LOCUS       NM_023740               1865 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus zinc finger, DHHC domain containing 16 (Zdhhc16),
            transcript variant 2, mRNA.
ACCESSION   NM_023740
VERSION     NM_023740.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1865)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1865)
  AUTHORS   Cao,N., Li,J.K., Rao,Y.Q., Liu,H., Wu,J., Li,B., Zhao,P., Zeng,L.
            and Li,J.
  TITLE     A potential role for protein palmitoylation and zDHHC16 in DNA
            damage response
  JOURNAL   BMC Mol Biol 17 (1), 12 (2016)
   PUBMED   27159997
  REMARK    GeneRIF: Knockout of zDHHC16, a palmitoyltransferase gene is
            identified as an interacting protein for c-Abl, a non-receptor
            tyrosine kinase involved in DNA damage response, reproduced most of
            the defects in DNA damage responses produced by the inhibition of
            protein palmitoylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1865)
  AUTHORS   Fukata,Y., Murakami,T., Yokoi,N. and Fukata,M.
  TITLE     Local Palmitoylation Cycles and Specialized Membrane Domain
            Organization
  JOURNAL   Curr Top Membr 77, 97-141 (2016)
   PUBMED   26781831
  REMARK    Review article
REFERENCE   4  (bases 1 to 1865)
  AUTHORS   Zhou,T., Li,J., Zhao,P., Liu,H., Jia,D., Jia,H., He,L., Cang,Y.,
            Boast,S., Chen,Y.H., Thibault,H., Scherrer-Crosbie,M., Goff,S.P.
            and Li,B.
  TITLE     Palmitoyl acyltransferase Aph2 in cardiac function and the
            development of cardiomyopathy
  JOURNAL   Proc Natl Acad Sci U S A 112 (51), 15666-15671 (2015)
   PUBMED   26644582
  REMARK    GeneRIF: Aph2 as a critical in vivo regulator of cardiac function
            and reveal roles for protein palmitoylation in the development of
            other organs including eyes.
REFERENCE   5  (bases 1 to 1865)
  AUTHORS   Blaskovic,S., Adibekian,A., Blanc,M. and van der Goot,G.F.
  TITLE     Mechanistic effects of protein palmitoylation and the cellular
            consequences thereof
  JOURNAL   Chem Phys Lipids 180, 44-52 (2014)
   PUBMED   24534427
REFERENCE   6  (bases 1 to 1865)
  AUTHORS   Chamberlain,L.H., Lemonidis,K., Sanchez-Perez,M., Werno,M.W.,
            Gorleku,O.A. and Greaves,J.
  TITLE     Palmitoylation and the trafficking of peripheral membrane proteins
  JOURNAL   Biochem Soc Trans 41 (1), 62-66 (2013)
   PUBMED   23356259
REFERENCE   7  (bases 1 to 1865)
  AUTHORS   Conibear,E. and Davis,N.G.
  TITLE     Palmitoylation and depalmitoylation dynamics at a glance
  JOURNAL   J Cell Sci 123 (Pt 23), 4007-4010 (2010)
   PUBMED   21084560
REFERENCE   8  (bases 1 to 1865)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   9  (bases 1 to 1865)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   10 (bases 1 to 1865)
  AUTHORS   Li,B., Cong,F., Tan,C.P., Wang,S.X. and Goff,S.P.
  TITLE     Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has
            pro-apoptotic activity
  JOURNAL   J Biol Chem 277 (32), 28870-28876 (2002)
   PUBMED   12021275
  REMARK    GeneRIF: Aph2 may be involved in ER stress-induced apoptosis in
            which c-Abl plays an important role
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV658063.1, CK619221.1, AK151505.1 and BY634308.1.
            
            On Feb 9, 2018 this sequence version replaced NM_023740.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151505.1, AK168042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                DV658063.1         13-60
            49-659              CK619221.1         9-619
            660-1857            AK151505.1         615-1812
            1858-1865           BY634308.1         258-265
FEATURES             Location/Qualifiers
     source          1..1865
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 35.48 cM"
     gene            1..1865
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /note="zinc finger, DHHC domain containing 16"
                     /db_xref="GeneID:74168"
                     /db_xref="MGI:MGI:1921418"
     exon            1..221
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /inference="alignment:Splign:2.1.0"
     exon            222..367
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..615
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..1458
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /EC_number="2.3.1.225"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable palmitoyltransferase ZDHHC16; ablphilin-2; zinc
                     finger DHHC domain-containing protein 16; Abl-philin 2"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC16 isoform 2"
                     /protein_id="NP_076229.2"
                     /db_xref="CCDS:CCDS29817.1"
                     /db_xref="GeneID:74168"
                     /db_xref="MGI:MGI:1921418"
                     /translation="MRGQRSLLLGPARLCLRLLLLLGYRRRCPPLLRGLVQRWRYGKV
                     CLRSLLYNSFGGSDTAVDAAFEPVYWLVDNVIRWFGVVFVVLVIVLTGSIVAIAYLCV
                     LPLILRTYSVPRLCWHFFYSHWNLILIVFHYYQAITTPPGYPPQGRNDIATVSICKKC
                     IYPKPARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSYGS
                     WDLFREAYAAIETYHQTPPPTFSFRERITHKSLVYLWFLCSSVALALGALTMWHAVLI
                     SRGETSIERHINKKERRRLQAKGRVFRNPYNYGCLDNWKVFLGVDTGRHWLTRVLLPS
                     SHLPHGNGMSWDPPPWVTAHSASVMAV"
     exon            616..810
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..899
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /inference="alignment:Splign:2.1.0"
     exon            900..928
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1062
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1148
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1272
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1343
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1865
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1838..1843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /note="hexamer: AATAAA"
     polyA_site      1864
                     /gene="Zdhhc16"
                     /gene_synonym="1500015N03Rik; Aph2"
                     /note="major polyA site"
ORIGIN      
        1 ctgggcgtgc ctttgcgggc tccgggcctc gcgcctgcgc agctgggtgg tgatgggcgg
       61 gcggcgggtc ccggtccgct ggctagcgct gtgggctgag ggccatggtg ggtcagcctt
      121 agctcggccc ggcctgggtc ctgagctgga aggggaggca gtgggtggcg gacagggaga
      181 ctgggcctaa tctggctgat tgagaagctg gcaggaggca gaaaggatga gcgcagcaaa
      241 tacttgggtg ttatcacatt ggtgagagtg tctttgctgg ctcctgtaca gctgccagcc
      301 tttcctgttc tgcatctctc caggtcattc attcaacaag tatttattga atacttctac
      361 aagccaggag ccatgcgagg ccagcgaagt ctgctgttgg ggccagcccg cctctgcctg
      421 cgcctccttt tgctcctggg ctaccggcgt cgatgcccac ctctgctccg gggcctggta
      481 cagcgctggc gttatggcaa ggtttgcctg cgctccctgc tctacaattc ctttggaggc
      541 agtgacactg ccgttgatgc tgcctttgag cctgtctact ggctggtgga caatgtgatc
      601 cgctggtttg gagtggtgtt tgtggtgctg gtgatcgtgc tgaccgggtc catcgtggcc
      661 attgcttatc tgtgtgtcct gcccctcatc ctccgaacct actcggtacc acggctctgc
      721 tggcatttct tctatagtca ctggaatctg atcctcatcg tcttccatta ctaccaggcc
      781 atcaccactc ctcctggata cccaccccag ggcaggaatg acattgctac tgtctccatc
      841 tgtaagaagt gcatttatcc caagccagcc cgaacacacc actgcagcat ctgtaatagg
      901 tgtgtgctga agatggatca tcactgcccc tggctaaaca actgtgtggg ccactataac
      961 catcgctact tcttctcttt ctgctttttc atgactctgg gctgtgtcta ctgtagctat
     1021 ggaagttggg accttttccg ggaggcttat gctgccattg agacgtacca ccagactcca
     1081 ccacctacct tctcctttcg agaaaggata actcacaaga gtcttgtcta cctctggttc
     1141 ctgtgcagtt ctgtggccct ggccctgggt gccctaacca tgtggcatgc tgttctcatc
     1201 agtcggggtg agactagcat cgaaaggcat atcaacaaga aggagaggcg ccggttacag
     1261 gccaagggca gggtgtttag gaatccttac aactatggct gcttggacaa ctggaaggtg
     1321 ttcctaggtg tggacacagg aaggcattgg ctgacccggg tgctgttacc ttctagtcac
     1381 ctgccccatg ggaatgggat gagctgggac cctcctccct gggtgactgc tcactcagcc
     1441 tctgtgatgg ccgtgtaagc cacaacttga acactatttg atgtttattg tctctcaaga
     1501 gcttccaagg gcagcttttc ctggaatcca tgaccatgaa gagccatcag gcttgcctta
     1561 gagtactaca cagggacaat caagaccaat cttctgccac ctaaaaacaa gatgcagtgt
     1621 ggagaaactc aaggattgaa gtccctttac tcaggcaaat aagttttagc tccagccgag
     1681 ctctaggtca cagcactggg gctagacacc atctctttct ttcactttgg gaaaagatcc
     1741 atcaggtatg ttgaaactct ggcttctcaa cgggacaaag acagtaagcc tattgccaag
     1801 gtcactgcca tttctcacgt gctacagagg gagcgaaaat aaaggcattt gatttgtaaa
     1861 aagat
//
