttgctctt ttctacaatt ttggaaagtc ttggaaatca
     1261 gatccaggga ttattaaagc tacagaagaa caaaagaaaa agacgatagt tgaacttgca
     1321 gagactggaa gtctggacct cagtatattc tgcagtacct gcttgattcg gaagccagtg
     1381 aggtccaaac actgtggtgt gtgcaaccgc tgtatagcga aatttgatca ccattgccca
     1441 tgggtgggta actgtgtagg tgcaggcaac cataggtact ttatggggta cctgttcttc
     1501 ttgcttttca tgatctgctg gatgatctat ggttgtgtct cttactgggg ccttcactgt
     1561 gagaccacgt acaccaagga tgggttttgg acatacataa ctcagatcgc cacatgctcc
     1621 ccgtggatgt tctggatgtt tctcaacagt gtgtttcact tcctgtgggt ggccgtgctg
     1681 ctcatgtgtc agctgtacca gataacatgt ttaggtatta ctacaaatga aagaatgaac
     1741 gccaggagat acaagcactt taaagttacg acaacatcta ttgaaagccc attcaaccat
     1801 ggatgtgtaa ggaatattat agacttcttt gaatttcgat gctgtggcct ctttcgtcct
     1861 gttatcgtgg actggaccag gcagtacact atagaatatg accaaatatc aggatctggg
     1921 taccagcttg tgtagcagca gcgtccggat gccaggaact cagtgttact gagtggtgcc
     1981 tgaggattgc gtctgtccct gtctctctct ccctcgaatc cacgtccttg gaacaatagc
     2041 atgctatatg tagggctaac cgtgaactcg acagccttgt tcagtacttt tattaacaaa
     2101 agcaaacata gacagaacac actgccacgc ctaggaagag aagatcatca aatgaatttt
     2161 catggttttt aatgtctgaa ttcacatcat actcgacttt ttggttttgt tctcataaca
     2221 tttttcatga aaaagtgaac ttattctgtt actagagatg gcataccgag gataaatgtc
     2281 gttataacta aaagtaaatt tatgttatac ggctacattg tattatgcag tacttaagag
     2341 tgttgcattt aattccaaga aaactgtctt aaattgatga ctagtattat gtacatttta
     2401 gatgtacatg taaatactgt gatgagaatc atgtggtttt attagaggtc tactgtactg
     2461 tgtccccaaa ggcacgggga ataatgttca tggaagcggc tcgctcttgt gtagccgccg
     2521 gctctgggga tgctggctta tttctagttc agtgagataa tttctagtaa ccttgctctg
     2581 gggtctcacg gtctgaaaat aaagcacttg catgagtata ctaagtcata ctattttgtt
     2641 gaaatttaaa gccctactaa gtgcatgata cactgcatag aatgtatact agcagatact
     2701 gtccagtgaa gcataaatta ggatttaatt tcatgtgcaa gacagcccaa tttttaaaag
     2761 agttaagatg gatttttttc aagaagcaaa aaaaaataag ctaatgcaaa attctttatt
     2821 aatagagata agtggatatg ctttttaaat tcagagctga gaaataaatt gtagacaaaa
     2881 taatggcgtc taggctaaag atggggcatg acctctgtac atagcacatg tgaataactg
     2941 aaaagctaat ggaatattct tgttttaatg atctatcaga aagtggaatt tacaccccag
     3001 ggttgtttta atttctccaa tattgagtat gttttgacat tggtaaccct ttctgaagcc
     3061 ttctcagcag atcttactgt taaatgtgat gcactgatca cgttgtgttg cagcgtttcc
     3121 acaccctcag ggtcgacttg ccactgcttc catgaatatt gtttacaggg agactctggt
     3181 tagccctcat ccaaactgtg gttcgcaacc tgtgggaggg actgggggcg gggtcagact
     3241 gacatcctag accagtgtaa agactgtgta tctgtatata aataacttat caaatagttt
     3301 tctctgtgtc tagacgtgtt agtgttttta cagctgctca gttcattttg tccaaccaaa
     3361 aagcaaaggg agatatgaat gagcttctcg tgacgttcca taccgctgtt aataggcact
     3421 cgcccctgca agttcactgc atgtccagtg ctaggcaaac ttaggattcc ctgtaaattg
     3481 ctggctacag gtattaaagc aatctagtgg tccacccgcc ctgccttagg aggaggagca
     3541 gcggacatgt acatagttga tgctcagtgt ttccaagtac taccatttta tagtaatctc
     3601 tgtgaccgta agtcacctcc acaaaatacc ctcattgtac ttgagggttt taatattaga
     3661 attggcatat gtactttatt tttgaaaagg gaagagatgg gtgtggggtg gtaatagcat
     3721 tgtaccattt tgtcatagaa tgtaaaaaaa ttggtcaact gtacaaatgt cggctagttt
     3781 tggctattaa tggggagaaa ttttaggtaa tttttaaatt caaagtttat aaaatgctag
     3841 gatttgtttt aattttctat ttcgagtcac ttcacatgga gactcagttg caatttttat
     3901 cagatacatt tttatcaaca gttagagtac gatggttttc tcagtttgag taagaatgtt
     3961 gttaccatgt tctttctttg tggtacagta tcctttcagt gcaagagatg cttctccgta
     4021 aagcaggcaa cccctgtaga tgtggaactc cacggaagat attggcaagg agatgcgttc
     4081 cagactgacg gcttgtttgg gtctccgcga gtctggaaca ggattgtcag atggtctgga
     4141 ggctactgtg cgccatgttt ccttactccg caggccttgt gtgcagggcc ggataaatcc
     4201 agttctcagg ctgtgtttga aggttccttg gagggagttc tcactgtcag ttggattcct
     4261 ttacgagcta gggacgaagt tcttgggagt tttttcattc atatttttgt tggttttgta
     4321 ggagtttatt ttaaatacta ggcataaaga agcatcctac ttaagctatg aatgtttttg
     4381 ttttatattt tctttattta taactgtgcc aagtattatt cagctactta ctgtgttact
     4441 ctgtggaaag aaaaacttgt aaagtgttta ataaatcagt cctccttaca taatttaaac
     4501 ctgtcaaaat tttgtaaaat attaatcaaa ataaatattg actcttaaaa aaaaaaaaaa
     4561 aaa
//
