LOCUS       NM_001358476            2155 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus zinc finger, CCHC domain containing 12 (Zcchc12),
            transcript variant 2, mRNA.
ACCESSION   NM_001358476 XM_006541395
VERSION     NM_001358476.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2155)
  AUTHORS   Xing,L., Simon,J.M., Ptacek,T.S., Yi,J.J., Loo,L., Mao,H.,
            Wolter,J.M., McCoy,E.S., Paranjape,S.R., Taylor-Blake,B. and
            Zylka,M.J.
  TITLE     Autism-linked UBE3A gain-of-function mutation causes interneuron
            and behavioral phenotypes when inherited maternally or paternally
            in mice
  JOURNAL   Cell Rep 42 (7), 112706 (2023)
   PUBMED   37389991
REFERENCE   2  (bases 1 to 2155)
  AUTHORS   Munz,M., Bharioke,A., Kosche,G., Moreno-Juan,V., Brignall,A.,
            Rodrigues,T.M., Graff-Meyer,A., Ulmer,T., Haeuselmann,S.,
            Pavlinic,D., Ledergerber,N., Gross-Scherf,B., Rozsa,B., Krol,J.,
            Picelli,S., Cowan,C.S. and Roska,B.
  TITLE     Pyramidal neurons form active, transient, multilayered circuits
            perturbed by autism-associated mutations at the inception of
            neocortex
  JOURNAL   Cell 186 (9), 1930-1949 (2023)
   PUBMED   37071993
REFERENCE   3  (bases 1 to 2155)
  AUTHORS   Moreau,M.X., Saillour,Y., Cwetsch,A.W., Pierani,A. and Causeret,F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (bases 1 to 2155)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2155)
  AUTHORS   Zhang,Z., Wei,S., Du,H., Su,Z., Wen,Y., Shang,Z., Song,X., Xu,Z.,
            You,Y. and Yang,Z.
  TITLE     Zfhx3 is required for the differentiation of late born D1-type
            medium spiny neurons
  JOURNAL   Exp Neurol 322, 113055 (2019)
   PUBMED   31491374
REFERENCE   6  (bases 1 to 2155)
  AUTHORS   Cho,G., Lim,Y. and Golden,J.A.
  TITLE     SUMO interaction motifs in Sizn1 are required for promyelocytic
            leukemia protein nuclear body localization and for transcriptional
            activation
  JOURNAL   J Biol Chem 284 (29), 19592-19600 (2009)
   PUBMED   19416967
REFERENCE   7  (bases 1 to 2155)
  AUTHORS   Li,H., Liu,Q., Hu,X., Feng,D., Xiang,S., He,Z., Hu,X., Zhou,J.,
            Ding,X., Zhou,C. and Zhang,J.
  TITLE     Human ZCCHC12 activates AP-1 and CREB signaling as a
            transcriptional co-activator
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 41 (7), 535-544 (2009)
   PUBMED   19578717
  REMARK    GeneRIF: ZCCHC12 enhanced the transcriptional activities of
            activator protein 1 (AP-1) and cAMP response element binding
            protein (CREB) as a coactivator
REFERENCE   8  (bases 1 to 2155)
  AUTHORS   Cho,G., Lim,Y., Zand,D. and Golden,J.A.
  TITLE     Sizn1 is a novel protein that functions as a transcriptional
            coactivator of bone morphogenic protein signaling
  JOURNAL   Mol Cell Biol 28 (5), 1565-1572 (2008)
   PUBMED   18160706
REFERENCE   9  (bases 1 to 2155)
  AUTHORS   Muhlfriedel,S., Kirsch,F., Gruss,P., Chowdhury,K. and Stoykova,A.
  TITLE     Novel genes differentially expressed in cortical regions during
            late neurogenesis
  JOURNAL   Eur J Neurosci 26 (1), 33-50 (2007)
   PUBMED   17614941
REFERENCE   10 (bases 1 to 2155)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL512597.11, BY099102.1 and AI846160.1.
            
            On Dec 1, 2017 this sequence version replaced XM_006541395.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.15887.1,
                                           SRR7345562.3052780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AL512597.11        61332-61368
            38-401              BY099102.1         1-364
            402-2139            AL512597.11        62854-64591
            2140-2155           AI846160.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..2155
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 20.58 cM"
     gene            1..2155
                     /gene="Zcchc12"
                     /gene_synonym="2810028A01Rik; Sizn1"
                     /note="zinc finger, CCHC domain containing 12"
                     /db_xref="GeneID:72693"
                     /db_xref="MGI:MGI:1919943"
     exon            1..109
                     /gene="Zcchc12"
                     /gene_synonym="2810028A01Rik; Sizn1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..168
                     /gene="Zcchc12"
                     /gene_synonym="2810028A01Rik; Sizn1"
                     /inference="alignment:Splign:2.1.0"
     exon            169..296
                     /gene="Zcchc12"
                     /gene_synonym="2810028A01Rik; Sizn1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..2140
                     /gene="Zcchc12"
                     /gene_synonym="2810028A01Rik; Sizn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..1616
                     /gene="Zcchc12"
                     /gene_synonym="2810028A01Rik; Sizn1"
                     /note="smad-interacting zinc finger protein 1"
                     /codon_start=1
                     /product="zinc finger CCHC domain-containing protein 12"
                     /protein_id="NP_001345405.1"
                     /db_xref="CCDS:CCDS30058.1"
                     /db_xref="GeneID:72693"
                     /db_xref="MGI:MGI:1919943"
                     /translation="MASILSRLGSSRGQNSPLPPWAHSMLRSLGRSLGPLMASMAERN
                     MRLFSGRAEPAQGEETFENWLSQVTGVLPDWHMPEEEKVRRLMRTLRGPAREVMRLLQ
                     AANPGLDVEDFLRAMKLVFGESESSVTAHSKFVNTVQEHGEKPSLYVIRLEVQLQNAI
                     QAGVFAEREANQARLHQLLVGAEMSTDLRFRLKNLLRVYANEPERLPNFLELIRMIRE
                     EEEWEETFINPKRPRRAESVMERALSPMAFQSSPPIMISSIDCNVIEIDDSPDDSDED
                     VILVEPEDPPLPSSSASSFLGRAVSEDQVLVIESPNIFEIQAPSTSSGAGRKNNRGFG
                     ELRRARKRKHTIHCSHCGEEGHSKETCDNESDKGQVFENLIITLQELTHAEERARGAP
                     GEPIGLSEPQ"
     regulatory      2105..2110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zcchc12"
                     /gene_synonym="2810028A01Rik; Sizn1"
                     /note="hexamer: AATAAA"
     polyA_site      2134
                     /gene="Zcchc12"
                     /gene_synonym="2810028A01Rik; Sizn1"
                     /note="major polyA site"
ORIGIN      
        1 tgattggctc cgctggccag ctcgtcacac tcttttgtgt cagtaggctg ctgataaaag
       61 ctttgcagct gccttggaaa ctgcgctatt cgaatccggt tacctgtggt agcagcccat
      121 caaagcggaa tctgaacttg aatttggtgc agctggttgt agagctggtc ttgagcatca
      181 ggatctgaga cccccagtcg atcgaggtcc atcaactgga ccctggaggc aggctttctc
      241 acgggaggga ggacacaggt tgcagaagct ggaaatactc cagtttccca gctgatcccc
      301 ctactgagat tggagactgc tgcactgctg aagataaagc gtttttgttt tgtttctaaa
      361 acgccttgaa cttcgtgtat taagatatcc tatcactgct gtcagacatg gctagcatcc
      421 tttcacgttt gggtagcagc cgggggcaga actcacccct gccaccttgg gctcattcca
      481 tgctgagatc cctggggagg agtcttggcc ctttaatggc cagcatggca gagagaaaca
      541 tgaggttgtt ctctgggagg gcagagccag cccaggggga agaaaccttt gaaaactggc
      601 tgagccaagt aactggggtg ctgcctgatt ggcatatgcc tgaggaggaa aaggtcagac
      661 gtctaatgag aacccttaga ggccctgccc gcgaggtcat gcgtttgctc caagctgcca
      721 atcctggcct agatgtagag gattttttgc gggcgatgaa actggtcttt ggggagtctg
      781 agagcagtgt gacagcccat agtaaatttg ttaacactgt tcaggaacat ggagagaaac
      841 catccctgta tgtgatccgt ttagaggtgc agctgcagaa tgctatccag gcaggggtgt
      901 ttgctgagag agaggcaaac caggctcgcc tgcatcagct cctggtagga gctgagatga
      961 gtacagacct tcgattcagg cttaagaatc ttctccgggt atatgcaaat gagccagagc
     1021 gccttcccaa tttcctagag ttaatcagga tgataaggga ggaagaggaa tgggaggaga
     1081 cttttattaa tccaaagcgg cccagaagag ccgagtcagt gatggagagg gcactcagcc
     1141 ctatggcatt tcagagctcc ccaccaataa tgatcagcag tatcgactgc aatgtgatcg
     1201 agatagatga ctctcctgat gattcggatg aggatgtgat cttggtggag cctgaggacc
     1261 caccactgcc atcctcaagt gcctcttcct tcctaggcag ggctgtatct gaggaccaag
     1321 tgctggtcat tgagtcccca aacatttttg agatccaggc tccttccact agcagtggtg
     1381 ctgggagaaa gaacaatcgg ggttttgggg agctgcgtag agccaggaag cgcaaacata
     1441 cgatccattg ttcccactgt ggtgaggagg gccactcaaa agaaacctgt gacaatgaga
     1501 gtgacaaggg ccaggttttt gagaatctga tcatcaccct gcaggagctg acacatgcag
     1561 aggagagggc aaggggggcc cctggtgaac ccattggcct atctgaacca cagtaagatg
     1621 cgactcccca gccttaaatt aacccttacc cgtattaaat gtttaacggt ggaaaagttg
     1681 tggggacaga tttctaattg catgaacaaa tccacaaagt ggctttcttt gggggtggag
     1741 aaagggtccc gaataccagt acagtaaaga gaggtggcct gacctatgat cgtgttccca
     1801 ttccccactg cttaacagtc tattttctgt gtgaacctct ctccttggtg gctttgttct
     1861 ctttgtgaaa gtggtattgt tcattgttca atcttcaagt aagaaaatta ttaaaaagta
     1921 caaattaccc agacctctct accttgtgaa acaattgtca gccctttggt gcctatcctt
     1981 ctaaatattt ctctatatct gtgttcctag attagaaata tgtatagacg aaagtgatca
     2041 aatagaagtg ttgttctata tgctgtattt tttcaccaaa acgtatgttg tggccttctt
     2101 tgtcaataaa tatatacata tatgtcagca tctactttaa aaaaaaaaaa aaaaa
//
