LOCUS       NM_175126               2837 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus zinc finger, CCHC domain containing 3 (Zcchc3), mRNA.
ACCESSION   NM_175126
VERSION     NM_175126.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2837)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2837)
  AUTHORS   Zang,R., Lian,H., Zhong,X., Yang,Q. and Shu,H.B.
  TITLE     ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment
            of TRIF to TLR3
  JOURNAL   J Mol Cell Biol 12 (4), 251-262 (2020)
   PUBMED   32133501
  REMARK    GeneRIF: ZCCHC3 modulates TLR3-mediated signaling by promoting
            recruitment of TRIF to TLR3.
REFERENCE   3  (bases 1 to 2837)
  AUTHORS   Lian,H., Zang,R., Wei,J., Ye,W., Hu,M.M., Chen,Y.D., Zhang,X.N.,
            Guo,Y., Lei,C.Q., Yang,Q., Luo,W.W., Li,S. and Shu,H.B.
  TITLE     The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA
            Sensing and Activation of the RIG-I-like Receptors
  JOURNAL   Immunity 49 (3), 438-448 (2018)
   PUBMED   30193849
  REMARK    GeneRIF: this study shows that the Zinc-Finger protein ZCCHC3 binds
            RNA and facilitates viral RNA sensing and activation of the
            RIG-I-like receptors
REFERENCE   4  (bases 1 to 2837)
  AUTHORS   Lian,H., Wei,J., Zang,R., Ye,W., Yang,Q., Zhang,X.N., Chen,Y.D.,
            Fu,Y.Z., Hu,M.M., Lei,C.Q., Luo,W.W., Li,S. and Shu,H.B.
  TITLE     ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate
            immune response
  JOURNAL   Nat Commun 9 (1), 3349 (2018)
   PUBMED   30135424
  REMARK    GeneRIF: ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in
            innate immune response
            Erratum:[Nat Commun. 2021 Sep 14;12(1):5526. doi:
            10.1038/s41467-021-25397-7.. PMID: 34521835]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2837)
  AUTHORS   Takasato,M., Osafune,K., Matsumoto,Y., Kataoka,Y., Yoshida,N.,
            Meguro,H., Aburatani,H., Asashima,M. and Nishinakamura,R.
  TITLE     Identification of kidney mesenchymal genes by a combination of
            microarray analysis and Sall1-GFP knockin mice
  JOURNAL   Mech Dev 121 (6), 547-557 (2004)
   PUBMED   15172686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928568.17.
            
            On Jan 12, 2022 this sequence version replaced NM_175126.4.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC055755.1, AK053859.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2837              AL928568.17        86035-88871         c
FEATURES             Location/Qualifiers
     source          1..2837
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.98 cM"
     gene            1..2837
                     /gene="Zcchc3"
                     /gene_synonym="2810406K24Rik"
                     /note="zinc finger, CCHC domain containing 3"
                     /db_xref="GeneID:67917"
                     /db_xref="MGI:MGI:1915167"
     exon            1..2837
                     /gene="Zcchc3"
                     /gene_synonym="2810406K24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1217
                     /gene="Zcchc3"
                     /gene_synonym="2810406K24Rik"
                     /codon_start=1
                     /product="zinc finger CCHC domain-containing protein 3"
                     /protein_id="NP_780335.1"
                     /db_xref="CCDS:CCDS16884.1"
                     /db_xref="GeneID:67917"
                     /db_xref="MGI:MGI:1915167"
                     /translation="MATGGGAEEESQRGRPQLPLPARPVARVEEPEGVREKMGWAQVV
                     KNLAEKKGDFREPRRRDETGSGASGGLGSPGGLATPNPGDFPPAARGDPKGRRRDPTG
                     EASDAYRKKSASGAGDPSRRKKAEVTAAMATPARPGTTEDATERPLQDEPPAAGPGKG
                     RFLVRICFQGDESACPTRDFVVGALILRSIGMDPDDIYAVIQIPGSREFDVSFRSAEK
                     LALFLRVYEEKRELEDCWENFVVLGRSRSSLKTLFILFRNETVDVEDIVTWLKRHCDV
                     LAVPVKVTDRFGIWTGEYKCEIELRQGEGGVRHLPGAFFLGAERGYSWYKGQPKTCFK
                     CGSRTHMSGTCTQDRCFRCGEEGHLSPYCRKVIVCNLCGKRGHAFAQCPKAVHNSVTA
                     QLTSVAGH"
     regulatory      2817..2822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zcchc3"
                     /gene_synonym="2810406K24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2837
                     /gene="Zcchc3"
                     /gene_synonym="2810406K24Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggaaagagg taacatggcc accggcggcg gagcggagga ggagtcacag cggggccggc
       61 ctcagctccc gctccccgcg cgacccgtgg cccgcgtcga ggaacccgag ggcgtccgcg
      121 agaagatggg ctgggcccag gtggtcaaga acctggcgga gaagaagggc gacttccgcg
      181 agccgcggcg gcgcgacgaa actggcagcg gtgcaagtgg cgggctcggc agccccgggg
      241 gcctggccac cccgaacccc ggcgacttcc cacccgccgc tcgcggggac ccaaagggcc
      301 gccgcagaga ccctacgggt gaggcgtcag acgcttacag gaaaaagagc gcgagcggcg
      361 cgggagaccc gagtcgaagg aagaaggccg aggtgacggc ggccatggcg acccccgcca
      421 ggcccggcac gaccgaagat gccaccgagc gaccgctcca ggacgagcca ccggctgccg
      481 gcccgggtaa gggccgcttc ctcgtgcgca tctgtttcca gggagacgaa agtgcctgtc
      541 cgacccggga cttcgtggtg ggcgcgctca tcctgcgctc catcggcatg gaccctgacg
      601 acatctacgc ggtcattcag atccccggca gccgcgagtt cgacgtgagt ttccgatccg
      661 ccgaaaagct agccctgttt ctccgcgtct acgaggagaa gcgagagctg gaggactgct
      721 gggagaactt tgtggttttg gggcggagca ggtccagcct gaagaccctc ttcatcctct
      781 tccggaacga gaccgtggac gtggaggaca tcgtgacctg gctcaagcgc cactgcgacg
      841 tgctggccgt gcccgtgaaa gtgaccgaca ggttcgggat ctggaccggg gagtacaagt
      901 gcgagatcga gctgcgccag ggggagggcg gagtgaggca cctgcccggg gccttcttct
      961 tgggagcgga gaggggctac agctggtaca aggggcagcc caagacgtgc tttaagtgtg
     1021 gttcccggac ccacatgagc ggcacctgca cgcaggacag gtgtttcagg tgcggggaag
     1081 aggggcacct gagcccttac tgccggaagg tcatcgtgtg caacctctgt ggcaaaagag
     1141 gacacgcctt tgcccagtgt cccaaagcag ttcacaattc cgtgacagct cagctcacca
     1201 gcgtggcggg gcactgaagg cgcgactgcc tgccagggtg aatacactgc cagcttaccc
     1261 ctcccttaag tgccaaaact ttttttttaa cctttttttt tttaatcgtt ttgaatggag
     1321 atatttctaa aacctaccag agacgttctc tctatgcctt ttttaaaccg cgtgtgctcc
     1381 tttttggcat gtttgaaatg gtgaattttt gcccgtaaga actattcaga accattgcat
     1441 acagatatat tttttttctc ccggtttgta tttgtttttg gtactttcgt ctactcccct
     1501 ccccactcta ctttttattt tactacctcc ctcctcatac atttaatcct taaaaggttt
     1561 tagccctttg ggccgccttg gtcattatgc ctccagccca gggtactggg cccaacgcgg
     1621 gatagacact cttatcaagt ctttcattga atcaaaacgg tatcgactgg cttctgtcaa
     1681 aagtgtctac cttttgcaac tctctgctgg gcccttttta tttgctgctt ctctgtggta
     1741 tcagactttg tgaaaacagt gttgctagaa gtgtgtattc tgaataagct ctgaatggtg
     1801 gccaagggcc tctcgtggca aaaaaaaaaa aaaaaaaaaa tgtccctcca ttgtgacagc
     1861 tccatgtggt ggctaagaag ccgagtttct acaagatcac agagcctagg cttccctgct
     1921 ggaaaagacc caagaggtgg tttttgttga gtttgggagg cgggttgctt ttggttttgt
     1981 gttttgagac agggtctcag tgtgtctccc gtaggccggc ttggaccggc tgcattcaga
     2041 gaacaggcta gctgcaaacg tgcagtaact ctccctcccg actcttgcct ttgcctcccc
     2101 ggacggtgtt ttaaactaac cttttggttt tccagcagat aaagtgaacc cagagaagtt
     2161 aaattacagg gacaaagtac acagcgcggt gcctcagata gcccacagta gagtcccctg
     2221 accccaagcc cggtgctcat cccactacct ctcacacttc acaacaatct cctcgacact
     2281 gctgggccca aagtccgctc tccaccgtgc ggaccccagc agtgtggaga aatcatcccg
     2341 aaagagccca gaaagctcgc cctgctgctt gggagctagg gaaggaaggg gccaggagca
     2401 ctccaggctg cttgcatcag ccctcggagt accacatctt gaatgttcca gggccatccc
     2461 tttccactat cactgtcacc agtgagaaac ggttcccctc agtaaagaaa cttagcagac
     2521 gtttacattt gcacctctgc ctcagccact aggaacccta gagaagctca cccacaacgt
     2581 ttaacctctg accctcagga gaaaggtggt tctaacccag aatcacgagt gagtggtaaa
     2641 ccagaaagcg ttcttgggga aacaggccag gccaggccag ggcctgggtc aatgacatgt
     2701 caccaagtta gcttgaaatt cgataaactg cttttcttca gctgttgtct tctctttgct
     2761 gttttgctat ttcctcgtgg cttagaatgt aaaatcaatt gttaagattt gttctgaata
     2821 aatatttatc tttcgta
//
