LOCUS       NM_027704               1462 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus zinc finger, DHHC domain containing 11 (Zdhhc11),
            transcript variant 1, mRNA.
ACCESSION   NM_027704 XM_127421 XM_908783 XM_992859
VERSION     NM_027704.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1462)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1462)
  AUTHORS   Murakami,Y., Konishi,H., Fujiya,M., Takahashi,K., Ando,K., Ueno,N.,
            Kashima,S., Moriichi,K., Tanabe,H. and Okumura,T.
  TITLE     Testis-specific hnRNP is expressed in colorectal cancer cells and
            accelerates cell growth mediating ZDHHC11 mRNA stabilization
  JOURNAL   Cancer Med 11 (19), 3643-3656 (2022)
   PUBMED   35384384
  REMARK    GeneRIF: Testis-specific hnRNP is expressed in colorectal cancer
            cells and accelerates cell growth mediating ZDHHC11 mRNA
            stabilization.
REFERENCE   3  (bases 1 to 1462)
  AUTHORS   Wu,Y., Zhang,X., Zhang,X., Liu,S., Zhang,J., Sun,S., Zhao,S.,
            Wang,Z., Cui,Y., Huang,X. and Liu,M.
  TITLE     ZDHHC19 localizes to the cell membrane of spermatids and is
            involved in spermatogenesisdagger
  JOURNAL   Biol Reprod 106 (3), 477-486 (2022)
   PUBMED   34897408
REFERENCE   4  (bases 1 to 1462)
  AUTHORS   Liu,E., Sun,J., Yang,J., Li,L., Yang,Q., Zeng,J., Zhang,J., Chen,D.
            and Sun,Q.
  TITLE     ZDHHC11 Positively Regulates NF-kappaB Activation by Enhancing
            TRAF6 Oligomerization
  JOURNAL   Front Cell Dev Biol 9, 710967 (2021)
   PUBMED   34490261
  REMARK    Erratum:[Front Cell Dev Biol. 2021 Sep 16;9:761639. doi:
            10.3389/fcell.2021.761639.. PMID: 34604244]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1462)
  AUTHORS   Liu,Y., Zhou,Q., Zhong,L., Lin,H., Hu,M.M., Zhou,Y., Shu,H.B. and
            Li,S.
  TITLE     ZDHHC11 modulates innate immune response to DNA virus by mediating
            MITA-IRF3 association
  JOURNAL   Cell Mol Immunol 15 (10), 907-916 (2018)
   PUBMED   29429998
  REMARK    GeneRIF: Mechanistically, ZDHHC11 facilitated the optimal
            recruitment of IRF3 to MITA.
REFERENCE   6  (bases 1 to 1462)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1462)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   8  (bases 1 to 1462)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 1462)
  AUTHORS   Oku,S., Takahashi,N., Fukata,Y. and Fukata,M.
  TITLE     In silico screening for palmitoyl substrates reveals a role for
            DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in
            its targeting to Rab5-positive endosomes
  JOURNAL   J Biol Chem 288 (27), 19816-19829 (2013)
   PUBMED   23687301
  REMARK    GeneRIF: In silico screening for palmitoyl substrates reveals a
            role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin
            palmitoylation in its targeting to Rab5-positive endosomes.
REFERENCE   10 (bases 1 to 1462)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK016865.1, BC116807.1 and BB012497.1.
            
            On Feb 14, 2018 this sequence version replaced NM_027704.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC116807.1, SRR5189685.201479.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AK016865.1         2-12
            12-1312             BC116807.1         1-1301
            1313-1461           AK016865.1         1368-1516
            1462-1462           BB012497.1         232-232
FEATURES             Location/Qualifiers
     source          1..1462
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.15 cM"
     gene            1..1462
                     /gene="Zdhhc11"
                     /gene_synonym="4933421L13Rik; DHHC-11; Zdhhc20"
                     /note="zinc finger, DHHC domain containing 11"
                     /db_xref="GeneID:71164"
                     /db_xref="MGI:MGI:1918414"
     exon            1..79
                     /gene="Zdhhc11"
                     /gene_synonym="4933421L13Rik; DHHC-11; Zdhhc20"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1114
                     /gene="Zdhhc11"
                     /gene_synonym="4933421L13Rik; DHHC-11; Zdhhc20"
                     /EC_number="2.3.1.225"
                     /note="zinc finger, DHHC domain containing 20;
                     DHHC-containing protein 10; zinc finger DHHC
                     domain-containing protein 11; probable
                     palmitoyltransferase ZDHHC11; DHHC10(z11)"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC11"
                     /protein_id="NP_081980.1"
                     /db_xref="CCDS:CCDS36729.1"
                     /db_xref="GeneID:71164"
                     /db_xref="MGI:MGI:1918414"
                     /translation="MKEMNICGINKNWVLPEAQENNVKKFLPRPLSRVNGWSPPLHSF
                     QAISWITYLAMSIVTFGIFIPFLPYSWKYAANIVMGGVFIFHLIVHLIAITIDPADTN
                     VRLKKDYTQPVPAFDRSKHTHVIQNQYCHLCEVTASKKAKHCSACNKCVSGFDHHCKW
                     LNNCVGRRNYWFFFWSVASAAVGILGVMIILCYICIQYFVNPDELRTDPLYKEIISEN
                     TWLLFLSLWPVPVKTPIVLSIAVMALLLAIASFVMLGHLLIFHLYLITKNMSTFDYLM
                     KTRFKKNLHPAEEKELPLQKKGDLPQEKSDNWAWPKSPPRVGSQKFPVSTLSPKSSVC
                     FVASPPKICHSED"
     exon            80..301
                     /gene="Zdhhc11"
                     /gene_synonym="4933421L13Rik; DHHC-11; Zdhhc20"
                     /inference="alignment:Splign:2.1.0"
     exon            302..480
                     /gene="Zdhhc11"
                     /gene_synonym="4933421L13Rik; DHHC-11; Zdhhc20"
                     /inference="alignment:Splign:2.1.0"
     exon            481..582
                     /gene="Zdhhc11"
                     /gene_synonym="4933421L13Rik; DHHC-11; Zdhhc20"
                     /inference="alignment:Splign:2.1.0"
     exon            583..707
                     /gene="Zdhhc11"
                     /gene_synonym="4933421L13Rik; DHHC-11; Zdhhc20"
                     /inference="alignment:Splign:2.1.0"
     exon            708..863
                     /gene="Zdhhc11"
                     /gene_synonym="4933421L13Rik; DHHC-11; Zdhhc20"
                     /inference="alignment:Splign:2.1.0"
     exon            864..976
                     /gene="Zdhhc11"
                     /gene_synonym="4933421L13Rik; DHHC-11; Zdhhc20"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1017
                     /gene="Zdhhc11"
                     /gene_synonym="4933421L13Rik; DHHC-11; Zdhhc20"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1109
                     /gene="Zdhhc11"
                     /gene_synonym="4933421L13Rik; DHHC-11; Zdhhc20"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1462
                     /gene="Zdhhc11"
                     /gene_synonym="4933421L13Rik; DHHC-11; Zdhhc20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1413..1418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc11"
                     /gene_synonym="4933421L13Rik; DHHC-11; Zdhhc20"
                     /note="hexamer: AATAAA"
     polyA_site      1447
                     /gene="Zdhhc11"
                     /gene_synonym="4933421L13Rik; DHHC-11; Zdhhc20"
                     /note="major polyA site"
ORIGIN      
        1 gctttgttcg tgggaacgcc ctaccactgt ttaacatgtc agcactgagc aagaagtgct
       61 gttcaacctg atgaaagaga tgaacatctg tggcatcaac aagaactggg tcctcccaga
      121 agcccaggaa aacaatgtga agaagttcct accacgccct ctgtctaggg tgaatggctg
      181 gtcaccaccc ctccactcct ttcaggcaat atcctggatc acctacctgg ccatgtccat
      241 tgtcaccttt gggatcttca tcccctttct gccatatagc tggaaatatg ctgccaatat
      301 tgtgatgggt ggggtgttca tattccacct catcgtgcac ttgatcgcaa ttaccatcga
      361 tccagctgac accaatgtcc gactcaaaaa ggactacacg cagcctgtgc cggccttcga
      421 caggtccaaa cacacacacg tgattcagaa ccagtactgc cacctgtgtg aggttaccgc
      481 gagcaaaaaa gccaaacatt gcagcgcctg caacaaatgt gtctctggct ttgaccacca
      541 ctgcaaatgg ctgaacaact gcgtgggcag gagaaactac tggttctttt tctggtctgt
      601 ggcctcagct gcagttggga ttcttggtgt gatgattatc ttgtgttata tctgcatcca
      661 gtactttgtc aaccctgatg agcttcgcac ggatcctctc tataaagaga tcatctctga
      721 gaacacatgg ctgctgttcc tctcactgtg gcctgtgcct gtgaagaccc ccatagtcct
      781 ttccatcgcg gtgatggcac tgctactagc tattgccagc ttcgtgatgc ttgggcacct
      841 cctcatcttc cacttatacc tgattactaa gaatatgagc acatttgact acctgatgaa
      901 gactcgattc aagaagaatt tacatccagc agaggagaaa gagctacctc tacagaagaa
      961 gggggacctt ccccaggaaa agagtgacaa ctgggcctgg ccgaagtccc cacccagagt
     1021 ggggtcccag aagttcccag tgtctactct ttcgccgaag tcaagtgtgt gttttgtggc
     1081 ttcacctcca aagatctgcc acagtgaaga ctagtggcaa ggatgagccc ttctttcatc
     1141 atggaaacac caaggtatca gcccaagatc atgaggagac ccttctactc tgtggtgcat
     1201 gatgctgctg agccatgatc ttcagtagaa tatgtgtatt atgtgtattt tggacttaag
     1261 atattttcaa tttatgatga gttcctcaga atgcaaagcc gttgtcatcc aagaatcatc
     1321 tatatagaag aatgttagca gtaatagagt ctaggtgtta agtacatatg cattttcact
     1381 ttcaactttt ctagatgttt gaaaattttc ataataaaat gttgatgtat gacttggtaa
     1441 aaataaacat ggcaaaagtt ca
//
