LOCUS       NM_153160               2162 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger, CCHC domain containing 17 (Zcchc17),
            transcript variant 1, mRNA.
ACCESSION   NM_153160 XM_925767
VERSION     NM_153160.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2162)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2162)
  AUTHORS   Lin,Y.M., Chu,P.H., Li,Y.Z. and Ouyang,P.
  TITLE     Ribosomal protein pNO40 mediates nucleolar sequestration of SR
            family splicing factors and its overexpression impairs mRNA
            metabolism
  JOURNAL   Cell Signal 32, 12-23 (2017)
   PUBMED   28069438
  REMARK    GeneRIF: pNO40 may function as a general recruiter for nucleolar
            association of SR proteins and regulation of its expression may be
            crucial in cellular homeostasis.
REFERENCE   3  (bases 1 to 2162)
  AUTHORS   Lin,Y.M., Wu,C.C., Chang,Y.C., Wu,C.H., Ho,H.L., Hu,J.W.,
            Chang,R.C., Wang,C.T. and Ouyang,P.
  TITLE     Target disruption of ribosomal protein pNO40 accelerates aging and
            impairs osteogenic differentiation of mesenchymal stem cells
  JOURNAL   Biochem Biophys Res Commun 469 (4), 903-910 (2016)
   PUBMED   26721440
  REMARK    GeneRIF: We herein established a mouse model of MSC aging through
            pNO40-targeted depletion and demonstrated the effects of loss of
            pNO40 on bone homeostasis.
REFERENCE   4  (bases 1 to 2162)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2162)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   6  (bases 1 to 2162)
  AUTHORS   Chang,W.L., Lee,D.C., Leu,S., Huang,Y.M., Lu,M.C. and Ouyang,P.
  TITLE     Molecular characterization of a novel nucleolar protein, pNO40
  JOURNAL   Biochem Biophys Res Commun 307 (3), 569-577 (2003)
   PUBMED   12893261
  REMARK    GeneRIF: molecular cloning and characterization; it is localized to
            nucleoli of diverse cultured cells, with some concentration in the
            granular component of nucleoli
REFERENCE   7  (bases 1 to 2162)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2162)
  AUTHORS   Gueydan,C., Wauquier,C., De Mees,C., Huez,G. and Kruys,V.
  TITLE     Identification of ribosomal proteins specific to higher eukaryotic
            organisms
  JOURNAL   J Biol Chem 277 (47), 45034-45040 (2002)
   PUBMED   12202495
  REMARK    GeneRIF: These observations indicate that PS1D is the first
            eukaryotic ribosomal protein that is specific to higher eukaryotes.
REFERENCE   9  (bases 1 to 2162)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY127571.1, AK152289.1 and AK168912.1.
            
            On Sep 15, 2017 this sequence version replaced NM_153160.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168912.1, AK012953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BY127571.1         1-49
            50-1460             AK152289.1         2-1412
            1461-2162           AK168912.1         1413-2114
FEATURES             Location/Qualifiers
     source          1..2162
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.43 cM"
     gene            1..2162
                     /gene="Zcchc17"
                     /gene_synonym="2810055E05Rik; HSPC251; LDC4; pNO40; pS1D"
                     /note="zinc finger, CCHC domain containing 17"
                     /db_xref="GeneID:619605"
                     /db_xref="MGI:MGI:1919955"
     exon            1..117
                     /gene="Zcchc17"
                     /gene_synonym="2810055E05Rik; HSPC251; LDC4; pNO40; pS1D"
                     /inference="alignment:Splign:2.1.0"
     exon            118..238
                     /gene="Zcchc17"
                     /gene_synonym="2810055E05Rik; HSPC251; LDC4; pNO40; pS1D"
                     /inference="alignment:Splign:2.1.0"
     exon            239..296
                     /gene="Zcchc17"
                     /gene_synonym="2810055E05Rik; HSPC251; LDC4; pNO40; pS1D"
                     /inference="alignment:Splign:2.1.0"
     exon            297..397
                     /gene="Zcchc17"
                     /gene_synonym="2810055E05Rik; HSPC251; LDC4; pNO40; pS1D"
                     /inference="alignment:Splign:2.1.0"
     exon            398..489
                     /gene="Zcchc17"
                     /gene_synonym="2810055E05Rik; HSPC251; LDC4; pNO40; pS1D"
                     /inference="alignment:Splign:2.1.0"
     exon            490..590
                     /gene="Zcchc17"
                     /gene_synonym="2810055E05Rik; HSPC251; LDC4; pNO40; pS1D"
                     /inference="alignment:Splign:2.1.0"
     exon            591..736
                     /gene="Zcchc17"
                     /gene_synonym="2810055E05Rik; HSPC251; LDC4; pNO40; pS1D"
                     /inference="alignment:Splign:2.1.0"
     exon            737..2162
                     /gene="Zcchc17"
                     /gene_synonym="2810055E05Rik; HSPC251; LDC4; pNO40; pS1D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1428..1433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zcchc17"
                     /gene_synonym="2810055E05Rik; HSPC251; LDC4; pNO40; pS1D"
                     /note="hexamer: CATAAA"
     polyA_site      1466
                     /gene="Zcchc17"
                     /gene_synonym="2810055E05Rik; HSPC251; LDC4; pNO40; pS1D"
     regulatory      1620..1625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zcchc17"
                     /gene_synonym="2810055E05Rik; HSPC251; LDC4; pNO40; pS1D"
                     /note="hexamer: CATAAA"
     polyA_site      1643
                     /gene="Zcchc17"
                     /gene_synonym="2810055E05Rik; HSPC251; LDC4; pNO40; pS1D"
                     /note="major polyA site"
ORIGIN      
        1 ggagctggcg ttctcccccg ccccctcggg cgcgcagtgc atcgtgggtg agaacgagcg
       61 gagcaggttt ggcgttccta gctatgaagc ggctgtcctg ctaggcgcgg acgcggagac
      121 gtttgaatta gctttagcag aagagagatg gaggagccat agactgttaa ggatgaattc
      181 aggaaggcct gagaccatgg agaacttgcc tgcactgtat actatttttc aaggagaggt
      241 tgctatggtg acagactatg gagcttttat caaaatccca ggctgtcgga agcaaggtct
      301 ggtccatcga actcacatgt cgtcctgtcg agtggataag ccttctgaga tagtagatgt
      361 tggagacaaa gtgtgggtga agctgattgg ccgagagatg aaaaatgata gaataaaagt
      421 gtccctctcc atgaaagttg tcaaccaagg aactgggaaa gacctcgatc ccaacaacgt
      481 tgtcattgag caagaagaga ggcgcagacg gtccttccag gattacactg ggcagaagat
      541 cacccttgag gccgtcctga acacgacctg caagaagtgt ggctgcaaag gccactttgc
      601 caaggactgt ttcatgcagc caggtggaac caagtattct ctgatccctg aagaggaaga
      661 ggaaaaagag gaggcaaagg cagaaggact tgagaagcct gatcccacga agaattcttc
      721 caggaagaga aagaaggaaa agaagaaaaa gaaacataga gacaggaagt catctgactg
      781 tgatagctct gactctgaga gtgacacggg caagaaggcg aggcattcat caaaagacag
      841 caaggccacc aagaagaaaa agaagaagaa gaagcacaag aagaagcaca aggaatgagg
      901 atggaacagg ccgcggcagc cctgactcct gcaaagactc actagtgaga gtgtggcctg
      961 cctcctaccc agacttgtcc ccatggtctc agatggcttc tccccctgca gcaagcagat
     1021 tggggcccca cagggcccct cccaacatga ttttcccttg ttgctcctga ccctttgcaa
     1081 gcgacccctg cagccattgc attcatgcgc tcagtgtctt catttcagca gaaggttcta
     1141 gtcccaaccg gctgccactg cccgagctgg agtcctctgc aggagtccat gctggagccc
     1201 cgggtgctgc tgtggagggg agcctggccg tgagagagag agcagcccca acctgcctgc
     1261 tgtctgcggt ggctgtgggt ggactctgcg gcctccatcc cctcagccag ggcctgtact
     1321 ccagtgactg ctgaaccaga gatttgcagc cacggtcatt gctctgcttc ctgtctgtca
     1381 cagtgtgagt gactggttcc atttcaagcc tctgcttaaa ctcctggcat aaatggaaat
     1441 gtgtttggtt ttaaactttc caaaaaggct ttattcctat aatccttcct gggcgactta
     1501 cagacttaac acattagttc acagaaaaca cttactatgt tatccaagac cctggaaaga
     1561 ggccaagccg aggcacaaag ccaaggccac cagcaggtca cagctttctt gagattactc
     1621 ataaaccttc tcttccatag tgatgaccgc tttcccttgt atttgtaacc ctggggactt
     1681 gctgggcatg agtgggcgac tcttagcagt cacctcccac cacagttgtt cacacctgga
     1741 ccttgatgtc ctgagcctgt actctagaga gagggtgacc acagcacacc atacagcaaa
     1801 tccaggaatg tctgtgcagg atgaatgtga aatagccaca cagtgacagc cagctgctct
     1861 gccatgggca ggccagtgta agggcttgca tagatgctag aatgacagct agcttctctg
     1921 agccttggca ggtcagtgta agggtattac ataggtgcta ctgttcccta actgagcctt
     1981 gagcctgtcc actcggctcc ttgacagtgc tgcttcccag gtgacctata ggccttcatt
     2041 tcaacctgac acacaggaaa ggaggaccaa agacagacaa ctgggtggcc ttggttctgc
     2101 tttattgacc ttggagcacc ctttggatac agttttaaaa aataaaccac atacatagta
     2161 gg
//
