LOCUS       NM_001005426            2271 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger, CW type with PWWP domain 1 (Zcwpw1),
            transcript variant 2, mRNA.
ACCESSION   NM_001005426 XM_355653
VERSION     NM_001005426.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2271)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2271)
  AUTHORS   Zhao,M., Zhou,G., Wang,J., Zhang,Y., Xue,J., Liu,J., Xie,J., Ren,L.
            and Zhou,X.
  TITLE     MiR-5622-3p inhibits ZCWPW1 to induce apoptosis in silica-exposed
            mice and spermatocyte cells
  JOURNAL   Nanotoxicology 17 (4), 372-384 (2023)
   PUBMED   37315217
  REMARK    GeneRIF: MiR-5622-3p inhibits ZCWPW1 to induce apoptosis in
            silica-exposed mice and spermatocyte cells.
REFERENCE   3  (bases 1 to 2271)
  AUTHORS   Hurley,S., Mohan,C., Suetterlin,P., Ellingford,R., Riegman,K.L.H.,
            Ellegood,J., Caruso,A., Michetti,C., Brock,O., Evans,R., Rudari,F.,
            Delogu,A., Scattoni,M.L., Lerch,J.P., Fernandes,C. and Basson,M.A.
  TITLE     Distinct, dosage-sensitive requirements for the autism-associated
            factor CHD8 during cortical development
  JOURNAL   Mol Autism 12 (1), 16 (2021)
   PUBMED   33627187
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2271)
  AUTHORS   Wells,D., Bitoun,E., Moralli,D., Zhang,G., Hinch,A., Jankowska,J.,
            Donnelly,P., Green,C. and Myers,S.R.
  TITLE     ZCWPW1 is recruited to recombination hotspots by PRDM9 and is
            essential for meiotic double strand break repair
  JOURNAL   Elife 9, e53392 (2020)
   PUBMED   32744506
  REMARK    GeneRIF: ZCWPW1 is recruited to recombination hotspots by PRDM9 and
            is essential for meiotic double strand break repair.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2271)
  AUTHORS   Huang,T., Yuan,S., Gao,L., Li,M., Yu,X., Zhan,J., Yin,Y., Liu,C.,
            Zhang,C., Lu,G., Li,W., Liu,J., Chen,Z.J. and Liu,H.
  TITLE     The histone modification reader ZCWPW1 links histone methylation to
            PRDM9-induced double-strand break repair
  JOURNAL   Elife 9, e53459 (2020)
   PUBMED   32374261
  REMARK    GeneRIF: The histone modification reader ZCWPW1 links histone
            methylation to PRDM9-induced double-strand break repair.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2271)
  AUTHORS   Mahgoub,M., Paiano,J., Bruno,M., Wu,W., Pathuri,S., Zhang,X.,
            Ralls,S., Cheng,X., Nussenzweig,A. and Macfarlan,T.S.
  TITLE     Dual histone methyl reader ZCWPW1 facilitates repair of meiotic
            double strand breaks in male mice
  JOURNAL   Elife 9, e53360 (2020)
   PUBMED   32352380
  REMARK    GeneRIF: Dual histone methyl reader ZCWPW1 facilitates repair of
            meiotic double strand breaks in male mice.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2271)
  AUTHORS   Li,M., Huang,T., Li,M.J., Zhang,C.X., Yu,X.C., Yin,Y.Y., Liu,C.,
            Wang,X., Feng,H.W., Zhang,T., Liu,M.F., Han,C.S., Lu,G., Li,W.,
            Ma,J.L., Chen,Z.J., Liu,H.B. and Liu,K.
  TITLE     The histone modification reader ZCWPW1 is required for meiosis
            prophase I in male but not in female mice
  JOURNAL   Sci Adv 5 (8), eaax1101 (2019)
   PUBMED   31453335
  REMARK    GeneRIF: The results suggest that ZCWPW1 may represent a previously
            unknown, sex-dependent epigenetic regulator of germ cell meiosis in
            mammals.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK080079.1, BC071186.1 and CF982070.1.
            
            On Jul 22, 2009 this sequence version replaced NM_001005426.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071186.1, SRR7345562.1979131.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-429               AK080079.1         2-430
            430-1329            BC071186.1         357-1256
            1330-1828           CF982070.1         51-549
            1829-2271           BC071186.1         1756-2198
FEATURES             Location/Qualifiers
     source          1..2271
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.71 cM"
     gene            1..2271
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /note="zinc finger, CW type with PWWP domain 1"
                     /db_xref="GeneID:381678"
                     /db_xref="MGI:MGI:2685899"
     exon            1..144
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            145..199
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2064
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /codon_start=1
                     /product="zinc finger CW-type PWWP domain protein 1"
                     /protein_id="NP_001005426.2"
                     /db_xref="CCDS:CCDS19779.1"
                     /db_xref="GeneID:381678"
                     /db_xref="MGI:MGI:2685899"
                     /translation="MMAALQTHKEYEKGTKKTFAPPTQKLHSEKPQPSSWKEDAPGTS
                     SPEAETKPSLLKASLKKEQKPTTEHGPNRGQERKLKAQDQPAKKKGKERTLTSAEFEE
                     IFQIVLQKSLQECLETSSCVQHIRPTKLDEEPGIVPPATDKKDADPEKVITPDTPKIA
                     SSLEEEVNSEMGTSKLGQPVTEPSKKKFNRLSLSKQKKKAEDEKMEKIQDGRECSLKE
                     KQKIVIQDQSQIRGPQKEEESGFGHCVIWVQCSSPKCEKWRQLRGNIDPSVLPDDWSC
                     DQNPDPNYNRCDIPEESWAGCESDVAYASYVPGSIIWAKQYGYPWWPGMIEADPDLGE
                     YFLFASHLDSLPSKYHVTFFGETVSRAWIPVRMLKNFQELSLELVKKCKNKNSNQKLE
                     AAIAMAHRAEQTSIQERVNLFGFWSRYNGADISEEGEDLTLCESNNPESCLEKEEKDL
                     EEEKEEEEEKKDPTLPRPKPAKMQTKKPKSRGPAGGPDGTPKKKTAKKSLVSESTVPP
                     VPTLGGKEEQGNSDLDHPVPKKKFKAPENKTSATNLSEEKEIKIVSKCPTPSAQHGAC
                     PLGKEGLVPHMPPTQEAASFPPDDDCSSDLDLEQLMEDIGEPEERGEMQQRGSSEEFL
                     AALFEE"
     exon            200..444
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            445..520
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            521..614
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            615..772
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            773..895
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1012
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1133
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1209
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1308
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1392
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1459
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1554
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1615
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1750
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..2218
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2189..2194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /note="hexamer: AATAAA"
     polyA_site      2211
                     /gene="Zcwpw1"
                     /gene_synonym="Gm1053"
                     /note="major polyA site"
ORIGIN      
        1 gcacgccgct tgggggcgga atttgtccgt gtcctcgcgc cttctcctgg tggcgggaaa
       61 agttgctcga ggtggaaggg atgtgcggaa tggctgcgac agcgttagct gcgcttcacc
      121 tttaggtcct cgtcgcccca gaaggcacag aaagtatagt ttctgaactg aatgatggca
      181 gcattacaga ctcacaaaga atacgaaaag ggaacaaaga aaacctttgc tccacctaca
      241 caaaaattac atagcgagaa acctcagccc agctcatgga aggaggacgc cccagggacc
      301 agttctccag aggcagagac caagccaagc ctgctcaaag ccagcttaaa gaaggagcag
      361 aaaccaacca cagagcatgg tccaaacagg ggccaggaga gaaagctaaa ggctcaggac
      421 cagccagcca agaagaaagg aaaggaaaga actcttacca gtgcagaatt tgaggagatt
      481 ttccagattg tactacagaa gtccctgcag gagtgcttgg agacttcttc ctgtgtccaa
      541 cacatcagac ctaccaaatt ggatgaagaa ccgggcattg ttcctcctgc aactgataag
      601 aaagatgctg atccagagaa ggtaataact cctgatactc caaagattgc atcttcttta
      661 gaagaggaag tgaattctga gatggggaca tctaagctag gccagccagt tactgaaccc
      721 tctaagaaga aatttaatag actctcttta agcaaacaaa agaagaaagc tgaagatgag
      781 aaaatggaga agatccaaga tggccgtgag tgcagtctga aggagaaaca gaagatagtg
      841 attcaggatc agtctcagat cagaggtccc cagaaggaag aggagagtgg ttttggccac
      901 tgtgtcatct gggttcagtg ttcctctcca aagtgtgaga agtggcggca gctacgtgga
      961 aacattgatc cctcagttct tccagacgac tggtcttgtg accagaatcc agatccgaat
     1021 tataatcgct gtgacattcc tgaggagagc tgggcagggt gcgagagtga tgtggcctat
     1081 gcctcctatg tcccaggatc catcatctgg gccaagcaat atggctaccc atggtggcca
     1141 ggcatgatag aagctgatcc tgacctgggg gagtactttc tgtttgcttc tcatcttgat
     1201 tccctgccgt ctaagtacca cgtgacattt tttggagaaa cggtttctcg tgcatggatc
     1261 ccagtccgca tgttaaagaa cttccaggag ctgtctttgg agctagtgaa aaaatgcaag
     1321 aacaagaact ctaatcagaa gctggaggca gccatagcga tggctcacag ggcagaacag
     1381 accagtattc aggagcgggt taacttgttt ggtttctgga gtcgatacaa tggagctgac
     1441 atcagtgagg aaggggaaga tttgactctc tgtgagtcca acaaccctga gtcttgtctg
     1501 gagaaggaag agaaggactt agaggaggag aaggaggagg aagaagagaa gaaagatcca
     1561 actttgccta gacccaagcc agctaaaatg cagacaaaaa agcccaagtc aagaggccca
     1621 gctggaggac cagatgggac tccaaagaag aagactgcga agaaatctct ggtcagtgaa
     1681 tccacagtcc ctcctgtacc cacactggga gggaaggaag agcaggggaa ctcagacctg
     1741 gaccatccag tccctaagaa aaaatttaaa gctcctgaga acaagacttc agccaccaac
     1801 ttatctgagg agaaagaaat taaaattgtg tccaaatgcc ctactccatc agctcagcat
     1861 ggggcttgtc cattgggaaa ggaagggctt gtgccccaca tgcccccgac acaggaggca
     1921 gcaagtttcc ctcctgacga tgattgctcc agtgacctgg acttggagca actcatggaa
     1981 gacattggag agccagaaga gagaggggag atgcagcaga gaggcagctc agaggagttc
     2041 ctggcggccc tctttgagga gtagagtatt ctggtccccc tgctgttgtt tgcctgcagg
     2101 gagagcctct catttcttcc cgagcagctg ataaatgttg gggttgttga cctgctctgt
     2161 tgttcaagtc agctgtgcag cctgggttaa taaagcaggt ctctggaatt actcctgaaa
     2221 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
