LOCUS       NM_001003916            2236 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus zinc finger, C4H2 domain containing (Zc4h2),
            transcript variant 1, mRNA.
ACCESSION   NM_001003916 XM_141965
VERSION     NM_001003916.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2236)
  AUTHORS   Zhu,L., Zhang,L., Cha,J., Li,C. and Mao,B.
  TITLE     Loss of ZC4H2, an Arthrogryposis Multiplex Congenita Associated
            Gene, Promotes Osteoclastogenesis in Mice
  JOURNAL   Genes (Basel) 15 (9), 1134 (2024)
   PUBMED   39336725
  REMARK    GeneRIF: Loss of ZC4H2, an Arthrogryposis Multiplex Congenita
            Associated Gene, Promotes Osteoclastogenesis in Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2236)
  AUTHORS   Zhang,L., Ye,M., Zhu,L., Cha,J., Li,C., Yao,Y.G. and Mao,B.
  TITLE     Loss of ZC4H2 and RNF220 Inhibits Neural Stem Cell Proliferation
            and Promotes Neuronal Differentiation
  JOURNAL   Cells 9 (7), 1600 (2020)
   PUBMED   32630355
  REMARK    GeneRIF: Loss of ZC4H2 and RNF220 Inhibits Neural Stem Cell
            Proliferation and Promotes Neuronal Differentiation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2236)
  AUTHORS   Ma,P., Song,N.N., Cheng,X., Zhu,L., Zhang,Q., Zhang,L.L., Yang,X.,
            Wang,H., Kong,Q., Shi,D., Ding,Y.Q. and Mao,B.
  TITLE     ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through
            modulating Shh/Gli signaling
  JOURNAL   J Mol Cell Biol 12 (5), 337-344 (2020)
   PUBMED   31336385
  REMARK    GeneRIF: ZC4H2 stabilizes RNF220 to pattern ventral spinal cord
            through modulating Shh/Gli signaling.
REFERENCE   4  (bases 1 to 2236)
  AUTHORS   Song,N.N., Ma,P., Zhang,Q., Zhang,L., Wang,H., Zhang,L., Zhu,L.,
            He,C.H., Mao,B. and Ding,Y.Q.
  TITLE     Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for
            noradrenergic neuron development
  JOURNAL   Development 147 (6) (2020)
   PUBMED   32094113
  REMARK    GeneRIF: Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is
            required for noradrenergic neuron development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2236)
  AUTHORS   Ma,P., Song,N.N., Li,Y., Zhang,Q., Zhang,L., Zhang,L., Kong,Q.,
            Ma,L., Yang,X., Ren,B., Li,C., Zhao,X., Li,Y., Xu,Y., Gao,X.,
            Ding,Y.Q. and Mao,B.
  TITLE     Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic
            Ubiquitination during Neural Patterning
  JOURNAL   Cell Rep 28 (2), 541-553 (2019)
   PUBMED   31291587
REFERENCE   6  (bases 1 to 2236)
  AUTHORS   Kim,J., Choi,T.I., Park,S., Kim,M.H., Kim,C.H. and Lee,S.
  TITLE     Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains
  JOURNAL   Development 145 (17) (2018)
   PUBMED   30177510
  REMARK    GeneRIF: RNF220 interacts with, and is co-expressed with, a
            zinc-finger protein ZC4H2, and they cooperate to degrade Dbx1/2 and
            Nkx2.2. Co-expression of RNF220 and ZC4H2 further promotes the
            ability of Nkx6.1 to induce ectopic Chx10+ V2 interneurons.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2236)
  AUTHORS   Ma,P., Ren,B., Yang,X., Sun,B., Liu,X., Kong,Q., Li,C. and Mao,B.
  TITLE     ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved
            in neural development in Xenopus
  JOURNAL   Open Biol 7 (8) (2017)
   PUBMED   28814648
  REMARK    GeneRIF: Results demonstrate that ZC4H2 promotes BMP signaling and
            is involved in BMP regulated myogenic and osteogenic
            differentiation of mouse myoblast cells.
REFERENCE   8  (bases 1 to 2236)
  AUTHORS   Hirata,H., Nanda,I., van Riesen,A., McMichael,G., Hu,H.,
            Hambrock,M., Papon,M.A., Fischer,U., Marouillat,S., Ding,C.,
            Alirol,S., Bienek,M., Preisler-Adams,S., Grimme,A., Seelow,D.,
            Webster,R., Haan,E., MacLennan,A., Stenzel,W., Yap,T.Y.,
            Gardner,A., Nguyen,L.S., Shaw,M., Lebrun,N., Haas,S.A., Kress,W.,
            Haaf,T., Schellenberger,E., Chelly,J., Viot,G., Shaffer,L.G.,
            Rosenfeld,J.A., Kramer,N., Falk,R., El-Khechen,D., Escobar,L.F.,
            Hennekam,R., Wieacker,P., Hubner,C., Ropers,H.H., Gecz,J.,
            Schuelke,M., Laumonnier,F. and Kalscheuer,V.M.
  TITLE     ZC4H2 mutations are associated with arthrogryposis multiplex
            congenita and intellectual disability through impairment of central
            and peripheral synaptic plasticity
  JOURNAL   Am J Hum Genet 92 (5), 681-695 (2013)
   PUBMED   23623388
  REMARK    GeneRIF: In mouse primary hippocampal neurons, transiently produced
            ZC4H2 localized to the postsynaptic compartment of excitatory
            synapses, and the altered protein influenced dendritic spine
            density.
REFERENCE   9  (bases 1 to 2236)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY200912.1, BC079862.1 and AI844550.1.
            
            On Jan 25, 2014 this sequence version replaced NM_001003916.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155445.1, BC079862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                BY200912.1         1-77
            78-2221             BC079862.1         1-2144
            2222-2236           AI844550.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..2236
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 41.99 cM"
     gene            1..2236
                     /gene="Zc4h2"
                     /gene_synonym="Gm372; mKIAA1166"
                     /note="zinc finger, C4H2 domain containing"
                     /db_xref="GeneID:245522"
                     /db_xref="MGI:MGI:2679294"
     exon            1..258
                     /gene="Zc4h2"
                     /gene_synonym="Gm372; mKIAA1166"
                     /inference="alignment:Splign:2.1.0"
     exon            259..430
                     /gene="Zc4h2"
                     /gene_synonym="Gm372; mKIAA1166"
                     /inference="alignment:Splign:2.1.0"
     exon            431..603
                     /gene="Zc4h2"
                     /gene_synonym="Gm372; mKIAA1166"
                     /inference="alignment:Splign:2.1.0"
     exon            604..766
                     /gene="Zc4h2"
                     /gene_synonym="Gm372; mKIAA1166"
                     /inference="alignment:Splign:2.1.0"
     exon            767..2225
                     /gene="Zc4h2"
                     /gene_synonym="Gm372; mKIAA1166"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2200..2205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zc4h2"
                     /gene_synonym="Gm372; mKIAA1166"
                     /note="hexamer: AATAAA"
     polyA_site      2225
                     /gene="Zc4h2"
                     /gene_synonym="Gm372; mKIAA1166"
                     /note="major polyA site"
ORIGIN      
        1 ggagttgtag ttctagaggc acccgggttg cctggctggc cccggaactg tggactacag
       61 ctcccaggcc ttctctaagc ccttaccaca caggctcaaa gccacaaacc agtaggaggt
      121 ggctgtattg tatctattgt atgccttggc tggtgcattt ttttttttaa acaattccct
      181 ggacgtgaaa ttgagagtga aaagcatggc agatgaacaa gaaatcatgt gcaaattgga
      241 aagcattaaa gagatcagga acaagactct gcagatggaa aagatcaagg cccgtttgaa
      301 ggctgagttc gaggctctgg agtctgaaga gaggcacctg aaagaataca aacaggagat
      361 ggatctcctg ctacaggaga agatggccca tgtggaggaa ctccgactca tccatgctga
      421 tatcaatgtg atggaaaaca ccattaaaca gtctgaaaat gacttaaaca agctgctgga
      481 gtcaacccgg aggcttcatg atgagtataa accactgaaa gaacacgtgg atgccctgcg
      541 catgacattg ggcctgcaaa ggcttcctga cctgtgtgaa gaggaagaga aactctcctt
      601 ggattacttt gagaagcaga aagcagaatg gcagactgaa cctcaagaac cccccatacc
      661 tgaatccctt gctgctgcag ctgctgctgc tcaacaactc caggtggcca ggaagcagga
      721 cacaaggcag acagccacct tcaggcagca gcctccacct atgaaggcct gtttgtcatg
      781 tcaccaacag attcatcgaa atgcacctat atgccctctt tgcaaagcca agagtcggtc
      841 acggaacccc aaaaagccaa aacggaagca agatgaatga agagaaggtg gagggataga
      901 cctctgttgg tcgtaaagcc tctctttggt cagagtgata gatgttctga ttttttttta
      961 atatcccttc cttatcccta ctgagtcttc tatttaattt gctggaagaa taaccccttt
     1021 ctccttgctc ttatttcttt ctgctcttgg aagttgtggt ttaagaccag ctgtgctttg
     1081 ggtgctaatc actgggactc atgacccctt ctctcctagt cacatttctc ttactgcccc
     1141 agtttggaac tgaatgaggg ggtaaaaggc cctagttgat actttctttt gttcctgagg
     1201 actggagtct aatgagctgt agggtgtaaa gactggagga gctccatgcc ttgctttgga
     1261 aaaaggcttc agtgatttcc ttccctctgt ttttgccttg ggttctgcag ggacaactac
     1321 tttatttttg ctgtacttcc taatgggctg atgcatatat ctttctcaat attcaggtca
     1381 tcattaaaat ctaggggtaa cttagacaag tgttcctttt atataaaatt gtgaggccct
     1441 ggtgttattc tatagttcca ctcaagtctt ccagttatac tgaagttctt acataccaga
     1501 cagggcatct tcagaatcgc aagatctgtg gatctttctc catacttgta ttatttgcaa
     1561 atcagtagac atttcctact gtgaaattag ggaccaagac ccatgccaca agagtcacct
     1621 agttcactgc ctaaaatact gggtcttatt gctgtggtat aggaattgtc ttagactgag
     1681 gaaccctaag tgaactttaa ctttgaattt tgttcaaacc cattacctga tcagtggtct
     1741 atcattctga ggatagaaag ggacatagtg ttatatgaat gccaatcatt ttatacatgt
     1801 aagtaggtag gacttttgct tttctattct ttcctccttt tgtcttttat gaggtagcgt
     1861 cagttaagga cagttggtca ctccttttct gtgggttatg taggtgacct ttcttccaca
     1921 aataaaagac acttaagctc tccatgcccc acatctcatt cctttatcaa aggtaagcct
     1981 cctagtcatg tcttagatct acaggctgaa atctagagct gactgatgaa aaagaattag
     2041 ctccaggact ctatccctgc caggggagaa gagggagcta tttatcctat ttttctttaa
     2101 cttttgtttt atgttaacat attatatctt caaaacatca atgattcctc tgccttttga
     2161 aagtaaaact gttatgatat gatttcataa atccttttaa ataaatgttc atttgttgga
     2221 ataaaaaaaa aaaaaa
//
