LOCUS       NM_175160               2248 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus zinc finger, DHHC domain containing 1 (Zdhhc1),
            transcript variant 1, mRNA.
ACCESSION   NM_175160
VERSION     NM_175160.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2248)
  AUTHORS   Nie,L., Fei,C., Fan,Y., Dang,F., Zhao,Z., Zhu,T., Wu,X., Dai,T.,
            Balasubramanian,A., Pan,J., Hu,Y., Luo,H.R., Wei,W. and Chen,J.
  TITLE     Consecutive palmitoylation and phosphorylation orchestrates NLRP3
            membrane trafficking and inflammasome activation
  JOURNAL   Mol Cell 84 (17), 3336-3353 (2024)
   PUBMED   39173637
REFERENCE   2  (bases 1 to 2248)
  AUTHORS   Zhou,Q., Lin,H., Wang,S., Wang,S., Ran,Y., Liu,Y., Ye,W., Xiong,X.,
            Zhong,B., Shu,H.B. and Wang,Y.Y.
  TITLE     The ER-associated protein ZDHHC1 is a positive regulator of DNA
            virus-triggered, MITA/STING-dependent innate immune signaling
  JOURNAL   Cell Host Microbe 16 (4), 450-461 (2014)
   PUBMED   25299331
REFERENCE   3  (bases 1 to 2248)
  AUTHORS   Oku,S., Takahashi,N., Fukata,Y. and Fukata,M.
  TITLE     In silico screening for palmitoyl substrates reveals a role for
            DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in
            its targeting to Rab5-positive endosomes
  JOURNAL   J Biol Chem 288 (27), 19816-19829 (2013)
   PUBMED   23687301
  REMARK    GeneRIF: In silico screening for palmitoyl substrates reveals a
            role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin
            palmitoylation in its targeting to Rab5-positive endosomes.
REFERENCE   4  (bases 1 to 2248)
  AUTHORS   Fukata,M., Fukata,Y., Adesnik,H., Nicoll,R.A. and Bredt,D.S.
  TITLE     Identification of PSD-95 palmitoylating enzymes
  JOURNAL   Neuron 44 (6), 987-996 (2004)
   PUBMED   15603741
REFERENCE   5  (bases 1 to 2248)
  AUTHORS   Putilina,T., Wong,P. and Gentleman,S.
  TITLE     The DHHC domain: a new highly conserved cysteine-rich motif
  JOURNAL   Mol Cell Biochem 195 (1-2), 219-226 (1999)
   PUBMED   10395086
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151573.2 and AC090480.11.
            
            On Mar 18, 2020 this sequence version replaced NM_175160.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1, 3, and
            4 all encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK038593.1, SRR7652917.689035.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AC151573.2         114142-114394       c
            254-329             AC090480.11        6858-6933
            330-376             AC090480.11        9216-9262
            377-615             AC090480.11        10297-10535
            616-858             AC090480.11        10941-11183
            859-1034            AC090480.11        15797-15972
            1035-1136           AC090480.11        17606-17707
            1137-1261           AC090480.11        17986-18110
            1262-1420           AC090480.11        18195-18353
            1421-1533           AC090480.11        18588-18700
            1534-1616           AC090480.11        21158-21240
            1617-1710           AC090480.11        21425-21518
            1711-1789           AC090480.11        21655-21733
            1790-2248           AC090480.11        21843-22301
FEATURES             Location/Qualifiers
     source          1..2248
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..2248
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /note="zinc finger, DHHC domain containing 1"
                     /db_xref="GeneID:70796"
                     /db_xref="MGI:MGI:1918046"
     exon            1..253
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            254..329
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..376
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..615
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             616..2070
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /EC_number="2.3.1.225"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable palmitoyltransferase ZDHHC1; zinc finger DHHC
                     domain-containing protein 1"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC1 isoform 1"
                     /protein_id="NP_780369.1"
                     /db_xref="CCDS:CCDS22603.1"
                     /db_xref="GeneID:70796"
                     /db_xref="MGI:MGI:1918046"
                     /translation="MNICNKPSNKTAPEKSVWTAPSQDSGPSPELQGQRSRRNGWSWP
                     PHPLQIVAWLLYLFFAVIGFGVLVPLLPHHWVPAGYACMGAIFAGHLVVHLTAVSIDP
                     ADANVRDKSYSGPLPIFNRSQHAHVIEDLHCNLCDVDVSARSKHCSACNKCVCGFDHH
                     CKWLNNCVGERNYRLFLHSVASALLGVLLLVLVATYVFVEFFVNPMRLRTNQHFEVLK
                     NHTDVWFVFLPAAPVETQAPAILALAALLILLGLLSTALLGHLLCFHIYLMWHKLTTY
                     EYIVQHRPAQEAKETHKELESCPRKVRSIQEMEFYMRTFSHVRPEPSGQARTAALNAN
                     PSQFLATQGQVEPPLPSSSDTLALPPRIQPQKKRKRRVYRLPRSGVLDRELPLPRLRE
                     TGTPSRRSSSSSDSTSASPVHAGGSAGAYYSASAESMEEIPVAQTRLGSAALGAPGAR
                     GRESGLALQARSPAVFVSPSSGEPGTPGGGDGLP"
     exon            616..858
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1034
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1136
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1261
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1420
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1533
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1616
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1710
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1789
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..2248
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2226..2231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /note="hexamer: AATAAA"
     polyA_site      2248
                     /gene="Zdhhc1"
                     /gene_synonym="4432412D04Rik; DHHC-1"
                     /note="major polyA site"
ORIGIN      
        1 aaggcccagc ctgccttggc ctggcacggc tgcactgcca gcgggtcctt gctaaggcgg
       61 aaggactctg aggcccaacc tccgtccggg atggagccgc gctccgggac gcgtctcctc
      121 cgtgtccggg ggaccgactt tgcccggacg gtctgaagtg cggccgccct ggggagggtg
      181 gacgggcagg gcggggccga gccgctggct gaccttggca ggccgcatct ggcgcggctg
      241 ccaccacgcg cagctgggtg cggtggcgca tgcctggcat cctggccctg aggaggaaca
      301 ggtagatcaa gaccagctat ggctacataa tgttttcacg tcagcgaaca ttcactgagc
      361 atctactacg tacaaggaat caaagaagag tcctcccttc tcttgtgtgc gggctcatcc
      421 ccagctgaga aaccagaaag aacccctctg aagcccaggg gagaagttgt tggtccctgg
      481 tcctaaaggg attatgtgcc tgccaagcag tgagcagtga ggccagctct ctctgaacac
      541 ccccactgcc tgtttccttc agcaaagaag aaggggcccc cctctctgac acttgatttg
      601 gatctcagga cggagatgaa catctgcaac aaaccctcca acaagacagc ccccgagaag
      661 agtgtgtgga cagcgccctc acaggacagt gggccttccc cagaactgca gggccagcgc
      721 tctcgaagga atggatggag ctggccgccc cacccgctcc agattgtggc ctggctgctc
      781 tacctcttct tcgcggtgat tggctttggg gtccttgttc ccctcttgcc tcaccactgg
      841 gtgcctgctg gctatgcttg catgggggcc atctttgctg gccaccttgt ggtgcacctg
      901 actgctgtct ccatcgatcc agcagatgcc aatgtgcggg acaagagcta ctctgggccc
      961 ctgcccatct tcaaccgcag ccagcatgcg catgtcattg aagacctgca ctgcaaccta
     1021 tgcgacgtgg acgtgagtgc gcgatccaaa cactgcagcg cctgcaataa gtgcgtatgc
     1081 ggcttcgatc accattgcaa gtggctcaac aactgcgtgg gcgagaggaa ctatcggctc
     1141 tttctacaca gtgtggcatc tgctttattg ggtgtcctgc tcctggtgct ggtggccact
     1201 tatgtcttcg tggagttctt tgtcaacccc atgcgacttc gtaccaacca acactttgaa
     1261 gtcttgaaga accacacgga tgtgtggttt gtgttcttgc ctgctgcccc tgtggagacc
     1321 caggctcctg ccatcctggc cctggccgcc ctgctcatcc ttctgggcct gctttctaca
     1381 gccctgcttg gccacctgct ctgcttccac atttatctaa tgtggcacaa gctcaccacc
     1441 tatgaataca tcgtgcagca ccgtccagct caggaagcaa aggagaccca caaggagctg
     1501 gagtcatgcc cccgcaaggt gcggtccatt caggagatgg agttctacat gaggaccttc
     1561 agccatgtgc gtccagagcc ctctggccag gctaggacag cagcattaaa tgccaatcct
     1621 tcccagtttc ttgccaccca aggccaagtg gaaccaccac taccctcctc ctcagacaca
     1681 ctggctctgc ctccacggat ccaaccccag aaaaagagga agcggcgagt gtatagattg
     1741 cccaggtctg gggtcttgga ccgagagctc ccactgccca ggttacggga gactgggact
     1801 cctagccgcc gctccagctc ttcatctgat tccaccagtg ccagcccagt gcatgctggt
     1861 ggctctgcag gcgcctacta ctcggcatca gctgagtcca tggaagagat tccagtggcc
     1921 cagacgcgcc tgggcagtgc cgcactgggt gccccaggag ccaggggtcg agagtctggg
     1981 ctggctctac aggcacgttc gcctgctgtt tttgtgagcc cgagcagtgg cgagcccgga
     2041 acacctggag gcggcgacgg cctgccttag cccactaagg ctaaggacta gaggcaggag
     2101 ggccttgact ctatgcaaca ccccacattc gcgtaacgag tgcactttag ggacctcaag
     2161 gtcgacagga tcggccttcc ttacccaaga ctcagcaata tccgctccac cagccctgat
     2221 gccccaataa actttttttt ttttttaa
//
