LOCUS       NM_001037762            1152 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus zinc finger, DHHC domain containing 12 (Zdhhc12),
            transcript variant 2, mRNA.
ACCESSION   NM_001037762
VERSION     NM_001037762.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1152)
  AUTHORS   Wang,L., Cai,J., Zhao,X., Ma,L., Zeng,P., Zhou,L., Liu,Y., Yang,S.,
            Cai,Z., Zhang,S., Zhou,L., Yang,J., Liu,T., Jin,S. and Cui,J.
  TITLE     Palmitoylation prevents sustained inflammation by limiting NLRP3
            inflammasome activation through chaperone-mediated autophagy
  JOURNAL   Mol Cell 83 (2), 281-297 (2023)
   PUBMED   36586411
  REMARK    GeneRIF: Palmitoylation prevents sustained inflammation by limiting
            NLRP3 inflammasome activation through chaperone-mediated autophagy.
REFERENCE   2  (bases 1 to 1152)
  AUTHORS   Dejanovic,B., Semtner,M., Ebert,S., Lamkemeyer,T., Neuser,F.,
            Luscher,B., Meier,J.C. and Schwarz,G.
  TITLE     Palmitoylation of gephyrin controls receptor clustering and
            plasticity of GABAergic synapses
  JOURNAL   PLoS Biol 12 (7), e1001908 (2014)
   PUBMED   25025157
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1152)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   4  (bases 1 to 1152)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087676.1, AK013074.1 and BX005298.9.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021432.1, AK087676.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AK087676.1         15-161
            148-787             AK013074.1         178-817
            788-1152            BX005298.9         59957-60321         c
FEATURES             Location/Qualifiers
     source          1..1152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.15 cM"
     gene            1..1152
                     /gene="Zdhhc12"
                     /gene_synonym="1190004A01Rik"
                     /note="zinc finger, DHHC domain containing 12"
                     /db_xref="GeneID:66220"
                     /db_xref="MGI:MGI:1913470"
     exon            1..147
                     /gene="Zdhhc12"
                     /gene_synonym="1190004A01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..851
                     /gene="Zdhhc12"
                     /gene_synonym="1190004A01Rik"
                     /EC_number="2.3.1.225"
                     /note="isoform b is encoded by transcript variant 2;
                     probable palmitoyltransferase ZDHHC12; DHHC-12; zinc
                     finger DHHC domain-containing protein 12; DHHC
                     domain-containing cysteine-rich protein 12"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC12 isoform b"
                     /protein_id="NP_001032851.1"
                     /db_xref="CCDS:CCDS15868.1"
                     /db_xref="GeneID:66220"
                     /db_xref="MGI:MGI:1913470"
                     /translation="MALWPPLNSGMLVRTGHTVLTWGITLVLFLHDTELRQWEEQGEL
                     LLPLTFLLLVLSSLLLYLAVSLMDPGYVTTQPQPQGEPKEEQAAMVPQAVPLRRCRHC
                     LVLQPLRARHCRDCRRCVRRYDHHCPWMENCVGERNHPLFVAYLALQLVVLLWGLCLA
                     WSGLQFFQPWGLWLRSTGLLFTTFLLLSFFALVVALLLASHLYLVARNTTTWEFISSH
                     RIAYLRQRTSNPFDRGPTRNLAHFFCGWPSGPWETLSAEEEEEGSSQVV"
     exon            148..284
                     /gene="Zdhhc12"
                     /gene_synonym="1190004A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            285..362
                     /gene="Zdhhc12"
                     /gene_synonym="1190004A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            363..529
                     /gene="Zdhhc12"
                     /gene_synonym="1190004A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            530..1152
                     /gene="Zdhhc12"
                     /gene_synonym="1190004A01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1132..1137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc12"
                     /gene_synonym="1190004A01Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1152
                     /gene="Zdhhc12"
                     /gene_synonym="1190004A01Rik"
                     /note="major polyA site"
ORIGIN      
        1 accttctgcg cgcttcttcc gggtgggctc gggcgggggc caaggccatg gctctttggc
       61 cgccgcttaa ctctgggatg ctggtgcgga ctgggcacac cgtgctgacc tggggaatca
      121 ctctggtgct cttcctgcac gacaccgagc tacgccaatg ggaagagcaa ggggagctgc
      181 tcctgcccct cacattcctg ctcctggtgc taagctccct gctgctttat ctggctgtgt
      241 cactcatgga ccccggctat gtgactactc agccccagcc tcagggcgag cccaaggagg
      301 aacaggcagc catggttcct caggccgtcc cactccggcg ctgcagacac tgtctggtgc
      361 tgcagcccct gcgtgcccgg cactgtcgtg attgccgccg ctgtgttcgg cgctatgatc
      421 accactgtcc ctggatggag aactgtgtgg gtgaacgcaa ccacccgctc tttgtggcct
      481 acctggcact gcagctggta gttctgctgt ggggcctgtg cctggcatgg tctggccttc
      541 agttcttcca gccctggggg ctgtggctcc ggtccactgg gctcctgttc accaccttcc
      601 tgctgctctc cttcttcgcg ttagtggttg ccctgctcct ggcctcccac ctctacctgg
      661 tagccaggaa cacgactacc tgggagttca tatcttcaca ccgaatcgcc tacctccgcc
      721 agcgcaccag caaccccttt gaccgagggc cgactcgaaa cctggcccac tttttctgtg
      781 gttggccctc tgggccctgg gagactctct cggctgagga agaggaagaa ggcagcagcc
      841 aggttgtcta gggttgctgg agagaaggct gctgttgtgc ctaaaagcca gaggctgtgc
      901 cagctaggga tcagcccact cagcctaagg cctttacgtc ttcctagggc ttccagccct
      961 caggagagaa gtagacagaa ccccccctgc cacccctaaa ggaagacata gaagaaaagg
     1021 aaataagttg ggggaggggt gttaaaagag aacctagaca ctacacaacc cctggcctgg
     1081 ctacctcgag tgtacagttt tattaattta atgctctata taaagtcaag tattaaaaag
     1141 aaaagccacc ca
//
