LOCUS       NM_027494               4286 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus zinc finger, CCHC domain containing 8 (Zcchc8), mRNA.
ACCESSION   NM_027494
VERSION     NM_027494.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4286)
  AUTHORS   Wu,Y., Liu,W., Chen,J., Liu,S., Wang,M., Yang,L., Chen,C., Qi,M.,
            Xu,Y., Qiao,Z., Yan,R., Kou,X., Zhao,Y., Shen,B., Yin,J., Wang,H.,
            Gao,Y. and Gao,S.
  TITLE     Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the
            Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells
  JOURNAL   Cell Rep 29 (8), 2461-2472 (2019)
   PUBMED   31747613
  REMARK    GeneRIF: Nuclear Exosome Targeting Complex Core Factor Zcchc8
            Regulates the Degradation of LINE1 RNA in Early Embryos and
            Embryonic Stem Cells.
REFERENCE   2  (bases 1 to 4286)
  AUTHORS   Gable,D.L., Gaysinskaya,V., Atik,C.C., Talbot,C.C. Jr., Kang,B.,
            Stanley,S.E., Pugh,E.W., Amat-Codina,N., Schenk,K.M., Arcasoy,M.O.,
            Brayton,C., Florea,L. and Armanios,M.
  TITLE     ZCCHC8, the nuclear exosome targeting component, is mutated in
            familial pulmonary fibrosis and is required for telomerase RNA
            maturation
  JOURNAL   Genes Dev 33 (19-20), 1381-1396 (2019)
   PUBMED   31488579
REFERENCE   3  (bases 1 to 4286)
  AUTHORS   Jerome-Majewska,L.A., Achkar,T., Luo,L., Lupu,F. and Lacy,E.
  TITLE     The trafficking protein Tmed2/p24beta(1) is required for
            morphogenesis of the mouse embryo and placenta
  JOURNAL   Dev Biol 341 (1), 154-166 (2010)
   PUBMED   20178780
REFERENCE   4  (bases 1 to 4286)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 4286)
  AUTHORS   Kajimura,S., Seale,P., Kubota,K., Lunsford,E., Frangioni,J.V.,
            Gygi,S.P. and Spiegelman,B.M.
  TITLE     Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta
            transcriptional complex
  JOURNAL   Nature 460 (7259), 1154-1158 (2009)
   PUBMED   19641492
REFERENCE   6  (bases 1 to 4286)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY090296.1, AK167126.1 and AK043312.1.
            
            On Mar 13, 2008 this sequence version replaced NM_027494.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032349.1, AK156770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                BY090296.1         3-98
            97-2823             AK167126.1         2-2728
            2824-4286           AK043312.1         33-1495
FEATURES             Location/Qualifiers
     source          1..4286
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.14 cM"
     gene            1..4286
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /note="zinc finger, CCHC domain containing 8"
                     /db_xref="GeneID:70650"
                     /db_xref="MGI:MGI:1917900"
     exon            1..322
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..2244
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /note="TRAMP-like complex RNA-binding factor ZCCHC8"
                     /codon_start=1
                     /product="zinc finger CCHC domain-containing protein 8"
                     /protein_id="NP_081770.3"
                     /db_xref="CCDS:CCDS80406.1"
                     /db_xref="GeneID:70650"
                     /db_xref="MGI:MGI:1917900"
                     /translation="MAAGVDFGDLELFEAFDPPEESTPKPVHTRFKDDEEEEDDDDDE
                     NGVGDAELQEQLRRCEATIEQLRAENQELKRKLNILTRPSGILVSNTKIDGPLLQILF
                     MNNAISKQYHQEIEEFVSNLVKRFEEQQKNDVEKTSFSLLPQPSSVMLEEDHKVEESC
                     AVKNNKEAFSVVGSVLYFTNFCLDKLGQPLLNENPQLTEGWEIPKYQQVFSHIVPLEG
                     QEMQVKAKRPKPHCFNCGSEEHQMKECPMPRNAARISEKRKEYMDACGEASGQSFQQR
                     YHAEEVEERFGRFKPGVISEELQDALGVTDKSLPPFIYRMRQLGYPPGWLKEAELENS
                     GLALYDGNDDADGETETGEIQNKNVTYDLSKLVNYPGFNISTPRGIPDEWRMFGSIPM
                     QACQQKDVFASYLNSNIQSPSMRSSGKRSSSQSSPNSPKKQRKEGSAAASPADMELDS
                     DVEIPPGSQSSKAFQFQPPLPPGTPPPLPQGTPPPLFTPPLPKGTPPLTPSDSPQARP
                     AASAMDEDALTLEELEEQQRQIWAALQQAEGGNGDSDVPGDTPLTGNSVASSPCPNEF
                     DLPVPEGKALEKPVLAEPQEPAASVDTAGPEPSCSPAAGAAVLSQREEEAAAEGGPGD
                     ALLDNGGVLNMNMSNGSNQQPIHPDSRPPMAPKTHSPVPDMSKFATGITPFEFENMAE
                     STGMYLRIRNLLKNSPRNQQKNKKTCE"
     exon            323..365
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            366..440
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            441..546
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            547..624
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            625..728
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            729..794
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            795..855
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            856..998
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1141
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1260
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1347
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1465
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..4286
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2765..2770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2790
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /note="major polyA site"
     regulatory      2800..2805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2825
                     /gene="Zcchc8"
                     /gene_synonym="5730565F05Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggacccgcc cctagacggc tttggaggcc tgtgtgtgga gaaaagcctc cagggagagc
       61 ggctctggcc tccaaccttc gccccctgcc ctccaagctt tcccacagcc caagatggcg
      121 gccggtgtgg attttggcga cctagagctc ttcgaggcgt ttgacccacc agaggagtcg
      181 acgccgaagc ccgttcacac ccggttcaag gacgacgagg aggaagagga cgacgacgac
      241 gacgagaacg gggtgggcga tgcggagctg caggagcagc tccggcgctg cgaggccacc
      301 atcgagcagc tccgcgccga gaatcaagaa cttaaaagaa agttgaacat tctgacaaga
      361 cccagtggta tactggtgag caatactaag atagatggac cgttactaca aattctattt
      421 atgaacaatg ctatctcaaa gcaataccac caagaaatag aggagtttgt atcaaactta
      481 gtaaaacgat ttgaggaaca gcaaaaaaat gacgtggaaa agacttcctt cagcctttta
      541 ccccagccgt ccagtgttat gttggaagag gaccataaag tggaagaatc atgtgccgtt
      601 aaaaacaaca aggaagcttt tagtgttgta ggaagtgtcc tgtattttac taatttttgc
      661 cttgataaat tggggcaacc gctactaaat gaaaaccctc agcttacgga aggatgggaa
      721 atacccaagt accagcaagt cttcagccac attgttcctc tagaagggca agagatgcaa
      781 gtgaaggcaa aaaggccaaa gcctcactgt ttcaactgtg gttctgaaga gcatcagatg
      841 aaggaatgcc caatgcctcg gaatgctgct cggatcagtg agaagaggaa agagtacatg
      901 gatgcctgtg gcgaggccag cggccagagc ttccagcagc gctatcatgc cgaagaagta
      961 gaagagagat ttggaagatt caagccagga gttattagtg aggaacttca agatgcactg
     1021 ggtgtgacag acaagagtct tccccctttc atctaccgga tgcgccagct gggctaccca
     1081 ccgggctggc tcaaggaggc tgaactggag aattctggac ttgcactcta tgatggaaac
     1141 gatgacgctg atggggaaac agaaactgga gaaatacaga ataaaaatgt cacctacgat
     1201 ctctcaaaat tggtaaacta tccaggtttt aatatatcta ctcccagagg tattccagat
     1261 gaatggagaa tgttcggttc cataccaatg caggcgtgtc aacagaagga tgtgtttgcc
     1321 agttacctta attctaacat ccagtcgccg agtatgagat ctagcggcaa gcggtcttcc
     1381 tcgcagtcca gccctaacag tccaaagaag cagcgaaagg agggcagtgc ggcggcctcc
     1441 cctgccgaca tggagctaga ctcagatgta gagattccac ctggttctca gagcagcaaa
     1501 gcatttcagt tccaaccacc gttgcctccc ggaacaccgc ctccactccc acagggaact
     1561 cccccgcctc tcttcacccc tccactccct aagggaaccc caccactgac tcccagtgac
     1621 tcaccccagg cccgacccgc agcctcagcc atggatgagg atgccctgac gctggaggag
     1681 ctggaagagc agcagaggca gatctgggcg gctctccagc aggccgaggg agggaatggc
     1741 gactcagatg ttcctggaga cacaccttta actgggaact cagtggcctc ctccccgtgt
     1801 ccaaacgagt ttgacctccc tgtccccgaa ggaaaggccc tggaaaagcc agtgctggct
     1861 gagccccagg aaccagctgc ttctgtagac acagctggac ccgagccatc ctgcagccca
     1921 gcagcagggg cagcagtgct ctctcagaga gaagaggaag ctgctgctga ggggggcccg
     1981 ggagatgctc ttctcgacaa tggcggtgtg ttgaacatga acatgagcaa tgggagcaac
     2041 cagcagccca ttcacccgga cagccggcct ccgatggccc caaaaaccca tagcccagta
     2101 cctgacatga gcaagtttgc cactggaata acaccctttg aatttgagaa catggctgaa
     2161 tccactggaa tgtacctcag gataagaaac ctgttgaaga attcaccccg aaatcagcag
     2221 aaaaacaaaa agacttgtga gtgagccctg gctgcgtggt gatgtgcagc tctgattgtc
     2281 ccaccagcct gaggccaggt gacccgtttg tccctcccac ctttcagaat ctggtgtaat
     2341 tgtgatctcg agtcaaggct gttttacaga atgaaagact gggtgtgagt ttgttctttt
     2401 cttctcactg acagcaaccc agagtttgcg tgcgggagct ggttcaggga tgcttggtcc
     2461 gggttagact atttttggat cgtgagtgtc tgtcaagagt gaagggtttt tttttttaat
     2521 gtcttttgta aattgttttc cctttctaca ttttgctatt atcctgtata tataagctta
     2581 atatatcact ttttaaagaa aattctaaca attttaaatt cacatttcaa tttcaacaac
     2641 caaatgagaa caatcaggga tcggcagctt gctcctgctt gctcggggta tttttgtaag
     2701 attttcatgc atgattttaa taacactttt actttttgta atttaattat tcaaatatgc
     2761 ttccaataaa ggtgtgctca cctttgtgta cagaggttta ataaattagt tttcttacac
     2821 atgaaccaag acttgggtag atatgactca cagttcaaat tgttctttta aacttgaatg
     2881 aaaattatga ggttgcaaag aaactgcatg tttggctgct gtaagtggat tccagcctta
     2941 catatactaa tatagaaaca aaattgttta attactttgg gcaattactt tgcacatgat
     3001 aatattgtgg cttccagctg gaaggtagac agacacatac tgagtgtgac tgtcctatgc
     3061 aagctggagc ctggtctggt tctctggctg ggcactctta agtctctgcc aggtcaagtt
     3121 ctggaacact tggagatctt gaataaccgc tcaggtagtg ttaagctgct cccaggccag
     3181 cagagggcgc aaaagggaat tggtccagat ttcagtgaca ctggagtagt ccaatttgcc
     3241 catttataat cagtacaggg agggatggtc agctgctttg tcacctgagt cttcagtgca
     3301 ttcttcaggg ttcgcatggt gctgtgactt gtggaagcag cagccttcct agcaggcctg
     3361 ccatgaggaa gggggttcct ggaggcctgg aggagataag gggtcctgtc aacattaaac
     3421 atgttttctc ctctctcact gttctttctt ccgagatagg ttattgctgt gtagcctagg
     3481 ctggccttac tcacagtctt cctgatactg cctactgctg agattacagg caagatgaca
     3541 tggttctttt taaaaaaaca aacatttatt tatgggggtt ggcggacatt cctcagcgtg
     3601 gatgttagaa gacagtgtgt ggtgtccacg tgttgttctc tcatcaatgt gtgtcttcat
     3661 caagcacctt tacccagtga gccagctcac cagcctgaag atgacatgga attctctcgt
     3721 cttccagatc cctgatcaca ggtgtgcact gccagtcctg ggggctaagg atccaaccca
     3781 gagcactgtc tgtctgtctg tgccaggcaa gcactaccaa ctacatatgt gtgtgccagg
     3841 caagcactac caactacata tgtgtgtgtg ccaggcaagc actaccaact acactgcctc
     3901 cccagcccca gtgatgtgac tatggaagtc ttagctgatc tacatcagaa gttattattt
     3961 agctctgtct ggtgtcttag acctgaaatc ctagcagttg ggtggcaggc tggaggatca
     4021 ggaccagcct tggttatata gcaaggttag ttagcctgag ctacaatgtg atactgcttc
     4081 agggggaaaa aagttttcct ttaaatattg tattgctggt atctgctgaa tattgaaata
     4141 attatttcca gcacatacag actctattaa ggtataaatt ataccatttt tcctttattg
     4201 ggtaggtatt gcctcttctt ttttgctttt ttttttttaa acaaatgtct aagacataga
     4261 taattgtaaa taaattcaga tctctt
//
